Amygdala Microcircuits Controlling Learned Fear

Duvarci, Sevil; Pare, Denis

doi:10.1016/j.neuron.2014.04.042

Cited by 751Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Amygdala Microcircuits Controlling Learned Fear

Open access

Duvarci, Sevil, Pare, Denis·2014·Neuron

DOI 10.1016/j.neuron.2014.04.042PMC PMC4103014

Open this paper in CoChat — free account Open PDF

Abstract

We review recent work on the role of intrinsic amygdala networks in the regulation of classically conditioned defensive behaviors, commonly known as conditioned fear. These new developments highlight how conditioned fear depends on far more complex networks than initially envisioned. Indeed, multiple parallel inhibitory and excitatory circuits are differentially recruited during the expression versus extinction of conditioned fear. Moreover, shifts between expression and extinction circuits involve coordinated interactions with different regions of the medial prefrontal cortex. However, key areas of uncertainty remain, particularly with respect to the connectivity of the different cell types. Filling these gaps in our knowledge is important because much evidence indicates that human anxiety disorders results from an abnormal regulation of the networks supporting fear learning.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2014.04.042

Cites

199 of 199 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In fear- or anxiety-provoking circumstances, projections from the BLA targeting the central amygdala and the BNST are activated.
“in fear- or anxiety-provoking circumstances, projections from the BLA targeting the central amygdala (CeA, containing the lateral (CeL) and medial (CeM) subdivisions)53,64 and the BNST31,65 are activated.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [53]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203 · cited 1× · see citing works
“Thus, the neuronal basis of fear should be well conserved across species, a corollary supported by congruent findings of animal and human studies (Phelps and LeDoux, 2005).”
Result
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 3× · see citing works
“Moreover, electrical stimulation of IL paired with CS onset reduces conditioned fear responses and accelerates the acquisition of extinction (Milad and Quirk, 2002).”
Background
Context and Behavioral Processes in Extinction: Table 1.
Bouton, M. E. (2004) · Learning & Memory · doi:10.1101/lm.78804 · Cited by 1,808 · see citing works
The Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745 · see citing works
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728 · see citing works
Context, ambiguity, and unlearning: sources of relapse after behavioral extinction
Bouton, M. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01546-9 · Cited by 1,662 · see citing works
Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580 · see citing works
The contextual brain: implications for fear conditioning, extinction and psychopathology
Maren, S., Phan, K. L., & Liberzon, I. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3492 · Cited by 1,547 · see citing works
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Milad, M. R., & Quirk, G. J. (2012) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131631 · Cited by 1,466 · see citing works
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310 · see citing works
Cortical pathways to the mammalian amygdala
McDonald, A. J. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00003-3 · Cited by 1,303 · see citing works
Mechanisms of fear extinction
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277 · see citing works
The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction
Scheel-Krüger, J. (1993) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(93)90037-5 · Cited by 1,277 · see citing works
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
SHIN, L. M., RAUCH, S. L., & PITMAN, R. K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.007 · Cited by 1,203 · see citing works
Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear
Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.184 · Cited by 1,190 · see citing works
The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning
LeDoux, J., Cicchetti, P., Xagoraris, A., & Romanski, L. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01062.1990 · Cited by 1,167 · see citing works
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049 · see citing works
Molecular mechanisms of fear learning and memory
Johansen, J. P., Cain, C. K., Ostroff, L. E., & LeDoux, J. E. (2011) · Cell · doi:10.1016/j.cell.2011.10.009 · Cited by 1,012 · see citing works
Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear
Pape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994 · see citing works
Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala
Pitkänen, A., Savander, V., & LeDoux, J. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01125-9 · Cited by 980 · see citing works
The Amygdala: a functional analysis
Aggleton, J. P. (2000) · Cited by 964 · see citing works
Switching on and off fear by distinct neuronal circuits
Herry, C., Ciocchi, S., Senn, V., Demmou, L., Müller, C., & Lüthi, A. (2008) · Nature · doi:10.1038/nature07166 · Cited by 950 · see citing works
The principles of learning and behavior
Domjan, M. P. (1982) · Cited by 926 · see citing works
Encoding of conditioned fear in central amygdala inhibitory circuits
Ciocchi, S., Herry, C., Grenier, F., Wolff, S. B. E., Letzkus, J. J., Vlachos, I., Ehrlich, I., Sprengel, R., Deisseroth, K., Stadler, M. B., et al. (2010) · Nature · doi:10.1038/nature09559 · Cited by 924 · see citing works
Coming to terms with fear
LeDoux, J. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400335111 · Cited by 891 · see citing works
Amygdala inhibitory circuits and the control of fear memory
Ehrlich, I., Humeau, Y., Grenier, F., Ciocchi, S., Herry, C., & Lüthi, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.026 · Cited by 878 · see citing works
Amygdaloid projections to the mesencephalon, pons and medulla oblongata in the cat
Hopkins, D. A., & Holstege, G. (1978) · Experimental Brain Research · doi:10.1007/bf00239551 · Cited by 866 · see citing works
Genetic dissection of an amygdala microcircuit that gates conditioned fear
Haubensak, W., Kunwar, P. S., Cai, H., Ciocchi, S., Wall, N. R., Ponnusamy, R., Biag, J., Dong, H.-W., Deisseroth, K., Callaway, E. M., et al. (2010) · Nature · doi:10.1038/nature09553 · Cited by 840 · see citing works
A disinhibitory microcircuit for associative fear learning in the auditory cortex
Letzkus, J. J., Wolff, S. B. E., Meyer, E. M. M., Tovote, P., Courtin, J., Herry, C., & Lüthi, A. (2011) · Nature · doi:10.1038/nature10674 · Cited by 840 · see citing works
A single standard for memory: The case for reconsolidation
Nader, K., & Hardt, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2590 · Cited by 811 · see citing works
Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: Parallel recordings in the freely behaving rat
Quirk, G. J., Repa, J. C., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90092-6 · Cited by 808 · see citing works
Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli
Brischoux, F., Chakraborty, S., Brierley, D. I., & Ungless, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811507106 · Cited by 801 · see citing works
Projections from the amygdaloid complex to the cerebral cortex and thalamus in the rat and cat
Krettek, J. E., & Price, J. L. (1977) · Journal of Comparative Neurology · doi:10.1002/cne.901720408 · Cited by 785 · see citing works
Postsynaptic receptor trafficking underlying a form of associative learning
Rumpel, S., LeDoux, J., Zador, A., & Malinow, R. (2005) · Science · doi:10.1126/science.1103944 · Cited by 775 · see citing works
Fear conditioning induces a lasting potentiation of synaptic currents in vitro
McKernan, M. G., & Shinnick-Gallagher, P. (1997) · Nature · doi:10.1038/37605 · Cited by 771 · see citing works
