The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.
Individual Differences in Reward Responding Explain Placebo-Induced Expectations and Effects
Open accessAbstract
Expectations, positive or negative, are modulating factors influencing behavior. They are also thought to underlie placebo effects, impacting perceptions and biological processes. Using healthy human subjects, we examined the role of the nucleus accumbens (NAC), a region centrally involved in the encoding of reward expectation, in the formation of placebo responses. Employing functional molecular imaging, activation of NAC dopamine (DA) release was observed during placebo administration and related to its anticipated effects, perception-anticipation mismatches, and placebo effect development. In additional functional MRI studies, the expectation of monetary gain increased NAC synaptic activity in a manner proportional to placebo-induced DA release, anticipated effects, perception-anticipation differentials, and actual placebo effects. Individual variations in NAC response to reward expectation accounted for 28% of the variance in the formation of placebo analgesia.
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In the citing paper
“The experience of pain results from both sensory input and psychological variables such as personality traits and anxiety level1–5.”
From Boundary effects of expectation in human pain perception (2019) · cites this paper as [3]
In the citing paper
“Our interest in individual differences was motivated by our own and others’ findings that the experience of pain is strongly affected by other psychological variables such as optimism, anxiety, suggestibility, and reward responsiveness1–5.”
From Boundary effects of expectation in human pain perception (2019) · cites this paper as [3]
In the citing paper
“It has been shown that individual variation in ventral striatal response to reward expectation accounted for 28% of the variance in the magnitude of placebo analgesia (Scott et al., 2007).”
From Distinct neural representations of placebo and nocebo effects (2015) · cites this paper as Scott et al., 2007
In the citing paper
“Previous studies have provided evidence that the dopaminergic system mediated expectation formation in placebo manipulation (50)”
From Placebo treatment facilitates social trust and approach behavior (2018) · cites this paper as [50]
Citations
Cites
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Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,551
A Controlled Trial of Arthroscopic Surgery for Osteoarthritis of the Knee
Moseley, J. B., O’Malley, K. J., Petersen, N. J., Menke, T. J., Brody, B. A., Kuykendall, D. H., Hollingsworth, J. C., Ashton, C. M., & Wray, N. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013259 · Cited by 2,262
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
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The neural basis of loss aversion in decision-making under risk
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Cited by
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Fredrickson, B. L., Cohn, M. A., Coffey, K. A., Pek, J., & Finkel, S. M. (2008) · Journal of Personality and Social Psychology · doi:10.1037/a0013262 · Cited by 2,365
“We underscore that the increase in positive emotions evident in the current study did not appear until Week 3 (see Figure 2), whereas placebo responses typically emerge rapidly (Scott et al., 2007).”
The Cerebral Signature for Pain Perception and Its Modulation
Tracey, I., & Mantyh, P. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.012 · Cited by 1,843
Prefrontal-Subcortical Pathways Mediating Successful Emotion Regulation
Wager, T. D., Davidson, M. L., Hughes, B. L., Lindquist, M. A., & Ochsner, K. N. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.006 · Cited by 1,761
Affective neuroscience of pleasure: reward in humans and animals
Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254
The neuroscience of placebo effects: connecting context, learning and health
Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844
Metadata
- Authors
- Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K.
- Affiliations
- University of Michigan (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Zubieta, Jon-Kar
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 55
- Issue
- 2
- Pages
- 325-336
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2079957063
- Cited by
- 466
- References
- 63
- Citations by year
- 2026: 7 · 2025: 24 · 2024: 12 · 2023: 13 · 2022: 12 · 2021: 17 · 2020: 27 · 2019: 24 · 2018: 27 · 2017: 19 · 2016: 24 · 2015: 28 · 2014: 48 · 2013: 38 · 2012: 27
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2239 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R01DA016423)
- National Institute of Dental and Craniofacial Research (R01DE015396, R01 DE 15396)
- National Center for Complementary and Integrative Health (R01AT001415)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- placebo effect, reward anticipation, nucleus accumbens, dopamine release, individual differences, placebo analgesia, expectations formation, monetary gain, synaptic activity
- MeSH terms
- Adult, Dopamine, Female, Games, Experimental, Humans, Individuality, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Pain, Reference Values, Reward, Set, Psychology, Placebo Effect, Positron-Emission Tomography
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