Cited by 1,930Acute Ischemic Stroke ManagementNeuroinflammation and Neurodegeneration MechanismsIntracerebral and Subarachnoid Hemorrhage Research

The DOI matches its Crossref record; 231 of the 232 references it cites were found in a registry or an index.

The Science of Stroke: Mechanisms in Search of Treatments

Open access

Moskowitz, Michael A., Lo, Eng H., Iadecola, Costantino·2010·Neuron

DOI 10.1016/j.neuron.2010.07.002PMC PMC2957363

Open this paper in CoChat — free account Open PDF

Abstract

This review focuses on mechanisms and emerging concepts that drive the science of stroke in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing evidence has led to the realization that the biological processes underlying stroke are driven by the interaction of neurons, glia, vascular cells, and matrix components, which actively participate in mechanisms of tissue injury and repair. As new targets are identified, new opportunities emerge that build on an appreciation of acute cellular events acting in a broader context of ongoing destructive, protective, and reparative processes. The burden of disease is great, and its magnitude widens as a role for blood vessels and stroke in vascular and nonvascular dementias becomes more clearly established. This review then poses a number of fundamental questions, the answers to which may generate new directions for research and possibly new treatments that could reduce the impact of this enormous economic and societal burden.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2010.07.002

Cites

231 of 231 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED ARTICLE: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C
Liu, D., Cheng, T., Guo, H., Fernández, J. A., Griffin, J. H., Song, X., & Zloković, B. V. (2004) · Nature Medicine · doi:10.1038/nm1122 · Cited by 198
Retracted
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Tissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
Bernard, S. A., Gray, T. W., Buist, M., Jones, B. M., Silvester, W., Gutteridge, G. A., & Smith, K. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa003289 · Cited by 5,388
Alzheimer’s disease
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Pathobiology of ischaemic stroke: an integrated view
Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01401-0 · Cited by 3,943
Self-citation
Heart Disease and Stroke Statistics—2009 Update
WRITING GROUP MEMBERS, Lloyd‐Jones, D. M., Adams, R. J., Carnethon, M. R., SIMONE, G. D., Ferguson, T. B., Flegal, K. M., Ford, E. S., Furie, K. L., Go, A. S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191259 · Cited by 3,915
Regeneration beyond the glial scar
Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,151
Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191261 · Cited by 3,140

Flagged first, then by citations

Show all 232 references

1 of the 232 references couldn’t be matched to a known paper.

