The DOI matches its Crossref record; 231 of the 232 references it cites were found in a registry or an index.
The Science of Stroke: Mechanisms in Search of Treatments
Open accessAbstract
This review focuses on mechanisms and emerging concepts that drive the science of stroke in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing evidence has led to the realization that the biological processes underlying stroke are driven by the interaction of neurons, glia, vascular cells, and matrix components, which actively participate in mechanisms of tissue injury and repair. As new targets are identified, new opportunities emerge that build on an appreciation of acute cellular events acting in a broader context of ongoing destructive, protective, and reparative processes. The burden of disease is great, and its magnitude widens as a role for blood vessels and stroke in vascular and nonvascular dementias becomes more clearly established. This review then poses a number of fundamental questions, the answers to which may generate new directions for research and possibly new treatments that could reduce the impact of this enormous economic and societal burden.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The brain depends on a continuous blood supply, and interruption of cerebral blood flow (CBF) leads to brain dysfunction and death.86”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Liu, D., Cheng, T., Guo, H., Fernández, J. A., Griffin, J. H., Song, X., & Zloković, B. V. (2004) · Nature Medicine · doi:10.1038/nm1122 · Cited by 198
RetractedTakahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Tissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
Bernard, S. A., Gray, T. W., Buist, M., Jones, B. M., Silvester, W., Gutteridge, G. A., & Smith, K. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa003289 · Cited by 5,388
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Pathobiology of ischaemic stroke: an integrated view
Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01401-0 · Cited by 3,943
Self-citationHeart Disease and Stroke Statistics—2009 Update
WRITING GROUP MEMBERS, Lloyd‐Jones, D. M., Adams, R. J., Carnethon, M. R., SIMONE, G. D., Ferguson, T. B., Flegal, K. M., Ford, E. S., Furie, K. L., Go, A. S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191259 · Cited by 3,915
Regeneration beyond the glial scar
Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,151
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191261 · Cited by 3,140
Flagged first, then by citations
1 of the 232 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 701–800 of 1,002
Lyophilized Powder of Catalpol and Puerarin Protects Neurovascular Unit from Stroke
Qiang, X. U. E., Liu, Y., He, R., Yang, S., Tong, J., Xu, L., Chen, Y., & Xu, X. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.14059 · Cited by 39
Sodium Fluctuations in Astroglia and Their Potential Impact on Astrocyte Function
Felix, L., Delekate, A., Petzold, G. C., & Rose, C. R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00871 · Cited by 38
Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19
Shabani, Z., Liu, J., & Su, H. (2023) · Biology · doi:10.3390/biology12081106 · Cited by 41
The Role of Oxidative Stress in Ischaemic Stroke and the Influence of Gut Microbiota
Golenia, A., & Olejnik, P. (2025) · Antioxidants · doi:10.3390/antiox14050542 · Cited by 41
Shahripour, R. B., Shamsaei, G., Pakdaman, H., Majdinasab, N., Nejad, E. M., Sajedi, S. A., Norouzi, M., Hemmati, A., Manouchehri, R. H., & Shiravi, A. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.01.002 · Cited by 38
The role of neuroendocrine pathways in prognosis after stroke
Husseini, N. E., & Laskowitz, D. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.877841 · Cited by 33
Li, H., Qiu, S., Li, X., Li, M., & Peng, Y. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0726-3 · Cited by 38
Giuliani, D., Ottani, A., Neri, L., Zaffe, D., Grieco, P., Jochem, J., Cavallini, G. M., Catania, A., & Guarini, S. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.11.004 · Cited by 38
Implications of Epigenetic Mechanisms and their Targets in Cerebral Ischemia Models
Jhelum, P., Karisetty, B. C., Kumar, A., & Chakravarty, S. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666161213143907 · Cited by 38
(−)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury
Chang, C.-F., Lai, J.-H., Wu, J. C.-C., Greig, N. H., Becker, R. E., Luo, Y., Chen, Y., Kang, S.-J., Chiang, Y. H., & Chen, K. (2017) · Brain Research · doi:10.1016/j.brainres.2017.09.015 · Cited by 38
Hou, X., & Cheng, H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.087 · Cited by 38
Krucoff, M. O., Miller, J. P., Saxena, T. K., Bellamkonda, R., Rahimpour, S., Harward, S. C., Lad, S. P., & Turner, D. A. (2018) · Neurosurgery · doi:10.1093/neuros/nyy128 · Cited by 38
Martire, A., Lambertucci, C., Pepponi, R., Ferrante, A., Benati, N., Buccioni, M., Ben, D. D., Marucci, G., Klotz, K., Volpini, R., et al. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14660 · Cited by 38
Cerebrovascular inflammation: A critical trigger for neurovascular injury?
