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Individual Differences in Reward Responding Explain Placebo-Induced Expectations and Effects
Open accessAbstract
Expectations, positive or negative, are modulating factors influencing behavior. They are also thought to underlie placebo effects, impacting perceptions and biological processes. Using healthy human subjects, we examined the role of the nucleus accumbens (NAC), a region centrally involved in the encoding of reward expectation, in the formation of placebo responses. Employing functional molecular imaging, activation of NAC dopamine (DA) release was observed during placebo administration and related to its anticipated effects, perception-anticipation mismatches, and placebo effect development. In additional functional MRI studies, the expectation of monetary gain increased NAC synaptic activity in a manner proportional to placebo-induced DA release, anticipated effects, perception-anticipation differentials, and actual placebo effects. Individual variations in NAC response to reward expectation accounted for 28% of the variance in the formation of placebo analgesia.
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In the citing paper
“The experience of pain results from both sensory input and psychological variables such as personality traits and anxiety level1–5.”
From Boundary effects of expectation in human pain perception (2019) · cites this paper as [3]
In the citing paper
“Our interest in individual differences was motivated by our own and others’ findings that the experience of pain is strongly affected by other psychological variables such as optimism, anxiety, suggestibility, and reward responsiveness1–5.”
From Boundary effects of expectation in human pain perception (2019) · cites this paper as [3]
In the citing paper
“It has been shown that individual variation in ventral striatal response to reward expectation accounted for 28% of the variance in the magnitude of placebo analgesia (Scott et al., 2007).”
From Distinct neural representations of placebo and nocebo effects (2015) · cites this paper as Scott et al., 2007
In the citing paper
“Previous studies have provided evidence that the dopaminergic system mediated expectation formation in placebo manipulation (50)”
From Placebo treatment facilitates social trust and approach behavior (2018) · cites this paper as [50]
Citations
Cites
Prospect Theory: An Analysis of Decision under Risk
Kahneman, D., & Tversky, A. (1979) · Econometrica · doi:10.2307/1914185 · Cited by 48,524
Prospect theory: An analysis of decision under risk
Kahneman, D. J., & Tversky, A. (1988) · Cambridge University Press eBooks · doi:10.1017/cbo9780511609220.014 · Cited by 32,720
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,551
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244
A Controlled Trial of Arthroscopic Surgery for Osteoarthritis of the Knee
Moseley, J. B., O’Malley, K. J., Petersen, N. J., Menke, T. J., Brody, B. A., Kuykendall, D. H., Hollingsworth, J. C., Ashton, C. M., & Wray, N. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013259 · Cited by 2,146
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
Berridge, K. C., & Robinson, T. E. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00233-9 · Cited by 1,869
The neural basis of loss aversion in decision-making under risk
Tom, S. M., Fox, C. R., Trepel, C., & Poldrack, R. A. (2007) · Science · doi:10.1126/science.1134239 · Cited by 1,733
Behavioral Theories and the Neurophysiology of Reward
Schultz, W. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070229 · Cited by 1,637
Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
Logan, J., Fowler, J. S., Volkow, N. D., Wang, G., Ding, Y., & Alexoff, D. L. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199609000-00008 · Cited by 1,515
The psychology and neurobiology of addiction: an incentive–sensitization view
Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507
Hróbjartsson, A., & Gøtzsche, P. C. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105243442106 · Cited by 1,504
Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002) · Science · doi:10.1126/science.1067176 · Cited by 1,488
FMRI visualization of brain activity during a monetary incentive delay task
Knutson, B., Westdorp, A., Kaiser, E., & Hommer, D. (2000) · NeuroImage · doi:10.1006/nimg.2000.0593 · Cited by 1,414
Functional imaging of neural responses to expectancy and experience of monetary gains and losses
Breiter, H. C., Aharon, I., Kahneman, D., Dale, A., & Shizgal, P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00303-8 · Cited by 1,404
Adaptive Coding of Reward Value by Dopamine Neurons
Tobler, P. N., Fiorillo, C. D., & Schultz, W. (2005) · Science · doi:10.1126/science.1105370 · Cited by 1,276
THE MECHANISM OF PLACEBO ANALGESIA
Levine, J., Gordon, N., & Fields, H. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92762-9 · Cited by 1,094
A CONTROLLED TRIAL OF ARTHROSCOPIC SURGERY FOR OSTEOARTHRITIS OF THE KNEE
Ruce, J. B., Imberly, K., Etersen, A. J. P., Enke, T. E. J. M., Rody, A., Uykendall, D. A. H. K., Ohn, J., Shton, C. A. M. A., & Ray, E. P. W. (2002) · Cited by 1,087
Mintun, M., Raichle, M., Kilbourn, M. R., Wooten, G., & Welch, M. J. (1984) · Annals of Neurology · doi:10.1002/ana.410150302 · Cited by 1,008
Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease
de la Fuente‐Fernández, R., Ruth, T. J., Sossi, V., Schulzer, M., Calne, D. B., & Stoessl, A. J. (2001) · Science · doi:10.1126/science.1060937 · Cited by 991
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
Horvitz, J. C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00019-1 · Cited by 967
Distributed Neural Representation of Expected Value
Knutson, B., Taylor, J., Kaufman, M., Peterson, R., & Glover, G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0642-05.2005 · Cited by 955
State-dependent opioid control of pain
Fields, H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1431 · Cited by 946
Amanzio, M., & Benedetti, F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00484.1999 · Cited by 899
Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
Zubieta, J.-K., Smith, Y. R., Bueller, J. A., Xu, Y., Kilbourn, M. R., Jewett, D. M., Meyer, C. R., Koeppe, R. A., & Stohler, C. S. (2001) · Science · doi:10.1126/science.1060952 · Cited by 842
Self-citationMellers, B., Schwartz, A., & Ritov, I. (1999) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.128.3.332 · Cited by 839
Neurobiological Mechanisms of the Placebo Effect
Benedetti, F., Mayberg, H. S., Wager, T. D., Stohler, C. S., & Zubieta, J.-K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3458-05.2005 · Cited by 812
Self-citationPlacebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors
Zubieta, J.-K., Bueller, J. A., Jackson, L. R., Scott, D. J., Xu, Y., Koeppe, R. A., Nichols, T. E., & Stohler, C. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0439-05.2005 · Cited by 779
Self-citationThe subjective experience of pain: where expectations become reality
Koyama, T., McHaffie, J. G., Laurienti, P. J., & Coghill, R. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408576102 · Cited by 747
Decision Affect Theory: Emotional Reactions to the Outcomes of Risky Options
Mellers, B. A., Schwartz, A., Ho, K., & Ritov, I. (1997) · Psychological Science · doi:10.1111/j.1467-9280.1997.tb00455.x · Cited by 736
Spiral‐in/out BOLD fMRI for increased SNR and reduced susceptibility artifacts
Glover, G. H., & Law, C. S. W. (2001) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1222 · Cited by 600
Martinez, D., Slifstein, M., Broft, A., Mawlawi, O., Hwang, D.-R., Huang, Y., Cooper, T., Kegeles, L., Zarahn, E., Abi-Dargham, A., et al. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000048520.34839.1a · Cited by 569
Erratum to: “Parsing reward” [Trends Neurosci. 26 (2003) 507–513]
Berridge, K. C., & Robinson, T. E. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.001 · Cited by 562
TREATMENT OF EXCESSIVE AXILLARY SWEATING
Gibbs, J. R. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91979-5 · Cited by 560
Yacubian, J., Gläscher, J., Schroeder, K., Sommer, T., Braus, D. F., & Büchel, C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2915-06.2006 · Cited by 537
Sawamoto, N., Honda, M., Okada, T., Hanakawa, T., Kanda, M., Fukuyama, H., Konishi, J., & Shibasaki, H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07438.2000 · Cited by 522
Petrovic, P., Dietrich, T., Fransson, P., Andersson, J., Carlsson, K., & Ingvar, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.023 · Cited by 437
Smith, Y. R., Stohler, C. S., Nichols, T. E., Bueller, J. A., Koeppe, R. A., & Zubieta, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5223-05.2006 · Cited by 386
Self-citationμ-Opioid Receptor-Mediated Antinociceptive Responses Differ in Men and Women
Zubieta, J.-K., Smith, Y. R., Bueller, J. A., Xu, Y., Kilbourn, M. R., Jewett, D. M., Meyer, C. R., Koeppe, R. A., & Stohler, C. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05100.2002 · Cited by 363
Self-citationBenedetti, F., Arduino, C., Costa, S., Vighetti, S., Tarenzi, L., Rainero, I., & Asteggiano, G. (2006) · Pain · doi:10.1016/j.pain.2005.12.016 · Cited by 347
Keltner, J. R., Furst, A., Fan, C., Redfern, R., Inglis, B., & Fields, H. L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4463-05.2006 · Cited by 346
Dopamine release in human ventral striatum and expectation of reward.
de la Fuente-Fernández, R., Phillips, A., Zamburlini, M., Sossi, V., Calne, D., Ruth, T. J., & Stoessl, A. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00130-4 · Cited by 329
Human striatal response to salient nonrewarding stimuli
Zink, C. F., Pagnoni, G., Martin, M. E., Dhamala, M., & Berns, G. S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-22-08092.2003 · Cited by 312
Scott, D., Heitzeg, M. M., Koeppe, R. A., Stohler, C. S., & Zubieta, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2577-06.2006 · Cited by 298
Self-citationde Craen, A. J. M., Tijssen, J. G. P., de Gans, J., & Kleijnen, J. (2000) · Journal of Neurology · doi:10.1007/s004150050560 · Cited by 293
Minoshima, S., Koeppe, R. A., Mintun, M. A., Berger, K. L., Taylor, S. F., Frey, K. A., & Kuhl, D. E. (1993) · PubMed · Cited by 255
Self-citationMogenson, G. J., & Yang, C. R. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-0145-6_14 · Cited by 238
Neural Encoding in Ventral Striatum during Olfactory Discrimination Learning
Setlow, B., Schoenbaum, G. M., & Gallagher, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00264-2 · Cited by 220
Amphetamine modulates human incentive processing
Knutson, B., Bjork, J. M., Fong, G. W., Hommer, D., Mattay, V. S., & Weinberger, D. R. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.030 · Cited by 174
Effects of naloxone on experimentally induced ischemic pain and on mood in human subjects.
