v-SNARE composition distinguishes synaptic vesicle pools
Open accessAbstract
Synaptic vesicles belong to two distinct pools, a recycling pool responsible for the evoked release of neurotransmitter and a resting pool unresponsive to stimulation. The uniform appearance of synaptic vesicles has suggested that differences in location or cytoskeletal association account for these differences in function. We now find that the v-SNARE tetanus toxin-insensitive vesicle-associated membrane protein (VAMP7) differs from other synaptic vesicle proteins in its distribution to the two pools, providing evidence that they differ in molecular composition. We also find that both resting and recycling pools undergo spontaneous release, and when activated by deletion of the longin domain, VAMP7 influences the properties of release. Further, the endocytosis that follows evoked and spontaneous release differs in mechanism, and specific sequences confer targeting to the different vesicle pools. The results suggest that different endocytic mechanisms generate synaptic vesicles with different proteins that can endow the vesicles with distinct properties.
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This Ca2+ elevation specifically increases the fusion of vesicles containing vesicle-associated membrane protein 7 (VAMP7), an alternative SNARE protein that participates in spontaneous vesicle release.
“This Ca2+ elevation specifically increases the fusion of vesicles containing vesicle-associated membrane protein 7 (VAMP7), an alternative ‘soluble N-ethylmaleimide sensitive factor attachment protein receptor’ (SNARE) protein that participates in spontaneous vesicle release [74].”
From ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease (2017) · cites this paper as [74]
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Cites
Shaner, N. C., Campbell, R. E., Steinbach, P. A., Giepmans, B. N. G., Palmer, A. E., & Tsien, R. Y. (2004) · Nature Biotechnology · doi:10.1038/nbt1037 · Cited by 4,619 · see citing works
Phosphoinositides in cell regulation and membrane dynamics
Di Paolo, G., & De Camilli, P. (2006) · Nature · doi:10.1038/nature05185 · Cited by 2,790 · see citing works
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
Miesenböck, G., Angelis, D. A. D., & Rothman, J. E. (1998) · Nature · doi:10.1038/28190 · Cited by 2,569 · see citing works
Molecular anatomy of a trafficking organelle
Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.030 · Cited by 2,373 · see citing works
Heuser, J. E., & Reese, T. S. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.57.2.315 · Cited by 2,147 · see citing works
Nemani, V. M., Lü, W., Berge‐Seidl, V., Nakamura, K., Onoa, B., Lee, M. K., Chaudhry, F. A., Nicoll, R. A., & Edwards, R. H. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.023 · Cited by 1,051 · see citing works
Self-citationRizzoli, S. O., & Betz, W. J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1583 · Cited by 975 · see citing works
Dendritic Protein Synthesis, Synaptic Plasticity, and Memory
Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 894 · see citing works
Granseth, B., Odermatt, B., Royle, S. J., & Lagnado, L. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.029 · Cited by 686 · see citing works
Chaudhry, F. A., Reimer, R. J., Bellocchio, E. E., Danbolt, N. C., Osen, K. K., Edwards, R. H., & Storm‐Mathisen, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09733.1998 · Cited by 640 · see citing works
Self-citationThe Use of pHluorins for Optical Measurements of Presynaptic Activity
Sankaranarayanan, S., Angelis, D. A. D., Rothman, J. E., & Ryan, T. A. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76468-x · Cited by 586 · see citing works
Miniature synaptic events maintain dendritic spines via AMPA receptor activation
McKinney, R. A., Capogna, M., Dürr, R., Gähwiler, B. H., & Thompson, A. S. M. (1999) · Nature Neuroscience · doi:10.1038/4548 · Cited by 523 · see citing works
The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses
Vogt, K. E., Mellor, J. R., Tong, G., & Nicoll, R. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)81149-6 · Cited by 491 · see citing works
Distinct Endocytic Pathways Control the Rate and Extent of Synaptic Vesicle Protein Recycling
Voglmaier, S. M., Kam, K., Yang, H., Fortin, D. L., Hua, Z., Nicoll, R. A., & Edwards, R. H. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.027 · Cited by 425 · see citing works
Self-citationThe synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynamin.
