Risk for depression and neural responses to fearful facial expressions of emotion
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Background: Depression is associated with neural abnormalities in emotional processing. Aims: This study explored whether these abnormalities underlie risk for depression. Method: We compared the neural responses of volunteers who were at high and low-risk for the development of depression (by virtue of high and low neuroticism scores; high-N group and low-N group respectively) during the presentation of fearful and happy faces using functional magnetic resonance imaging (fMRI). Results: The high-N group demonstrated linear increases in response in the right fusiform gyrus and left middle temporal gyrus to expressions of increasing fear, whereas the low-N group demonstrated the opposite effect. The high-N group also displayed greater responses in the right amygdala, cerebellum, left middle frontal and bilateral parietal gyri to medium levels of fearful v. happy expressions. Conclusions: Risk for depression is associated with enhanced neural responses to fearful facial expressions similar to those observed in acute depression.
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People vulnerable to depression via the personality trait of neuroticism show enhanced amygdala responses to fearful faces.
“Similarly, people vulnerable to depression via the personality trait of neuroticism show enhanced amygdala responses to fearful faces (Chan et al., 2009), disrupted coupling of amygdala and ACC in response to emotional faces (Cremers et al., 2010) and abnormal patterns of ACC response during categorisation and memory of negative words (Chan et al., 2008).”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Chan et al., 2009
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- Authors
- Chan, S. W. Y., Norbury, R., Goodwin, G. M., & Harmer, C. J.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Harmer, Catherine J.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2009-02
- Volume
- 194
- Issue
- 2
- Pages
- 139-145
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2132797873
- Cited by
- 117
- References
- 49
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 1 · 2021: 8 · 2020: 2 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 12 · 2012: 9
- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Eli Lilly and Company
- AstraZeneca
- Sanofi
- Stanley Medical Research Institute
- University of Oxford
- Eisai
- Servier
- H. Lundbeck A/S (P1vital)
- Medical Research Council
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- depression risk, neuroticism, fearful faces, emotional face processing, amygdala, fusiform gyrus, middle temporal gyrus, cerebellum
- MeSH terms
- Adolescent, Adult, Amygdala, Cerebral Cortex, Depressive Disorder, Emotions, Facial Expression, Fear, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Pattern Recognition, Visual, Personality Assessment, Risk Factors, Young Adult
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