The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Long-Range Connectivity Defines Behavioral Specificity of Amygdala Neurons
Open accessAbstract
Memories are acquired and encoded within large-scale neuronal networks spanning different brain areas. The anatomical and functional specificity of such long-range interactions and their role in learning is poorly understood. The amygdala and the medial prefrontal cortex (mPFC) are interconnected brain structures involved in the extinction of conditioned fear. Here, we show that a defined subpopulation of basal amygdala (BA) projection neurons targeting the prelimbic (PL) subdivision of mPFC is active during states of high fear, whereas BA neurons targeting the infralimbic (IL) subdivision are recruited, and exhibit cell-type-specific plasticity, during fear extinction. Pathway-specific optogenetic manipulations demonstrate that the activity balance between pathways is causally involved in fear extinction. Together, our findings demonstrate that, although intermingled locally, long-range connectivity defines distinct subpopulations of amygdala projection neurons and indicate that the formation of long-term extinction memories depends on the balance of activity between two defined amygdala-prefrontal pathways.
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“There is evidence to suggest that there is a dorso-ventral topographic segregation of BLA input to the mPFC; more dorsal projections (to PL) encode threat-stimulating information while more ventral projections (to IL) encode threat extinction-related information [51].”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [51]
In the citing paper
“Moreover, optogenetic excitation of BLA→dmPFC PNs has been shown to increase conditioned fear after extinction (19).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [19]
In the citing paper
“By contrast, extinction of the learned fear association increases activity in basal amygdala neurons targeting the infralimbic cortex105.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [105]
In the citing paper
“During auditory fear conditioning, activity in basal amygdala neurons projecting to the prelimbic cortex is increased105”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [105]
Citations
Cites
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
Sesack, S. R., Deutch, A. Y., Roth, R. H., & Bunney, B. S. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902900205 · Cited by 1,568
Differential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550
Bursts as a unit of neural information: making unreliable synapses reliable
Lisman, J. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10070-9 · Cited by 1,418
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227
Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.184 · Cited by 1,190
Switching on and off fear by distinct neuronal circuits
Herry, C., Ciocchi, S., Senn, V., Demmou, L., Müller, C., & Lüthi, A. (2008) · Nature · doi:10.1038/nature07166 · Cited by 950
Self-citationThe other side of the engram: experience-driven changes in neuronal intrinsic excitability
Zhang, W., & Linden, D. J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1248 · Cited by 889
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From circuits to behaviour in the amygdala
Janak, P. H., & Tye, K. M. (2015) · Nature · doi:10.1038/nature14188 · Cited by 2,011
Neuronal circuits for fear and anxiety
Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786
Self-citationOptogenetics: 10 years of microbial opsins in neuroscience
Deisseroth, K. A. (2015) · Nature Neuroscience · doi:10.1038/nn.4091 · Cited by 1,335
Resolving the neural circuits of anxiety
Calhoon, G. G., & Tye, K. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4101 · Cited by 766
Amygdala Microcircuits Controlling Learned Fear
Duvarci, S., & Pare, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.042 · Cited by 751
Metadata
- Authors
- Senn, V., Wolff, S. B. E., Herry, C., Grenier, F., Ehrlich, I., Gründemann, J., Fadok, J. P., Müller, C., Letzkus, J. J., & Lüthi, A.
- Affiliations
- University of Basel (CH)
- Friedrich Miescher Institute (CH)
- Corresponding author
- Lüthi, Andreas
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 81
- Issue
- 2
- Pages
- 428-437
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1977502547
- Cited by
- 522
- References
- 38
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 35 · 2023: 35 · 2022: 40 · 2021: 55 · 2020: 45 · 2019: 52 · 2018: 55 · 2017: 47 · 2016: 30 · 2015: 49 · 2014: 34
- FWCI
- 29.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- amygdala, medial prefrontal cortex, fear extinction, long-range connectivity, prelimbic cortex, infralimbic cortex, memory extinction, optogenetic manipulation, fear conditioning
- MeSH terms
- Channelrhodopsins, Acoustic Stimulation, Action Potentials, Amygdala, Analysis of Variance, Animals, Bacterial Proteins, Biophysics, Cell Count, Conditioning, Classical, Elapid Venoms, Electric Stimulation, Extinction, Psychological, Fear, Hippocampus, Light, Luminescent Proteins, Male, Neural Pathways, Neurons, Peptides, Time Factors, Oncogene Proteins v-fos, Prefrontal Cortex, Herpesvirus 1, Human, Patch-Clamp Techniques, Mice, Biophysical Phenomena, Optogenetics, In Vitro Techniques
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