Dynamic causal modelling of EEG and fMRI to characterize network architectures in a simple motor task
Open accessAbstract
Dynamic causal modelling (DCM) has extended the understanding of brain network dynamics in a variety of functional systems. In the motor system, DCM studies based on functional magnetic resonance imaging (fMRI) or on magneto-/electroencephalography (M/EEG) have demonstrated movement-related causal information flow from secondary to primary motor areas and have provided evidence for nonlinear cross-frequency interactions among motor areas. The present study sought to investigate to what extent fMRI- and EEG-based DCM might provide complementary and synergistic insights into neuronal network dynamics. Both modalities share principal similarities in the formulation of the DCM. Thus, we hypothesized that DCM based on induced EEG responses (DCM-IR) and on fMRI would reveal congruent task-dependent network dynamics. Brain electrical (63-channel surface EEG) and Blood Oxygenation Level Dependent (BOLD) signals were recorded in separate sessions from 14 healthy participants performing simple isometric right and left hand grips. DCM-IR and DCM-fMRI were used to estimate coupling parameters modulated by right and left hand grips within a core motor network of six regions comprising bilateral primary motor cortex (M1), ventral premotor cortex (PMv) and supplementary motor area (SMA). We found that DCM-fMRI and DCM-IR similarly revealed significant grip-related increases in facilitatory coupling between SMA and M1 contralateral to the active hand. A grip-dependent interhemispheric reciprocal inhibition between M1 bilaterally was only revealed by DCM-fMRI but not by DCM-IR. Frequency-resolved coupling analysis showed that the information flow from contralateral SMA to M1 was predominantly a linear alpha-to-alpha (9-13Hz) interaction. We also detected some cross-frequency coupling from SMA to contralateral M1, i.e., between lower beta (14-21Hz) at the SMA and higher beta (22-30Hz) at M1 during right hand grip and between alpha (9-13Hz) at SMA and lower beta (14-21Hz) at M1 during left hand grip. In conclusion, the strategy of informing EEG source-space configurations with fMRI-derived coordinates, cross-validating basic connectivity maps and analysing frequency coding allows for deeper insight into the motor network architecture of the human brain. The present results provide evidence for the robustness of non-invasively measured causal information flow from secondary motor areas such as SMA towards M1 and further contribute to the validation of the methodological approach of multimodal DCM to explore human network dynamics.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Interhemispheric connections may be difficult to identify robustly in source-level EEG.
“interhemispheric connections may be difficult to identify robustly in source-level EEG36”
From Deviations in effective connectivity explain different hallucination subtypes in Parkinson's disease psychosis (2026) · cites this paper as [36]
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Oostenveld, R., Fries, P., Maris, E., & Schoffelen, J.-M. (2011) · Computational Intelligence and Neuroscience · doi:10.1155/2011/156869 · Cited by 10,323 · see citing works
Ashburner, J., & Friston, K. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.018 · Cited by 7,507 · see citing works
Event-related EEG/MEG synchronization and desynchronization: basic principles
Pfurtscheller, G., & Lopes da Silva, F. H. (1999) · Clinical Neurophysiology · doi:10.1016/s1388-2457(99)00141-8 · Cited by 7,328 · see citing works
Neuronal Oscillations in Cortical Networks
Buzsáki, G., & Draguhn, A. (2004) · Science · doi:10.1126/science.1099745 · Cited by 6,576 · see citing works
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,542 · see citing works
The brainweb: phase synchronization and large-scale integration
Varela, F., Lachaux, J.-P., Rodriguez, E., & Martinerie, J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35067550 · Cited by 4,761 · see citing works
Friston, K. J., Harrison, L., & Penny, W. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00202-7 · Cited by 4,583 · see citing works
Event-Related fMRI: Characterizing Differential Responses
Friston, K. J., Fletcher, P. C., Josephs, O., Holmes, A., Rugg, M. D., & Turner, R. (1998) · NeuroImage · doi:10.1006/nimg.1997.0306 · Cited by 2,017 · see citing works
Localization of the motor hand area to a knob on the precentral gyrus. A new landmark
Yousry, T. A. (1997) · Brain · doi:10.1093/brain/120.1.141 · Cited by 1,840 · see citing works
Interhemispheric inhibition of the human motor cortex.