Naveed, M., Zhou, Q., & Han, F. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.03.011 · Cited by 37
Blood-Brain Barrier Disruption: A Common Driver of Central Nervous System Diseases
Segura‐Collar, B., Mata-Martínez, P., Hernández‐Laín, A., Sánchez‐Gómez, P., & Gargini, R. (2021) · The Neuroscientist · doi:10.1177/1073858420985838 · Cited by 39
Tang, C., Wang, Q., Li, K., Li, X., Wang, C., Xue, L., Ju, C., & Zhang, C. (2021) · Biomaterials Science · doi:10.1039/d1bm00566a · Cited by 38
Bitar, L., Uphaus, T., Thalman, C., Muthuraman, M., Gyr, L., Ji, H., Domingues, M., Endle, H., Groppa, S., Steffen, F., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abk0135 · Cited by 41
Agarwal, S., Scoffings, D. J., Jones, P. S., Marrapu, S. T., Barry, P. J., O'Brien, E. W., Baron, J., & Warburton, E. A. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303258 · Cited by 38
Meningeal mast cells as key effectors of stroke pathology.
Arac, A., Grimbaldeston, M. A., Galli, S. J., Bliss, T. M., & Steinberg, G. K. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00126 · Cited by 37
Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years
Lee, G., Choi, S., Chang, J., Choi, D., Son, J. S., Kim, K., Kim, S. M., Jeong, S., & Park, S. M. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.36008 · Cited by 37
Promising targets of cell death signaling of NR2B receptor subunit in stroke pathogenesis
Shu, S., Pei, L., & Lu, Y. (2014) · Regenerative Medicine Research · doi:10.1186/2050-490x-2-8 · Cited by 38
Yang, L., Islam, M. R., Karamyan, V. T., & Abbruscato, T. J. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.022 · Cited by 37
Inflammatory and neuroendocrine biomarkers of prognosis after ischemic stroke
Mira, K., & Elkind, M. S. V. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.200 · Cited by 37
Yang, W., Yan, A., Zhang, T., Shao, J., Liu, T., Yang, X. Y., Xia, W., & Fu, Y. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00008 · Cited by 37
P66Shc-SIRT1 Regulation of Oxidative Stress Protects Against Cardio-cerebral Vascular Disease
Kong, X., Guan, J., Li, J., Wei, J., & Wang, R. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0073-2 · Cited by 37
Centipede venoms as a source of drug leads
Undheim, E. A. B., Jenner, R. A., & King, G. F. (2016) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2016.1235155 · Cited by 37
Härtig, W., Krueger, M., Hofmann, S., Preißler, H., Märkel, M., Frydrychowicz, C., Mueller, W. C., Bechmann, I., & Michalski, D. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.09.004 · Cited by 37
Inhibiting the Migration of M1 Microglia at Hyperacute Period Could Improve Outcome of tMCAO Rats
Huang, M., Wan, Y., Mao, L., He, Q., Xia, Y., Li, M., Li, Y., Jin, H., & Hu, B. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12665 · Cited by 36
Chen, X., Zhang, J., & Wu, L. (2017) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.03.006 · Cited by 37
Li, Y., Xu, L., Zeng, K.-Y., Xu, Z.-T., Suo, D.-Q., Peng, L., Ren, T., Sun, Z.-H., Yang, W.-S., Jin, X., et al. (2017) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2017.07.015 · Cited by 36
Role of Steroid Therapy after Ischemic Stroke by n-Methyl-d-Aspartate Receptor Gene Regulation
Tameh, A. A., Karimian, M., Zare-Dehghanani, Z., Aftabı, Y., & Beyer, C. (2018) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2018.06.041 · Cited by 37
The effect of age, sex and strains on the performance and outcome in animal models of stroke
