Physical exercise and environment exploration affect synaptogenesis in adult-generated neurons in the rat dentate gyrus: possible role of BDNF
Abstract
A brief training in a pool maze, with or without cognitive tasks, modifies the synaptogenesis and maturation of newborn neurons in adult rat dentate gyrus. These types of trainings have many aspects, including physical activity and exploration. Therefore, to evaluate whether physical exercise and environment exploration are able to affect synapse formation and the maturation of adult-generated neurons, GFP-retrovirus infusion was performed on rats which, on the fourth day after injection, were housed under running conditions or allowed to explore an enriched environment briefly in the absence of exercise for the following three days. Afterward, at the end of the trainings, electrophysiological and morphological studies were conducted. Considering that neurotrophic factors increase after exercise or environment exploration, hippocampal BDNF levels and TrkB receptor activation were evaluated. In this study, we show that both spontaneous physical activity and enriched environment exploration induced synaptogenesis and T-type voltage-dependent Ca(2+) currents in very immature neurons. Hippocampal BDNF levels and TrkB receptor activation were determined to be increasing following physical activity and exploration. A possible contribution of BDNF signaling in mediating the observed effects was supported by the use of 7-8-dihydroxyflavone, a selective TrkB agonist, and of ANA-12, an inhibitor of TrkB receptors.
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Physical exercise enhances the survival of new cells, increases the development of their dendrites, and increases the complexity of both their afferent and efferent connections.
“After these new cells are produced and start down the path toward neuronal differentiation, physical exercise enhances their survival, as it increases the development of their dendrites, and the complexity of both their afferent and efferent connections (Ambrogini et al., 2013; Gonçalves et al., 2016b; Llorens-Martín et al., 2015; Snyder et al., 2009b; Zhao et al., 2015) (Table 1).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Ambrogini et al., 2013
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- Authors
- Ambrogini, P., Lattanzi, D., Ciuffoli, S., Betti, M., Fanelli, M., & Cuppini, R.
- Affiliations
- University of Urbino (IT)
- Corresponding author
- Ambrogini, P.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 1534
- Pages
- 1-12
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2073196527
- Cited by
- 61
- References
- 45
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 5
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- adult neurogenesis, synaptogenesis, dentate gyrus, brain-derived neurotrophic factor, TrkB receptor, environmental enrichment, physical activity, running, T-type calcium current, immature neurons, hippocampus, 7,8-dihydroxyflavone, ANA-12, neurotrophic factors
- MeSH terms
- Adaptation, Physiological, Animals, Dendrites, Exercise Test, Exploratory Behavior, Male, Neurons, Physical Conditioning, Animal, Synapses, Rats, Sprague-Dawley, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Receptor, trkB, Rats
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