Ferbert, A., Priori, A., Rothwell, J. C., Day, B. L., Colebatch, J. G., & MARSDEN, C. D. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019243 · Cited by 1,490 · see citing works
The origin of corticospinal projections from the premotor areas in the frontal lobe
Dum, R., & Strick, P. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-03-00667.1991 · Cited by 1,447 · see citing works
Bayesian model selection for group studies
Stephan, K. E., Penny, W. D., Daunizeau, J., Moran, R. J., & Friston, K. J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.03.025 · Cited by 1,423 · see citing works
Picard, N., & Strick, P. L. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(01)00266-5 · Cited by 1,184 · see citing works
Simultaneous EEG and fMRI of the alpha rhythm
Goldman, R. I., Stern, J. M., Engel, J., & Cohen, M. S. (2002) · Neuroreport · doi:10.1097/00001756-200212200-00022 · Cited by 1,131 · see citing works
Localization of grasp representations in humans by PET: 1. Observation versus execution
Rizzolatti, G., Fadiga, L., Matelli, M., Bettinardi, V., Paulesu, E., Perani, D., & Fazio, F. (1996) · Experimental Brain Research · doi:10.1007/bf00227301 · Cited by 1,028 · see citing works
EEG-correlated fMRI of human alpha activity
Laufs, H., Kleinschmidt, A., Beyerle, A., Eger, E., Salek-Haddadi, A., Preibisch, C., & Krakow, K. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00286-6 · Cited by 1,025 · see citing works
Coupling Between Neuronal Firing, Field Potentials, and fMRI in Human Auditory Cortex
Mukamel, R., Gelbard, H., Arieli, A., Hasson, U., Fried, I., & Malach, R. (2005) · Science · doi:10.1126/science.1110913 · Cited by 1,023 · see citing works
Modeling Geometric Deformations in EPI Time Series
Andersson, J., Hutton, C., Ashburner, J., Turner, R., & Friston, K. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0746 · Cited by 1,004 · see citing works
Simultaneous EEG and fMRI of the alpha rhythm
Stern (2002) · Neuroreport · doi:10.1097/01.wnr.0000047685.08940.d0 · Cited by 945 · see citing works
Crone, N. E. (1998) · Brain · doi:10.1093/brain/121.12.2271 · Cited by 943 · see citing works
Conway, B. A., Halliday, D. M., Farmer, S. F., Shahani, U., Maas, P. M., Weir, A., & Rosenberg, J. R. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp021104 · Cited by 927 · see citing works
He, S., Dum, R. P., & Strick, P. L. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-00952.1993 · Cited by 873 · see citing works
Comparing dynamic causal models.
Penny, W. D., Stephan, K. E., Mechelli, A., & Friston, K. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.03.026 · Cited by 848 · see citing works
Ten simple rules for dynamic causal modeling
Stephan, K. E., Penny, W. D., Moran, R. J., den Ouden, H. E. M., Daunizeau, J., & Friston, K. J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.015 · Cited by 803 · see citing works
Corticocortical connections of area F3 (SMA‐proper) and area F6 (pre‐SMA) in the macaque monkey
Luppino, G., Matelli, M., Camarda, R., & Rizzolatti, G. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903380109 · Cited by 795 · see citing works
Comparing families of dynamic causal models
Penny, W. D., Stephan, K. E., Daunizeau, J., Rosa, M. J., Friston, K. J., Schofield, T. M., & Leff, A. P. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000709 · Cited by 688 · see citing works
Role for supplementary motor area cells in planning several movements ahead
Tanji, J., & Shima, K. (1994) · Nature · doi:10.1038/371413a0 · Cited by 683 · see citing works
Mushiake, H., Inase, M., & Tanji, J. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.3.705 · Cited by 680 · see citing works
Phase Synchrony among Neuronal Oscillations in the Human Cortex
Palva, J. M., Palva, S., & Kaila, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4250-04.2005 · Cited by 663 · see citing works
Synchronization of fast (30-40 Hz) spontaneous cortical rhythms during brain activation
Steriade, M., Amzica, F., & Contreras, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00392.1996 · Cited by 646 · see citing works
Temporal dynamics of cortical representation for action
Nishitani, N., & Hari, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.913 · Cited by 625 · see citing works
Cortical Activity in Precision- Versus Power-Grip Tasks: An fMRI Study
Ehrsson, H. H., Fagergren, A., Jonsson, T., Westling, G., Johansson, R. S., & Forssberg, H. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.1.528 · Cited by 619 · see citing works
Motor and cognitive functions of the ventral premotor cortex
Rizzolatti, G., Fogassi, L., & Gallese, V. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00308-2 · Cited by 592 · see citing works
Cortical connectivity after subcortical stroke assessed with functional magnetic resonance imaging