Reinstatement of fear to an extinguished conditioned stimulus.
Rescorla, R. A., & Heth, C. D. (1975) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.1.1.88 · Cited by 768 · see citing works
A description of the amygdaloid complex in the rat and cat with observations on intra‐amygdaloid axonal connections
Krettek, J. E., & Price, J. L. (1978) · Journal of Comparative Neurology · doi:10.1002/cne.901780205 · Cited by 727 · see citing works
Topography of projections from amygdala to bed nuclei of the stria terminalis
Dong, H.-W., Petrovich, G. D., & Swanson, L. W. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00079-0 · Cited by 714 · see citing works
Projections of the medial and lateral prefrontal cortices to the amygdala: a Phaseolus vulgaris leucoagglutinin study in the rat
McDonald, A. J., Mascagni, F., & Guo, L. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00417-3 · Cited by 689 · see citing works
Neuronal competition and selection during memory formation
Han, J.-H., Kushner, S. A., Yiu, A. P., Cole, C. J., Matynia, A., Brown, R. A., Neve, R. L., Guzowski, J. F., Silva, A. J., & Josselyn, S. A. (2007) · Science · doi:10.1126/science.1139438 · Cited by 682 · see citing works
Contextual and temporal modulation of extinction: behavioral and biological mechanisms
Bouton, M. E., Westbrook, R. F., Corcoran, K. A., & Maren, S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.015 · Cited by 671 · see citing works
Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission
Katona, I., Rancz, E. A., Acsády, L., Ledent, C., Mackie, K., Hájos, N., & Freund, T. F. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09506.2001 · Cited by 668 · cited 4× · see citing works
“Indeed, CB1 receptors are only found on the axon terminals of a specific subpopulation of BLA interneurons, which express the peptide cholecystokinin (CCK) (Katona et al., 2001).”
BackgroundInfluential
Prefrontal control of fear: more than just extinction
Sotres-Bayon, F., & Quirk, G. J. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.02.005 · Cited by 625 · cited 2× · see citing works
“Whereas PL supports fear expression (see above), IL is implicated in extinction (Sotres-Bayon and Quirk, 2010).”
Background
Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning
Blair, H. T., Schafe, G. E., Bauer, E. P., Rodrigues, S. M., & LeDoux, J. E. (2001) · Learning & Memory · doi:10.1101/lm.30901 · Cited by 610 · see citing works
BLA to vHPC inputs modulate anxiety-related behaviors
Felix-Ortiz, A. C., Beyeler, A., Seo, C., Leppla, C. A., Wildes, C. P., & Tye, K. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.016 · Cited by 592 · see citing works
Activity in Prelimbic Cortex Is Necessary for the Expression of Learned, But Not Innate, Fears
Corcoran, K., & Quirk, G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5327-06.2007 · Cited by 580 · see citing works
CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala
Zhou, Y., Won, J., Karlsson, M. G., Zhou, M., Rogerson, T., Balaji, J., Neve, R. L., Poirazi, P., & Silva, A. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2405 · Cited by 577 · see citing works
Selective Erasure of a Fear Memory
Han, J., Kushner, S. A., Yiu, A. P., Hsiang, H., Buch, T., Waisman, A., Bontempi, B., Neve, R. L., Frankland, P. W., & Josselyn, S. A. (2009) · Science · doi:10.1126/science.1164139 · Cited by 570 · see citing works
Fear Conditioning Enhances Different Temporal Components of Tone-Evoked Spike Trains in Auditory Cortex and Lateral Amygdala
Quirk, G. J., Armony, J. L., & LeDoux, J. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80375-x · Cited by 563 · see citing works
The Influence of Stress Hormones on Fear Circuitry
Rodrigues, S. M., LeDoux, J. E., & Sapolsky, R. M. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135620 · Cited by 556 · see citing works
Topographic organization of neurons in the acoustic thalamus that project to the amygdala
LeDoux, J., Farb, C. R., & Ruggiero, D. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01043.1990 · Cited by 546 · see citing works
Rethinking the Fear Circuit: The Central Nucleus of the Amygdala Is Required for the Acquisition, Consolidation, and Expression of Pavlovian Fear Conditioning
Wilensky, A. E., Schafe, G. E., Kristensen, M. P., & LeDoux, J. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4316-06.2006 · Cited by 533 · see citing works
Sustained Conditioned Responses in Prelimbic Prefrontal Neurons Are Correlated with Fear Expression and Extinction Failure
Burgos-Robles, A., Vidal-Gonzalez, I., & Quirk, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0378-09.2009 · Cited by 530 · see citing works
Projections to the subcortical forebrain from anatomically defined regions of the medial geniculate body in the rat
LeDoux, J. E., Ruggiero, D. A., & Reis, D. J. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902420204 · Cited by 530 · see citing works
Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression
Courtin, J., Chaudun, F., Rozeske, R. R., Karalis, N., Gonzalez-Campo, C., Wurtz, H., Abdi, A., Baufreton, J., Bienvenu, T. C. M., & Herry, C. (2014) · Nature · doi:10.1038/nature12755 · Cited by 524 · see citing works
Long-range connectivity defines behavioral specificity of amygdala neurons
Senn, V., Wolff, S. B. E., Herry, C., Grenier, F., Ehrlich, I., Gründemann, J., Fadok, J. P., Müller, C., Letzkus, J. J., & Lüthi, A. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.006 · Cited by 522 · see citing works
Consolidation of Fear Extinction Requires NMDA Receptor-Dependent Bursting in the Ventromedial Prefrontal Cortex
Burgos-Robles, A., Vidal-Gonzalez, I., Santini, E., & Quirk, G. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.021 · Cited by 516 · see citing works
Experience-dependent modification of a central amygdala fear circuit
Li, H., Penzo, M. A., Taniguchi, H., Kopec, C. D., Huang, Z. J., & Li, B. (2013) · Nature Neuroscience · doi:10.1038/nn.3322 · Cited by 497 · cited 2× · see citing works
“Second, selective ICM lesions (Likhtik et al., 2008) as well as pharmacological inhibition of BLA inputs to ICM cells by neuropeptide S (Jü ngling et al., 2008) interfere with extinction.”
Background
Amygdala interneuron subtypes control fear learning through disinhibition
Wolff, S. B. E., Gründemann, J., Tovote, P., Krabbe, S., Jacobson, G. A., Müller, C. R., Herry, C., Ehrlich, I., Friedrich, R. W., Letzkus, J. J., et al. (2014) · Nature · doi:10.1038/nature13258 · Cited by 489 · see citing works
Neuronal circuits of fear extinction
Herry, C., Ferraguti, F., Singewald, N., Letzkus, J. J., Ehrlich, I., & Lüthi, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07101.x · Cited by 484 · see citing works
The organization of projections from the central nucleus of the amygdala to brainstem sites involved in central autonomic regulation: A combined retrograde transport-immunohistochemical study
Veening, J. G., Swanson, L. W., & Sawchenko, P. E. (1984) · Brain Research · doi:10.1016/0006-8993(84)91220-4 · Cited by 476 · see citing works
Amygdala intercalated neurons are required for expression of fear extinction
Likhtik, E., Popa, D., Apergis-Schoute, J., Fidacaro, G. A., & Paré, D. (2008) · Nature · doi:10.1038/nature07167 · Cited by 474 · see citing works
Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality
Herkenham, M. A., & Pert, C. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-08-01129.1982 · Cited by 466 · see citing works
Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs
Sotres-Bayón, F., Sierra‐Mercado, D., Pardilla‐Delgado, E., & Quirk, G. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.028 · Cited by 451 · see citing works
Contextual and Auditory Fear Conditioning are Mediated by the Lateral, Basal, and Central Amygdaloid Nuclei in Rats
Goosens, K. A., & Maren, S. (2001) · Learning & Memory · doi:10.1101/lm.37601 · Cited by 451 · see citing works
The spino(trigemino)pontoamygdaloid pathway: electrophysiological evidence for an involvement in pain processes