Grevert, P., & Goldstein, A. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.3.1291 · Cited by 153
Chen, J. F., Aloyo, V. J., & Weiss, B. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90238-b · Cited by 133
Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons
Badiani, A., Oates, M. M., Day, H. E. W., Watson, S. J., Akil, H., & Robinson, T. E. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00041-8 · Cited by 126
Involvement of the Pallidal‐thalamocortical Circuit in Adaptive Behavior
Kalivas, P. W., Churchill, L., & ROMANIDES, A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09261.x · Cited by 120
Belief or Need? Accounting for individual variations in the neurochemistry of the placebo effect
Zubieta, J.-K., Yau, W. W., Scott, D., & Stohler, C. S. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.08.006 · Cited by 113
Self-citationSpatial and temporal summation of sensory and affective dimensions of deep somatic pain
Stohler, S., & Kowalski, J. C. (1999) · Pain · doi:10.1016/s0304-3959(98)00171-7 · Cited by 102
Volkow, N., Wang, G.-J., Ma, Y.-M., Fowler, J., Wong, C. T., Jayne, M., Telang, F., & Swanson, J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.04.192 · Cited by 100
A closed-loop system for maintaining constant experimental muscle pain in man
Zhang, X., Ashton‐Miller, J. A., & Stohler, C. S. (1993) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.222327 · Cited by 78
Self-citationDopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus
Seeman, P. M., Wilson, A. A., Gmeiner, P., & Kapur, S. (2006) · Synapse · doi:10.1002/syn.20298 · Cited by 76
Huppert, J. D., Schultz, L. T., Foa, E. B., Barlow, D. H., Davidson, J. R. T., Gorman, J. M., Shear, M. K., Simpson, H. B., & Woods, S. W. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.8.1485 · Cited by 67
Placebo effect in randomized, controlled studies of acute bipolar mania and depression
Keck, P. E., Welge, J. A., McElroy, S. L., Arnold, L. M., & Strakowski, S. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00311-x · Cited by 64
An Explanation for the Placebo Effect?
Irizarry, K. J. L., & Licinio, J. (2005) · Science · doi:10.1126/science.307.5714.1411 · Cited by 18
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Fredrickson, B. L., Cohn, M. A., Coffey, K. A., Pek, J., & Finkel, S. M. (2008) · Journal of Personality and Social Psychology · doi:10.1037/a0013262 · Cited by 2,365
“We underscore that the increase in positive emotions evident in the current study did not appear until Week 3 (see Figure 2), whereas placebo responses typically emerge rapidly (Scott et al., 2007).”
The Cerebral Signature for Pain Perception and Its Modulation
Tracey, I., & Mantyh, P. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.012 · Cited by 1,843
Prefrontal-Subcortical Pathways Mediating Successful Emotion Regulation
Wager, T. D., Davidson, M. L., Hughes, B. L., Lindquist, M. A., & Ochsner, K. N. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.006 · Cited by 1,761
Affective neuroscience of pleasure: reward in humans and animals
Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254
The neuroscience of placebo effects: connecting context, learning and health
Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844
Metadata
- Authors
- Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K.
- Affiliations
- University of Michigan (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Zubieta, Jon-Kar
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 55
- Issue
- 2
- Pages
- 325-336
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2079957063
- Cited by
- 466
- References
- 63
- Citations by year
- 2026: 7 · 2025: 24 · 2024: 12 · 2023: 13 · 2022: 12 · 2021: 17 · 2020: 27 · 2019: 24 · 2018: 27 · 2017: 19 · 2016: 24 · 2015: 28 · 2014: 48 · 2013: 38 · 2012: 27
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2239 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R01DA016423)
- National Institute of Dental and Craniofacial Research (R01DE015396, R01 DE 15396)
- National Center for Complementary and Integrative Health (R01AT001415)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- placebo effect, reward anticipation, nucleus accumbens, dopamine release, individual differences, placebo analgesia, expectations formation, monetary gain, synaptic activity
- MeSH terms
- Adult, Dopamine, Female, Games, Experimental, Humans, Individuality, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Pain, Reference Values, Reward, Set, Psychology, Placebo Effect, Positron-Emission Tomography
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