Cited by 104Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsMultiple Sclerosis Research Studies

The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?

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Doty, Kevin R., Guillot-Sestier, Marie-Victoire, Town, Terrence·2015·Brain Research

Abstract

Neurodegenerative diseases share common features, including catastrophic neuronal loss that leads to cognitive or motor dysfunction. Neuronal injury occurs in an inflammatory milieu that is populated by resident and sometimes, infiltrating, immune cells - all of which participate in a complex interplay between secreted inflammatory modulators and activated immune cell surface receptors. The importance of these immunomodulators is highlighted by the number of immune factors that have been associated with increased risk of neurodegeneration in recent genome-wide association studies. One of the more difficult tasks for designing therapeutic strategies for immune modulation against neurodegenerative diseases is teasing apart beneficial from harmful signals. In this regard, learning more about the immune components of these diseases has yielded common themes. These unifying concepts should eventually enable immune-based therapeutics for treatment of Alzheimer׳s and Parkinson׳s diseases and amyotrophic lateral sclerosis. Targeted immune modulation should be possible to temper maladaptive factors, enabling beneficial immune responses in the context of neurodegenerative diseases. This article is part of a Special Issue entitled SI: Neuroimmunology in Health And Disease.

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Authors
Doty, K. R., Guillot-Sestier, M.-V., & Town, T.
Affiliations
University of Southern California (US)
Corresponding author
Town, Terrence
Venue
Brain Research
Publisher
Elsevier BV
Published
2015-08
Volume
1617
Pages
155-173
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2085480745
Cited by
104
References
238
Citations by year
2026: 3 · 2025: 11 · 2024: 12 · 2023: 10 · 2022: 9 · 2021: 11 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 13 · 2016: 10 · 2015: 4 · 2014: 1
FWCI
0.75
Type
journal article
Language
en
Open access
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (5R00AG029726-04, 3R00AG029726-04S1)
  • National Institute on Neurologic Disorders and Stroke (1R01NS076794-01)
  • Alzheimer׳s Association Zenith Fellows Award (ZEN-10-174633)
  • American Federation of Aging Research/Ellison Medical Foundation Julie Martin Mid-Career Award in Aging Research (M11472)
  • Zilkha Neurogenetic Institute
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Keywords
neurodegenerative diseases, neuroinflammation, immune system, adaptive immunity, immunomodulation, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, neuronal loss
MeSH terms
Alzheimer Disease, Amyotrophic Lateral Sclerosis, Animals, Astrocytes, Brain, Encephalitis, Humans, Neurons, Parkinson Disease, Risk Factors, Microglia, Inflammation Mediators, Neurodegenerative Diseases

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