Takei, K., Mundigl, O., DANIELL, L. W., & Camilli, P. V. D. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.6.1237 · Cited by 416 · see citing works
Real-time measurements of vesicle-SNARE recycling in synapses of the central nervous system
Sankaranarayanan, S., & Ryan, T. A. (2000) · Nature Cell Biology · doi:10.1038/35008615 · Cited by 410 · see citing works
An Isolated Pool of Vesicles Recycles at Rest and Drives Spontaneous Neurotransmission
Sara, Y., Virmani, T., Deák, F., Liu, X., & Kavalali, E. T. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.056 · Cited by 399 · see citing works
Kantheti, P., Qiao, X., Díaz, M. E., Peden, A. A., Meyer, G. E., Carskadon, S. L., Kapfhamer, D., Sufalko, D., Robinson, M. S., Noebels, J. L., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80519-x · Cited by 399 · see citing works
The Dynamic Control of Kiss-And-Run and Vesicular Reuse Probed with Single Nanoparticles
Zhang, Q., Li, Y., & Tsien, R. W. (2009) · Science · doi:10.1126/science.1167373 · Cited by 367 · see citing works
Synapsin dispersion and reclustering during synaptic activity
Chi, P., Greengard, P., & Ryan, T. A. (2001) · Nature Neuroscience · doi:10.1038/nn756 · Cited by 362 · see citing works
Two Endocytic Recycling Routes Selectively Fill Two Vesicle Pools in Frog Motor Nerve Terminals
Richards, D. A., Guatimosim, C., & Betz, W. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00065-9 · Cited by 353 · see citing works
The Structural Organization of the Readily Releasable Pool of Synaptic Vesicles
Rizzoli, S. O., & Betz, W. J. (2004) · Science · doi:10.1126/science.1094682 · Cited by 340 · see citing works
Actin has a molecular scaffolding, not propulsive, role in presynaptic function
Sankaranarayanan, S., Atluri, P. P., & Ryan, T. A. (2003) · Nature Neuroscience · doi:10.1038/nn1002 · Cited by 324 · see citing works
Doc2b Is a High-Affinity Ca <sup>2+</sup> Sensor for Spontaneous Neurotransmitter Release
Groffen, A. J., Martens, S., Arazola, R. D., Cornelisse, L. N., Lozovaya, N., de Jong, A. P. H., Goriounova, N. A., Habets, R. L. P., Takai, Y., Borst, J. G., et al. (2010) · Science · doi:10.1126/science.1183765 · Cited by 313 · see citing works
A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth
Huntwork, S., & Littleton, J. T. (2007) · Nature Neuroscience · doi:10.1038/nn1980 · Cited by 292 · see citing works
A Function for the AP3 Coat Complex in Synaptic Vesicle Formation from Endosomes
Faúndez, V., Horng, J., & Kelly, R. B. (1998) · Cell · doi:10.1016/s0092-8674(00)81170-8 · Cited by 290 · see citing works
CDK5 Serves as a Major Control Point in Neurotransmitter Release
Kim, S. H., & Ryan, T. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.003 · Cited by 277 · see citing works
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release
Xu, J., Pang, Z. P., Shin, O.-H., & Südhof, T. C. (2009) · Nature Neuroscience · doi:10.1038/nn.2320 · Cited by 274 · see citing works
Wienisch, M., & Klingauf, J. (2006) · Nature Neuroscience · doi:10.1038/nn1739 · Cited by 251 · see citing works
Role of ACh-GABA cotransmission in detecting image motion and motion direction
Lee, S., Kim, K., & Zhou, Z. J. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.031 · Cited by 241 · see citing works
Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion
Harata, N. C., Ryan, T. A., Smith, S. J., Buchanan, J., & Tsien, R. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171442798 · Cited by 237 · see citing works
A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapse
Fredj, N. B., & Burrone, J. (2009) · Nature Neuroscience · doi:10.1038/nn.2317 · Cited by 231 · see citing works
Martı́nez-Arca, S., Alberts, P., Zahraoui, A., Louvard, D., & Galli, T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.4.889 · Cited by 223 · see citing works
Takao-Rikitsu, E., Mochida, S., Inoue, E., Deguchi-Tawarada, M., Inoue, M., Ohtsuka, T., & Takai, Y. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307101 · Cited by 221 · see citing works
Synaptic Vesicle Pools at the Frog Neuromuscular Junction
Richards, D. A., Guatimosim, C., Rizzoli, S. O., & Betz, W. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00405-7 · Cited by 208 · see citing works
A dual mechanism controlling the localization and function of exocytic v-SNAREs
Martı́nez-Arca, S., Rudge, R. E., Vacca, M., Raposo, G., Camonis, J., Proux‐Gillardeaux, V., Daviet, L., Formstecher, É., Hamburger, A., Filippini, F., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1431910100 · Cited by 207 · see citing works
Fernández-Alfonso, T., Kwan, R., & Ryan, T. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.008 · Cited by 202 · see citing works
Atasoy, D., Ertunç, M., Moulder, K., Blackwell, J., Chung, C.-Y., Su, J.-Z., & Kavalali, E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2432-08.2008 · Cited by 201 · see citing works
Biogenesis of synaptic vesicle-like structures in a pheochromocytoma cell line PC-12.