Sorted by citations

Items 901–1,000 of 1,002

Long non-coding RNA HOTAIR promotes ischemic infarct induced by hypoxia through up-regulating the expression of NOX2
Yang, L., & Lu, Z. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.023 · Cited by 27
Excitotoxicity and Oxidative Stress in Acute Stroke
Rama, R., & García, J. C. (2016) · InTech eBooks · doi:10.5772/64991 · Cited by 29
Ergostatrien-7,9(11),22-trien-3β-ol from Antrodia camphorata ameliorates ischemic stroke brain injury via downregulation of p65NF-κ-B and caspase 3, and activation of Akt/GSK3/catenin-associated neurogenesis
Wang, Y., Chern, C., Liou, K., Kuo, Y., & Shen, Y. (2019) · Food & Function · doi:10.1039/c9fo00908f · Cited by 27
H 2 S-based therapies for ischaemic stroke: opportunities and challenges
Jia, J., Li, J., & Cheng, J. G. (2019) · Stroke and Vascular Neurology · doi:10.1136/svn-2018-000194 · Cited by 27
Preparation and characterization of biocompatible and thermoresponsive micelles based on poly( N -isopropylacrylamide- co-N , N -dimethylacrylamide) grafted on polysuccinimide for drug delivery
Yeh, J., Hsu, Y.-T., Su, C.-M., Wang, M., Lee, T., & Lou, S.-L. (2014) · Journal of Biomaterials Applications · doi:10.1177/0885328214533736 · Cited by 27
In-Depth Proteomic Analysis of the Hippocampus in a Rat Model after Cerebral Ischaemic Injury and Repair by Danhong Injection (DHI)
Cui, Y., Liu, X., Li, X., & Yang, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071355 · Cited by 26
Loss of neuronal CD200 contributed to microglial activation after acute cerebral ischemia in mice.
Yang, Y., Zhang, X.-J., Zhang, C., Chen, R., Li, L., He, J.-N., Xie, Y.-C., & Chen, Y. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.004 · Cited by 27
Functional improvement and immune-inflammatory cytokines profile of ischaemic stroke patients after treatment with boswellic acids: a randomized, double-blind, placebo-controlled, pilot trial
Baram, S. M., Karima, S., Shateri, S., Tafakhori, A., Fotouhi, A., Lima, B. S., Rajaei, S., Mahdavi, M., Tehrani, H. S., Aghamollaii, V., et al. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00627-z · Cited by 26
Pterostilbene induces Nrf2/HO-1 and potentially regulates NF-κB and JNK–Akt/mTOR signaling in ischemic brain injury in neonatal rats
Zeng, Q., Lian, W., Wang, G., Qiu, M., Lin, L., & Zeng, R. (2020) · 3 Biotech · doi:10.1007/s13205-020-02167-8 · Cited by 29
Extracellular Vesicle Application as a Novel Therapeutic Strategy for Ischemic Stroke
Li, Y., Liu, B., Chen, Y., Quan, X., Han, Y., Zheng, Y., & Zhao, Y. (2021) · Translational Stroke Research · doi:10.1007/s12975-021-00915-3 · Cited by 26
Exosomal microRNAs have great potential in the neurorestorative therapy for traumatic brain injury
Yang, Y., Yang, H., Yang, Y., & Ma, Y. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114026 · Cited by 27
The role of brain oscillations in post-stroke motor recovery: An overview
Leonardi, G., Ciurleo, R., Cucinotta, F., Fonti, B., Borzelli, D., Costa, L., Tisano, A., Portaro, S., & Alito, A. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.947421 · Cited by 26
Selenium supplementation provides potent neuroprotection following cerebral ischemia in mice
Zhuo, Z., Wang, H., Zhang, S., Bartlett, P. F., Walker, T. L., & Hou, S. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231156981 · Cited by 25
MLIF Alleviates SH-SY5Y Neuroblastoma Injury Induced by Oxygen-Glucose Deprivation by Targeting Eukaryotic Translation Elongation Factor 1A2
Zhu, Q., Zhang, Y., Liu, Y., Cheng, H., Wang, J., Zhang, Y., Rui, Y., & Li, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149965 · Cited by 26
YiQiFuMai Powder Injection Ameliorates Cerebral Ischemia by Inhibiting Endoplasmic Reticulum Stress‐Mediated Neuronal Apoptosis
Cao, G., Zhou, H., Jiang, N., Han, Y., Hu, Y., Zhang, Y., Qi, J., Kou, J., & Yu, B. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5493279 · Cited by 26
Pandora's Box: mitochondrial defects in ischaemic heart disease and stroke
Andalib, S., Divani, A. A., Michel, T. M., Høilund‐Carlsen, P. F., Vafaee, M. S., & GJEDDE, A. H. (2017) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2017.5 · Cited by 25
Cerebrovascular disorders associated with genetic lesions
