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Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Open accessAbstract
Adult neurogenesis, a process of generating functional neurons from adult neural precursors, occurs throughout life in restricted brain regions in mammals. The past decade has witnessed tremendous progress in addressing questions related to almost every aspect of adult neurogenesis in the mammalian brain. Here we review major advances in our understanding of adult mammalian neurogenesis in the dentate gyrus of the hippocampus and from the subventricular zone of the lateral ventricle, the rostral migratory stream to the olfactory bulb. We highlight emerging principles that have significant implications for stem cell biology, developmental neurobiology, neural plasticity, and disease mechanisms. We also discuss remaining questions related to adult neural stem cells and their niches, underlying regulatory mechanisms, and potential functions of newborn neurons in the adult brain. Building upon the recent progress and aided by new technologies, the adult neurogenesis field is poised to leap forward in the next decade.
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“The process by which newly generated neurons in normal development are incorporated into the granular cell layer is well established and involves expression of specific markers and development of defined neuronal morphology24,26,34,35.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [24]
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“The dentate gyrus of the hippocampus is the brain region where the most active neurogenesis has been documented to take place23–25.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [24]
Experimental — accuracy not yet measuredIn the citing paper
“There is evidence of neurogenesis from adult neural stem cells deriving from the subventricular zone (SVZ) and the subgranular zone (SGZ) of the hippocampal dentate gyrus, that can give rise to neurons, oligodendrocytes and astrocytes [107,108].”
From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [107]
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Self-citationTangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain
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Self-citationPerfumers' expertise induces structural reorganization in olfactory brain regions
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Metadata
- Authors
- Ming, G.-L., & Song, H.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Ming, Guo-li
- Song, Hongjun
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 70
- Issue
- 4
- Pages
- 687-702
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3106107
- OpenAlex
- W2135046848
- Cited by
- 2,651
- References
- 198
- Citations by year
- 2026: 87 · 2025: 135 · 2024: 140 · 2023: 149 · 2022: 168 · 2021: 189 · 2020: 164 · 2019: 204 · 2018: 205 · 2017: 209 · 2016: 225 · 2015: 177 · 2014: 219 · 2013: 188 · 2012: 160
- FWCI
- 16.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG24984, R01AG024984)
- National Institute of Mental Health (R21MH087874, R33MH087874, MH087874)
- National Institute of Neurological Disorders and Stroke (NS 048271, R01NS047344, NS 047344, R01NS048271, R37NS047344, R56NS047344)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD069184, HD069184)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- adult neurogenesis, neural stem cells, dentate gyrus, hippocampus, subventricular zone, rostral migratory stream, olfactory bulb, neural stem cell niche, neuroplasticity, developmental neuroscience, disease mechanisms
- MeSH terms
- Age Factors, Animals, Brain, Humans, Nervous System Diseases, Neuronal Plasticity, Neurogenesis, Neural Stem Cells
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