Cited by 2,651Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

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Ming, Guo-li, Song, Hongjun·2011·Neuron

DOI 10.1016/j.neuron.2011.05.001PMC PMC3106107

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Abstract

Adult neurogenesis, a process of generating functional neurons from adult neural precursors, occurs throughout life in restricted brain regions in mammals. The past decade has witnessed tremendous progress in addressing questions related to almost every aspect of adult neurogenesis in the mammalian brain. Here we review major advances in our understanding of adult mammalian neurogenesis in the dentate gyrus of the hippocampus and from the subventricular zone of the lateral ventricle, the rostral migratory stream to the olfactory bulb. We highlight emerging principles that have significant implications for stem cell biology, developmental neurobiology, neural plasticity, and disease mechanisms. We also discuss remaining questions related to adult neural stem cells and their niches, underlying regulatory mechanisms, and potential functions of newborn neurons in the adult brain. Building upon the recent progress and aided by new technologies, the adult neurogenesis field is poised to leap forward in the next decade.

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Authors: Ming, G.-L., & Song, H.
Affiliations: Johns Hopkins University (US)
Corresponding author: Ming, Guo-li
Song, Hongjun
ORCID: Ming, Guo-li
Song, Hongjun
Venue: Neuron
Publisher: Elsevier BV
Published: 2011-05
Volume: 70
Issue: 4
Pages: 687-702
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2011.05.001
PMC: PMC3106107
OpenAlex: W2135046848
Cited by: 2,651
References: 198
Citations by year: 2026: 87 · 2025: 135 · 2024: 140 · 2023: 149 · 2022: 168 · 2021: 189 · 2020: 164 · 2019: 204 · 2018: 205 · 2017: 209 · 2016: 225 · 2015: 177 · 2014: 219 · 2013: 188 · 2012: 160
FWCI: 16.60
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 808 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG24984, R01AG024984)
National Institute of Mental Health (R21MH087874, R33MH087874, MH087874)
National Institute of Neurological Disorders and Stroke (NS 048271, R01NS047344, NS 047344, R01NS048271, R37NS047344, R56NS047344)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD069184, HD069184)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: adult neurogenesis, neural stem cells, dentate gyrus, hippocampus, subventricular zone, rostral migratory stream, olfactory bulb, neural stem cell niche, neuroplasticity, developmental neuroscience, disease mechanisms
MeSH terms: Age Factors, Animals, Brain, Humans, Nervous System Diseases, Neuronal Plasticity, Neurogenesis, Neural Stem Cells

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Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

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