Karschnia, P., Nishimura, S., & Louvi, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2934-5 · Cited by 25
Storax Protected Oxygen-Glucose Deprivation/Reoxygenation Induced Primary Astrocyte Injury by Inhibiting NF-κB Activation in vitro
Zhang, M., Ma, Y., Chai, L., Mao, H., Zhang, J., & Fan, X. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01527 · Cited by 26
Mitochondrial connection to ginsenosides
Wang, F., & Roh, Y. S. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01279-2 · Cited by 25
Mediator complex in neurological disease
Schiano, C., Luongo, L., Maione, S., & Claudio Napoli, A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121986 · Cited by 24
Involvement of GPR40, a long-chain free fatty acid receptor, in the production of central post-stroke pain after global cerebral ischemia
Harada, S., Haruna, Y., Aizawa, F., Matsuura, W., Nakamoto, K., Yamashita, T., Kasuya, F., & Tokuyama, S. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.09.036 · Cited by 25
Estradiol Attenuates Ischemia-Induced Death of Hippocampal Neurons and Enhances Synaptic Transmission in Aged, Long-Term Hormone-Deprived Female Rats
Inagaki, T., Kaneko, N., Zukin, R. S., Castillo, P. E., & Etgen, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038018 · Cited by 25
Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults
Hogins, J., Crawford, D. C., Jiang, X., & Mennerick, S. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.05.005 · Cited by 25
Enhanced oxidative stress response and neuroprotection of combined limb remote ischemic conditioning and atorvastatin after transient ischemic stroke in rats
Ji, X., Ren, C., Li, S., Liu, K., Rajah, G., Zhang, A., Han, R., Liu, Y., Huang, Q., Li, H., et al. (2017) · Brain Circulation · doi:10.4103/bc.bc_29_17 · Cited by 25
Rab7b Overexpression–Ameliorated Ischemic Brain Damage Following tMCAO Involves Suppression of TLR4 and NF-κB p65
Qi, J., Rong, Y., Wang, L., Xu, J., & Zhao, K. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01295-y · Cited by 25
Key Role of Cytochrome C for Apoptosis Detection Using Raman Microimaging in an Animal Model of Brain Ischemia with Insulin Treatment
Russo, V., Candeloro, P., Malara, N., Perozziello, G., Iannone, M., Scicchitano, M., Mollace, R., Musolino, V., Gliozzi, M., Carresi, C., et al. (2019) · Applied Spectroscopy · doi:10.1177/0003702819858671 · Cited by 26
Selegiline (l-Deprenyl) Mitigated Oxidative Stress, Cognitive Abnormalities, and Histopathological Change in Rats: Alternative Therapy in Transient Global Ischemia
Ahmari, M., Sharafi, A., Mahmoudi, J., Anarkooli, I. J., Gharbavi, M., & Hosseini, M. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01544-5 · Cited by 25
Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?
Park, J., Chang, J. Y., Kim, J. Y., & Lee, J. E. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.578003 · Cited by 25
Transcriptome-Wide Analysis to Identify the Inflammatory Role of lncRNA Neat1 in Experimental Ischemic Stroke
Jin, F., Ou, W., Wei, B., Fan, H., Wei, C., Fang, D., Li, G., Liu, W., Liu, J., Jin, L., et al. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s315281 · Cited by 25
Modulation of gene expression on a transcriptome-wide level following human neural stem cell transplantation in aged mouse stroke brains
Hamblin, M. H., Murad, R., Yin, J., Vallim, G., & Lee, J. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113913 · Cited by 28
Higher total white blood cell and neutrophil counts are associated with an increased risk of fatal stroke occurrence: the Guangzhou biobank cohort study
Hu, Z.-B., Lu, Z.-X., Zhu, F., Jiang, C.-Q., Zhang, W., Pan, J., Jin, Y., Xu, L., Thomas, G. N., Cheng, K. K., et al. (2021) · BMC Neurology · doi:10.1186/s12883-021-02495-z · Cited by 25
Immune Modulation as a Key Mechanism for the Protective Effects of Remote Ischemic Conditioning After Stroke
Habashi, S. A., Jickling, G. C., & Winship, I. R. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.746486 · Cited by 25
The crosstalk signals of Sodium Tanshinone ⅡA Sulfonate in rats with cerebral ischemic stroke: Insights from proteomics
Wang, Z., Sun, Y., Bian, L.-H., Zhang, Y., Zhang, Y., Wang, C., Tian, J., & Lü, T. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113059 · Cited by 25