Zhang, H., Lin, S., Chen, X., Gu, L., Zhu, X., Zhang, Y., Reyes, K., Wang, B. Z., & Jin, K. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.10.005 · Cited by 38
Ramezani, M., Sahraei, Z., Simani, L., Heydari, K., & Shahidi, F. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1541269 · Cited by 37
Bayat, F., Hosseinpour-Moghadam, R., Mehryab, F., Fatahi, Y., Shakeri, N., Dinarvand, R., ten Hagen, T. L. M., & Haeri, A. (2020) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2020.102121 · Cited by 38
Ripley, A., Jeffers, M. S., McDonald, M. W., Montroy, J. R., Dykes, A., Fergusson, D. A., Silasi, G., Lalu, M. M., & Corbett, D. (2021) · Translational Stroke Research · doi:10.1007/s12975-020-00882-1 · Cited by 37
Translational Block in Stroke: A Constructive and “Out-of-the-Box” Reappraisal
Lourbopoulos, A. I., Mourouzis, I. S., Xinaris, C., Zerva, N., Filippakis, K., Pavlopoulos, A., & Pantos, C. I. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.652403 · Cited by 40
The emerging roles of absent in melanoma 2 (AIM2) inflammasome in central nervous system disorders
Li, Y.-K., Chen, J., & Wang, F. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105122 · Cited by 36
Desai, S. M., Jha, R. M., & Linfante, I. (2021) · Neurology · doi:10.1212/wnl.0000000000012809 · Cited by 37
Molecular Basis of Impaired Glycogen Metabolism during Ischemic Stroke and Hypoxia
Hossain, M. I., Roulston, C. L., & Stapleton, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097570 · Cited by 40
Zhang, J., Fu, B., Zhang, X., Zhang, L., Bai, X., Zhao, X., Chen, L., Cui, L., Zhu, C., Wang, L., et al. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.11.001 · Cited by 37
Eom, J.-W., Lee, J., Koh, J., & Kim, Y. H. (2016) · Molecular Brain · doi:10.1186/s13041-016-0194-6 · Cited by 38
Hou, B., Ma, J., Guo, X., Ju, F., Gao, J., Wang, D., Liu, J., Li, X., Zhang, S., & Ren, H. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9740-6 · Cited by 37
Lima, R. R., Santana, L. N. S., Fernandes, R. M., do Nascimento, E. M., de Oliveira, A. C. A., Fernandes, L. M. P., dos Santos, E. M. N., Tavares, P. A. N., Santos, I. R., Santos, A. G., et al. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3173564 · Cited by 37
Ko, G., Kim, J., Jeon, Y.-J., Lee, D., Baek, H., & Chang, K. (2023) · Antioxidants · doi:10.3390/antiox12040785 · Cited by 36
Lou, H., Yao, J., Zhang, Y., Wu, X., Sun, L., Wang, Y., & Cong, D. (2024) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2024.107636 · Cited by 36
GPR34 senses demyelination to promote neuroinflammation and pathologies
Lin, B., Zhou, Y., Huang, Z., Ma, M., Qi, M., Jiang, Z., Li, G., Xu, Y., Yan, J., Wang, D., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01204-3 · Cited by 39
Pekcec, A., Yiğitkanlı, K., Jung, J. E., Pallast, S., Xing, C., Antipenko, A., Minchenko, M., Nikolov, D. B., Holman, T. R., Lo, E. H., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-206896 · Cited by 36
Self-citationIn Vivo Imaging of the Mouse Neurovascular Unit Under Chronic Cerebral Hypoperfusion
Yata, K., Nishimura, Y., Unekawa, M., 冨田, 裕., Suzuki, N., Tanaka, T., Mizoguchi, A., & Tomimoto, H. (2014) · Stroke · doi:10.1161/strokeaha.114.005891 · Cited by 36
Cervantes, M. I., Balderas, P. M. D. O., Gutiérrez-Baños, J. D. J., Orozco‐Ibarra, M., Fernández-Rojas, B., Medina‐Campos, O. N., Espinoza-Rojo, M., Tachiquín, M. E. R., Ortíz-Plata, A., Salazar, M. I., et al. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.02.053 · Cited by 36
Deng, G., Yonchek, J. C., Quillinan, N., Strnad, F. A., Exo, J. L., Herson, P. S., & Traystman, R. J. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.10.015 · Cited by 36
How Can You Mend a Broken Brain? - Neurorestorative Approaches to Stroke Recovery
Corbett, D., Nguemeni, C., & Gomez-Smith, M. (2014) · Cerebrovascular Diseases · doi:10.1159/000368887 · Cited by 38
Chen, Z., Yang, D., Zhao, Z., Yan, H., Ji, J., & Sun, X. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.081 · Cited by 36
Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients
Guedes, P. M. D. M., Andrade, C. D. M., Nunes, D. F., Pereira, N. D. S., Queiroga, T. B. D., Machado-Coelho, G. L. L., Nascimento, M. S. L., Matta, M. A. D. V., da Câmara, A. C. J., Chiari, É., et al. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004669 · Cited by 38
Brunner, C., Isabel, C., Martín, A., Dussaux, C., Savoye, A., Emmrich, J., Montaldo, G., Mas, J., Baron, J., & Urban, A. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15622466 · Cited by 36
Wei, J., Zhang, Y., Jia, Q., Liu, M., Li, D., Zhang, Y., Song, L., Hu, Y., Xian, M., Yang, H., et al. (2016) · Scientific Reports · doi:10.1038/srep29823 · Cited by 36
Chakravarty, S., Jhelum, P., Bhat, U. A., Rajan, W. D., Maitra, S., Pathak, S. S., Patel, A. B., & Kumar, A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.09.014 · Cited by 36
Targeting mast cell as a neuroprotective strategy
Ocak, U., Ocak, P. E., Wang, A., Zhang, J. H., Boling, W., Wu, P., Mo, J., Zhang, T., & Huang, L. (2018) · Brain Injury · doi:10.1080/02699052.2018.1556807 · Cited by 35
Formulation strategies for nose-to-brain delivery of therapeutic molecules
Pandey, V., Gadeval, A., Asati, S., Jain, P., Jain, N., Roy, R. K., Tekade, M., Soni, V., & Tekade, R. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814487-9.00007-7 · Cited by 36
Tumor Necrosis Factor Alpha: A Major Cytokine of Brain Neuroinflammation
Muhammad, M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.85476 · Cited by 37
Seol, S.-I., Kim, H. J., Choi, E. B., Kang, I. S., Lee, H., Lee, J.-K., & Kim, C. (2021) · Antioxidants · doi:10.3390/antiox10030372 · Cited by 36
Nie, Q., Zheng, Z.-Q., Liao, J., Li, Y.-C., Chen, Y., Wang, T.-Y., Yuan, G.-Q., Wang, Z., & Xue, Q. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s369690 · Cited by 36
Yin, M., Liu, Z., Wang, J., & Gao, W. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115953 · Cited by 36
Han, Z., Yang, J., Jiang, S. X., Hou, S., & Zheng, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064894 · Cited by 36
Anrather, J., Gallo, E. F., Kawano, T., Orio, M., Abe, T., Gooden, C., Zhou, P., & Iadecola, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025916 · Cited by 36
Self-citationINF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury
Calabrese, B., Jones, S. L., Shiraishi‐Yamaguchi, Y., Lingelbach, M., Manor, U., Svitkina, T., Higgs, H. N., Shih, A. Y., & Halpain, S. (2022) · Nature Communications · doi:10.1038/s41467-022-33268-y · Cited by 37
The interaction between intestinal microenvironment and stroke
Zhao, L., Xiao, J., Li, S., Guo, Y., Fu, R., Hua, S., Du, Y., & Xu, S. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14275 · Cited by 38
Song, W., Huo, T., Guo, F., Wang, H., Wei, H., Yang, Q., Dong, H., Wang, Q., & Xiong, L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.063 · Cited by 35
Huang, T., Gao, D., Jiang, X., Hu, S., Zhang, L., & Fei, Z. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2239 · Cited by 35
Neuronal necrosis is regulated by a conserved chromatin-modifying cascade
Liu, K., Ding, L., Li, Y., Yang, H., Zhao, C., Ye, L., Han, S., Tao, W., Miao, D., Steller, H., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413644111 · Cited by 36
Emerging Therapies: Pleiotropic Multi-target Drugs to Treat Stroke Victims
Lapchak, P. A. (2011) · Translational Stroke Research · doi:10.1007/s12975-011-0074-4 · Cited by 35
Melanocortins as potential therapeutic agents in severe hypoxic conditions
Giuliani, D., Minutoli, L., Ottani, A., Spaccapelo, L., Bitto, A., Galantucci, M., Altavilla, D., Squadrito, F., & Guarini, S. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.04.001 · Cited by 35
Pace, M., Adamantidis, A., Facchin, L., & Bassetti, C. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0168430 · Cited by 34
Stroke triggers nigrostriatal plasticity and increases alcohol consumption in rats
Huang, C. C., Ma, T., Roltsch, E. A., Wang, X., Selvamani, A., Lu, J., Sohrabji, F., & Wang, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-02714-z · Cited by 31
Zhang, X., Zhang, Y., Tang, S., Yu, L., Zhao, Y., Ren, Q., Huang, X., Xu, W., Huang, M., & Peng, J. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.03.018 · Cited by 35
Wang, Y., Tang, Y., Yang, M., & Huang, X. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28058 · Cited by 36
Wang, S., Sun, Z.-Y., Wang, F., Guo, H. W., Chen, L., Chai, L., Li, R., Hu, L., & Wang, H. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.249226 · Cited by 35
Liu, L., Vollmer, M. K., Kelly, M. G., Fernandez, V. M., Fernandez, T. G., Kim, H., & Doré, S. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01760-0 · Cited by 35
Selective activation of estrogen receptor β alleviates cerebral ischemia neuroinflammatory injury
Guo, H., Yang, J., Liu, M., Wang, L., Hou, W., Zhang, L., & Ma, Y. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146536 · Cited by 35
Endothelial and Leukocyte-Derived Microvesicles and Cardiovascular Risk After Stroke
Huo, S., Kränkel, N., Nave, A. H., Sperber, P. S., Rohmann, J. L., Piper, S. K., Heuschmann, P. U., Landmesser, U., Endres, M., Siegerink, B., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000011223 · Cited by 35
Metabolomics and metabolites in ischemic stroke
Chumachenko, M. S., Waseem, T. V., & Fedorovich, S. V. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0048 · Cited by 35
Mechanisms of Preconditioning Exercise-Induced Neurovascular Protection in Stroke
Hafez, S. S., Eid, Z., Alabasi, S., Darwiche, Y., Channaoui, S., & Hess, D. C. (2021) · Journal of Stroke · doi:10.5853/jos.2020.03006 · Cited by 39
Gong, S., Ma, H., Zheng, F., Huang, J., Zhang, Y., Yu, B., Li, F., & Kou, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.777680 · Cited by 33
Salidroside Reduces Cell Mobility via NF‐κB and MAPK Signaling in LPS‐Induced BV2 Microglial Cells
Hu, H., Li, Z., Zhu, X., Lin, R., & Chen, L. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/383821 · Cited by 34
Gao, D., Huang, T., Jiang, X., Hu, S., Zhang, L., & Fei, Z. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2086 · Cited by 34
Ku, J., Taher, M., Chin, K.-Y., Barsby, T., Austin, V., Wong, C. H. Y., Andrews, Z., Spencer, S., & Miller, A. A. (2016) · Clinical science · doi:10.1042/cs20160077 · Cited by 32
Targeting CDK5 post-stroke provides long-term neuroprotection and rescues synaptic plasticity
Vargas, J. A. G., Moreno, H., & Cardona‐Gómez, G. P. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16662476 · Cited by 34
Chen, C.-H., Chen, N.-F., Feng, C.-W., Cheng, S.-Y., Hung, H.-C., Tsui, K.-H., Hsu, C.-H., Sung, P.-J., Chen, W.-F., & Wen, Z.-H. (2016) · Marine Drugs · doi:10.3390/md14090160 · Cited by 33
Ge, H., Yu, A., Chen, J., Yuan, J., Yin, Y., Duanmu, W., Tan, L., Yang, Y., Lan, C., Chen, W., et al. (2016) · Scientific Reports · doi:10.1038/srep37681 · Cited by 34
Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future
Shibata, K., Hashimoto, T., Miyazaki, T., Miyazaki, A., & Nobe, K. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190319115018 · Cited by 34
Cyclic nucleotide phosphodiesterases (PDEs) and endothelial function in ischaemic stroke. A review
Yasmeen, S., Akram, B. H., Hainsworth, A. H., & Kruuse, C. R. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.05.011 · Cited by 34
Li, S., Lu, X., Shao, Q., Chen, Z., Huang, Q., Jiao, Z., Huang, X., Yue, M., Peng, J., Zhou, X., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00893 · Cited by 34
Liu, H., An, N., Wang, L., Li, Y., Song, K., Sun, Y., & Gao, Y. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115836 · Cited by 34
Gao, X., Yang, H., Xiao, W., Su, J., Zhang, Y., Wang, H., Ni, W., & Gu, Y. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00311-4 · Cited by 35
Wu, Y. H., Fan, X., Chen, S., Deng, L., Jiang, L., Yang, S., & Dong, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010544 · Cited by 34
The Imbalance of Vascular Molecules in Alzheimer's Disease
Bell, R. D. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121060 · Cited by 37
Li, F., Gong, Q., Wang, L., & Shi, J. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00133 · Cited by 31
A Promising Application of Injectable Hydrogels in Nerve Repair and Regeneration for Ischemic Stroke
Gao, Y., Zhang, T., Zhang, H., Gao, J., & Yang, P. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s442304 · Cited by 33
Prostaglandin FP receptor inhibitor reduces ischemic brain damage and neurotoxicity
Kim, Y. T., Moon, S.-K., Maruyama, T., Narumiya, S., & Doré, S. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.06.003 · Cited by 33
Cofilin-actin rod formation in neuronal processes after brain ischemia
Won, S. J., Minnella, A. M., Wu, L., Eun, C. H., Rome, E., Shaw, A. E., Herson, P. S., Bamburg, J. R., & Swanson, R. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198709 · Cited by 37
Mollet, I. G., Marto, J. P., Mendonça, M., Baptista, M. V., & Vieira, H. L. A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02585-6 · Cited by 35
Metadata
- Authors
- Moskowitz, M. A., Lo, E. H., & Iadecola, C.
- Affiliations
- Massachusetts General Hospital (US)
- Weill Cornell Medicine (US)
- Corresponding author
- Moskowitz, Michael A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 67
- Issue
- 2
- Pages
- 181-198
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2957363
- OpenAlex
- W2063541896
- Cited by
- 1,930
- References
- 232
- Citations by year
- 2026: 76 · 2025: 108 · 2024: 99 · 2023: 118 · 2022: 136 · 2021: 183 · 2020: 140 · 2019: 140 · 2018: 125 · 2017: 152 · 2016: 129 · 2015: 114 · 2014: 125 · 2013: 104 · 2012: 101
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-10-06)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS034179, R01NS037853)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- stroke, stroke pathophysiology, neurovascular interactions, glial cells, vascular cells, extracellular matrix, tissue damage, tissue repair, vascular dementia, stroke burden
- MeSH terms
- Animals, Blood Vessels, Humans, Models, Biological, Risk Factors, Cost of Illness, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
