The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Long-Range Connectivity Defines Behavioral Specificity of Amygdala Neurons
Open accessAbstract
Memories are acquired and encoded within large-scale neuronal networks spanning different brain areas. The anatomical and functional specificity of such long-range interactions and their role in learning is poorly understood. The amygdala and the medial prefrontal cortex (mPFC) are interconnected brain structures involved in the extinction of conditioned fear. Here, we show that a defined subpopulation of basal amygdala (BA) projection neurons targeting the prelimbic (PL) subdivision of mPFC is active during states of high fear, whereas BA neurons targeting the infralimbic (IL) subdivision are recruited, and exhibit cell-type-specific plasticity, during fear extinction. Pathway-specific optogenetic manipulations demonstrate that the activity balance between pathways is causally involved in fear extinction. Together, our findings demonstrate that, although intermingled locally, long-range connectivity defines distinct subpopulations of amygdala projection neurons and indicate that the formation of long-term extinction memories depends on the balance of activity between two defined amygdala-prefrontal pathways.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There is evidence to suggest that there is a dorso-ventral topographic segregation of BLA input to the mPFC; more dorsal projections (to PL) encode threat-stimulating information while more ventral projections (to IL) encode threat extinction-related information [51].”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [51]
In the citing paper
“Moreover, optogenetic excitation of BLA→dmPFC PNs has been shown to increase conditioned fear after extinction (19).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [19]
In the citing paper
“By contrast, extinction of the learned fear association increases activity in basal amygdala neurons targeting the infralimbic cortex105.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [105]
In the citing paper
“During auditory fear conditioning, activity in basal amygdala neurons projecting to the prelimbic cortex is increased105”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [105]
Citations
Cites
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
Sesack, S. R., Deutch, A. Y., Roth, R. H., & Bunney, B. S. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902900205 · Cited by 1,568
Differential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550
Bursts as a unit of neural information: making unreliable synapses reliable
Lisman, J. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10070-9 · Cited by 1,418
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227
Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.184 · Cited by 1,190
Switching on and off fear by distinct neuronal circuits
Herry, C., Ciocchi, S., Senn, V., Demmou, L., Müller, C., & Lüthi, A. (2008) · Nature · doi:10.1038/nature07166 · Cited by 950
Self-citationThe other side of the engram: experience-driven changes in neuronal intrinsic excitability
Zhang, W., & Linden, D. J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1248 · Cited by 889
Flagged first, then by citations
Cited by
Sorted by citations
From circuits to behaviour in the amygdala
Janak, P. H., & Tye, K. M. (2015) · Nature · doi:10.1038/nature14188 · Cited by 2,011
Neuronal circuits for fear and anxiety
Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786
Self-citationOptogenetics: 10 years of microbial opsins in neuroscience
Deisseroth, K. A. (2015) · Nature Neuroscience · doi:10.1038/nn.4091 · Cited by 1,335
Resolving the neural circuits of anxiety
Calhoon, G. G., & Tye, K. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4101 · Cited by 766
Amygdala Microcircuits Controlling Learned Fear
Duvarci, S., & Pare, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.042 · Cited by 751
A framework for studying emotions across species
Anderson, D. J., & Adolphs, R. (2014) · Cell · doi:10.1016/j.cell.2014.03.003 · Cited by 691
“The basolateral amygdala, in contrast, projects to the medial prefrontal cortex (Senn et al., 2014), and this projection may underlie cognitive or subjective”
Temporal evolution of cortical ensembles promoting remote memory retrieval
DeNardo, L. A., Liu, C. D., Allen, W. E., Adams, E. L., Friedmann, D., Dadgar‐Kiani, E., Fu, L., Guenthner, C. J., Lee, J. H., Tessier‐Lavigne, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0318-7 · Cited by 646
Memory Engram Cells Have Come of Age
Tonegawa, S., Liu, X., Ramirez, S., & Redondo, R. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.002 · Cited by 661
“The amygdala receives inputs from all sensory modalities, including processed inputs from the hippocampus, perirhinal and entorhinal cortex, and prefrontal cortex (Sah et al., 2003; Senn et al., 2014; Trouche et al., 2013).”
The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear
Giustino, T. F., & Maren, S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00298 · Cited by 519
“In summary, there is compelling evidence to support the notion that the amygdala is a crucial locus for the acquisition and extinction of learned fear with both ‘‘fear’’ and ‘‘extinction’’ neurons existing within the same subnuclei whose CS-evoked activity strongly correlates with the level of fear expression (Quirk e…”
BackgroundInfluentialEncoding of fear learning and memory in distributed neuronal circuits
Herry, C., & Johansen, J. P. (2014) · Nature Neuroscience · doi:10.1038/nn.3869 · Cited by 474
Context Processing and the Neurobiology of Post-Traumatic Stress Disorder
Liberzon, I., & Abelson, J. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.039 · Cited by 489
The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders
Gilpin, N. W., Herman, M. A., & Roberto, M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.008 · Cited by 457
“Basal amygdala projection neurons display anatomic and functional specificity in fear expression versus extinction conditions (60), raising the possibility that CeAM populations are likewise differentially activated by specific stimulus conditions.”