Promising Strategies for the Development of Advanced In Vitro Models with High Predictive Power in Ischaemic Stroke Research
Breedam, E. V., & Ponsaerts, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137140 · Cited by 26
Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury
Zhu, T., & Wan, Q. (2022) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2022.06.008 · Cited by 25
Bibliometric analysis of tumor necrosis factor in post-stroke neuroinflammation from 2003 to 2021
Zhao, Y., Zhu, Q., Bi, C., Yuan, J., Chen, Y., & Xiao-fei, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1040686 · Cited by 26
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis
Duan, W.-L., Ma, Y., Wang, X.-J., Ma, C., Han, B., Sheng, Z.-M., Dong, H., Zhang, L., Li, P. A., Zhang, B., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176553 · Cited by 25
Neurovascular protection conferred by 2-BFI treatment during rat cerebral ischemia
Han, Z., Zhao-hui, C., Liu, S., Yang, J., Xiao, M., Zheng, R., & Hou, S. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.06.152 · Cited by 25
Circulating CD133+CD34+ progenitor cells inversely correlate with soluble ICAM-1 in early ischemic stroke patients
Bogoslovsky, T., Spatz, M., Chaudhry, A., Maric, D., Luby, M. L., Frank, J. A., & Warach, S. J. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-145 · Cited by 25
YiQiFuMai powder injection ameliorates blood–brain barrier dysfunction and brain edema after focal cerebral ischemia–reperfusion injury in mice
Kou, J., Cao, G., Ye, X., Xu, Y., Yin, M., Chen, H., & Yu, B. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s96818 · Cited by 25
Human Umbilical Cord Blood Cells Induce Neuroprotective Change in Gene Expression Profile in Neurons after Ischemia through Activation of Akt Pathway
Shahaduzzaman, M., Mehta, V. K., Golden, J. E., Rowe, D. D., Green, S., Tadinada, R., Foran, E. A., Sanberg, P. R., Pennypacker, K. R., & Willing, A. E. (2015) · Cell Transplantation · doi:10.3727/096368914x685311 · Cited by 25
Dexpramipexole improves bioenergetics and outcome in experimental stroke
Muzzi, M., Gerace, E., Buonvicino, D., Coppi, E., Resta, F., Formentini, L., Zecchi, R., Tigli, L., Guasti, D., Ferri, M., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13790 · Cited by 25
Neuroprotective Effects of Grape Seed Procyanidin Extract on Ischemia-Reperfusion Brain Injury
Xiangyi, K., Jian, G., Gong, S., & 王任直 (2017) · Chinese Medical Sciences Journal · doi:10.24920/j1001-9294.2017.020 · Cited by 25
AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke
Kobayashi, M., Benakis, C., Anderson, C. J., Moore, M. J., Poon, C., Uekawa, K., Dyke, J. P., Fak, J. J., Mele, A., Park, C. Y., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.075 · Cited by 25
Self-citation
A novel biscoumarin compound ameliorates cerebral ischemia reperfusion-induced mitochondrial oxidative injury via Nrf2/Keap1/ARE signaling
Wang, J., Zhang, W., Lv, C., Wang, Y., Ma, B., Zhang, H., Fan, Z., Li, M., & Li, X. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107918 · Cited by 25
Inhibition of microRNA‐148b‐3p alleviates oxygen‐glucose deprivation/reoxygenation‐induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signalling
Du, Y., Ma, X., Ma, L., Li, S., Zheng, J., Lv, J., Cui, L., & Lv, J. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13231 · Cited by 25
Simulation of human ischemic stroke in realistic 3D geometry
Dumont, T., Duarte, M., Descombes, S., Dronne, M.-A., Massot, M., & Louvet, V. (2012) · Communications in Nonlinear Science and Numerical Simulation · doi:10.1016/j.cnsns.2012.10.002 · Cited by 25
Xuesaitong injection (lyophilized) combined with aspirin and clopidogrel protect against focal cerebral ischemic/reperfusion injury in rats by suppressing oxidative stress and inflammation and regulating the NOX2/IL-6/STAT3 pathway
Zhu, T., Meng, X., Dong, D.-X., Li-yu, Z., Qu, M., Sun, G., & Sun, X. (2020) · Annals of Palliative Medicine · doi:10.21037/apm-20-1681 · Cited by 24
Pericytes: Intrinsic Transportation Engineers of the CNS Microcirculation
Eltanahy, A. M., Koluib, Y. A., & Gonzales, A. L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.719701 · Cited by 27
