Cited by 1,025Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsTreatment of Major Depression

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Shrinkage of Dendritic Spines Associated with Long-Term Depression of Hippocampal Synapses

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Zhou, Qiang, Homma, Koichi J., Poo, Mu-ming·2004·Neuron

DOI 10.1016/j.neuron.2004.11.011

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Abstract

Activity-induced modification of neuronal connections is essential for the development of the nervous system and may also underlie learning and memory functions of mature brain. Previous studies have shown an increase in dendritic spine density and/or enlargement of spines after the induction of long-term potentiation (LTP). Using two-photon time-lapse imaging of dendritic spines in acute hippocampal slices from neonatal rats, we found that the induction of long-term depression (LTD) by low-frequency stimulation is accompanied by a marked shrinkage of spines, which can be reversed by subsequent high-frequency stimulation that induces LTP. The spine shrinkage requires activation of NMDA receptors and calcineurin, similar to that for LTD. However, spine shrinkage is mediated by cofilin, but not by protein phosphatase 1 (PP1), which is essential for LTD, suggesting that different downstream pathways are involved in spine shrinkage and LTD. This activity-induced spine shrinkage may contribute to activity-dependent elimination of synaptic connections.

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Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.
Dudek, S. M., & Bear, M. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4363 · Cited by 1,708
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,412
Synaptic plasticity: LTP and LTD
Bear, M. F., & Malenka, R. C. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90101-5 · Cited by 1,355
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208
Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus
Mulkey, R. M., & Malenka, R. C. (1992) · Neuron · doi:10.1016/0896-6273(92)90248-c · Cited by 1,113
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083
Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics
Harris, K., & Stevens, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-08-02982.1989 · Cited by 1,073
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046

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Kim, J.-S., Lilliehöök, C., Dudak, A., Prox, J., Säftig, P., Federoff, H. J., & Seung Taik, L. I. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126649 · Cited by 53
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Burk, K., Ramachandran, B., Ahmed, S., Hurtado-Zavala, J. I., Awasthi, A., Benito, E., Faram, R., Ahmad, H., Swaminathan, A., McIlhinney, J., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx009 · Cited by 52
The synaptic cytoskeleton in development and disease
Goellner, B., & Aberle, H. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20892 · Cited by 52
The pathological interaction between diabetes and presymptomatic Alzheimer's disease
Burdo, J. R., Chen, Q., Calcutt, N. A., & Schubert, D. A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.02.010 · Cited by 53
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The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation
Morikawa, M., Tanaka, Y., Cho, H., Yoshihara, M., & Hirokawa, N. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.089 · Cited by 49
Morphological constraints on calcium dependent glutamate receptor trafficking into individual dendritic spine
Korkotian, E., & Segal, M. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.11.006 · Cited by 56
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Authors: Zhou, Q., Homma, K. J., & Poo, M.-M.
Affiliations: University of California, Berkeley (US)
Corresponding author: Poo, Mu-ming
ORCID: Zhou, Qiang
Homma, Koichi J.
Poo, Mu-ming
Venue: Neuron
Publisher: Elsevier BV
Published: 2004-12
Volume: 44
Issue: 5
Pages: 749-757
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2004.11.011
OpenAlex: W2107611011
Cited by: 1,025
References: 56
Citations by year: 2026: 17 · 2025: 30 · 2024: 29 · 2023: 24 · 2022: 35 · 2021: 49 · 2020: 55 · 2019: 45 · 2018: 55 · 2017: 43 · 2016: 44 · 2015: 54 · 2014: 64 · 2013: 54 · 2012: 58
FWCI: 14.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3150 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Institutional Repositories DataBase (IRDB) (submittedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (NS37831, R01NS036999, NS 36999, R01NS037831)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: long-term depression, long-term potentiation, hippocampal synapses, NMDA receptor, calcineurin, cofilin, protein phosphatase 1, synaptic plasticity, low-frequency stimulation, high-frequency stimulation
MeSH terms: Animals, Electrophysiology, Hippocampus, Microfilament Proteins, Synapses, Signal Transduction, Rats, Sprague-Dawley, Long-Term Synaptic Depression, Dendritic Spines, Actin Depolymerizing Factors, Rats, In Vitro Techniques

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Shrinkage of Dendritic Spines Associated with Long-Term Depression of Hippocampal Synapses

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