Cited by 466Pain Management and Placebo EffectNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

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Individual Differences in Reward Responding Explain Placebo-Induced Expectations and Effects

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Scott, David J., Stohler, Christian S., Egnatuk, Christine M., Wang, Heng, Koeppe, Robert A., Zubieta, Jon-Kar·2007·Neuron

DOI 10.1016/j.neuron.2007.06.028

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Abstract

Expectations, positive or negative, are modulating factors influencing behavior. They are also thought to underlie placebo effects, impacting perceptions and biological processes. Using healthy human subjects, we examined the role of the nucleus accumbens (NAC), a region centrally involved in the encoding of reward expectation, in the formation of placebo responses. Employing functional molecular imaging, activation of NAC dopamine (DA) release was observed during placebo administration and related to its anticipated effects, perception-anticipation mismatches, and placebo effect development. In additional functional MRI studies, the expectation of monetary gain increased NAC synaptic activity in a manner proportional to placebo-induced DA release, anticipated effects, perception-anticipation differentials, and actual placebo effects. Individual variations in NAC response to reward expectation accounted for 28% of the variance in the formation of placebo analgesia.

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Authors: Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K.
Affiliations: University of Michigan (US)
University of Maryland, Baltimore (US)
Corresponding author: Zubieta, Jon-Kar
ORCID: Scott, David J.
Stohler, Christian S.
Wang, Heng
Koeppe, Robert A.
Venue: Neuron
Publisher: Elsevier BV
Published: 2007-07
Volume: 55
Issue: 2
Pages: 325-336
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2007.06.028
OpenAlex: W2079957063
Cited by: 466
References: 63
Citations by year: 2026: 7 · 2025: 24 · 2024: 12 · 2023: 13 · 2022: 12 · 2021: 17 · 2020: 27 · 2019: 24 · 2018: 27 · 2017: 19 · 2016: 24 · 2015: 28 · 2014: 48 · 2013: 38 · 2012: 27
FWCI: 14.36
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2239 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (R01DA016423)
National Institute of Dental and Craniofacial Research (R01DE015396, R01 DE 15396)
National Center for Complementary and Integrative Health (R01AT001415)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: placebo effect, reward anticipation, nucleus accumbens, dopamine release, individual differences, placebo analgesia, expectations formation, monetary gain, synaptic activity
MeSH terms: Adult, Dopamine, Female, Games, Experimental, Humans, Individuality, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Pain, Reference Values, Reward, Set, Psychology, Placebo Effect, Positron-Emission Tomography

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Individual Differences in Reward Responding Explain Placebo-Induced Expectations and Effects

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