Vespakinin-M, a natural peptide from Vespa magnifica, promotes functional recovery in stroke mice
Zhao, H., Wang, M., Gao, Y., Wu, X., Xiao, H., Yang, D., He, F., Lv, J., Xie, D., Wang, Q., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03024-5 · Cited by 25
Brain Microvascular Endothelial Cell-Derived Exosomes Protect Neurons from Ischemia–Reperfusion Injury in Mice
Sun, J., Yuan, Q., Guo, L., Xiao, G., Zhang, T., Liang, B., Yao, R., Zhu, Y., Li, Y., & Hu, L. (2022) · Pharmaceuticals · doi:10.3390/ph15101287 · Cited by 24
Vav1 promotes inflammation and neuronal apoptosis in cerebral ischemia/reperfusion injury by upregulating microglial and NLRP3 inflammasome activation
Qiu, J., Guo, J., Liu, L., Liu, X., Sun, X., & Chen, D. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.371368 · Cited by 25
Association between systemic immune-inflammation index and post-stroke depression: a cross-sectional study of the national health and nutrition examination survey 2005–2020
Wang, M., Peng, C., Jiang, T., Wu, Q., Li, D., & Lu, M. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1330338 · Cited by 25
Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability
Zhang, X., Du, W., Qian, S., Lü, X., Yu, X., Fang, H.-L., Dong, J., Song, M. K., Sun, Y., Wu, X., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01323-7 · Cited by 25
Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration
Troulinaki, K., & Bano, D. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00244 · Cited by 24
Aberrant regulation and function of Src family tyrosine kinases: Their potential contributions to glutamate‐induced neurotoxicity
Hossain, M. I., Kamaruddin, M. A., & Cheng, H. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05621.x · Cited by 24
Inhibition of cytosolic phospholipase A2 alpha protects against focal ischemic brain damage in mice
Zhang, J., Barasch, N., Li, R.-C., & Sapirstein, A. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.031 · Cited by 24
A novel method to promote behavioral improvement and enhance mitochondrial function following an embolic stroke
Lapchak, P. A., & Boitano, P. D. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.039 · Cited by 24
Neuroprotective constituents from the fruits of Maclura tricuspidata
Hiep, N. T., Kwon, J., Kim, D.-W., Hong, S., Guo, Y., Hwang, B. Y., Kim, N., Mar, W., & Lee, D. (2017) · Tetrahedron · doi:10.1016/j.tet.2017.03.064 · Cited by 24
Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury
Zhai, L., Liu, M., Wang, T., Zhang, H., Li, S., & Guo, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174414 · Cited by 24
NRG-1β exerts neuroprotective effects against ischemia reperfusion-induced injury in rats through the JNK signaling pathway
Ji, Y., Teng, L., Zhang, R., Sun, J., & Guo, Y. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.032 · Cited by 24
Immunity and inflammation predictors for short-term outcome of stroke in young adults
Zhou, X., Yu, F., Feng, X., Wang, J., Li, Z., Zhan, Q., & Xia, J. (2017) · International Journal of Neuroscience · doi:10.1080/00207454.2017.1408614 · Cited by 24
Metabolic regulation of synaptic activity
Fedorovich, S. V., & Waseem, T. V. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0090 · Cited by 24
Panax notoginseng Saponins Attenuate Oxygen–Glucose Deprivation/Reoxygenation-Induced Injury in Human SH-SY5Y Cells by Regulating the Expression of Inflammatory Factors through miR-155
Meng, L., Lin, J., Huang, Q., Liang, P., Huang, J., Jian, C., Lin, C., & Li, X. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00799 · Cited by 24
Expression of Histone Deacetylases HDAC1 and HDAC2 and Their Role in Apoptosis in the Penumbra Induced by Photothrombotic Stroke
Demyanenko, S. V., Dzreyan, V., Neginskaya, M. A., & Uzdensky, A. B. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01772-w · Cited by 24
Surface engineered liposomal delivery of therapeutics across the blood brain barrier: recent advances, challenges and opportunities
Ghosh, S., Lalani, R., Patel, V., Bhowmick, S., & Misra, A. R. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1676721 · Cited by 25
Advances in Engineered Nanoparticles for the Treatment of Ischemic Stroke by Enhancing Angiogenesis
