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Cited by 31Visual perception and processing mechanismsNeural dynamics and brain functionMemory Processes and Influences

Early cortical signals in visual stimulus detection

Open access
Kwon, Hunki, Kronemer, Sharif I., Christison-Lagay, Kate L., Khalaf, Aya, Li, Jiajia, Ding, Julia Z, Freedman, Noah C, Blumenfeld, Hal·2021·NeuroImage
DOI 10.1016/j.neuroimage.2021.118608
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Abstract

During visual conscious perception, the earliest responses linked to signal detection are little known. The current study aims to reveal the cortical neural activity changes in the earliest stages of conscious perception using recordings from intracranial electrodes. Epilepsy patients (N=158) were recruited from a multi-center collaboration and completed a visual word recall task. Broadband gamma activity (40-115Hz) was extracted with a band-pass filter and gamma power was calculated across subjects on a common brain surface. Our results show early gamma power increases within 0-50ms after stimulus onset in bilateral visual processing cortex, right frontal cortex (frontal eye fields, ventral medial/frontopolar, orbital frontal) and bilateral medial temporal cortex regardless of whether the word was later recalled. At the same early times, decreases were seen in the left rostral middle frontal gyrus. At later times after stimulus onset, gamma power changes developed in multiple cortical regions. These included sustained changes in visual and other association cortical networks, and transient decreases in the default mode network most prominently at 300-650ms. In agreement with prior work in this verbal memory task, we also saw greater increases in visual and medial temporal regions as well as prominent later (> 300ms) increases in left hemisphere language areas for recalled versus not recalled stimuli. These results suggest an early signal detection network in the frontal, medial temporal, and visual cortex is engaged at the earliest stages of conscious visual perception.

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  • The right middle frontal gyrus acts as a key hub for attention allocation and motor control, and its connectivity with the calcarine gyrus plays a crucial role in conscious visual perception.

    “The right middle frontal gyrus acts as a key hub for attention allocation and motor control,[29] and its connectivity with the calcarine gyrus plays a crucial role in conscious visual perception.[30]”

    From Brain Rewires to Stabilize Walking During Visual Impairment · cites this paper as [30]

    The citation [30] follows the claim about connectivity and conscious visual perception, so the earlier attention-and-motor-control clause is not assessed here. Section 4.1 reports early activity in right caudal middle frontal cortex during visual perception, and the Introduction discusses interactions between prefrontal and visual areas. Neither passage identifies connectivity with the calcarine gyrus or establishes that this specific connection plays a crucial role in conscious perception. (LLM, conf=0.82)

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  1. Kronemer, S.I. , Aksen, M. , Ding, J. , Ryu, J.H. , Xin, Q. , Ding, Z. , Prince, J.S. , Kwon, H. , Khalaf, A. , Forman, S. , Jin, D. , Wang, K. , Chen, K. , Hu, C. , Agarwal, A. , Sabirski, E. , Wafa, S.A. , Morgan, O. , Wu, J. , Christison-Lagay, K. , Hasulak, N. , Morrell, M. , Ur- ban, A. , Constable, R.T. , Pitts, M. , Richardson, R.M. , Crowley, M. , Blumenfeld, H. , 2021. Brain networks in human conscious visual perception. In review Submitted for publication .
  2. Li, R. , Ryu, J.H. , Vincent, P. , Springer, M. , Kluger, D. , Levinsohn, E.A. , Chen, Y. , Chen, H. , Blumenfeld, H. , 2021. A pulse of fMRI increases in subcortical arousal systems during transitions in attention. Neuroimage 232, 117873 .

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Authors
Kwon, H., Kronemer, S. I., Christison-Lagay, K. L., Khalaf, A., Li, J., Ding, J. Z., Freedman, N. C., & Blumenfeld, H.
Affiliations
  • Yale University (US)
  • Cairo University (EG)
  • Xi'an University of Architecture and Technology (CN)
Corresponding author
Blumenfeld, Hal
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2021-12
Volume
244
Pages
118608
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2021.118608
OpenAlex
W3200297002
Cited by
31
References
84
Citations by year
2026: 4 · 2025: 5 · 2024: 11 · 2023: 4 · 2022: 5 · 2021: 2
FWCI
2.89
Type
journal article
Language
en
Open access
Licence
Locations
  • NeuroImage (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
University of Pennsylvania
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
signal detection, verbal memory, medial temporal cortex, frontal eye field, default mode network, language areas, intracranial EEG, epilepsy patients
MeSH terms
Adolescent, Adult, Brain, Cerebral Cortex, Cognition, Consciousness, Electroencephalography, Epilepsy, Female, Frontal Lobe, Humans, Language, Male, Memory, Middle Aged, Mental Recall, Temporal Lobe, Visual Cortex, Visual Perception, Young Adult

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