Bernard, J., & Besson, J. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.63.3.473 · Cited by 447 · see citing works
Somatosensory and auditory convergence in the lateral nucleus of the amygdala.
Romanski, L. M., Clugnet, M.-C., Bordi, F., & LeDoux, J. E. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.3.444 · Cited by 446 · see citing works
Two different lateral amygdala cell populations contribute to the initiation and storage of memory
Repa, J. C., Muller, J., Apergis, J., Desrochers, T. M., Zhou, Y., & LeDoux, J. E. (2001) · Nature Neuroscience · doi:10.1038/89512 · Cited by 440 · see citing works
Thalamoamygdaloid projections in the rat: A test of the amygdala's role in sensory processing
Turner, B. H., & Herkenham, M. (1991) · The Journal of comparative neurology · doi:10.1002/cne.903130208 · Cited by 437 · see citing works
Role of the Basolateral Amygdala in the Storage of Fear Memories across the Adult Lifetime of Rats
Gale, G. D., Anagnostaras, S., Godsil, B. P., Mitchell, S., Nozawa, T., Sage, J. R., Wiltgen, B. J., & Fanselow, M. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4100-03.2004 · Cited by 427 · see citing works
Intrinsic connections of the rat amygdaloid complex: Projections originating in the basal nucleus
Savander, V., Go, C. ‐., LeDoux, J. E., & Pitkänen, A. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903610211 · Cited by 416 · see citing works
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Bissière, S., Humeau, Y., & Lüthi, A. (2003) · Nature Neuroscience · doi:10.1038/nn1058 · Cited by 415 · see citing works
The organization of the efferent projections from the pontine parabrachial area to the amygdaloid complex: A phaseolus vulgaris leucoagglutinin (PHA‐L) study in the rat
Bernard, J. F., Alden, M., & Besson, J. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903290205 · Cited by 411 · see citing works
Information Cascade from Primary Auditory Cortex to the Amygdala: Corticocortical and Corticoamygdaloid Projections of Temporal Cortex in the Rat
Romanski, L. M., & LeDoux, J. E. (1993) · Cerebral Cortex · doi:10.1093/cercor/3.6.515 · Cited by 398 · see citing works
The Study of Fear Extinction: Implications for Anxiety Disorders
Graham, B. M., & Milad, M. R. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11040557 · Cited by 387 · see citing works
Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli.
Muller, J., Corodimas, K. P., Fridel, Z., & LeDoux, J. E. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.4.683 · Cited by 382 · see citing works
Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli.
Muller, J., Corodimas, K. P., Fridel, Z., & LeDoux, J. E. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.4.683 · Cited by 382 · cited 1× · see citing works
“Conversely, activation of GABA-A receptors in LA impairs acquisition of conditioned fear (Muller et al., 1997; Wilensky et al., 1999) and fear conditioning is associated with reduced BLA levels of GABA (Stork et al., 2002) and mRNA for GABA-synthesizing enzymes (Pape and Stork, 2003; Heldt and…”
Background
Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala
Viviani, D., Charlet, A., van den Burg, E., Robinet, C., Hurni, N., Abatis, M., Magara, F., & Stoop, R. (2011) · Science · doi:10.1126/science.1201043 · Cited by 381 · see citing works
Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear
Chhatwal, J. P., Davis, M., Maguschak, K. A., & Ressler, K. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300655 · Cited by 376 · see citing works
Different lateral amygdala outputs mediate reactions and actions elicited by a fear-arousing stimulus
Amorapanth, P., LeDoux, J. E., & Nader, K. (2000) · Nature Neuroscience · doi:10.1038/71145 · Cited by 374 · see citing works
Synaptic correlates of fear extinction in the amygdala
Amano, T., Ünal, Ç. T., & Paré, D. (2010) · Nature Neuroscience · doi:10.1038/nn.2499 · Cited by 369 · see citing works
Structural and functional plasticity of the human brain in posttraumatic stress disorder
Bremner, J. D., Elzinga, B. M., Schmahl, C. G., & Vermetten, E. H. G. J. M. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)67012-5 · Cited by 368 · see citing works
Synaptic Encoding of Fear Extinction in mPFC-amygdala Circuits
Cho, J.-H., Deisseroth, K. A., & Bolshakov, V. Y. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.025 · Cited by 367 · see citing works
Forebrain pain mechanisms
Neugebauer, V., Galhardo, V., Maione, S., & Mackey, S. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.014 · Cited by 353 · see citing works
An Inhibitory Interface Gates Impulse Traffic between the Input and Output Stations of the Amygdala
Royer, S., Martina, M., & Paré, D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10575.1999 · Cited by 350 · see citing works
Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning
Rosenkranz, J. A., & Grace, A. A. (2002) · Nature · doi:10.1038/417282a · Cited by 348 · see citing works
A Specialized Subclass of Interneurons Mediates Dopaminergic Facilitation of Amygdala Function
Marowsky, A., Yanagawa, Y., Obata, K., & Vogt, K. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.029 · Cited by 328 · see citing works
Long-term potentiation in the amygdala: A cellular mechanism of fear learning and memory
Sigurdsson, T., Doyère, V., Cain, C. K., & LeDoux, J. E. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.06.022 · Cited by 325 · see citing works
Identification of a Signaling Network in Lateral Nucleus of Amygdala Important for Inhibiting Memory Specifically Related to Learned Fear
Shumyatsky, G. P., Tsvetkov, E., Malleret, G., Vronskaya, S., Hatton, M., Hampton, L. L., Battey, J. F., Dulac, C. G., Kandel, E. R., & Bolshakov, V. Y. (2002) · Cell · doi:10.1016/s0092-8674(02)01116-9 · Cited by 324 · see citing works
Fear Conditioning Occludes LTP-Induced Presynaptic Enhancement of Synaptic Transmission in the Cortical Pathway to the Lateral Amygdala
Tsvetkov, E., Carlezon, W. A., Benes, F. M., Kandel, E. R., & Bolshakov, V. Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00645-1 · Cited by 321 · see citing works
Hippocampal and Prefrontal Projections to the Basal Amygdala Mediate Contextual Regulation of Fear after Extinction
Orsini, C. A., Kim, J. H., Knapska, E., & Maren, S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4095-11.2011 · Cited by 315 · see citing works
Serotonergic Modulation of Neurotransmission in the Rat Basolateral Amygdala
Rainnie, D. G. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.1.69 · Cited by 310 · see citing works
Neuropeptide S-Mediated Control of Fear Expression and Extinction: Role of Intercalated GABAergic Neurons in the Amygdala
Jüngling, K., Seidenbecher, T., Sosulina, L., Lesting, J., Sangha, S., Clark, S. D., Okamura, N., Duangdao, D. M., Xu, Y.-L., Reinscheid, R. K., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.002 · Cited by 299 · see citing works
A retrieval cue for extinction attenuates spontaneous recovery.
Brooks, D. C., & Bouton, M. E. (1993) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.19.1.77 · Cited by 272 · see citing works
Damage to the Lateral and Central, but Not Other, Amygdaloid Nuclei Prevents the Acquisition of Auditory Fear ConditioningPreprint
Nader, K., Majidishad, P., Amorapanth, P., & LeDoux, J. E. (2001) · Learning & Memory · doi:10.1101/lm.38101 · Cited by 272 · see citing works
Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear
Knapska, E., & Maren, S. (2009) · Learning & Memory · doi:10.1101/lm.1463909 · Cited by 264 · see citing works
Amygdala depotentiation and fear extinction
Kim, J., Lee, S., Park, K., Hong, I., Song, B., Son, G. H., Park, H., Kim, W. R., Park, E. J., Choe, H. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710548105 · Cited by 252 · see citing works
Glucocorticoids Enhance the Excitability of Principal Basolateral Amygdala Neurons
Duvarci, S., & Paré, D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0680-07.2007 · Cited by 249 · see citing works