Wang, G., Li, Z., Wang, G., Sun, Q., Lin, P., Wang, Q., Zhang, H., Wang, Y., Zhang, T., Cui, F., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s463333 · Cited by 25
Mechanistic insights of neuronal death and neuroprotective therapeutic approaches in stroke
Li, C., Luo, Y., & Li, S. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01324 · Cited by 24
Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome
Wang, Y., Galeffi, F., Wang, W., Li, X., Lu, L., Sheng, H., Hoffmann, U., Turner, D. A., & Yang, W. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113206 · Cited by 23
Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
Saviuk, M. O., Krivonosov, M., Mishchenko, T. A., Gazaryan, I. G., Ivanchenko, M., Khristichenko, A. Y., Poloznikov, A. A., Hushpulian, D. M., Nikulin, S. V., Tonevitsky, E. A., et al. (2020) · Antioxidants · doi:10.3390/antiox9080662 · Cited by 23
Protective effects of polysaccharides on cerebral ischemia: A mini-review of the mechanisms
Meng, H., Jin, W., Yu, L., Xu, S., Wan, H., & He, Y. T. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.124 · Cited by 23
Effect of Melatonin on Endoplasmic Reticulum-Mitochondrial Crosstalk in Stroke
Abolhasanpour, N., Alihosseini, S., Golipourkhalili, S., Badalzadeh, R., Mahmoudi, J., & Hosseini, L. (2021) · Archives of Medical Research · doi:10.1016/j.arcmed.2021.04.002 · Cited by 24
Drug-Like Property Profiling of Novel Neuroprotective Compounds to Treat Acute Ischemic Stroke: Guidelines to Develop Pleiotropic Molecules
Lapchak, P. A. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0200-y · Cited by 23
Neuroprotective effects of Gualou Guizhi decoction in vivo and in vitro
Zhang, Y., Li, H., Huang, M., Chu, K., Xu, W., Zhang, S., Que, J., & Chen, L. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.10.020 · Cited by 23
Effects of stromal cell-derived factor 1α delivered at different phases of transient focal ischemia in rats
Yoo, J. H., Seo, J.-J., Eom, J.-H., & Hwang, D. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.02.031 · Cited by 23
Targeting Fatigue in Stroke Patients
Barritt, A. W., & Smithard, D. G. (2011) · ISRN Neurology · doi:10.5402/2011/805646 · Cited by 23
Repairing the Brain by SCF+G-CSF Treatment at 6 Months Postexperimental Stroke
Cui, L., Wang, D., McGillis, S. L. B., Kyle, M. M., & Zhao, L.-R. (2016) · ASN NEURO · doi:10.1177/1759091416655010 · Cited by 23
Therapeutic Potential of Novel Twin Compounds Containing Tetramethylpyrazine and Carnitine Substructures in Experimental Ischemic Stroke
Wang, Z., Zhou, Z., Wei, X., Wang, M., Wang, B.-O., Zhang, Y., He, X., Sun, Y., Wang, X., Sun, M., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7191856 · Cited by 23
Human Neural Stem Cells for Ischemic Stroke Treatment
Kokaia, Z., & Darsalia, V. (2018) · Results and problems in cell differentiation · doi:10.1007/978-3-319-93485-3_11 · Cited by 23
Nrg1 Intracellular Signaling Is Neuroprotective upon Stroke
Navarro-González, C., Huerga-Gómez, A., & Fazzari, P. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3930186 · Cited by 24
The Neuroprotective Effect of the HDAC2/3 Inhibitor MI192 on the Penumbra After Photothrombotic Stroke in the Mouse Brain
Demyanenko, S. V., Nikul, V. V., & Uzdensky, A. B. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01773-9 · Cited by 23
The brain and eye: Treating cerebral and retinal ischemia through mitochondrial transfer
Heyck, M., Bonsack, B., Zhang, H., Sadanandan, N., Cozene, B., Kingsbury, C., Lee, J.-Y., & Borlongan, C. V. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219881623 · Cited by 23
Exogenous insulin-like growth factor 1 attenuates acute ischemic stroke-induced spatial memory impairment via modulating inflammatory response and tau phosphorylation
Yang, W., Li, G., Cao, K., Ma, P., Guo, Y., Tong, W., & Wan, J. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102082 · Cited by 23
Post-ischemic treatment with L-kynurenine sulfate exacerbates neuronal damage after transient middle cerebral artery occlusion
Gellért, L., Knapp, L., Németh, K., Herédi, J., Varga, D. P., Oláh, G., Kocsis, K., Menyhárt, Á., Kis, Z., Farkas, T., et al. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.063 · Cited by 26