Grefkes, C., Nowak, D. A., Eickhoff, S. B., Dafotakis, M., Küst, J., Karbe, H., & Fink, G. R. (2007) · Annals of Neurology · doi:10.1002/ana.21228 · Cited by 575 · see citing works
Dum, R. P., & Strick, P. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3902-04.2005 · Cited by 568 · see citing works
Halsband, U., Ito, N., Tanji, J., & Freund, H. (1993) · Brain · doi:10.1093/brain/116.1.243 · Cited by 549 · see citing works
Cortical Control of Human Motoneuron Firing During Isometric Contraction
Salenius, S., Portin, K., Kajola, M., Salmelin, R. H., & Hari, R. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.6.3401 · Cited by 545 · see citing works
Srinivasan, R., Winter, W., Ding, J., & Nunez, P. L. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.06.026 · Cited by 538 · see citing works
Age-related changes in the neural correlates of motor performance
Ward, N. (2003) · Brain · doi:10.1093/brain/awg071 · Cited by 480 · see citing works
Intrinsic Coupling Modes: Multiscale Interactions in Ongoing Brain Activity
Engel, A. K., Gerloff, C., Hilgetag, C. C., & Nolte, G. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.038 · Cited by 471 · see citing works
Self-citationGerloff, C. P. (1998) · Brain · doi:10.1093/brain/121.8.1513 · Cited by 469 · see citing works
Self-citationTanji, J., Okano, K., & Sato, K. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.60.1.325 · Cited by 454 · see citing works
Monto, S., Palva, S., Voipio, J., & Palva, J. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1910-08.2008 · Cited by 453 · see citing works
Grefkes, C., Eickhoff, S. B., Nowak, D. A., Dafotakis, M., & Fink, G. R. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.048 · Cited by 436 · see citing works
Functional neuroimaging correlates of finger-tapping task variations: An ALE meta-analysis
Witt, S. T., Laird, A. R., & Meyerand, M. E. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.04.025 · Cited by 406 · see citing works
Rouiller, E. M., Babalian, A. L., Kazennikov, O. V., Moret, V., Yu, X.-H., & Wiesendanger, M. (1994) · Experimental Brain Research · doi:10.1007/bf00227511 · Cited by 392 · see citing works
Halliday, D. M., Conway, B. A., Farmer, S. F., & Rosenberg, J. R. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00964-6 · Cited by 386 · see citing works
EEG-vigilance and BOLD effect during simultaneous EEG/fMRI measurement
Olbrich, S., Mulert, C., Karch, S., Trenner, M. U., Leicht, G., Pogarell, O. M., & Hegerl, U. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.014 · Cited by 356 · see citing works
Shima, K., & Tanji, J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.4.2148 · Cited by 351 · see citing works
Deecke, L., & Kornhuber, H. H. (1978) · Brain Research · doi:10.1016/0006-8993(78)90561-9 · Cited by 347 · see citing works
Grefkes, C., Nowak, D. A., Wang, L. E., Dafotakis, M., Eickhoff, S. B., & Fink, G. R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.029 · Cited by 345 · see citing works
Dynamic causal modeling of cortical activity from the acute to the chronic stage after stroke
Rehme, A. K., Eickhoff, S. B., Wang, L. E., Fink, G. R., & Grefkes, C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.01.014 · Cited by 334 · see citing works
Gerloff, C. P. (1997) · Brain · doi:10.1093/brain/120.9.1587 · Cited by 329 · see citing works
Self-citationConcurrent EEG/fMRI analysis by multiway Partial Least Squares
Martínez‐Montes, E., Valdes-Sosa, P. A., Miwakeichi, F., Goldman, R. I., & Cohen, M. S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.03.038 · Cited by 327 · see citing works
Involvement of the ipsilateral motor cortex in finger movements of different complexities
Chen, R. E., Gerloff, C. P., Hallett, M., & Cohen, L. G. (1997) · Annals of Neurology · doi:10.1002/ana.410410216 · Cited by 323 · see citing works
Self-citationGroß, J., Tass, P. A., Salenius, S., Hari, R., Freund, H., & Schnitzler, A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00623.x · Cited by 298 · see citing works
Ehrsson, H. H., Fagergren, A., & Forssberg, H. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2613 · Cited by 293 · see citing works
Singh, K. D., Barnes, G. R., Hillebrand, A., Forde, E. M. E., & Williams, A. L. (2002) · NeuroImage · doi:10.1006/nimg.2001.1050 · Cited by 286 · see citing works
Yuan, H., Liu, T., Szarkowski, R., Rios, C., Ashe, J., & He, B. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.028 · Cited by 274 · see citing works
Effects of transcranial magnetic stimulation on ipsilateral muscles
Wassermann, E. M., Fuhr, P., Cohen, L. G., & Hallett, M. (1991) · Neurology · doi:10.1212/wnl.41.11.1795 · Cited by 271 · see citing works
Gerloff, C. P., Cohen, L. G., Floeter, M. K., Chen, R. E., Corwell, B., & Hallett, M. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.249bz.x · Cited by 264 · see citing works
Self-citationNeural synchrony within the motor system: what have we learned so far?
