Cited by 1,930Acute Ischemic Stroke ManagementNeuroinflammation and Neurodegeneration MechanismsIntracerebral and Subarachnoid Hemorrhage Research

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The Science of Stroke: Mechanisms in Search of Treatments

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Moskowitz, Michael A., Lo, Eng H., Iadecola, Costantino·2010·Neuron

DOI 10.1016/j.neuron.2010.07.002PMC PMC2957363

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Abstract

This review focuses on mechanisms and emerging concepts that drive the science of stroke in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing evidence has led to the realization that the biological processes underlying stroke are driven by the interaction of neurons, glia, vascular cells, and matrix components, which actively participate in mechanisms of tissue injury and repair. As new targets are identified, new opportunities emerge that build on an appreciation of acute cellular events acting in a broader context of ongoing destructive, protective, and reparative processes. The burden of disease is great, and its magnitude widens as a role for blood vessels and stroke in vascular and nonvascular dementias becomes more clearly established. This review then poses a number of fundamental questions, the answers to which may generate new directions for research and possibly new treatments that could reduce the impact of this enormous economic and societal burden.

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Authors: Moskowitz, M. A., Lo, E. H., & Iadecola, C.
Affiliations: Massachusetts General Hospital (US)
Weill Cornell Medicine (US)
Corresponding author: Moskowitz, Michael A.
ORCID: Moskowitz, Michael A.
Lo, Eng H.
Iadecola, Costantino
Venue: Neuron
Publisher: Elsevier BV
Published: 2010-07
Volume: 67
Issue: 2
Pages: 181-198
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2010.07.002
PMC: PMC2957363
OpenAlex: W2063541896
Cited by: 1,930
References: 232
Citations by year: 2026: 76 · 2025: 108 · 2024: 99 · 2023: 118 · 2022: 136 · 2021: 183 · 2020: 140 · 2019: 140 · 2018: 125 · 2017: 152 · 2016: 129 · 2015: 114 · 2014: 125 · 2013: 104 · 2012: 101
FWCI: 10.27
Type: journal article
Language: en
Update notices: erratum (2010-10-06)
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1112 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS034179, R01NS037853)
Topics: Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
Keywords: stroke, stroke pathophysiology, neurovascular interactions, glial cells, vascular cells, extracellular matrix, tissue damage, tissue repair, vascular dementia, stroke burden
MeSH terms: Animals, Blood Vessels, Humans, Models, Biological, Risk Factors, Cost of Illness, Stroke

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