Clift-O'Grady, L., Linstedt, A. D., Lowe, A. W., Grote, E., & Kelly, R. B. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.5.1693 · Cited by 189 · see citing works
Bulk Membrane Retrieval in the Synaptic Terminal of Retinal Bipolar Cells
Holt, M. G., Cooke, A., Wu, M. M., & Lagnado, L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01329.2003 · Cited by 183 · see citing works
Endosomal sorting of readily releasable synaptic vesicles
Hoopmann, P., Punge, A., Barysch, S. V., Westphal, V., Bückers, J., Opazo, F., Bethani, I., Lauterbach, M. A., Hell, S. W., & Rizzoli, S. O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007037107 · Cited by 166 · see citing works
A Common Exocytotic Mechanism Mediates Axonal and Dendritic Outgrowth
Martı́nez-Arca, S., Coco, S., Mainguy, G., Schenk, U., Alberts, P., Bouillé, P., Mezzina, M., Prochiantz, A., Matteoli, M., Louvard, D., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03830.2001 · Cited by 164 · see citing works
High Mobility of Vesicles Supports Continuous Exocytosis at a Ribbon Synapse
Holt, M. G., Cooke, A., Neef, A., & Lagnado, L. (2004) · Current Biology · doi:10.1016/j.cub.2003.12.053 · Cited by 161 · see citing works
Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis
Leal‐Ortiz, S., Waites, C. L., Terry-Lorenzo, R. T., Zamorano, P. L., Gundelfinger, E. D., & Garner, C. C. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711167 · Cited by 157 · see citing works
Self-citationPolo‐Parada, L., Böse, C., & Landmesser, L. T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00521-9 · Cited by 155 · see citing works
Pryor, P. R., Jackson, L. P., Gray, S. R., Edeling, M. A., Thompson, A., Sanderson, C. M., Evans, P. R., Owen, D. J., & Luzio, J. P. (2008) · Cell · doi:10.1016/j.cell.2008.07.023 · Cited by 154 · see citing works
Chung, C., Baryłko, B., Leitz, J., Liu, X., & Kavalali, E. T. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3427-09.2010 · Cited by 154 · see citing works
Factors regulating the abundance and localization of synaptobrevin in the plasma membrane
Dittman, J. S., & Kaplan, J. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600784103 · Cited by 148 · see citing works
Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle pool
Groemer, T. W., & Klingauf, J. (2007) · Nature Neuroscience · doi:10.1038/nn1831 · Cited by 147 · see citing works
Neuronal and non-neuronal functions of the AP-3 sorting machinery
Litwa, K., Seong, E., Burmeister, M., & Faúndez, V. (2007) · Journal of Cell Science · doi:10.1242/jcs.03365 · Cited by 135 · see citing works
BLOC-1 Complex Deficiency Alters the Targeting of Adaptor Protein Complex-3 Cargoes
Salazar, G., Craige, B., Styers, M. L., Litwa, K., Doucette, M. M., Wainer, B. H., Falcón‐Pérez, J. M., Dell’Angelica, E. C., Peden, A. A., Werner, E., et al. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-02-0103 · Cited by 130 · see citing works
Synaptic Vesicle Recycling at CNS Synapses without AP-2
Kim, S. H., & Ryan, T. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5639-08.2009 · Cited by 123 · see citing works
Salazar, G., Love, R., Werner, E., Doucette, M. M., Cheng, S., Levey, A. I., & Faúndez, V. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-06-0401 · Cited by 118 · see citing works
A Leucine-based Motif Mediates the Endocytosis of Vesicular Monoamine and Acetylcholine Transporters
Tan, P. K., Waites, C. L., Liu, Y., Krantz, D. E., & Edwards, R. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17351 · Cited by 116 · see citing works
Self-citationAP‐1/σ1B‐adaptin mediates endosomal synaptic vesicle recycling, learning and memory
Glyvuk, N., Tsytsyura, Y., Geumann, C., D’Hooge, R., Hüve, J., Kratzke, M., Baltes, J., Böning, D., Klingauf, J., & Schu, P. V. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.15 · Cited by 113 · see citing works
Maximov, A., Shin, O., Liu, X., & Südhof, T. C. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200607021 · Cited by 112 · see citing works
The same synaptic vesicles drive active and spontaneous release
Wilhelm, B. G., Groemer, T. W., & Rizzoli, S. O. (2010) · Nature Neuroscience · doi:10.1038/nn.2690 · Cited by 111 · see citing works
Coco, S., Raposo, G., Martı́nez-Arca, S., Fontaine, J., Takamori, S., Zahraoui, A., Jahn, R., Matteoli, M., Louvard, D., & Galli, T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09803.1999 · Cited by 110 · see citing works
Vinatier, J., Herzog, É., Plamont, M., Wojcik, S. M., Schmidt, A., Brose, N., Daviet, L., Mestikawy, S. E., & Bruno Giros, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03821.x · Cited by 103 · see citing works
Fenster, S. D., Kessels, M. M., Qualmann, B., Chung, W. J., Nash, J. E., Gundelfinger, E. D., & Garner, C. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210792200 · Cited by 103 · see citing works
Self-citationLoss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses
Scheuber, A., Rudge, R. E., Danglot, L., Raposo, G., Binz, T., Poncer, J. C., & Galli, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603511103 · Cited by 103 · see citing works
The neuronal form of adaptor protein-3 is required for synaptic vesicle formation from endosomes
Blumstein, J., Faundez, V., Nakatsu, F., Saito, T., Ohno, H., & Kelly, R. B. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08034.2001 · Cited by 98 · see citing works
A common origin of synaptic vesicles undergoing evoked and spontaneous fusion
Hua, Y., Sinha, R., Martineau, M., Kahms, M., & Klingauf, J. (2010) · Nature Neuroscience · doi:10.1038/nn.2695 · Cited by 95 · see citing works
Fernández-Alfonso, T., & Ryan, T. A. (2008) · Journal of Neurocytology · doi:10.1007/s11068-008-9030-y · Cited by 95 · see citing works
Roles of BLOC-1 and Adaptor Protein-3 Complexes in Cargo Sorting to Synaptic Vesicles
Litwa, K., Salazar, G., Smith, Y., & Faúndez, V. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0456 · Cited by 94 · see citing works
Alberts, P., Rudge, R. E., Irinopoulou, T., Danglot, L., Gauthier‐Rouvière, C., & Galli, T. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0643 · Cited by 94 · see citing works
Role of Varp, a Rab21 exchange factor and TI‐VAMP/VAMP7 partner, in neurite growth
Burgo, A., Sotirakis, E., Simmler, M., Verraes, A., Chamot, C., Simpson, J. C., Lanzetti, L., Proux‐Gillardeaux, V., & Galli, T. (2009) · EMBO Reports · doi:10.1038/embor.2009.186 · Cited by 91 · see citing works
Li, H., Waites, C. L., Staal, R. G. W., Dobry, Y., Park, J., Sulzer, D. L., & Edwards, R. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.033 · Cited by 88 · see citing works
Self-citationAlberts, P., Rudge, R. E., Hinners, I., Muzerelle, A., Martı́nez-Arca, S., Irinopoulou, T., Marthiens, V., Tooze, S. A., Rathjen, F. G., Gaspar, P., et al. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-03-0147 · Cited by 86 · see citing works
Role of HRB in Clathrin-dependent Endocytosis
Chaineau, M., Danglot, L., Proux‐Gillardeaux, V., & Galli, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804587200 · Cited by 67 · see citing works
Vesicular Monoamine and Glutamate Transporters Select Distinct Synaptic Vesicle Recycling Pathways
Onoa, B., Li, H., Gagnon-Bartsch, J. A., Elias, L., & Edwards, R. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5298-09.2010 · Cited by 66 · see citing works
Self-citationGois, S. D., Jeanclos, E. M., Morris, M. E. K., Grewal, S., Varoqui, H., & Erickson, J. D. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9054-8 · Cited by 63 · see citing works
Do different endocytic pathways make different synaptic vesicles?
Voglmaier, S. M., & Edwards, R. H. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.002 · Cited by 63 · see citing works
Self-citationMuzerelle, A., Alberts, P., Martı́nez-Arca, S., Jeannequin, O., Lafaye, P. J., Mazié, J. C., Galli, T., & Gaspar, P. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00567-0 · Cited by 57 · see citing works
Syntaxin-1A Is Excluded from Recycling Synaptic Vesicles at Nerve Terminals
Mitchell, S. J., & Ryan, T. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0174-04.2004 · Cited by 57 · see citing works
Leaky synapses: Regulation of spontaneous neurotransmission in central synapses
Wasser, C. R., & Kavalali, E. T. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.028 · Cited by 55 · see citing works
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Pathak, D., Shields, L. Y., Mendelsohn, B. A., Haddad, D., Lin, W., Gerencser, A. A., Kim, H., Brand, M. D., Edwards, R. H., & Nakamura, K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.656405 · Cited by 311 · see citing works
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Berthet, A., Margolis, E. B., Zhang, J., Hsieh, I., Zhang, J.-S., Hnasko, T., Ahmad, J., Edwards, R., Sesaki, H., Huang, E., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0930-14.2014 · Cited by 187 · see citing works
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Melom, J. E., Akbergenova, Y., Gavornik, J. P., & Littleton, J. T. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3334-13.2013 · Cited by 210 · see citing works
Ramirez, D. M. O., Khvotchev, M. V., Trauterman, B., & Kavalali, E. T. (2012) · Neuron · doi:10.1016/j.neuron.2011.10.034 · Cited by 166 · see citing works
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“This Ca2+ elevation specifically increases the fusion of vesicles containing vesicle-associated membrane protein 7 (VAMP7), an alternative ‘soluble N-ethylmaleimide sensitive factor attachment protein receptor’ (SNARE) protein that participates in spontaneous vesicle release [74].”
BackgroundMullin, A. P., Gokhale, A., Moreno-De-Luca, A., Sanyal, S., Waddington, J. L., & Faúndez, V. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.108 · Cited by 165 · see citing works
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Raingo, J., Khvotchev, M. V., Liu, P., Darios, F. D., Li, Y. C., Ramirez, D. M. O., Adachi, M., Lemieux, P., Tóth, K., Davletov, B. A., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3067 · Cited by 164 · see citing works
Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation
Waites, C. L., Leal‐Ortiz, S., Okerlund, N. D., Dalke, H., Fejtová, A., Altrock, W. D., Gundelfinger, E. D., & Garner, C. C. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.27 · Cited by 154 · see citing works
Self-citationA new probe for super-resolution imaging of membranes elucidates trafficking pathways
Revelo, N. H., Kamin, D., Truckenbrodt, S., Wong, A. B., Reuter‐Jessen, K., Reisinger, E., Moser, T., & Rizzoli, S. O. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201402066 · Cited by 150 · see citing works
Distinct Initial SNARE Configurations Underlying the Diversity of Exocytosis
Kasai, H., Takahashi, N., & Tokumaru, H. (2012) · Physiological Reviews · doi:10.1152/physrev.00007.2012 · Cited by 150 · see citing works
The blockade of the neurotransmitter release apparatus by botulinum neurotoxins
Pantano, S., & Montecucco, C. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1380-7 · Cited by 134 · see citing works
Visualizing presynaptic function
Kavalali, E. T., & Jorgensen, E. M. (2014) · Nature Neuroscience · doi:10.1038/nn.3578 · Cited by 126 · see citing works
Bal, M., Leitz, J., Reese, A. L., Ramirez, D. M. O., Durakoglugil, M., Herz, J., Monteggia, L. M., & Kavalali, E. T. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.024 · Cited by 131 · see citing works
Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties
Silm, K., Yang, J., Marcott, P. F., Asensio, C. S., Eriksen, J., Guthrie, D. A., Newman, A. H., Ford, C., & Edwards, R. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.031 · Cited by 131 · see citing works
Self-citationA Molecular Network for the Transport of the TI-VAMP/VAMP7 Vesicles from Cell Center to Periphery
Burgo, A., Proux‐Gillardeaux, V., Sotirakis, E., Bun, P., Casano, A. M., Verraes, A., Liem, R. K. H., Formstecher, É., Coppey‐Moisan, M., & Galli, T. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.04.019 · Cited by 124 · see citing works
Cheng, X., Zhang, X., Gao, Q., Samie, M. A., Azar, M., Tsang, W. L., Dong, L., Sahoo, N., Li, X., Yue, Z., et al. (2014) · Nature Medicine · doi:10.1038/nm.3611 · Cited by 115 · see citing works
Drosophila melanogaster as a genetic model system to study neurotransmitter transporters
Martin, C. A., & Krantz, D. E. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.03.015 · Cited by 113 · see citing works
Shields, L. Y., Kim, H., Zhu, L., Haddad, D., Berthet, A., Pathak, D., Lam, M., Ponnusamy, R., Diaz‐Ramirez, L. G., Gill, T. M., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.94 · Cited by 112 · see citing works
Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses
Wu, X.-S., Lee, S. H., Sheng, J., Zhang, Z., Zhao, W.-D., Wang, D., Jin, Y., Charnay, P., Ervasti, J. M., & Wu, L.-G. (2016) · Neuron · doi:10.1016/j.neuron.2016.10.014 · Cited by 109 · see citing works
Structure and function of longin SNAREs
Daste, F., Galli, T., & Tareste, D. C. (2015) · Journal of Cell Science · doi:10.1242/jcs.178574 · Cited by 107 · see citing works
Mishima, T., Fujiwara, T., Sanada, M., Kofuji, T., Kanai‐Azuma, M., & Akagawa, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090004 · Cited by 89 · see citing works
Synapsin Selectively Controls the Mobility of Resting Pool Vesicles at Hippocampal Terminals
Orenbuch, A., Shalev, L., Marra, V., Sinai, I., Lavy, Y., Kahn, J., Burden, J. J., Staras, K., & Gitler, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5058-11.2012 · Cited by 88 · see citing works
Marra, V., Burden, J. J., Thorpe, J. R., Smith, I. T., Smith, S. L., Häusser, M., Branco, T., & Staras, K. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.042 · Cited by 84 · see citing works
Synaptic Ribbons Influence the Size and Frequency of Miniature-like Evoked Postsynaptic Currents
Mehta, B., Snellman, J., Chen, S., Li, W., & Zenisek, D. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.024 · Cited by 82 · see citing works
Multiple Roles of Actin in Exo- and Endocytosis
Wu, L.-G., & Chan, C.-Y. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.841704 · Cited by 38 · see citing works
Molecular Underpinnings of Synaptic Vesicle Pool Heterogeneity
Crawford, D. C., & Kavalali, E. T. (2015) · Traffic · doi:10.1111/tra.12262 · Cited by 84 · see citing works
Presynaptic origins of distinct modes of neurotransmitter release
Chanaday, N. L., & Kavalali, E. T. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.03.005 · Cited by 78 · see citing works
VAMP4 Is an Essential Cargo Molecule for Activity-Dependent Bulk Endocytosis
Nicholson-Fish, J. C., Kokotos, A. C., Gillingwater, T. H., Smillie, K. J., & Cousin, M. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.043 · Cited by 76 · see citing works
Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and composition
Werner, C., Pauli, M., Doose, S., Weishaupt, A., Haselmann, H., Grünewald, B., Sauer, M., Heckmann, M., Toyka, K. V., Asan, E., et al. (2016) · Brain · doi:10.1093/brain/awv324 · Cited by 75 · see citing works
Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets
Li, Y. C., & Kavalali, E. T. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013342 · Cited by 73 · see citing works
Corelease of Dopamine and GABA by a Retinal Dopaminergic Neuron
Hirasawa, H., Betensky, R. A., & Raviola, E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2213-12.2012 · Cited by 73 · see citing works
Absence of TI-VAMP/Vamp7 Leads to Increased Anxiety in Mice
Danglot, L., Zylbersztejn, K., Petković, M., Gauberti, M., Méziane, H., Combe, R., Champy, M., Birling, M., Pavlovic, G., Bizot, J., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4436-11.2012 · Cited by 68 · see citing works
Peng, A., Rotman, Z., Deng, P., & Klyachko, V. A. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.023 · Cited by 65 · see citing works
The Voltage-Gated Calcium Channel Functions as the Molecular Switch of Synaptic Transmission
Atlas, D. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-080411-121438 · Cited by 65 · see citing works
Bourne, J. N., Chirillo, M. A., & Harris, K. M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23384 · Cited by 65 · see citing works
Isoflurane inhibition of endocytosis is an anesthetic mechanism of action
Jung, S., Zimin, P. I., Woods, C. B., Kayser, E., Haddad, D., Reczek, C. R., Nakamura, K., Ramirez, J., Sedensky, M. M., & Morgan, P. G. (2022) · Current Biology · doi:10.1016/j.cub.2022.05.037 · Cited by 62 · see citing works
Functionally heterogeneous synaptic vesicle pools support diverse synaptic signalling
Chamberland, S., & Tóth, K. (2015) · The Journal of Physiology · doi:10.1113/jp270194 · Cited by 59 · see citing works
Developmental Refinement of Vesicle Cycling at Schaffer Collateral Synapses
Rose, T., Schoenenberger, P., Ježek, K., & Oertner, T. G. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.021 · Cited by 57 · see citing works
Scarnati, M. S., Kataria, R., Biswas, M., & Paradiso, K. G. (2018) · eLife · doi:10.7554/elife.36697 · Cited by 55 · see citing works
Synaptic Vesicle Recycling and the Endolysosomal System: A Reappraisal of Form and Function
Ivanova, D., & Cousin, M. A. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.826098 · Cited by 56 · see citing works
Activity-dependent secretion of synaptic organizer Cbln1 from lysosomes in granule cell axons
Ibata, K., Kono, M., Narumi, S., Motohashi, J., Kakegawa, W., Kohda, K., & Yuzaki, M. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.044 · Cited by 56 · see citing works
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B
Tian, X., Zheng, P., Zhou, C., Wang, X., Ma, H., Ma, W., Zhou, X., Teng, J., & Chen, J. (2019) · Autophagy · doi:10.1080/15548627.2019.1637199 · Cited by 56 · see citing works
Joensuu, M., Martínez-Mármol, R., Padmanabhan, P., Glass, N., Durisic, N., Pelekanos, M., Mollazade, M., Balistreri, G., Amor, R., Cooper-White, J., et al. (2017) · Nature Protocols · doi:10.1038/nprot.2017.116 · Cited by 53 · see citing works
Fast retrieval and autonomous regulation of single spontaneously recycling synaptic vesicles
Leitz, J., & Kavalali, E. T. (2014) · eLife · doi:10.7554/elife.03658 · Cited by 51 · see citing works
Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
Crawford, D. C., Ramirez, D. M. O., Trauterman, B., Monteggia, L. M., & Kavalali, E. T. (2017) · Nature Communications · doi:10.1038/ncomms14436 · Cited by 51 · see citing works
Multiple Dileucine-like Motifs Direct VGLUT1 Trafficking
Foss, S., Li, H., Santos, M., Edwards, R. H., & Voglmaier, S. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5662-12.2013 · Cited by 50 · see citing works
Self-citationSantos, M., Park, C. K., Foss, S., Li, H., & Voglmaier, S. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0329-13.2013 · Cited by 49 · see citing works
Self-citationRegulation of synaptic activity by snapin‐mediated endolysosomal transport and sorting
Giovanni, J. D., & Sheng, Z. (2015) · The EMBO Journal · doi:10.15252/embj.201591125 · Cited by 49 · see citing works
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
Ghosh, D., Pinto, S., Danglot, L., Vandewauw, I., Segal, A., Ranst, N. V., Benoit, M., Janssens, A., Vennekens, R., Berghe, P. V., et al. (2016) · Nature Communications · doi:10.1038/ncomms10489 · Cited by 49 · see citing works
A discrete presynaptic vesicle cycle for neuromodulator receptors
Jullié, D., Stoeber, M., Sibarita, J., Zieger, H. L., Bartol, T., Arttamangkul, S., Sejnowski, T., Hosy, E., & von Zastrow, M. (2019) · Neuron · doi:10.1016/j.neuron.2019.11.016 · Cited by 48 · see citing works
Evstratova, A., Chamberland, S., Faúndez, V., & Tóth, K. (2014) · Nature Communications · doi:10.1038/ncomms6530 · Cited by 46 · see citing works
Cyclic Nucleotide Control of Microtubule Dynamics for Axon Guidance
Akiyama, H., Fukuda, T., Tojima, T., Nikolaev, V. O., & Kamiguchi, H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3596-15.2016 · Cited by 46 · see citing works
Nano-Organization at the Synapse: Segregation of Distinct Forms of Neurotransmission
Guzikowski, N. J., & Kavalali, E. T. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.796498 · Cited by 45 · see citing works
The Synaptic Extracellular Matrix: Long-Lived, Stable, and Still Remarkably Dynamic
Dankovich, T. M., & Rizzoli, S. O. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.854956 · Cited by 44 · see citing works
Vivona, S., Cipriano, D. J., O’Leary, S. E., Li, Y. H., Fenn, T. D., & Brünger, A. T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.489807 · Cited by 44 · see citing works
The Sybtraps: Control of Synaptobrevin Traffic by Synaptophysin, α‐Synuclein and AP‐180
Gordon, S. L., & Cousin, M. A. (2013) · Traffic · doi:10.1111/tra.12140 · Cited by 43 · see citing works
Lavoie, N., Jeyaraju, D. V., Peralta, M. R., Seress, L., Pellegrini, L., & Tóth, K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4164-11.2011 · Cited by 42 · see citing works
The structure and function of presynaptic endosomes
Jähne, S., Rizzoli, S. O., & Helm, M. S. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.04.017 · Cited by 41 · see citing works
Botulinum neurotoxin type-A enters a non-recycling pool of synaptic vesicles
Harper, C. B., Papadopulos, A., Martin, S., Matthews, D. R., Morgan, G., Nguyen, T. H., Wang, T., Nair, D. K., Choquet, D., & Meunier, F. A. (2016) · Scientific Reports · doi:10.1038/srep19654 · Cited by 41 · see citing works
The function of VAMP2 in mediating membrane fusion: An overview
Yan, C., Jiang, J., Yang, Y., Geng, X., & Dong, W. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.948160 · Cited by 38 · see citing works
Morgan, J. R., Comstra, H. S., Cohen, M., & Faúndez, V. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016915 · Cited by 38 · see citing works
Synaptic Vesicle Generation from Central Nerve Terminal Endosomes
Kokotos, A. C., & Cousin, M. A. (2014) · Traffic · doi:10.1111/tra.12235 · Cited by 38 · see citing works
SCAMP5 Plays a Critical Role in Synaptic Vesicle Endocytosis during High Neuronal Activity
Zhao, H., Kim, Y., Park, J. M., Park, D., Lee, S., Chang, I., & Chang, S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2156-14.2014 · Cited by 38 · see citing works
Nanoscale Organization of Vesicle Release at Central Synapses
Gramlich, M. W., & Klyachko, V. A. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.03.001 · Cited by 35 · see citing works
Burgo, A., Casano, A. M., Kuster, A., Arold, S. T., Wang, G., Nola, S., Verraes, A., Dingli, F., Loew, D., & Galli, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.415075 · Cited by 33 · see citing works
A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry
Ullman, J. C., Yang, J., Sullivan, M., Bendor, J., Levy, J. M., Pham, E., Silm, K., Seifikar, H., Sohal, V. S., Nicoll, R. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02716-5 · Cited by 32 · see citing works
Self-citationTRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47
Urbina, F., Menon, S., Goldfarb, D., Edwards, R. J., Major, M. B., Brennwald, P., & Gupton, S. L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108743 · Cited by 33 · see citing works
Self-citationLoss of Doc2-Dependent Spontaneous Neurotransmission Augments Glutamatergic Synaptic Strength
Ramirez, D. M. O., Crawford, D. C., Chanaday, N. L., Trauterman, B., Monteggia, L. M., & Kavalali, E. T. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0418-17.2017 · Cited by 31 · see citing works
Ultrastructural and functional fate of recycled vesicles in hippocampal synapses
Rey, S. A., Smith, C. A., Fowler, M. W., Crawford, F., Burden, J. J., & Staras, K. (2015) · Nature Communications · doi:10.1038/ncomms9043 · Cited by 27 · see citing works
ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals
Binotti, B., Ninov, M., Cepeda, A. P., Ganzella, M., Matti, U., Riedel, D., Urlaub, H., Sambandan, S., & Jahn, R. (2023) · Autophagy · doi:10.1080/15548627.2023.2274204 · Cited by 30 · see citing works
The role of non-canonical SNAREs in synaptic vesicle recycling
Ramirez, D. M. O., & Kavalali, E. T. (2012) · Cellular Logistics · doi:10.4161/cl.20114 · Cited by 30 · see citing works
Vesicle dynamics: how synaptic proteins regulate different modes of neurotransmission
Chung, C., & Raingo, J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12245 · Cited by 28 · see citing works
Vesicular Release of GABA by Mammalian Horizontal Cells Mediates Inhibitory Output to Photoreceptors
Hirano, A. A., Vuong, H. E., Kornmann, H. L., Schietroma, C., Stella, S., Barnes, S., & Brecha, N. C. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.600777 · Cited by 28 · see citing works
Gao, M., Whitt, J. L., Huang, S., Lee, A., Mihalaş, Ş., Kirkwood, A., & Lee, H. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0156 · Cited by 25 · see citing works
Copine-6 Binds to SNAREs and Selectively Suppresses Spontaneous Neurotransmission
Liu, P., Khvotchev, M. V., Li, Y. C., Chanaday, N. L., & Kavalali, E. T. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0461-18.2018 · Cited by 28 · see citing works
Farsi, Z., Walde, M., Klementowicz, A. E., Paraskevopoulou, F., & Woehler, A. (2020) · iScience · doi:10.1016/j.isci.2020.101909 · Cited by 25 · see citing works
Cork, K. M., Hook, M. J. V., & Thoreson, W. B. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13288 · Cited by 25 · see citing works
VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3
Li, H., Santos, M., Park, C. K., Dobry, Y., & Voglmaier, S. M. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00324 · Cited by 26 · see citing works
Self-citationGuo, D.-Z., Xiao, L., Liu, Y.-J., Shen, C., Lou, H.-F., Lv, Y., & Pan, S.-Y. (2018) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.291 · Cited by 25 · see citing works
Liu, Y., Sugiura, Y., Südhof, T. C., & Lin, W. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0403-19.2019 · Cited by 24 · see citing works
Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis
Zhu, Y.-H., Hyun, J., Pan, Y.-Z., Hopper, J., Rizo, J., & Wu, J.-Q. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-04-0225 · Cited by 21 · see citing works
Endocytic Structures and Synaptic Vesicle Recycling at a Central Synapse in Awake Rats
Körber, C., Horstmann, H., Sätzler, K., & Kuner, T. (2012) · Traffic · doi:10.1111/tra.12007 · Cited by 24 · see citing works
Rodrigues, H. A., Lima, R. F., Fonseca, M. D. C., Amaral, E. A., Martinelli, P. M., Naves, L. A., Gomez, M. V., Kushmerick, C., Prado, M. A. M., & Guatimosim, C. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12300 · Cited by 24 · see citing works
Synaptic vesicle pools: Principles, properties and limitations
Fowler, M. W., & Staras, K. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.03.007 · Cited by 24 · see citing works
Morton, A., Marland, J. R. K., & Cousin, M. A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13132 · Cited by 23 · see citing works
Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity
Shields, L. Y., Li, H., Nguyen, K., Kim, H., Doric, Z., Garcia, J. H., Gill, T. M., Haddad, D., Vossel, K. A., Calvert, M., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100469 · Cited by 22 · see citing works
Mori, Y., Takenaka, K.-I., Fukazawa, Y., & Takamori, S. (2021) · Communications Biology · doi:10.1038/s42003-021-02512-4 · Cited by 22 · see citing works
Adaptor protein-3 produces synaptic vesicles that release phasic dopamine
Jain, S., Yee, A. G., Maas, J., Gierok, S., Xu, H., Stansil, J. A., Eriksen, J., Nelson, A., Silm, K., Ford, C., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2309843120 · Cited by 22 · see citing works
Self-citationSpontaneous vesicle recycling in the synaptic bouton
Truckenbrodt, S., & Rizzoli, S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00409 · Cited by 21 · see citing works
Afuwape, O. A., Wasser, C. R., Schikorski, T., & Kavalali, E. T. (2016) · The Journal of Physiology · doi:10.1113/jp273115 · Cited by 21 · see citing works
Candiello, E., Kratzke, M., Wenzel, D., Cassel, D., & Schu, P. V. (2016) · Scientific Reports · doi:10.1038/srep29950 · Cited by 21 · see citing works
- Authors
- Hua, Z., Leal-Ortiz, S., Foss, S. M., Waites, C. L., Garner, C. C., Voglmaier, S. M., & Edwards, R. H.
- Affiliations
- University of California, San Francisco (US)
- Stanford University (US)
- Corresponding author
- Edwards, Robert H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 71
- Issue
- 3
- Pages
- 474-487
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3155686
- OpenAlex
- W2003748392
- Cited by
- 168
- References
- 76
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 12 · 2017: 16 · 2016: 11 · 2015: 15 · 2014: 19 · 2013: 22 · 2012: 20
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Institute of Mental Health (R01MH050712, R01MH083691, K08MH071626)
- National Institute on Drug Abuse (P01DA010154)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- synaptic vesicle pools, VAMP7, VAMP, synaptic vesicle recycling, spontaneous neurotransmitter release, longin domain, endocytosis, vesicle composition, vesicle targeting
- MeSH terms
- Animals, Cells, Cultured, Exocytosis, Mice, Mutant Strains, Neurons, Synaptic Vesicles, Adaptor Protein Complex 3, Adaptor Protein Complex beta Subunits, Vesicular Glutamate Transport Protein 1, SNARE Proteins, R-SNARE Proteins, Mice
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