van Wijk, B. C. M., Beek, P. J., & Daffertshofer, A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00252 · Cited by 243 · see citing works
Tomaiuolo, F., MacDonald, J. D., Caramanos, Z., Posner, G., Chiavaras, M. M., Evans, A. C., & Petrides, M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00718.x · Cited by 234 · see citing works
Task-related coherence and task-related spectral power changes during sequential finger movements
Manganotti, P., Gerloff, C. P., Toro, C., Katsuta, H., Sadato, N., Zhuang, P., Leocani, L., & Hallett, M. (1998) · Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control · doi:10.1016/s0924-980x(97)00074-x · Cited by 233 · see citing works
Self-citationKurata, K. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.1.187 · Cited by 232 · see citing works
Kurata, K., & Hoffman, D. S. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.3.1151 · Cited by 216 · see citing works
EEG-fMRI; Physiological Basis, Technique, and Applications
Mulert, C., & Lemieux, L. (2010) · doi:10.1007/978-3-540-87919-0 · Cited by 211 · see citing works
Test–retest reliability of resting EEG spectra validates a statistical signature of persons
Näpflin, M., Wildi, M., & Sarnthein, J. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.07.022 · Cited by 196 · see citing works
Brookes, M. J., Gibson, A. M., Hall, S. D., Furlong, P. L., Barnes, G. R., Hillebrand, A., Singh, K. D., Holliday, I. E., Francis, S. T., & Morris, P. G. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.050 · Cited by 178 · see citing works
Analyzing event-related EEG data with multivariate autoregressive parameters
Schlögl, A., & Supp, G. G. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)59009-0 · Cited by 175 · see citing works
Beta-Range EEG-EMG Coherence With Isometric Compensation for Increasing Modulated Low-Level Forces
Chakarov, V., Naranjo, J. R., Schulte‐Mönting, J., Omlor, W., Huethe, F., & Kristeva, R. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91095.2008 · Cited by 166 · see citing works
Ohara, S., Mima, T., Baba, K., Ikeda, A., Kunieda, T., Matsumoto, R., Yamamoto, J., Matsuhashi, M., Nagamine, T., Hirasawa, K., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09377.2001 · Cited by 166 · see citing works
Brain symmetry and topographic analysis of lateralized event-related potentials
Oostenveld, R., Stegeman, D. F., Praamstra, P., & van Oosterom, A. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00059-2 · Cited by 155 · see citing works
Dynamic causal modelling of induced responses
Chen, C. C., Kiebel, S. J., & Friston, K. J. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.026 · Cited by 136 · see citing works
Noradrenergic Enhancement Improves Motor Network Connectivity in Stroke Patients
Wang, L. E., Fink, G. R., Diekhoff, S., Rehme, A., Eickhoff, S., & Grefkes, C. (2010) · Annals of Neurology · doi:10.1002/ana.22237 · Cited by 130 · see citing works
Handedness and effective connectivity of the motor system
Pool, E., Rehme, A. K., Fink, G. R., Eickhoff, S. B., & Grefkes, C. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.05.048 · Cited by 127 · see citing works
Phase synchronization between alpha and beta oscillations in the human electroencephalogram
Nikulin, V. V., & Brismar, T. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.031 · Cited by 117 · see citing works
Boussaoud, D., Tanné‐Gariépy, J., Wannier, T., & Rouiller, E. M. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-67 · Cited by 111 · see citing works
Modulation of human corticomuscular beta‐range coherence with low‐level static forces
Witte, M., Patino, L., Andrykiewicz, A., Hepp‐Reymond, M., & Kristeva, R. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05942.x · Cited by 110 · see citing works
Cortical activities associated with voluntary movements and involuntary movements.
