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Association between neuroticism and amygdala responsivity emerges under stressful conditions
Open accessAbstract
Increased amygdala reactivity in response to salient stimuli is seen in patients with affective disorders, in healthy subjects at risk for these disorders, and in stressed individuals, making it a prime target for mechanistic studies into the pathophysiology of affective disorders. However, whereas individual differences in neuroticism are thought to modulate the effect of stress on mental health, the mechanistic link between stress, neuroticism and amygdala responsivity is unknown. Thus, we studied the relationship between experimentally induced stress, individual differences in neuroticism, and amygdala responsivity. To this end, fearful and happy faces were presented to a large cohort of young, healthy males (n=120) in two separate functional MRI sessions (stress versus control) in a randomized, controlled cross-over design. We revealed that amygdala reactivity was modulated by an interaction between the factors of stress, neuroticism, and the emotional valence of the facial stimuli. Follow-up analysis showed that neuroticism selectively enhanced amygdala responses to fearful faces in the stress condition. Thus, we show that stress unmasks an association between neuroticism and amygdala responsivity to potentially threatening stimuli. This effect constitutes a possible mechanistic link within the complex pathophysiology of affective disorders, and our novel approach appears suitable for further studies targeting the underlying mechanisms.
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“The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP)26 is a cognitive-behavioral intervention designed to address neuroticism, which has been considered a predictor of depressive and anxiety disorders.27-30”
From Improved quality of life and reduced depressive symptoms in medical students after a single-session intervention (2020) · cites this paper as [28]
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Metadata
- Authors
- Everaerd, D., Klumpers, F., van Wingen, G., Tendolkar, I., & Fernández, G.
- Affiliations
- Radboud University Nijmegen (NL)
- Corresponding author
- Everaerd, Daphne
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 112
- Pages
- 218-224
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2055314272
- Cited by
- 115
- References
- 57
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 50 · 2019: 7 · 2018: 5 · 2017: 10 · 2016: 7 · 2015: 6
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Netherlands Organization for Scientific Research (918.66.613)
- Radboud University Medical Center
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- neuroticism, stress, individual differences, emotional valence, fearful faces, happy faces, mood disorders, threat detection
- MeSH terms
- Neuroticism, Adolescent, Adult, Amygdala, Anxiety Disorders, Emotions, Facial Expression, Fear, Hemodynamics, Humans, Hydrocortisone, Individuality, Magnetic Resonance Imaging, Male, Photic Stimulation, Stress, Psychological, Cohort Studies, Cross-Over Studies, Young Adult, Healthy Volunteers
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