Self-citation
Lesions of the Basal Amygdala Block Expression of Conditioned Fear But Not Extinction
Anglada-Figueroa, D., & Quirk, G. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2600-05.2005 · Cited by 238 · see citing works
Projections from the lateral part of the central amygdalar nucleus to the postulated fear conditioning circuit
Petrovich, G. D., & Swanson, L. W. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01361-3 · Cited by 234 · see citing works
Physiological Role of Calcium-Activated Potassium Currents in the Rat Lateral Amygdala
Faber, E. S. L., & Sah, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01618.2002 · Cited by 234 · see citing works
Colocalization of calcium-binding proteins and GABA in neurons of the rat basolateral amygdala
McDonald, A. J., & Mascagni, F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00214-7 · Cited by 221 · see citing works
Functional Inactivation of the Amygdala before But Not after Auditory Fear Conditioning Prevents Memory Formation
Wilensky, A. E., Schafe, G. E., & LeDoux, J. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-24-j0006.1999 · Cited by 217 · see citing works
Rapid strengthening of thalamo-amygdala synapses mediates cue–reward learning
Tye, K. M., Stuber, G. D., de Ridder, B., Bonci, A., & Janak, P. H. (2008) · Nature · doi:10.1038/nature06963 · Cited by 216 · see citing works
Localization of GABA-like immunoreactivity in the monkey amygdala
McDonald, A. J., & Augustine, J. R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90156-a · Cited by 216 · see citing works
Regulation of Gephyrin and GABAAReceptor Binding within the Amygdala after Fear Acquisition and Extinction
Chhatwal, J. P., Myers, K. M., Ressler, K. J., & Davis, M. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3301-04.2005 · Cited by 214 · see citing works
The intercalated cell masses project to the central and medial nuclei of the amygdala in cats
Paré, D., & Smith, Y. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90050-p · Cited by 209 · see citing works
Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition
Shaban, H., Humeau, Y., Herry, C., Casassus, G., Shigemoto, R., Ciocchi, S., Barbieri, S., van der Putten, H., Kaupmann, K., Bettler, B., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1732 · Cited by 208 · see citing works
Amygdaloid D1 dopamine receptor involvement in Pavlovian fear conditioning
Guarraci, F. A., Frohardt, R. J., & Kapp, B. S. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01291-3 · Cited by 207 · see citing works
Intra‐amygdaloid projections of the lateral nucleus in the cat: PHA‐L anterograde labeling combined with postembedding GABA and glutamate immunocytochemistry
Smith, Y., & Paré, D. (1994) · Journal of Comparative Neurology · doi:10.1002/cne.903420207 · Cited by 205 · see citing works
Self-citation
Interneurons in the basolateral amygdala
Spampanato, J. G., Polepalli, J. S., & Sah, P. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.006 · Cited by 205 · see citing works
Networks of Parvalbumin-Positive Interneurons in the Basolateral Amygdala
Woodruff, A. R., & Sah, P. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3686-06.2007 · Cited by 205 · see citing works
The intercalated cells of the amygdala
Millhouse, O. E. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902470209 · Cited by 204 · see citing works
Pyramidal cells of the rat basolateral amygdala: Synaptology and innervation by parvalbumin‐immunoreactive interneurons
Muller, J. F., Mascagni, F., & McDonald, A. J. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20832 · Cited by 203 · see citing works
Central Amygdala Activity during Fear Conditioning
Duvarci, S., Popa, D., & Paré, D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4985-10.2011 · Cited by 202 · see citing works
Self-citation
Projection and innervation patterns of individual thalamic reticular axons in the thalamus of the adult rat: A three-dimensional, graphic, and morphometric analysis
Pinault, D., & Desch�nes, M. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980209)391:2 · Cited by 199 · see citing works
Norepinephrine enables the induction of associative long-term potentiation at thalamo-amygdala synapses
Tully, K., Li, Y., Tsvetkov, E., & Bolshakov, V. Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704621104 · Cited by 199 · see citing works
GABAergic Antagonists Block the Inhibitory Effects of Serotonin in the Lateral Amygdala: A Mechanism for Modulation of Sensory Inputs Related to Fear Conditioning
Stutzmann, G. E., & LeDoux, J. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-j0005.1999 · Cited by 198 · see citing works
The Fear Circuit Revisited: Contributions of the Basal Amygdala Nuclei to Conditioned Fear
Amano, T., Duvarci, S., Popa, D., & Paré, D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3410-11.2011 · Cited by 197 · see citing works
Self-citation
Inhibition of the mesoamygdala dopaminergic pathway impairs the retrieval of conditioned fear associations.
Nader, K., & LeDoux, J. E. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.5.891 · Cited by 194 · see citing works
Context-Dependent Neuronal Activity in the Lateral Amygdala Represents Fear Memories after Extinction
Hobin, J. A., Goosens, K. A., & Maren, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-23-08410.2003 · Cited by 187 · see citing works
Fear Conditioning Potentiates Synaptic Transmission onto Long-Range Projection Neurons in the Lateral Subdivision of Central Amygdala
Penzo, M. A., Robert, V., & Li, B. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4166-13.2014 · Cited by 187 · see citing works
Functional anatomy of neural circuits regulating fear and extinction
Knapska, E., Macias, M., Mikosz, M., Nowak, A., Owczarek, D., Wawrzyniak, M., Pieprzyk, M., Cymerman, I. A., Werka, T., Sheng, M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202087109 · Cited by 187 · see citing works
Corticoamygdaloid and corticocortical projections of the rat temporal cortex: APhaseolus vulgaris leucoagglutinin study
Mascagni, F., McDonald, A. J., & Coleman, J. R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90016-9 · Cited by 186 · see citing works
Distribution of GABA‐like immunoreactivity in the rat amygdaloid complex
Nitecka, L., & Ben‐Ari, Y. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902660105 · Cited by 179 · see citing works
Parvalbumin-containing neurons in the rat basolateral amygdala: morphology and co-localization of Calbindin-D28k
McDonald, A. J., & Betette, R. L. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00481-4 · Cited by 177 · see citing works
Inhibition of the mesoamygdala dopaminergic pathway impairs the retrieval of conditioned fear associations.
Nader, K., & LeDoux, J. E. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.891 · Cited by 174 · see citing works
Differential Fear Conditioning Induces Reciprocal Changes in the Sensory Responses of Lateral Amygdala Neurons to the CS+ and CS−
Collins, D. R., & Paré, D. (2000) · Learning & Memory · doi:10.1101/lm.7.2.97 · Cited by 171 · see citing works
Cell-Type-Specific Recruitment of Amygdala Interneurons to Hippocampal Theta Rhythm and Noxious Stimuli In Vivo
Bienvenu, T., Busti, D., Magill, P. J., Ferraguti, F., & Capogna, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.022 · Cited by 168 · see citing works
Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses
Trouche, S., Sasaki, J. M., Tu, T., & Reijmers, L. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.047 · Cited by 166 · see citing works
Intra-amygdaloid projections of the basolateral and basomedial nuclei in the cat: Phaseolus vulgaris-leucoagglutinin anterograde tracing at the light and electron microscopic level
Paré, D., Smith, Y., & Paré, J.-F. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00272-k · Cited by 164 · see citing works
Topography of projections from the medial prefrontal cortex to the amygdala in the rat