Shibasaki, H. (2012) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.07.042 · Cited by 102 · see citing works
Nguyen, V. T., Breakspear, M. J., & Cunnington, R. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2571-14.2014 · Cited by 94 · see citing works
Differential force scaling of fine‐graded power grip force in the sensorimotor network
von Hartog-Keisker, B. V., Hepp‐Reymond, M., Blickenstorfer, A., Meyer, M. E., & Kollias, S. (2009) · Human Brain Mapping · doi:10.1002/hbm.20676 · Cited by 87 · see citing works
Daffertshofer, A., Peper, C. E., & Beek, P. J. (2005) · Biological Cybernetics · doi:10.1007/s00422-004-0539-6 · Cited by 84 · see citing works
Matelli, M., Rizzolatti, G., Bettinardi, V., Gilardi, M. C., Perani, D., Rizzo, G., & Fazio, F. (1993) · Neuroreport · doi:10.1097/00001756-199309150-00002 · Cited by 82 · see citing works
Gerloff, C. P., Braun, C., Staudt, M., Hegner, Y. L., DICHGANS, J., & Krägeloh‐Mann, I. (2006) · Human Brain Mapping · doi:10.1002/hbm.20220 · Cited by 79 · see citing works
Self-citationHerz, D. M., Siebner, H. R., Hulme, O. J., Florin, E., Christensen, M. S., & Timmermann, L. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.11.023 · Cited by 66 · see citing works
Fernández, T., Harmony, T., Rodrı́guez, M., Reyes, A., Marosi, E., & Bernal, J. (1993) · International Journal of Neuroscience · doi:10.3109/00207459308994280 · Cited by 66 · see citing works
A dynamic causal model for evoked and induced responses
Chen, C., Kiebel, S. J., Kilner, J. M., Ward, N., Stephan, K. E., Wang, W. J., & Friston, K. J. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.066 · Cited by 66 · see citing works
Age-related changes in causal interactions between cortical motor regions during hand grip
Boudrias, M., Gonçalves, C. S., Penny, W. D., Park, C.-H., Rossiter, H. E., Talelli, P., & Ward, N. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.025 · Cited by 65 · see citing works
Palva, J. M., & Palva, S. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00022-3 · Cited by 63 · see citing works
Nonlinear Coupling in the Human Motor System
Chen, C., Kilner, J. M., Friston, K. J., Kiebel, S. J., Jolly, R., & Ward, N. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1194-09.2010 · Cited by 62 · see citing works
Neely, K. A., Coombes, S. A., Planetta, P. J., & Vaillancourt, D. E. (2011) · Human Brain Mapping · doi:10.1002/hbm.21467 · Cited by 58 · see citing works
Herz, D. M., Christensen, M. S., Reck, C., Florin, E., Barbe, M. T., Stahlhut, C., Pauls, K. A. M., Tittgemeyer, M., Siebner, H. R., & Timmermann, L. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.042 · Cited by 56 · see citing works
Chella, F., Marzetti, L., Pizzella, V., Zappasodi, F., & Nolte, G. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.12.064 · Cited by 53 · see citing works
Yuan, H., Perdoni, C., Yang, L., & He, B. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5312-10.2011 · Cited by 52 · see citing works
Differential representation of dynamic and static power grip force in the sensorimotor network
von Hartog-Keisker, B. V., Hepp‐Reymond, M., Blickenstorfer, A., & Kollias, S. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07172.x · Cited by 51 · see citing works
van Wijk, B. C. M., Beek, P. J., & Daffertshofer, A. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08122.x · Cited by 48 · see citing works
The effects of 1 Hz rTMS over the hand area of M1 on movement kinematics of the ipsilateral hand
Dafotakis, M., Grefkes, C., Wang, L. E., Fink, G. R., & Nowak, D. A. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0064-1 · Cited by 38 · see citing works
Hari, R., Bourguignon, M., Piitulainen, H., Smeds, E., Tiège, X. D., & Jousmäki, V. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0171 · Cited by 38 · see citing works
Effect of Visual Feedback on Brain Activation During Motor Tasks: An fMRI Study
Noble, J. W., Eng, J. J., & Boyd, L. A. (2013) · Motor Control · doi:10.1123/mcj.17.3.298 · Cited by 33 · see citing works
Variability of the BOLD response over time: An examination of within-session differences
Menz, M. M., Neumann, J., Müller, K., & Zysset, S. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.06.003 · Cited by 32 · see citing works
White matter integrity of motor connections related to training gains in healthy aging
Schulz, R., Zimerman, M., Timmermann, J. E., Wessel, M. J., Gerloff, C. P., & Hummel, F. C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.024 · Cited by 32 · see citing works
Self-citationChen, S., Entakli, J., Bonnard, M., Berton, É., & Graaf, J. B. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060291 · Cited by 29 · see citing works
Bönstrup, M., Feldheim, J., Heise, K.-F., Gerloff, C. P., & Hummel, F. C. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12657 · Cited by 21 · see citing works
Self-citationDetecting change in BOLD signal between sessions for atlas-based anatomical ROIs
Buck, R. J., Singhal, H., Arora, J., Schlitt, H., & Constable, R. T. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.01.001 · Cited by 17 · see citing works
Principles of Multimodal Functional Imaging and Data Integration
Villringer, A., Mulert, C., & Lemieux, L. (2009) · Springer eBooks · doi:10.1007/978-3-540-87919-0_1 · Cited by 14 · see citing works
Chen, S., Entakli, J., Bonnard, M., Berton, É., & Graaf, J. B. D. (2013) · HAL · doi:10.1371/journal.pone.0060291.t001 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Methods for analysis of brain connectivity: An IFCN-sponsored review
Rossini, P. M., Iorio, R. D., Bentivoglio, M., Bertini, G., Ferreri, F., Gerloff, C. P., Ilmoniemi, R. J., Miraglia, F., Nitsche, M. A., Pestilli, F., et al. (2019) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.06.006 · Cited by 165 · see citing works
Self-citationHuman brain connectivity: Clinical applications for clinical neurophysiology
Hallett, M., de Haan, W., Deco, G., Dengler, R., Iorio, R. D., Galléa, C., Gerloff, C. P., Grefkes, C., Helmich, R. C. G., Kringelbach, M. L., et al. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2020.03.031 · Cited by 118 · see citing works
Self-citationAre unimanual movements bilateral?
Chettouf, S., Rueda‐Delgado, L. M., de Vries, R., Ritter, P., & Daffertshofer, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.002 · Cited by 73 · see citing works
Schulz, R., Buchholz, A., Frey, B. M., Bönstrup, M., Cheng, B., Thomalla, G., Hummel, F. C., & Gerloff, C. P. (2016) · Stroke · doi:10.1161/strokeaha.115.011641 · Cited by 66 · see citing works
Self-citationFunctional Integration and Segregation in Multiplex Brain Networks for Alzheimer's Disease
Cai, L., Wei, X., Liu, J., Zhu, L., Wang, J., Deng, B., Yu, H., & Wang, R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00051 · Cited by 61 · see citing works
Rashid, M. U., Singh, H., & Goyal, V. (2020) · Expert Systems · doi:10.1111/exsy.12644 · Cited by 64 · see citing works
Ageing changes effective connectivity of motor networks during bimanual finger coordination
Loehrer, P. A., Nettersheim, F. S., Jung, F., Weber, I., Huber, C. A., Dembek, T. A., Pelzer, E. A., Fink, G. R., Tittgemeyer, M., & Timmermann, L. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.09.014 · Cited by 58 · see citing works
Mash, L. E., Reiter, M. A., Linke, A. C., Townsend, J., & Müller, R. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22570 · Cited by 52 · see citing works
Predicting Motor Imagery Performance From Resting-State EEG Using Dynamic Causal Modeling
Lee, M., Yoon, J.-G., & Lee, S.-W. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00321 · Cited by 55 · see citing works
A survey of brain network analysis by electroencephalographic signals
Luo, C., Li, F., Li, P., Yi, C., Li, C., Tao, Q., Zhang, X., Si, Y., Yao, D., Yin, G., et al. (2021) · Cognitive Neurodynamics · doi:10.1007/s11571-021-09689-8 · Cited by 54 · see citing works
Parietofrontal network upregulation after motor stroke
Bönstrup, M., Schulz, R., Schön, G., Cheng, B., Feldheim, J., Thomalla, G., & Gerloff, C. P. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.03.006 · Cited by 49 · see citing works
Self-citationHinault, T., Larcher, K. M.-H., Zazubovits, N., Gotman, J., & Dagher, A. (2018) · Human Brain Mapping · doi:10.1002/hbm.24356 · Cited by 41 · see citing works
Empirical validation of directed functional connectivity
Mill, R. D., Bagic, A. I., Bostan, A. C., Schneider, W., & Cole, M. W. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.11.037 · Cited by 37 · see citing works
Nettersheim, F. S., Loehrer, P. A., Weber, I., Jung, F., Dembek, T. A., Pelzer, E. A., Dafsari, H. S., Huber, C. A., Tittgemeyer, M., & Timmermann, L. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.04.030 · Cited by 31 · see citing works
EEG emotion recognition using multichannel weighted multiscale permutation entropy
Wang, Z., Zhang, J., He, Y., & Zhang, J. (2022) · Applied Intelligence · doi:10.1007/s10489-021-03070-2 · Cited by 32 · see citing works
Moulton, E. J., Galléa, C., Kemlin, C., Valabrègue, R., Maier, M. A., Lindberg, P. G., & Rosso, C. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00511 · Cited by 32 · see citing works
Bechtold, L., Ghio, M., Lange, J., & Bellebaum, C. (2018) · Brain and Language · doi:10.1016/j.bandl.2018.01.004 · Cited by 29 · see citing works
Chen, C., Lee, S.-H., Wang, W.-J., Lin, Y.-C., & Su, M.-C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178822 · Cited by 29 · see citing works
Hinault, T., Larcher, K. M.-H., Bherer, L., Courtney, S. M., & Dagher, A. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.06.013 · Cited by 25 · see citing works
Lee, S., Park, Y., Jin, M. J., Lee, Y. J., & Hahn, S. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00148 · Cited by 24 · see citing works
Cortical signatures of precision grip force control in children, adolescents, and adults
Beck, M. M., Spedden, M. E., Dietz, M. J., Karabanov, A. N., Christensen, M. S., & Lundbye‐Jensen, J. (2021) · eLife · doi:10.7554/elife.61018 · Cited by 22 · see citing works
Ricci, G., Magosso, E., & Ursino, M. (2021) · Brain Sciences · doi:10.3390/brainsci11040487 · Cited by 20 · see citing works
Wilkins, K. B., Dewald, J., & Yao, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-64179-x · Cited by 15 · see citing works
Braaß, H., Feldheim, J. F., Chu, Y., Tinnermann, A., Finsterbusch, J., Büchel, C., Schulz, R., & Gerloff, C. P. (2023) · Human Brain Mapping · doi:10.1002/hbm.26523 · Cited by 17 · see citing works
Self-citationJoint Filter-Band-Combination and Multi-View CNN for Electroencephalogram Decoding
Fan, Z., Xi, X., Gao, Y., Wang, T., Fang, F. Z., Houston, M. J., Zhang, Y., Li, L., & Lu, Z. Y. (2023) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2023.3269055 · Cited by 18 · see citing works
Berger, A., Steinberg, F., Thomas, F., & Doppelmayr, M. M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.594810 · Cited by 18 · see citing works
Heise, K.-F., Rueda‐Delgado, L. M., Chalavi, S., King, B. R., Monteiro, T. S., Edden, R. A. E., Mantini, D., & Swinnen, S. P. (2022) · Communications Biology · doi:10.1038/s42003-022-03378-w · Cited by 15 · see citing works
Wilkins, K. B., & Yao, J. (2019) · bioRxiv · doi:10.1016/j.neuroimage.2019.116344 · Cited by 14 · see citing works
Zhang, C., Zhang, Z., Li, Y., Yi, Y. I. N., Feng, C., Wenfeng, Z. H. A. N., Fu, R., Yu, Q., Jiang, G., & Wang, C. (2024) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.24.08087-0 · Cited by 14 · see citing works
Dynamic Causal Modeling of the Cortical Responses to Wrist Perturbations
Yang, Y., Guliyev, B., & Schouten, A. C. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00518 · Cited by 13 · see citing works
Differentiating the Brain’s involvement in Executed and Imagined Stepping using fMRI
Kline, A. S., Pittman, D. J., Ronsky, J. L., & Goodyear, B. G. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112829 · Cited by 12 · see citing works
Collaborative neural processes predict successful cognitive‐motor performance
Chueh, T., Lu, C., Huang, C., Hatfield, B. D., & Hung, T. (2022) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14262 · Cited by 11 · see citing works
Cai, Z., Pellegrino, G., Lina, J., Benali, H., & Grova, C. (2022) · Human Brain Mapping · doi:10.1002/hbm.26107 · Cited by 8 · see citing works
Pugh, Z. H., Huang, J., Leshin, J. C., Lindquist, K. A., & Nam, C. S. (2022) · Cognitive Neurodynamics · doi:10.1007/s11571-022-09805-2 · Cited by 11 · see citing works
Oscillatory dynamics of motor learning across adulthood life span: a systematic review
Najafabadi, A. J., & Davoodi, E. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1646172 · Cited by 5 · see citing works
Connectivity study on resting-state EEG between motor imagery BCI-literate and BCI-illiterate groups
Park, H., & Jun, S. C. (2024) · Journal of Neural Engineering · doi:10.1088/1741-2552/ad6187 · Cited by 3 · see citing works
Changes in effective connectivity between motor and sensory regions in finger movement task
Ebrahiminia, F., & Hossein‐Zadeh, G. (2016) · National and International Iranian Conference on Biomedical Engineering (ICBME) · doi:10.1109/icbme.2016.7890965 · Cited by 3 · see citing works
Mohamed, A.-K., Aswat, M., & Aharonson, V. (2024) · Sensors · doi:10.3390/s24175801 · Cited by 2 · see citing works
A fast dynamic causal modeling regression method for fMRI
Wu, H., Hu, X., & Zeng, Y. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120954 · Cited by 2 · see citing works
A Review on the Functional Connectivity of the Human Opercular Cortex
Oane, I., Barborică, A., & Mı̂ndruță, I. (2026) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000001258 · Cited by 1 · see citing works
Nikouei, M., & Abdali-Mohammadi, F. (2023) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/10255842.2023.2244110 · Cited by 1 · see citing works
Krawinkel, L. A., Bönstrup, M., Feldheim, J. F., Schulz, R. J., Backhaus, W., Schneider, T. R., Misselhorn, J., Cheng, B., & Gerloff, C. P. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/529818 · Cited by 1 · see citing works
Self-citationHeise, K.-F., Rueda‐Delgado, L. M., Chalavi, S., King, B. R., Monteiro, T. S., Edden, R. A. E., Mantini, D., & Swinnen, S. P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.08.331637 · Cited by 1 · see citing works
Wilkins, K. B., Dewald, J., & Yao, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/547083 · Cited by 1 · see citing works
Vignando, M., Ffytche, D., Mazibuko, N., Palma, G., Bhat, A., Montagnese, M., Dave, S., Tai, Y. F., Batzu, L., Leta, V., et al. (2026) · Nature Mental Health · doi:10.1038/s44220-026-00669-7
“Nevertheless, we interpret this cautiously, as interhemi-spheric connections may be difficult to identify robustly in source-level EEG 36 , with the possibility of increasing model complexity without necessarily improving model evidence 21,22 .”
Chaudhuri, A., & Routray, A. (2016) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2016.7591625
Chaudhuri, A., & Routray, A. (2016) · European Signal Processing Conference (EUSIPCO) · doi:10.1109/eusipco.2016.7760463
Hybrid Active InferencePreprint
Ofner, A., & Stober, S. (2018) · arXiv (Cornell University) · doi:10.48550/arxiv.1810.02647
Krawinkel, L. A., Forisch, J., Feldheim, J. F., Backhaus, W., Quandt, F., & Gerloff, C. P. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/525584
Self-citationWang, Z., Zhang, J., Chen, L., He, Y., & Zhang, J. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4153708
Alpha, Beta, and Gamma Oscillations in Cortical Communication During Motor PreparationPreprint
Yun, Z., Wilkins, K. B., & Yao, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1486221/v1
Exploring connectivity of resting-state EEG between BCI-literate and -illiterate groupsPreprint
Park, H., & Jun, S. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.25.568691
Mohamed, A.-K., & Aharonson, V. (2025) · Biomimetics · doi:10.3390/biomimetics10030187
Autistic vs. Control Differences in MRI Scan Quality Across ABIDE-II Sites
Pinheiro, J., Afonso, B., Seiça, E. C., Gonçalves, R., Ribeiro, L., & Reis, J. (2026) · Diagnostics · doi:10.3390/diagnostics16101478
Rashnavadi, T., Sabaroedin, K., Wilson, W., Pittman, D. J., Federico, P., & LeVan, P. (2026) · Human Brain Mapping · doi:10.1002/hbm.70646
Multimodal EEG-fNIRS complexity analysis can reveal the neurovascular coupling change with aging
Lv, L., Liu, Z., Li, W., Zhai, F., Chen, R., & Zhu, Y. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1912923
- Authors
- Bönstrup, M., Schulz, R., Feldheim, J., Hummel, F. C., & Gerloff, C.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Gerloff, Christian
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 124
- Issue
- Pt A
- Pages
- 498-508
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1205325697
- Cited by
- 56
- References
- 107
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 6
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- German Research Foundation (SFB936, SFB 936-C1, SFB 936-C4)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- dynamic causal modeling, motor cortex, supplementary motor area, primary motor cortex, ventral premotor cortex, interhemispheric inhibition, cross-frequency coupling, alpha oscillations, beta oscillations, EEG-fMRI integration, brain network dynamics
- MeSH terms
- Adult, Alpha Rhythm, Bayes Theorem, Beta Rhythm, Brain Mapping, Electroencephalography, Female, Humans, Isometric Contraction, Magnetic Resonance Imaging, Male, Models, Neurological, Motor Activity, Motor Cortex, Neural Pathways, Hand Strength, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
