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Prefrontal-Subcortical Pathways Mediating Successful Emotion Regulation
Open accessAbstract
Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional experience during cognitive reappraisal of aversive images. We then applied a pathway-mapping analysis on subcortical regions to locate mediators of the association between vlPFC activity and reappraisal success (i.e., reductions in reported emotion). Results identified two separable pathways that together explained approximately 50% of the reported variance in self-reported emotion: (1) a path through nucleus accumbens that predicted greater reappraisal success, and (2) a path through ventral amygdala that predicted reduced reappraisal success (i.e., more negative emotion). These results provide direct evidence that vlPFC is involved in both the generation and regulation of emotion through different subcortical pathways, suggesting a general role for this region in appraisal processes.
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“Further, greater dmPFC activation and connectivity with the amygdala corresponded to reappraisal success in both healthy individuals (Banks, Eddy, Angstadt, Nathan, & Phan, 2007; Wager, Davidson, Hughes, Lindquist, & Ochsner, 2008) and patients with social anxiety disorder (Goldin et al., 2009).”
From Changes in functional connectivity with cognitive behavioral therapy for social anxiety disorder predict outcomes at follow-up (2020) · cites this paper as Wager, Davidson, Hughes, Lindquist, & Ochsner, 2008
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“In one of the studies (Wager et al., 2008), when the rated success of emotional regulation was regressed on the cognitive reappraisal of emotion contrast, the dlPFC contribution was smaller and that of the lOFC/vlPFC larger than in the standard subtraction analysis (Figure 5).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Wager et al., 2008
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“some studies demonstrated the role of VLPFC on mediating Amygdala activity in respect to negative stimuli41,42”
From Ventrolateral but not Dorsolateral Prefrontal Cortex tDCS effectively impact emotion reappraisal – effects on Emotional Experience and Interbeat Interval (2018) · cites this paper as [41]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
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“The emotional Stroop task regularly shows prefrontal activations both in dlPFC and lateral orbitofrontal cortex (lOFC)/vlPFC (Eippert et al., 2007; Wager et al., 2008; Kanske et al., 2011; Golkar et al., 2012; Buhle et al., 2014)”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Wager et al., 2008
Experimental — accuracy not yet measuredIn the citing paper
“This dual role of the VLPFC in emotion regulation may be reflected in positive amygdala-VLPFC associations which negatively predict regulation success and positive VS-VLPFC associations which positively predict regulation success (Wager et al., 2008).”
From Neural network of cognitive emotion regulation—an ALE meta-analysis and MACM analysis (2014) · cites this paper as Wager et al., 2008
In the citing paper
“but one can infer from our analyses and the literature, that a highly plausible candidate structure in the direct pathway model would be the VLPFC as it detects salience, is a core structure for appraisal processes (Hampshire et al., 2010; Wager et al., 2008) and would also be in a good position to initiate higher order cognitive processes or complex behaviors through its involvement in the medial”
From Neural network of cognitive emotion regulation—an ALE meta-analysis and MACM analysis (2014) · cites this paper as Wager et al., 2008
In the citing paper
“In this study, vmPFC activity was associated with increased reappraisal success in a manner mediated by changes in the ventral striatum, though other dorsomedial and lateral prefrontal regions are likely to be important as well [54,55].”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [54]
In the citing paper
“In one recent study, positive reappraisal reduced amygdala responses to aversive visual images and increases activity in the ventral striatum, which in turn predict reappraisal effects on emotional experience [54] (figure 1h).”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [54]
In the citing paper
“A second prediction is that reappraisal-related fMRI activity will emerge when controlling for activity in lateral cortical ‘attention systems’ (partially done in [54]; see Supplementary Online Materials for additional discussion).”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [54]
In the citing paper
“the NAc-vmPFC pathway previously shown to be important for emotion/pain regulation, and valuation in a range of contexts [6],[53],[74]–[77]”
From Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain (2015) · cites this paper as [6]
In the citing paper
“Ex-partner versus Friend was predicted by increased activity in dorsomedial prefrontal cortex (dmPFC), right temporal parietal junction (TPJ) and precuneus, which are reliably associated with mentalizing about others38,39, and several other regions associated with negative emotion and its regulation20,40,41, including thalamus, supplementary motor area and inferior frontal gyrus.”
From Separate neural representations for physical pain and social rejection (2014) · cites this paper as [40]
In the citing paper
“and VS activity mediated the relationship between ventrolateral PFC activation and reappraisal success (i.e. less negative emotional experience).”
From Neural correlates of social exclusion across ages: A coordinate-based meta-analysis of functional MRI studies (2017) · cites this paper as Wager et al., 2008
In the citing paper
“Wager and colleagues (2008) found that ventrolateral PFC activation was positively correlated with that of the VS when engaging in cognitive reappraisal of aversive images”
From Neural correlates of social exclusion across ages: A coordinate-based meta-analysis of functional MRI studies (2017) · cites this paper as Wager et al., 2008
In the citing paper
“Similarly, ventral lPFC has also been identified in studies of negative affect following social exclusion (Sebastian et al., 2009), emotion regulation in labeling negative affect (Lieberman et al., 2007), and negative emotion reappraisal (Wager et al., 2008).”
From Risk-taking and social exclusion in adolescence: neural mechanisms underlying peer influences on decision-making (2013) · cites this paper as Wager et al., 2008
In the citing paper
“Given its role in reward processing, the ventral striatum may serve to aid in the reappraisal of negative experiences into positive interpretations (Masten et al., 2009, Wager et al., 2009).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Wager et al., 2009
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MethodInfluentialOpioid-Independent and Opioid-Mediated Modes of Pain Modulation
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Self-citationBrain Substrates of Recovery from Misleading Influence
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“For each subject, the indirect effect of interest is defined as the multiplication product of the aforementioned parameter estimates of interest (i.e., points 1 until 3) (Wager et al., 2008; Hayes, 2013).”
BackgroundMethodBrain Metabolism during Hallucination-Like Auditory Stimulation in Schizophrenia
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“4A for detailed explanation), where the statistical significance of the mediator (the mean BOLD signals within the contralateral middle IC and S1) was determined by the proportion of covariance between age and pain intensity ratings that was accounted for by the full model containing 3 variables (age ? BOLD signals in…”
MethodAffective and Executive Network Processing Associated with Persuasive Antidrug Messages
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“Activation of the alPFC during perceived pain control implicates this area with coping strategies (Salomons et al., 2007) and with emotional re-assessment (Ochsner and Gross, 2005; Kalisch et al., 2006; Wager et al., 2008).”
BackgroundIndividual differences in emotion regulation and hemispheric metabolic asymmetry.
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“The amygdala and insula, in particular, are limbic regions which have been associated with the perception of emotions in others (Banks et al., 2007; Wager et al., 2008).”
BackgroundWorking memory training improves emotional states of healthy individuals
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“The premotor cortex is closely related to DLPFC, both anatomically, and functionally (Fuster, 2006; Takeuchi et al., 2012), and it plays important roles in some executive functions of WM (Wager et al., 2008).”
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“Thus, in order to study the specific emotional regulation component the assessment must control for the non-emotional attentional processes (Wager et al., 2008; Golkar et al., 2012).”
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“The commonly-used mediation approach (Baron and Kenny, 1986), implemented in the M3 mediation toolbox (Wager et al., 2008, 2009), was used.”
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Anterior insula activity predicts the influence of positively framed messages on decision making
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InfluentialNeurobiology of Substance Addictions
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“…perspective, medial frontal areas, the thalamus, and the PCC have been linked to both generation and modulation of emotion (Kober et al., 2008; Lindquist et al., 2015; Wager et al., 2008) and are described as key regions of the DMN (Buckner et al., 2008; Gusnard et al., 2001; Raichle et al., 2001).”
Emotion regulation changes the duration of the BOLD response to emotional stimuli
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“The vLPFC is often engaged during emotion regulation studies and has been shown to be associated with labeling emotions (Lieberman et al., 2007), reappraisal of emotion (Ochsner et al., 2012) and correlated with reappraisal success (Wager et al., 2008a).”
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“Finally, products a*b and a2*b2 separately test the significance of the mediators (Wager et al., 2009, 2008).”
InfluentialSelf-citationDecision Preceding Negativity in the Iowa Gambling Task: An ERP study
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“Interestingly, in a mediation analysis on deliberate emotion regulation, VLPFC activity mediated regulation success [15].”
BackgroundSmith, R. S., Alkozei, A., Killgore, W. D. S., & Lane, R. D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.09.011 · Cited by 39
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“Accordingly, findings in the current cohort may support a direct pathway hypothesis postulating that reappraisal primarily impacts cortical systems involved in cognitive appraisals and emotional evaluation and only has a minimal impact on subcortical systems (41).”
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Blum, A. W., & Grant, J. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.038 · Cited by 44
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Raschle, N. M., Fehlbaum, L. V., Menks, W. M., Martinelli, A., Prätzlich, M., Bernhard, A., Ackermann, K., Freitag, C. M., Brito, S. A. D., Fairchild, G. F., et al. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.05.003 · Cited by 32
Beames, J. R., O’Dean, S., Grisham, J. R., Moulds, M. L., & Denson, T. F. (2019) · Journal of Social and Personal Relationships · doi:10.1177/0265407518819295 · Cited by 47
Roesmann, K., Terrighena, E. L., Chan, C. C. H., Junghoefer, M., & Lee, T. M. C. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00412 · Cited by 32
Distinct but overlapping neural networks subserve depression and insecure attachment
GALYNKER, I. I., Yaseen, Z. S., Katz, C., Zhang, X., Jennings-Donovan, G., Dashnaw, S. M., Hirsch, J., Mayberg, H. S., Cohen, L. J., & Winston, A. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr074 · Cited by 32
Gentil, A. F., Eskandar, E. N., Marci, C. D., Evans, K. C., & Dougherty, D. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.009 · Cited by 29
del Río-Casanova, L., González, A., Páramo, M., Van Dijke, A., & Brenlla, J. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0045 · Cited by 32
“The dlPFC is well known as a critical region for cognitive control, inhibitory processes and selection of information (Wager et al., 2008).”
BackgroundAn OpenMind for 3D Medical Vision Self-supervised Learning
Wald, T., Ulrich, C., Suprijadi, J., Ziegler, S., Nohel, M., Peretzke, R., Koehler, G., & Maier-Hein, K. (2024) · IEEE International Conference on Computer Vision · doi:10.1109/iccv51701.2025.02213 · Cited by 32
Monachesi, B., Grecucci, A., Ghomroudi, P. A., & Messina, I. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1187092 · Cited by 38
Postpartum Stress and Neural Regulation of Emotion among First-Time Mothers
Grande, L. A., Olsavsky, A. K., Erhart, A., Dufford, A. J., Tribble, R. C., Phan, K. L., & Kim, P. (2021) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-021-00914-9 · Cited by 37
Wonderlich, J. A., Bershad, M., & STEINGLASS, J. E. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s282554 · Cited by 47
Test-retest reliability of emotion regulation networks using fMRI at ultra-high magnetic field
Berboth, S., Windischberger, C., Kohn, N., & Morawetz, C. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.117917 · Cited by 40
Behavioral Economics and Addictive Disorders
Jarmolowicz, D. P., & Schneider, T. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.005 · Cited by 42
Liu, Z., Li, L., Liu, S., Sun, Y., Li, S., Yi, M., Zheng, L., & Guo, X. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa111 · Cited by 35
“, 1986), and the functional connectivity between these brain regions are thought to play a key role in emotion regulation (Ochsner and Gross, 2005; Wager et al., 2008; Lozoff, 2011).”
BackgroundLiu, W., Peeters, N., Fernández, G., & Kohn, N. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa073 · Cited by 35
“The idea that inhibitory control is the underlying core cogni-tivefunctioninemotionregulationwasalreadysuggestedbefore (Ochsner et al., 2002; Ochsner and Gross, 2005; Schmeichel et al., 2008; Wager et al., 2008; McRae et al., 2012).”
A neural mediator of human anxiety sensitivity
Harrison, B. J., Fullana, M. A., Soriano‐Mas, C., Via, E., Pujol, J., Martínez‐Zalacaín, I., Tinoco, D., Davey, C. G., López‐Solà, M., Pérez, V., et al. (2015) · Human Brain Mapping · doi:10.1002/hbm.22889 · Cited by 42
“path model [a, b, a*b; Wager et al. 2008], which corresponded to minimum P 5 0.”
MethodInfluentialSperduti, M., Martinelli, P., Kalenzaga, S., Devauchelle, A.-D., Lion, S., Malherbe, C., Gallarda, T., Amado, I., Krebs, M., Oppenheim, C., et al. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00041 · Cited by 35
The involvement of the left ventrolateral prefrontal cortex in tinnitus: a TMS study
Vanneste, S., & Ridder, D. D. (2012) · Experimental Brain Research · doi:10.1007/s00221-012-3177-6 · Cited by 32
Impaired error-likelihood prediction in medial prefrontal cortex in schizophrenia
Krawitz, A., Braver, T. S., Barch, D. M., & Brown, J. W. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.027 · Cited by 35
“005, uncorrected, and 3 contiguous voxels, to balance the need for sensitivity with avoidance of false positives (Wager et al., 2008).”
The brain bases of emotion generation and emotion regulation
Zhang, J., Bo, K., Wager, T. D., & Gross, J. J. (2025) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2025.04.013 · Cited by 45
Self-citationLi, G., Chen, Y. S., Chaudhary, S., Li, C. S.-P., Hao, D., Yang, L., & Li, C.-S. R. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120340 · Cited by 31
“5 Mediation analyses We performed mediation analyses following published routines (MacKinnon et al., 2007; Wager et al., 2008), as detailed earlier (Hu et al.”
MethodPupil dilation predicts individual self-regulation success across domains
Maier, S. U., & Grueschow, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-93121-y · Cited by 35
Garland, E. L. (2020) · Pain · doi:10.1097/j.pain.0000000000001988 · Cited by 36
The effect of emotion regulation on risk-taking and decision-related activity in prefrontal cortex
Morawetz, C., Mohr, P. N. C., Heekeren, H. R., & Bode, S. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz078 · Cited by 48
“Overall reappraisal success was defined as the mean decrease in reported emotion when applying cognitive reappraisal (Decrease) relative to the mean affect ratings of the control condition (Look-Negative), the latter representing the ‘natural’ emotional response to the stimuli (Morawetz et al., 2016a, 2016b; Wager et…”
MethodYuan, M., Pantazatos, S. P., Zhu, H., Li, Y., Miller, J. M., Rubin‐Falcone, H., Zanderigo, F., Ren, Z., Yuan, C., Lui, S., et al. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.07.238 · Cited by 33
“The SMA was believed to be among the network of neural regions mediating top-down control of negative affect (Ray and Zald, 2012) and has previously been implicated in emotion regulation success (Wager et al., 2008).”
BackgroundChen, J., Chen, Y., Gao, Q., Chen, G., Dai, Y., Yao, Z., & Lü, Q. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00157 · Cited by 31
Distributed Neural Processing Predictors of Multi-dimensional Properties of Affect
Bush, K., Inman, C. S., Hamann, S. B., Kilts, C. D., & James, G. A. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00459 · Cited by 30
Scheuer, H., Alarcón, G., Demeter, D. V., Earl, E., Fair, D. A., & Nagel, B. J. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.05.012 · Cited by 32
Neurodevelopmental changes across adolescence in viewing and labeling dynamic peer emotions
Flannery, J., Giuliani, N. R., Flournoy, J. C., & Pfeifer, J. H. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.02.003 · Cited by 26
“Labeling these expressions continued to engage the reactivity egions, but additionally recruited bilateral LPFC (both dorsal and entral aspects), which is involved in linguistic and regulatory proesses (Buhle et al., 2014; Silvers et al., 2015; Somerville et al., 011b; Wager et al., 2008).”
Neural Efficiency in Expert Cognitive-Motor Performers During Affective Challenge
Costanzo, M. E., VanMeter, J. W., Janelle, C. M., Braun, A. R., Miller, M. W., Oldham, J., Russell, B. A. H., & Hatfield, B. D. (2016) · Journal of Motor Behavior · doi:10.1080/00222895.2016.1161591 · Cited by 33
The Relationship Between Cortical Excitability and Pain Catastrophizing in Myofascial Pain
Volz, M. S., Medeiros, L. F., Tarragó, M. D. G. L., Vidor, L. P., Dall’Agnol, L., Deitos, A., Brietzke, A. P., Rozisky, J. R., Razzolini, B. R., Torres, I. L. D. S., et al. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.04.013 · Cited by 36
Neuropeptide S receptor gene: Fear-specific modulations of prefrontal activation
Tupak, S. V., Reif, A., Pauli, P., Dresler, T., Herrmann, M. J., Domschke, K., Jochum, C., Haas, E., Baumann, C. R., Weber, H., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.033 · Cited by 32
“Accordingly, decreased prefrontal brain activity was associated with less efficient emotion regulation (Goldin et al., 2008; Wager et al., 2008) and panic disorder (Dresler et al., 2009a, 2011).”
Russman Block, S., Norman, L. J., Zhang, X., Mannella, K. A., Yang, H., Angstadt, M., Abelson, J. L., Himle, J. A., Taylor, S. F., & Fitzgerald, K. D. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21111173 · Cited by 30
Neural correlates of control over pain in fibromyalgia patients
Mosch, B., Hagena, V., Herpertz, S., Ruttorf, M., & Diers, M. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103355 · Cited by 35
Willinger, D., Karipidis, I. I., Häberling, I. S., Berger, G. E., Walitza, S., & Brem, S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01955-5 · Cited by 36
Wang, S., Yang, C.-M., Zhao, Y.-J., Lai, H., Zhang, L., & Gong, Q. (2019) · European Child and Adolescent Psychiatry · doi:10.1007/s00787-019-01421-6 · Cited by 30
“In addition, the function of the OFC has been found to play an important role in hope [67], life satisfaction [110] and emotion regulation [111], which are important constructs closely related to psychological resilience [112, 113].”
BackgroundConnectome‐based model predicts individual differences in propensity to trust
Lu, X., Li, T., Xia, Z., Zhu, R., Wang, L., Luo, Y., Feng, C., & Krüeger, F. (2019) · Human Brain Mapping · doi:10.1002/hbm.24503 · Cited by 37
Shahane, A. D., Lopez, R. B., & Denny, B. T. (2018) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-018-00676-x · Cited by 34
Zhornitsky, S., Ide, J. S., Wang, W., Chao, H. H., Zhang, S., Hu, S., Krystal, J. H., & Li, C. R. (2018) · Brain Connectivity · doi:10.1089/brain.2018.0633 · Cited by 30
“In the literature, a, b, c, and c¢ were referred as path coefficients or simply paths (MacKinnon et al., 2007; Wager et al., 2008), and we followed this notation.”
BackgroundKatsumi, Y., & Dolcos, S. M. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2018.02.010 · Cited by 34
Fettes, P., Moayedi, M., Dunlop, K., Mansouri, F., Vila‐Rodriguez, F., Giacobbe, P., Davis, K. D., Lam, R. W. M., Kennedy, S. H., Daskalakis, Z. J., et al. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.12.003 · Cited by 32
Machiavellian emotion regulation in a cognitive reappraisal task: An fMRI study
Deák, A., Bodrogi, B., Biró, B., Perlaki, G., Orsi, G., & Bereczkei, T. (2017) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-016-0495-3 · Cited by 34
Representation of Cognitive Reappraisal Goals in Frontal Gamma Oscillations
Kang, J.-H., Jeong, J. W., Kim, H. T., Kim, S. H., & Kim, S.-P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113375 · Cited by 30
“Our findings are also in line with previous fMRI studies showing an increased functional coupling between cortical and subcortical regions during conscious reappraisal of emotions [21,27,65].”
ResultResponses of medial and ventrolateral prefrontal cortex to interpersonal conflict for resources
Koban, L., Pichon, S., & Vuilleumier, P. O. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst020 · Cited by 25
“An activation of this region has frequently been reported for emotional processing, especially in tasks involving affect labeling and emotion regulation by cognitive reappraisal (Ochsner and Gross, 2005; Lieberman et al., 2007; Kober et al., 2008; Wager et al., 2008; Kanske et al., 2011).”
BackgroundSimón, D., Kaufmann, C., Kniesche, R., Kischkel, E., & Kathmann, N. (2013) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2013.08.005 · Cited by 29
Cristea, I. A., Tâtar, A. S., Nagy, D., & David, D. (2012) · Motivation and Emotion · doi:10.1007/s11031-012-9277-6 · Cited by 28
“A few neurobiological studies (Wager et al. 2008) also focused on positive reappraisal, demonstrating both reductions in negative emotions, as well as patterns of brain activation similar, though not completely identical, to those from studies which used only a detached form of reappraisal (Eippert et al.”
ResultTemporal distance insulates against immediate social pain: An NIRS study of social exclusion
Yanagisawa, K., Masui, K., Furutani, K., Nomura, M., Yoshida, H., & Ura, M. (2011) · Social Neuroscience · doi:10.1080/17470919.2011.559127 · Cited by 34
“The VLPFC activity plays a key role in the processing of emotional regulation via cortical-subcortical pathways (Wager, Davidson, Hughes, Lindquist, & Ochsner, 2008 ).”
BackgroundOosterwijk, S., Lindquist, K. A., Adebayo, M., & Barrett, L. F. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv088 · Cited by 28
“For example, previous research has observed patterns of activation in the dmPFC/SMA, lOFC and 5 vlPFC when individuals regulate their emotional state by reappraising the meaning of a stimulus (Wager et al., 2008; Diekhof et al., 2011; Buhle et al., 2013) or interpret neutral stimuli as negative (Ochsner et al.”
MethodLi, H., Wei, D., Sun, J., Zhang, Q., & Qiu, J. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01354 · Cited by 29
“Activation of the IFG were associated with reduced emotional responses through an attentional bias mechanism that acts on the subcortical region, such as amygdala (Wager et al., 2008; Beevers et al., 2010).”
Background
Metadata
- Authors
- Wager, T. D., Davidson, M. L., Hughes, B. L., Lindquist, M. A., & Ochsner, K. N.
- Affiliations
- Columbia University (US)
- Corresponding author
- Wager, Tor D.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 59
- Issue
- 6
- Pages
- 1037-1050
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2742320
- OpenAlex
- W2049423401
- Cited by
- 1,761
- References
- 130
- Citations by year
- 2026: 65 · 2025: 84 · 2024: 68 · 2023: 91 · 2022: 94 · 2021: 122 · 2020: 210 · 2019: 103 · 2018: 129 · 2017: 105 · 2016: 105 · 2015: 97 · 2014: 106 · 2013: 104 · 2012: 90
- FWCI
- 31.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1780 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (0631637)
- National Institutes of Health (MH076136, MH076137)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- emotion regulation, cognitive reappraisal, ventrolateral prefrontal cortex, nucleus accumbens, negative emotions, appraisal process, pathway mapping
- MeSH terms
- Adaptation, Psychological, Adult, Amygdala, Brain Mapping, Concept Formation, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Prefrontal Cortex, Comprehension
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