Cassell, M. D., & Wright, D. J. (1986) · Brain Research Bulletin · doi:10.1016/0361-9230(86)90237-6 · Cited by 161 · see citing works
Inhibition of amygdaloid dopamine D2 receptors impairs emotional learning measured with fear-potentiated startle
Greba, Q., Gifkins, A., & Kokkinidis, L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02243-0 · Cited by 160 · see citing works
Immunohistochemical characterization of cholecystokinin containing neurons in the rat basolateral amygdala
Mascagni, F., & McDonald, A. J. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02625-8 · Cited by 157 · see citing works
Postsynaptic targets of somatostatin‐containing interneurons in the rat basolateral amygdala
Muller, J. F., Mascagni, F., & McDonald, A. J. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21185 · Cited by 153 · see citing works
Distribution of GABA immunoreactivity in the amygdaloid complex of the cat
Paré, D., & Smith, Y. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90049-l · Cited by 152 · see citing works
Immunohistochemical characterization of somatostatin containing interneurons in the rat basolateral amygdala
McDonald, A. J., & Mascagni, F. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02650-1 · Cited by 152 · see citing works
Bursting and oscillating neurons of the cat basolateral amygdaloid complex in vivo: electrophysiological properties and morphological features
Paré, D., Pape, H., & Dong, J. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.3.1179 · Cited by 147 · see citing works
Physiological and morphological characterization of parvalbumin‐containing interneurons of the rat basolateral amygdala
Rainnie, D. G., Mania, I., Mascagni, F., & McDonald, A. J. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21049 · Cited by 145 · see citing works
Differential Effects of Amygdala Lesions on Early and Late Plastic Components of Auditory Cortex Spike Trains during Fear Conditioning
Armony, J. L., Quirk, G. J., & LeDoux, J. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02592.1998 · Cited by 143 · see citing works
The medial geniculate, not the amygdala, as the root of auditory fear conditioning
Weinberger, N. M. (2010) · Hearing Research · doi:10.1016/j.heares.2010.03.093 · Cited by 142 · see citing works
Auditory-Evoked Spike Firing in the Lateral Amygdala and Pavlovian Fear Conditioning
Goosens, K. A., Hobin, J. A., & Maren, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00728-1 · Cited by 135 · see citing works
Different Fear States Engage Distinct Networks within the Intercalated Cell Clusters of the Amygdala
Busti, D., Geracitano, R., Whittle, N., Dalezios, Y., Mańko, M., Kaufmann, W. A., Sätzler, K., Singewald, N., Capogna, M., & Ferraguti, F. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6100-10.2011 · Cited by 134 · see citing works
Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala.Preprint
Maren, S., & Hobin, J. A. (2007) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.477007 · Cited by 128 · see citing works
Training‐induced changes in the expression of GABAA‐associated genes in the amygdala after the acquisition and extinction of Pavlovian fear
Heldt, S. A., & Ressler, K. J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05970.x · Cited by 125 · see citing works
The amygdala of the cat: A golgi study
Hall, E. (1972) · Cell and Tissue Research · doi:10.1007/bf00307668 · Cited by 124 · see citing works
Activity-Dependent Synaptic Plasticity in the Central Nucleus of the Amygdala
Samson, R., & Paré, D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3713-04.2005 · Cited by 122 · see citing works
The Endocannabinoid System and Extinction Learning
Lutz, B. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-8004-x · Cited by 121 · see citing works
Coupled Networks of Parvalbumin-Immunoreactive Interneurons in the Rat Basolateral Amygdala
Muller, J. F., Mascagni, F., & McDonald, A. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0899-05.2005 · Cited by 121 · see citing works
Beta-Adrenergic Receptors in the Lateral Nucleus of the Amygdala Contribute to the Acquisition but Not the Consolidation of Auditory Fear Conditioning
Bush, D. E. A., Caparosa, E. M., Gekker, A., & LeDoux, J. E. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00154 · Cited by 117 · see citing works
Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memoryPreprint
Viosca, J., de Armentia, M. L., Jančić, D., & Barco, Á. (2009) · Learning & Memory · doi:10.1101/lm.1254209 · Cited by 115 · see citing works
Distribution of parvalbumin‐immunoreactive cells and fibers in the human amygdaloid complex
Sorvari, H., Soininen, H., Paljärvi, L., Karkola, K. O., & Pitkänen, A. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903600202 · Cited by 114 · see citing works
Contextual Inhibitory Gating of Impulse Traffic in the Intra‐amygdaloid Network
Paré, D., Royer, S., Smith, Y., & Lang, E. J. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07073.x · Cited by 114 · see citing works
Pretraining NMDA receptor blockade in the basolateral complex, but not the central nucleus, of the amygdala prevents savings of the conditional fear.
Goosens, K. A., & Maren, S. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.4.738 · Cited by 112 · see citing works
Dissociated theta phase synchronization in amygdalo‐ hippocampal circuits during various stages of fear memory
Narayanan, R. T., Seidenbecher, T., Kluge, C., Bergado, J. A., Stork, O., & Pape, H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05437.x · Cited by 111 · see citing works
Physiological identification and infralimbic responsiveness of rat intercalated amygdala neurons
Amir, A., Amano, T., & Paré, D. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00136.2011 · Cited by 110 · see citing works
Differential projection of the posterior paralaminar thalamic nuclei to the amygdaloid complex in the rat
Linke, R., Braune, G., & Schwegler, H. (2000) · Experimental Brain Research · doi:10.1007/s002210000475 · Cited by 106 · see citing works
Enkephalin co‐expression with classic neurotransmitters in the amygdaloid complex of the rat
Poulin, J., Castonguay-Lebel, Z., Laforest, S., & Drolet, G. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21587 · Cited by 104 · see citing works
Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memoryPreprint
Bergado-Acosta, J. R., Sangha, S., Narayanan, R. T., Obata, K., Pape, H., & Stork, O. (2008) · Learning & Memory · doi:10.1101/lm.705408 · Cited by 103 · see citing works
Synaptic connections of distinct interneuronal subpopulations in the rat basolateral amygdalar nucleus
Muller, J. F., Mascagni, F., & McDonald, A. J. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10435 · Cited by 100 · see citing works
Deficiency of the 65 kDa Isoform of Glutamic Acid Decarboxylase Impairs Extinction of Cued But Not Contextual Fear Memory
Sangha, S., Narayanan, R. T., Bergado-Acosta, J. R., Stork, O., Seidenbecher, T., & Pape, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2620-09.2009 · Cited by 99 · see citing works
Roles of GABAA, NMDA and muscarinic receptors in induction of long-term potentiation in the medial and lateral amygdala in vitro
Watanabe, Y., Ikegaya, Y., Saito, H., & Abe, K. (1995) · Neuroscience Research · doi:10.1016/0168-0102(94)00867-f · Cited by 93 · see citing works
Thy1-Expressing Neurons in the Basolateral Amygdala May Mediate Fear Inhibition
Jasnow, A. M., Ehrlich, D., Choi, D. C., Dabrowska, J., Bowers, M. E., McCullough, K. M., Rainnie, D. G., & Ressler, K. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5539-12.2013 · Cited by 92 · see citing works
Firing Properties and Connectivity of Neurons in the Rat Lateral Central Nucleus of the Amygdala
de Armentia, M. L., & Sah, P. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00211.2004 · Cited by 91 · see citing works
Molecular genetics of anxiety in mice and men
Hovatta, I., & Barlow, C. (2008) · Annals of Medicine · doi:10.1080/07853890701747096 · Cited by 90 · see citing works
Polarized Synaptic Interactions Between Intercalated Neurons of the Amygdala
Royer, S., Martina, M., & Paré, D. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.6.3509 · Cited by 87 · see citing works
Response of locus coeruleus neurons to footshock stimulation is mediated by neurons in the rostral ventral medulla
Chiang, C., & Aston‐Jones, G. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90618-p · Cited by 84 · see citing works
The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats
Roche, M., O'Connor, E., Diskin, C., & Finn, D. P. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05861.x · Cited by 83 · see citing works
GABAergic Interneurons in the Mouse Lateral Amygdala: A Classification Study
Sosulina, L., Graebenitz, S., & Pape, H. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00207.2010 · Cited by 83 · see citing works
Spatiotemporal asymmetry of associative synaptic plasticity in fear conditioning pathways.
Shin, R.-M., Tsvetkov, E., & Bolshakov, V. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.010 · Cited by 82 · see citing works
Reduction of extracellular GABA in the mouse amygdala during and following confrontation with a conditioned fear stimulus
Stork, O., Ji, F.-Y., & Obata, K. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00387-7 · Cited by 82 · see citing works
Classification of projection neurons and interneurons in the rat lateral amygdala based upon cluster analysis
Sosulina, L., Meis, S., Seifert, G., Steinhäuser, C., & Pape, H. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.06.005 · Cited by 81 · see citing works
Physiological Properties of Central Medial and Central Lateral Amygdala Neurons
Martina, M., Royer, S., & Paré, D. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.4.1843 · Cited by 80 · see citing works
Subpopulations of somatostatin-immunoreactive non-pyramidal neurons in the amygdala and adjacent external capsule project to the basal forebrain: evidence for the existence of GABAergic projection neurons in the cortical nuclei and basolateral nuclear complex
McDonald, A. J., Mascagni, F., & Zaric, V. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00046 · Cited by 78 · see citing works
Distribution of parvalbumin‐immunoreactive cells and fibers in the monkey temporal lobe: The amygdaloid complex
Pitkänen, A., & Amaral, D. G. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903310103 · Cited by 78 · see citing works
Physiological properties of central amygdala neurons: species differences
Dumont, É. C., Martina, M., Samson, R. D., Drolet, G., & Paré, D. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01879.x · Cited by 78 · see citing works
Genes and Mechanisms in the Amygdala Involved in the Formation of Fear Memory
Pape, H., & Stork, O. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07074.x · Cited by 73 · see citing works
Prefrontal single-unit firing associated with deficient extinction in mice
Fitzgerald, P. J., Whittle, N., Flynn, S., Graybeal, C., Pinard, C. R., Gunduz‐Cinar, O., Kravitz, A. V., Singewald, N., & Holmes, A. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.002 · Cited by 72 · see citing works
Block of γ-Aminobutyric Acid-A Receptor Insertion in the Amygdala Impairs Extinction of Conditioned Fear
Lin, H., Mao, S.-C., & Gean, P. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.003 · Cited by 66 · see citing works
A novel subpopulation of 5-HT type 3A receptor subunit immunoreactive interneurons in the rat basolateral amygdala
Mascagni, F., & McDonald, A. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.044 · Cited by 61 · see citing works
Distinct Subtypes of Cholecystokinin (CCK)-Containing Interneurons of the Basolateral Amygdala Identified Using a CCK Promoter-Specific Lentivirus
Jasnow, A. M., Ressler, K. J., Hammack, S. E., Chhatwal, J. P., & Rainnie, D. G. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91149.2008 · Cited by 60 · see citing works
Synaptic heterogeneity between mouse paracapsular intercalated neurons of the amygdala
Geracitano, R., Kaufmann, W. A., Szabó, G., Ferraguti, F., & Capogna, M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142570 · Cited by 59 · see citing works
Golgi studies on the amygdaloid nuclei of the cat.
Kamal, A. M., & Tömböl, T. (1975) · PubMed · Cited by 58 · see citing works
Assignment of Model Amygdala Neurons to the Fear Memory Trace Depends on Competitive Synaptic Interactions
Kim, D., Paré, D., & Nair, S. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2430-13.2013 · Cited by 56 · see citing works
The distribution of dopamine D1 receptor and μ-opioid receptor 1 receptor immunoreactivities in the amygdala and interstitial nucleus of the posterior limb of the anterior commissure: Relationships to tyrosine hydroxylase and opioid peptide terminal systems
Jacobsen, K. X., Höistad, M., Staines, W. A., & Fuxé, K. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.054 · Cited by 56 · see citing works
Lateral nucleus of the rat amygdala is reciprocally connected with basal and accessory basal nuclei: a light and electron microscopic study
Savander, V., Miettinen, R., LeDoux, J. E., & Pitkänen, A. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00513-1 · Cited by 56 · see citing works
Mechanisms contributing to the induction and storage of Pavlovian fear memories in the lateral amygdalaPreprint
Kim, D., Paré, D., & Nair, S. S. (2013) · Learning & Memory · doi:10.1101/lm.030262.113 · Cited by 53 · see citing works
Bistable Behavior of Inhibitory Neurons Controlling Impulse Traffic through the Amygdala: Role of a Slowly Deinactivating K+Current
Royer, S., Martina, M., & Paré, D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09034.2000 · Cited by 44 · see citing works
Feedback Inhibition Defines Transverse Processing Modules in the Lateral Amygdala
Samson, R. D., Dumont, É. C., & Paré, D. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01966.2003 · Cited by 35 · see citing works
Aversive-Bias and Stage-Selectivity in Neurons of the Primate Amygdala during Acquisition, Extinction, and Overnight Retention
Livneh, U., & Paz, R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0323-12.2012 · Cited by 34 · see citing works
A spatially structured network of inhibitory and excitatory connections directs impulse traffic within the lateral amygdala
Samson, R. D., & Paré, D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.077 · Cited by 33 · see citing works
Embryonic development of the nervous system of the rhabdocoel flatwormMesostoma lingua (Abildgaard, 1789)
Younossi‐Hartenstein, A., Ehlers, U., & Hartenstein, V. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000124)416:4 · Cited by 33 · see citing works
Cortical inputs innervate calbindin‐immunoreactive interneurons of the rat basolateral amygdaloid complex
Ünal, G., Paré, J., Smith, Y., & Paré, D. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23511 · Cited by 31 · see citing works
Persistence of fear-reducing behavior: Relevance for the conditioning theory of neurosis.
McAllister, W. R., McAllister, D. E., Scoles, M. T., & Hampton, S. R. (1986) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.95.4.365 · Cited by 31 · see citing works
Persistence of fear-reducing behavior: Relevance for the conditioning theory of neurosis.
McAllister, W. R., McAllister, D. E., Scoles, M. T., et al. (1986) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.95.4.365 · Cited by 25 · see citing works
Gating in Cerebral Networks: Contents
Steriade, M., & Paré, D. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541735 · Cited by 20 · see citing works
Functional expression of the GABAA receptor α2 and α3 subunits at synapses between intercalated medial paracapsular neurons of mouse amygdala
Geracitano, R., Fischer, D., Kasugai, Y., Ferraguti, F., & Capogna, M. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00032 · Cited by 19 · see citing works
Untitled work
(1998) · doi:10.1002/(sici)1096-9861(19980525)395:1

Flagged first, then by citations

Research works printed but not linked: 1

Pitkanen A Aggleton JP 2000 The connectivity of the rat amygdaloid complex The Amygdala: A Functional Analysis Oxford Oxford University Press 31 116

Sorted by citations

From circuits to behaviour in the amygdala
Janak, P. H., & Tye, K. M. (2015) · Nature · doi:10.1038/nature14188 · Cited by 2,011 · see citing works
Neuronal circuits for fear and anxiety
Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786 · see citing works
Resolving the neural circuits of anxiety
Calhoon, G. G., & Tye, K. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4101 · Cited by 766 · see citing works
The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear
Giustino, T. F., & Maren, S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00298 · Cited by 519 · see citing works
Encoding of fear learning and memory in distributed neuronal circuits
Herry, C., & Johansen, J. P. (2014) · Nature Neuroscience · doi:10.1038/nn.3869 · Cited by 474 · see citing works
Fear memory
Izquierdo, I., Furini, C. R. G., & Myskiw, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00018.2015 · Cited by 453 · see citing works
Antagonistic control of social versus repetitive self-grooming behaviors by separable amygdala neuronal subsets
Hong, W., Kim, D.-W., & Anderson, D. J. (2014) · Cell · doi:10.1016/j.cell.2014.07.049 · Cited by 405 · see citing works
Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390 · see citing works
“The basal AMY (BA) contains extinction-encoding neurons which drive GABAergic cells in themedial intercalated cell masses (ITC) and neurons in the centrolateral AMY (CeL) to inhibit the CeM and the expression of fear (Duvarci & Pare, 2014; Herry et al., 2008).”
BackgroundInfluential
Synapse-specific astrocyte gating of amygdala-related behavior
Martin-Fernandez, M., Jamison, S., Robin, L. M., Zhao, Z., Martin, E. D., Aguilar, J., Benneyworth, M. A., Marsicano, G., & Araque, A. (2017) · Nature Neuroscience · doi:10.1038/nn.4649 · Cited by 345 · see citing works
The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm
LeDoux, J. E., Moscarello, J., Sears, R., & Campese, V (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.166 · Cited by 348 · see citing works
Why fish do not feel pain
Key, B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1011 · Cited by 318 · see citing works
Organization of valence-encoding and projection-defined neurons in the basolateral amygdala
Beyeler, A., Chang, C.-J., Silvestre, M., Lévêque, C., Namburi, P., Wildes, C. P., & Tye, K. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.097 · Cited by 306 · see citing works
“…may synthesize apparently conflicting studies reporting the role of the CeA in freezing and avoidance (Ciocchi et al., 2010; Davis and Shi, 1999; Duvarci and Pare, 2014; Fadok et al., 2017; Goosens and Maren, 2001; Haubensak et al., 2010; Jimenez and Maren, 2009; Li et al., 2013; Maren and…”
Background
The basolateral amygdala in reward learning and addiction
Wassum, K. M., & Izquierdo, A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.017 · Cited by 306 · see citing works
An excitatory synapse hypothesis of depression
Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works
The neurobiology of emotion regulation in posttraumatic stress disorder: amygdala downregulation via real‐time fMRI neurofeedback
Nicholson, A. A., Rabellino, D., Densmore, M., Frewen, P. A., Paret, C., Kluetsch, R., Schmahl, C., Théberge, J., Neufeld, R. W. J., McKinnon, M. C., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23402 · Cited by 273 · see citing works
Insects have the capacity for subjective experience
Klein, C., & Barron, A. B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1113 · Cited by 243 · see citing works
Prefrontal inputs to the amygdala instruct fear extinction memory formation
Bukalo, O., Pinard, C. R., Silverstein, S., Brehm, C., Hartley, N. D., Whittle, N., Colacicco, G., Busch, E., Patel, S., Singewald, N., et al. (2015) · Science Advances · doi:10.1126/sciadv.1500251 · Cited by 234 · see citing works
Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear
Marek, R., Jin, J., Goode, T. D., Giustino, T. F., Wang, Q., Acca, G. M., Holehonnur, R., Ploski, J. E., Fitzgerald, P. J., Lynagh, T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0073-9 · Cited by 226 · see citing works
An emerging circuit pharmacology of GABAA receptors
Engin, E., Benham, R. S., & Rudolph, U. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.04.003 · Cited by 225 · see citing works
Viewpoints: Approaches to defining and investigating fear
Mobbs, D., Adolphs, R., Fanselow, M. S., Barrett, L. F., LeDoux, J. E., Ressler, K., & Tye, K. M. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0456-6 · Cited by 202 · see citing works
The dissociative subtype of posttraumatic stress disorder: unique resting-state functional connectivity of basolateral and centromedial amygdala complexes.
Nicholson, A. A., Densmore, M., Frewen, P. A., Théberge, J., Neufeld, R. W., McKinnon, M. C., & Lanius, R. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.79 · Cited by 180 · see citing works
Dynamic causal modeling in PTSD and its dissociative subtype: Bottom–up versus top–down processing within fear and emotion regulation circuitry
Nicholson, A. A., Friston, K. J., Zeidman, P., Harricharan, S., McKinnon, M. C., Densmore, M., Neufeld, R. W. J., Théberge, J., Corrigan, F., Jetly, R., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23748 · Cited by 159 · see citing works
A Review of the Neurobiological Basis of Trauma-Related Dissociation and Its Relation to Cannabinoid- and Opioid-Mediated Stress Response: a Transdiagnostic, Translational Approach
Lanius, R. A., Boyd, J. E., McKinnon, M. C., Nicholson, A. A., Frewen, P., Vermetten, E., Jetly, R., & Spiegel, D. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0983-y · Cited by 138 · see citing works
Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson’s disease
de Faria, S. M., de Morais Fabrício, D., Tumas, V., Castro, P. C., Ponti, M. A., Hallak, J. E., Zuardi, A. W., Crippa, J. A. S., & Chagas, M. H. N. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881119895536 · Cited by 140 · see citing works
Control of amygdala circuits by 5-HT neurons via 5-HT and glutamate cotransmission
Sengupta, A., Bocchio, M., Bannerman, D. M., Sharp, T., & Capogna, M. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2238-16.2016 · Cited by 136 · see citing works
Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase
Fuertig, R., Azzinnari, D., Bergamini, G., Cathomas, F., Sigrist, H., Seifritz, E., Vavassori, S., Luippold, A., Hengerer, B., Ceci, A., et al. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.12.020 · Cited by 135 · see citing works
Manipulating a “Cocaine Engram” in Mice
Hsiang, H.-L. (., Epp, J. R., van den Oever, M. C., Yan, C., Rashid, A. J., Insel, N., Ye, L., Niibori, Y., Deisseroth, K., Frankland, P. W., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-14.2014 · Cited by 131 · see citing works
The Physiology of Fear: Reconceptualizing the Role of the Central Amygdala in Fear Learning
Keifer, O. P., Hurt, R. C., Ressler, K. J., & Marvar, P. J. (2015) · Physiology · doi:10.1152/physiol.00058.2014 · Cited by 124 · see citing works
Amygdala signaling during foraging in a hazardous environment
Amir, A., Lee, S.-C., Headley, D. B., Herzallah, M. M., & Pare, D. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.0407-15.2015 · Cited by 104 · see citing works
Central amygdala circuits mediate hyperalgesia in alcohol-dependent rats
Avegno, E. M., Lobell, T. D., Itoga, C. A., Baynes, B. B., Whitaker, A. M., Weera, M. M., Edwards, S., Middleton, J. W., & Gilpin, N. W. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0483-18.2018 · Cited by 104 · see citing works
The study of active avoidance: a platform for discussion
Diehl, M. M., Bravo-Rivera, C., & Quirk, G. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.010 · Cited by 95 · see citing works
Concepts, goals and the control of survival-related behaviors
Feldman Barrett, L., & Finlay, B. L. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.10.001 · Cited by 89 · see citing works
Early life trauma increases threat response of peri-weaning rats, reduction of axo-somatic synapses formed by parvalbumin cells and perineuronal net in the basolateral nucleus of amygdala
Santiago, A. N., Lim, K. Y., Opendak, M., Sullivan, R. M., & Aoki, C. (2018) · Journal of Comparative Neurology · doi:10.1002/cne.24522 · Cited by 87 · see citing works
Fear as a translational mechanism in the psychopathology of anorexia nervosa
Murray, S. B., Strober, M., Craske, M. G., Griffiths, S., Levinson, C. A., & Strigo, I. A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.10.013 · Cited by 75 · see citing works
Metastable dynamics of neural circuits and networks
Brinkman, B. A. W., Yan, H., Maffei, A., Park, I. M., Fontanini, A., Wang, J., & La Camera, G. (2022) · Applied Physics Reviews · doi:10.1063/5.0062603 · Cited by 64 · see citing works
A Central Amygdala-Globus Pallidus Circuit Conveys Unconditioned Stimulus-Related Information and Controls Fear Learning
Giovanniello, J., Yu, K., Furlan, A., Nachtrab, G. T., Sharma, R., Chen, X., & Li, B. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.2090-20.2020 · Cited by 65 · see citing works
Differential efferent projections of GABAergic neurons in the basolateral and central nucleus of amygdala in mice
Liu, J., Hu, T., Zhang, M.-Q., Xu, C.-Y., Yuan, M.-Y., & Li, R.-X. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135621 · Cited by 52 · see citing works
Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice
Gasser, P. J., Hurley, M. M., Chan, J., & Pickel, V. M. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1315-9 · Cited by 52 · see citing works
Atypical amygdala response to fear conditioning in autism spectrum disorder
Top Jr., D. N., Stephenson, K. G., Doxey, C. R., Crowley, M. J., Kirwan, C. B., & South, M. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.01.008 · Cited by 45 · see citing works
Transcriptional regulatory dynamics drive coordinated metabolic and neural response to social challenge in mice
Saul, M. C., Seward, C. H., Troy, J. M., Zhang, H., Sloofman, L. G., Lu, X., Weisner, P. A., Caetano-Anolles, D., Sun, H., Zhao, S. D., et al. (2017) · Genome Research · doi:10.1101/gr.214221.116 · Cited by 46 · see citing works
Synaptic adaptations in the central amygdala and hypothalamic paraventricular nucleus associated with protracted ethanol abstinence in male rhesus monkeys
Jimenez, V. A., Herman, M. A., Cuzon Carlson, V. C., Walter, N. A., Grant, K. A., & Roberto, M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0290-7 · Cited by 29 · see citing works
Anomalous static and dynamic functional connectivity of amygdala subregions in individuals with high trait anxiety
Wang, C., Wang, Y., Lau, W. K. W., Wei, X., Feng, X., Zhang, C., Liu, Y., Huang, R., & Zhang, R. (2021) · Depression and Anxiety · doi:10.1002/da.23195 · Cited by 31 · see citing works
Exploring the neural basis for paternal protection: An investigation of the neural response to infants in danger
van ‘t Veer, A. E., Thijssen, S., Witteman, J., van IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz018 · Cited by 25 · see citing works
Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma
Pennington, Z. T., Trott, J. M., Rajbhandari, A. K., Li, K., Walwyn, W. M., Evans, C. J., & Fanselow, M. S. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0559-5 · Cited by 19 · see citing works

Authors: Duvarci, S., & Pare, D.
Affiliations: Goethe University Frankfurt (DE)
ORCID: Duvarci, Sevil
Venue: Neuron
Publisher: Elsevier BV
Published: 2014-06
Volume: 82
Issue: 5
Pages: 966-980
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2014.04.042
PMC: PMC4103014
OpenAlex: W1963723820
Cited by: 751
References: 199
Citations by year: 2026: 38 · 2025: 44 · 2024: 62 · 2023: 50 · 2022: 69 · 2021: 81 · 2020: 75 · 2019: 57 · 2018: 82 · 2017: 53 · 2016: 68 · 2015: 58 · 2014: 14
FWCI: 6.06
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH-098738, R01MH098738, R01MH083710, MH083710)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: amygdala, fear conditioning, fear extinction, fear expression, inhibitory circuits, medial prefrontal cortex, neural circuits, anxiety disorders, fear learning
MeSH terms: Amygdala, Animals, Conditioning, Classical, Extinction, Psychological, Fear, Humans, Nerve Net, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Amygdala Microcircuits Controlling Learned Fear

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks