Co-transmission of acetylcholine and GABA regulates hippocampal states
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Abstract
Abstract The basal forebrain cholinergic system is widely assumed to control cortical functions via non-synaptic transmission of a single neurotransmitter. Yet, we find that mouse hippocampal cholinergic terminals invariably establish GABAergic synapses, and their cholinergic vesicles dock at those synapses only. We demonstrate that these synapses do not co-release but co-transmit GABA and acetylcholine via different vesicles, whose release is triggered by distinct calcium channels. This co-transmission evokes composite postsynaptic potentials, which are mutually cross-regulated by presynaptic autoreceptors. Although postsynaptic cholinergic receptor distribution cannot be investigated, their response latencies suggest a focal, intra- and/or peri-synaptic localisation, while GABA A receptors are detected intra-synaptically. The GABAergic component alone effectively suppresses hippocampal sharp wave-ripples and epileptiform activity. Therefore, the differentially regulated GABAergic and cholinergic co-transmission suggests a hitherto unrecognised level of control over cortical states. This novel model of hippocampal cholinergic neurotransmission may lead to alternative pharmacotherapies after cholinergic deinnervation seen in neurodegenerative disorders.
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Ach and glutamate are copackaged into the same synaptic vesicles at the mHb-to-IPN synapse.
“Several groups have found evidence for Ach and glutamate being copackaged into the same synaptic vesicles at this synapse 21,22,56,124”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [124]
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- Authors
- Takács, V. T., Cserép, C., Schlingloff, D., Pósfai, B., Szőnyi, A., Sos, K. E., Környei, Z., Dénes, Á., Gulyás, A. I., Freund, T. F., & Nyiri, G.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- Semmelweis University (HU)
- ORCID
- Venue
- Nature Communications
- Published
- 2018-07-20
- Volume
- 9
- Issue
- 1
- Pages
- 2848-2848
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6054650
- OpenAlex
- W2883601426
- Cited by
- 169
- References
- 122
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 24 · 2023: 25 · 2022: 23 · 2021: 24 · 2020: 19 · 2019: 13 · 2018: 4 · 2017: 1
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- EC | European Research Council (ERC-2011-ADG-294313, SERRACO)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- co-transmission, acetylcholine, GABA, basal forebrain cholinergic system, GABAergic synapses, vesicle docking, calcium channels, presynaptic autoreceptors, postsynaptic potentials, GABAA receptor, sharp-wave ripples, epileptiform activity, cortical state, neurodegenerative diseases
- MeSH terms
- Acetylcholine, Animals, Calcium, Dendrites, Female, gamma-Aminobutyric Acid, Hippocampus, Male, Mice, Inbred C57BL, Synaptic Transmission, Perfusion, Receptors, GABA-A, Synapses, Synaptic Vesicles, Neurotransmitter Agents, Neurodegenerative Diseases, Imaging, Three-Dimensional, Mice, Synaptic Potentials
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