The mitochondria as a potential therapeutic target in cerebral I/R injury
Fang, S., Huang, W., Qu, X.-H., & Chai, W. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1500647 · Cited by 26
Piezo1 disrupts blood–brain barrier via CaMKII/Nrf2 in ischemic stroke
Fu, H., Yu, Y., Wang, S., Xu, P., Sun, Y., Li, J., Ge, X., & Pan, S. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05804-8 · Cited by 22
Clinacanthus nutans Mitigates Neuronal Apoptosis and Ischemic Brain Damage Through Augmenting the C/EBPβ-Driven PPAR-γ Transcription
Wu, J., Kao, M.-H., Tsai, H., Cheung, W., Chen, J., Ong, W., Sun, G. Y., & Lin, T. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0776-z · Cited by 22
Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-κB signaling pathway
Umukoro, S., Oghwere, E. E., Ben‐Azu, B., Owoeye, O., Ajayi, A. M., Omorogbe, O., & Okubena, O. (2018) · Pathophysiology · doi:10.1016/j.pathophys.2018.10.002 · Cited by 22
KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion
Kinoshita, H., Maki, T., Yasuda, K., Kishida, N., Sasaoka, N., Takagi, Y., Kakizuka, A., & Takahashi, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-47993-w · Cited by 20
Neurovascular Coupling is Preserved in Chronic Stroke Recovery After Targeted Photothrombosis
Sunil, S., Jiang, J., Shah, S., Kura, S., Kılıç, K., Erdener, Ş. E., Ayata, C., Devor, A., & Boas, D. A. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103377 · Cited by 22
Salvianolic acid C attenuates cerebral ischemic injury through inhibiting neuroinflammation via the TLR4-TREM1-NF-κB pathway
Guo, W., Xu, X., Xiao, Y., Zhang, J., Shen, P., Lu, X., & Fan, X. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00914-0 · Cited by 22
Integrative microbiomics, proteomics and lipidomics studies unraveled the preventive mechanism of Shouhui Tongbian Capsules on cerebral ischemic stroke injury
Wei, F., Zhou, J., Pan, L., Shen, M., Niu, D., Zeng, Z., Cheng, G., Yao, J., Zhang, G., & Sun, C. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118874 · Cited by 23
The pharmacology and therapeutic potential of small molecule inhibitors of acid-sensing ion channels in stroke intervention
Leng, T., & Xiong, Z. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.81 · Cited by 22
Estradiol pretreatment ameliorates impaired synaptic plasticity at synapses of insulted CA1 neurons after transient global ischemia
Takeuchi, K., Yang, Y., Takayasu, Y., Gertner, M. J., Hwang, J.-Y., Aromolaran, K. A., Bennett, M. V. L., & Zukin, R. S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.11.016 · Cited by 22
Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus
Woltjer, R. L., Reese, L. C., Richardson, B. E., Tran, H. T. D., Green, S., Pham, T., Chalupsky, M., Gabriel, I., Light, T. J., Sanford, L., et al. (2015) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2015.10.012 · Cited by 21
Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke
Rodhe, J., Burguillos, M. Á., de Pablos, R. M., Kavanagh, E. T., Persson, A., Englund, E. M., Deierborg, T., Venero, J. L., & Joseph, B. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0365-9 · Cited by 23
Role of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke
Cisbani, G., Béhot, A. L., Plante, M.-M., Préfontaine, P., Lecordier, M., & Rivest, S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.03.008 · Cited by 23
The effect of age-related risk factors and comorbidities on white matter injury and repair after ischemic stroke
Xu, M., Wang, M. M., Gao, Y., Keep, R. F., & Shi, Y. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.07.008 · Cited by 22
GSK-3 inhibition through GLP-1R allosteric activation mediates the neurogenesis promoting effect of P7C3 after cerebral ischemic/reperfusional injury in mice
Wang, Y., Liou, K., Tsai, K., Liu, H., Yang, L. M., Chern, C., & Shen, Y. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.08.023 · Cited by 22
Sema3E/PlexinD1 signaling inhibits postischemic angiogenesis by regulating endothelial DLL4 and filopodia formation in a rat model of ischemic stroke
Zhou, Y., Chen, A., Wu, J., Mao, L., Xia, Y., Jin, H., He, Q., Miao, Q., Yue, Z., Liu, X., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201801706rr · Cited by 23

Authors: Moskowitz, M. A., Lo, E. H., & Iadecola, C.
Affiliations: Massachusetts General Hospital (US)
Weill Cornell Medicine (US)
Corresponding author: Moskowitz, Michael A.
ORCID: Moskowitz, Michael A.
Lo, Eng H.
Iadecola, Costantino
Venue: Neuron
Publisher: Elsevier BV
Published: 2010-07
Volume: 67
Issue: 2
Pages: 181-198
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2010.07.002
PMC: PMC2957363
OpenAlex: W2063541896
Cited by: 1,930
References: 232
Citations by year: 2026: 76 · 2025: 108 · 2024: 99 · 2023: 118 · 2022: 136 · 2021: 183 · 2020: 140 · 2019: 140 · 2018: 125 · 2017: 152 · 2016: 129 · 2015: 114 · 2014: 125 · 2013: 104 · 2012: 101
FWCI: 10.27
Type: journal article
Language: en
Update notices: erratum (2010-10-06)
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1112 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS034179, R01NS037853)
Topics: Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
Keywords: stroke, stroke pathophysiology, neurovascular interactions, glial cells, vascular cells, extracellular matrix, tissue damage, tissue repair, vascular dementia, stroke burden
MeSH terms: Animals, Blood Vessels, Humans, Models, Biological, Risk Factors, Cost of Illness, Stroke

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Science of Stroke: Mechanisms in Search of Treatments

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks