The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo
Open accessAbstract
SUMMARY Axon regeneration failure accounts for permanent functional deficits following CNS injury in adult mammals. However, the underlying mechanisms remain elusive. In analyzing axon regeneration in different mutant mouse lines, we discovered that deletion of suppressor of cytokine signaling 3 (SOCS3), in adult retinal ganglion cells (RGCs), promotes robust regeneration of injured optic nerve axons. This regeneration-promoting effect is efficiently blocked in SOCS3-gp130 double knockout mice, suggesting that SOCS3 deletion promotes axon regeneration via a gp130-dependent pathway. Consistently, a transient up-regulation of ciliary neurotrophic factor (CNTF) was observed within the retina following optic nerve injury. Intravitreal application of CNTF further enhances axon regeneration from SOCS3-deleted RGCs. Together, our results suggest that compromised responsiveness to injury-induced growth factors in mature neurons contributes significantly to regeneration failure. Thus, developing strategies to modulate negative signaling regulators may be an efficient strategy of promoting axon regeneration after CNS injury.
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Cites
Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., et al. (2008) · Science · doi:10.1126/science.1161566 · Cited by 1,686
Self-citationFitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007 · cited 2×
“While several myelin-associated molecules and chondroitin sulfate proteoglycans (CSPGs) in the glial scar have been implicated as inhibitors of axon regeneration (Filbin, 2006; Fitch and Silver, 2008), blockade of these inhibitory signals results in limited axon regeneration (Case and Tessier-Lavigne, 2005).”
BackgroundMori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Nature Medicine · doi:10.1038/nm1071 · Cited by 651
Re-establishing the regenerative potential of central nervous system axons in postnatal mice
Cho, K.-S., Yang, L., Lu, B., Feng Ma, H., Huang, X., Pekny, M., & Chen, D. F. (2005) · Journal of Cell Science · doi:10.1242/jcs.01658 · Cited by 164
Cited by
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
Sun, F., Park, K. K., Belin, S., Wang, D., Lu, T., Chen, G., Zhang, K., Yeung, C., Feng, G., Yankner, B. A., et al. (2011) · Nature · doi:10.1038/nature10594 · Cited by 754
Self-citationNeuronal Intrinsic Mechanisms of Axon Regeneration
Liu, K., Tedeschi, A., Park, K. K., & He, Z. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113723 · Cited by 458
Self-citationRegulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
Glaucoma 2.0: Neuroprotection, Neuroregeneration, Neuroenhancement
Chang, E. E., & Goldberg, J. L. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2011.11.003 · Cited by 327
Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation
Leibinger, M., Andreadaki, A., & Fischer, D. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.01.004 · Cited by 89
Wong, K. A., & Benowitz, L. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710179 · Cited by 66
Sekine, Y., Lin-Moore, A., Chenette, D. M., Wang, X., Jiang, Z., Cafferty, W. B., Hammarlund, M., & Strittmatter, S. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.058 · Cited by 52
KLF 4 Knockdown Attenuates TBI ‐Induced Neuronal Damage through p53 and JAK ‐ STAT 3 Signaling
Cui, D., Zeng, T., Ren, J., Wang, K., Jin, Y., Zhou, L., & Gao, L. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12633 · Cited by 51
The Regenerative Activity of Interleukin-6
Galun, E., & Rose-John, S. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-308-4_4 · Cited by 34
Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury
Petrova, V., Nieuwenhuis, B., Fawcett, J. W., & Eva, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041798 · Cited by 32
Cao, X., Yung, J., Mak, H., & Leung, C. K. S. (2019) · Gene Therapy · doi:10.1038/s41434-019-0060-0 · Cited by 20
Nystuen, A., Gonzalez-Lopez, E., Kauper, K. A., Eade, K., & Aaberg, T. M. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.06.005 · Cited by 11
Metadata
- Authors
- Smith, P. D., Sun, F., Park, K. K., Cai, B., Wang, C., Kuwako, K., Martinez-Carrasco, I., Connolly, L., & He, Z.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 64
- Issue
- 5
- Pages
- 617-623
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2066858330
- Cited by
- 502
- References
- 4
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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