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Cited by 150Tactile and Sensory InteractionsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Experience-Dependent Adult Cortical Plasticity Requires Cognitive Association between Sensation and Reward

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Blake, David T., Heiser, Marc A., Caywood, Matthew, Merzenich, Michael M.·2006·Neuron
DOI 10.1016/j.neuron.2006.08.009PMC PMC2826987
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Abstract

We tested the involvement of cognition in adult experience-dependent neuroplasticity using primate cortical implants. In a prior study, learning an operant sensory discrimination increased cortical excitability and target selectivity. Here, the prior task was separated into three behavioral phases. First, naive animals were exposed to stimulus-reward pairings from the prior study. These yoked animals did not have to discriminate to be rewarded and did not learn the discrimination. The plasticity observed in the prior study did not occur. Second, the animals were classically conditioned to discriminate the same stimuli in a simplified format. Learning was accompanied by increased sensory response strength and an increased range of sensory inputs eliciting responses. The third study recreated the original operant discrimination, and selectivity for task targets increased. These studies demonstrate that cognitive association between sensory stimuli and reinforcers accompanies adult experience-dependent cortical plasticity and suggest that selectivity in representation and action are linked.

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Crossref · 10.1016/j.neuron.2006.08.009

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  • Early visual cortical areas are distinguished from primary somatosensory and auditory cortices, which in both monkeys and humans can show dramatic changes with perceptual learning.

    “Our results also further distinguish early visual cortical areas from primary somatosensory and auditory cortices, which in both monkeys and humans can show dramatic changes with perceptual learning5, 6, 37–39.”

    From Neural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area (2008) · cites this paper as [39]

  • Primary somatosensory and auditory cortices in monkeys and humans can show dramatic changes with perceptual learning.

    “primary somatosensory and auditory cortices, which in both monkeys and humans can show dramatic changes with perceptual learning5, 6, 37–39.”

    From Neural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area (2008) · cites this paper as [39]

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Authors
Blake, D. T., Heiser, M. A., Caywood, M., & Merzenich, M. M.
Affiliations
  • Augusta University (US)
  • University of California, San Francisco (US)
Corresponding author
Blake, David T.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2006-10
Volume
52
Issue
2
Pages
371-381
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2006.08.009
PMC
PMC2826987
OpenAlex
W2044097045
Cited by
150
References
49
Citations by year
2026: 5 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 12 · 2014: 7 · 2013: 14 · 2012: 10
FWCI
3.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (5R01NS010413, 5R03DC005708)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
experience-dependent plasticity, stimulus-reward associations, mental associations, cortical excitability, target selectivity, classical conditioning, operant discrimination
MeSH terms
Acoustic Stimulation, Action Potentials, Age Factors, Aging, Animals, Aotus trivirgatus, Auditory Cortex, Auditory Perception, Behavior, Animal, Cognition, Conditioning, Psychological, Nerve Net, Neural Pathways, Neuronal Plasticity, Neuropsychological Tests, Reinforcement, Psychology, Reward, Sensation

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