BackgroundDivergent routing of positive and negative information from the amygdala during memory retrieval
Beyeler, A., Namburi, P., Glober, G. F., Simonnet, C., Calhoon, G. G., Conyers, G. F., Luck, R., Wildes, C. P., & Tye, K. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.004 · Cited by 412
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript Nieh et al., 2015; Senn et al., 2014).”
Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety
Liu, W.-Z., Zhang, W., Zheng, Z.-H., Zou, J., Liu, X., Huang, S.-H., You, W.-J., He, Y., Zhang, J., Wang, X.-D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15920-7 · Cited by 486
Felix‐Ortiz, A. C., Burgos-Robles, A., Bhagat, N. D., Leppla, C. A., & Tye, K. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.041 · Cited by 434
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390
“While other neuroptides such as hypocretin/Orexin (Flores et al., 2014) may also be involved in fear extinction, we will here address the role of oxytocin, neuropeptide Y, neuropeptide S and opioids in extinction.”
BackgroundBehavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
Bouton, M. E., Maren, S., & McNally, G. P. (2020) · Physiological Reviews · doi:10.1152/physrev.00016.2020 · Cited by 440
Maren, S., & Holmes, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.180 · Cited by 412
“Neuronal projections from the BLA to the PL and IL are recruited to generate fear responses and extinction memories, respectively (Garcia et al, 1999; Senn et al, 2014).”
BackgroundNeural ensemble dynamics underlying a long-term associative memory
Grewe, B. F., Gründemann, J., Kitch, L. J., Lecoq, J. A., Parker, J. G., Marshall, J. D., Larkin, M. C., Jercog, P. E., Grenier, F., Li, J. Z., et al. (2017) · Nature · doi:10.1038/nature21682 · Cited by 351
Prefrontal cortex, amygdala, and threat processing: implications for PTSD
Alexandra Kredlow, M., Fenster, R. J., Laurent, E. S., Ressler, K. J., & Phelps, E. A. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01155-7 · Cited by 346
“There is evidence to suggest that there is a dorso-ventral topographic segregation of BLA input to the mPFC; more dorsal projections (to PL) encode threatstimulating information while more ventral projections (to IL) encode threat extinction-related information [51].”
BackgroundNeurobehavioral perspectives on the distinction between fear and anxietyPreprint
Perusini, J. N., & Fanselow, M. S. (2015) · Learning & Memory · doi:10.1101/lm.039180.115 · Cited by 390
“IL and PL have opposing roles in expression of fear following extinction learning (Senn et al. 2014), which suggests that these reciprocal connections influence the outcome of fear and extinction learning.”
BackgroundAmygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment
Burgos-Robles, A., Kimchi, E. Y., Izadmehr, E. M., Porzenheim, M. J., Ramos-Guasp, W. A., Nieh, E. H., Felix-Ortiz, A. C., Namburi, P., Leppla, C. A., Presbrey, K. N., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4553 · Cited by 318
Stress and the adolescent brain
Tottenham, N., & Galván, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.030 · Cited by 324
“These projections, depending on their source, can function to attenuate or potentiate (Senn et al., 2014) affective responding, and thus these connections are fundamental to mature affect regulation (Banks, Eddy, Angstadt, Nathan, & Phan, 2007; Delgado, Nearing, Ledoux, & Phelps, 2008; Monk, 2008).”
Distinct hippocampal engrams control extinction and relapse of fear memory
Lacagnina, A. F., Brockway, E. T., Crovetti, C. R., Shue, F., McCarty, M. J., Sattler, K. P., Lim, S. C., Santos, S. L., Denny, C. A., & Drew, M. R. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0361-z · Cited by 311
Fear and safety engage competing patterns of theta-gamma coupling in the basolateral amygdala
Stujenske, J. M., Likhtik, E., Topiwala, M. A., & Gordon, J. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.026 · Cited by 303
“, 2008), with fear recall neurons preferentially projecting to the PL and extinction neurons preferentially projecting to the IL (Senn et al., 2014).”
Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning
Allsop, S. A., Wichmann, R., Mills, F., Burgos-Robles, A., Chang, C.-J., Felix-Ortiz, A. C., Vienne, A., Beyeler, A., Izadmehr, E. M., Glober, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.04.004 · Cited by 288
“…about the aversive cue is transmitted from the ACC to the BLA during observational conditioning, we used an intersectional viral strategy (Senn et al., 2014) to express channelrhodopsin-2 (ChR2) in ACC neurons that monosynaptically project to the BLA (Figures 4A and 4B) (Burgos-Robles et…”
Fuchikami, M., Thomas, A., Liu, R., Wohleb, E. S., Land, B. B., DiLeone, R. J., Aghajanian, G. K., & Duman, R. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414728112 · Cited by 265
Distinct Hippocampal Pathways Mediate Dissociable Roles of Context in Memory Retrieval
Xu, C., Krabbe, S., Gründemann, J., Botta, P., Fadok, J. P., Osakada, F., Saur, D., Grewe, B. F., Schnitzer, M. J., Callaway, E. M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.051 · Cited by 297
The cannabinoid system and pain
Woodhams, S. G., Chapman, V., Finn, D. P., Hohmann, A. G., & Neugebauer, V. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.015 · Cited by 285
Space, Time, and Fear: Survival Computations along Defensive Circuits
Mobbs, D., Headley, D. B., Ding, W., & Dayan, P. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.12.016 · Cited by 281
“The BLA is capable of driving different post-encounter defense-related behaviors through its efferent targets, such as freezing via PFC (prelimbic subregion [69]) and central amygdala [70], passive avoidance via the central amygdala [71], and active avoidance via the nucleus accumbens [72].”
BackgroundBocchio, M., Nabavi, S., & Capogna, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.022 · Cited by 265
“For example, BLA neurons projecting to the prelimbic mPFC promote fear expression (‘fear neurons’), whereas the ones projecting to the infralimbic region promote fear extinction (‘extinction neurons’, see section on fear extinction below for further details; Senn et al., 2014).”
InfluentialThe mouse that roared: neural mechanisms of social hierarchy
Wang, F., Kessels, H. W. H. G., & Hu, H. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.07.005 · Cited by 276
Amygdala Inhibitory Circuits Regulate Associative Fear Conditioning
Krabbe, S., Gründemann, J., & Lüthi, A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.006 · Cited by 268
“The basal amygdala (BA) receives less direct sensory information, but is rather reciprocally connected with other brain regions, such as the prefrontal cortex or ventral hippocampus (12; 14-17).”
BackgroundThompson, J. M., & Neugebauer, V. (2017) · Pain Research and Management · doi:10.1155/2017/8296501 · Cited by 238
“(e BLA sends glutamatergic projections to the pre- and infralimbic mPFC [61, 66, 67].”
BackgroundFear extinction requires infralimbic cortex projections to the basolateral amygdala
Bloodgood, D. W., Sugam, J. A., Holmes, A., & Kash, T. L. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0106-x · Cited by 229
“reciprocal connections from BLA to IL (11, 12) and projections from BLA to NAc (13) are important for extinction.”
BackgroundAmygdala ensembles encode behavioral states
Gründemann, J., Bitterman, Y., Lu, T., Krabbe, S., Grewe, B. F., Schnitzer, M. J., & Lüthi, A. (2019) · Science · doi:10.1126/science.aav8736 · Cited by 234
Abstract context representations in primate amygdala and prefrontal cortex
Saez, A., Rigotti, M., Ostojic, S., Fusi, S., & Salzman, C. D. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.024 · Cited by 183
Prefrontal somatostatin interneurons encode fear memory
Cummings, K. A., & Clem, R. L. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0552-7 · Cited by 211
“4), BLA contains prelimbic cortex-projecting neurons that exhibit increased firing during memory retrieval 25,26 and regulate fear memory expression 27,28 .”
The mouse prefrontal cortex: Unity in diversity
Le Merre, P., Ährlund-Richter, S., & Carlén, M. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.035 · Cited by 207
Distributed circuits underlying anxiety
Adhikari, A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00112 · Cited by 204
Prefrontal cortical regulation of fear learning
Gilmartin, M. R., Balderston, N. L., & Helmstetter, F. J. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.05.004 · Cited by 207
Selective synaptic remodeling of amygdalocortical connections associated with fear memory
Yang, Y., Liu, D., Huang, W., Deng, J., Sun, Y.-G., Zuo, Y., & Poo, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4370 · Cited by 191
Amygdala Circuit Substrates for Stress Adaptation and Adversity
Zhang, W.-H., Zhang, J.-Y., Holmes, A., & Pan, B.-X. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.026 · Cited by 196
Pathological circuit function underlying addiction and anxiety disorders
Lüthi, A., & Lüscher, C. (2014) · Nature Neuroscience · doi:10.1038/nn.3849 · Cited by 192
Amygdala–prefrontal interactions in (mal)adaptive learning
Likhtik, E., & Paz, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.12.007 · Cited by 198
A robust activity marking system for exploring active neuronal ensembles
Sørensen, A. T., Cooper, Y. A., Baratta, M. V., Weng, F., Zhang, Y., Ramamoorthi, K., Fropf, R., LaVerriere, E., Xue, J., Young, A., et al. (2016) · eLife · doi:10.7554/elife.13918 · Cited by 199
Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner
Zhang, J.-Y., Liu, T.-H., He, Y., Pan, H.-Q., Zhang, W.-H., Yin, X.-P., Tian, X.-L., Li, B.-M., Wang, X.-D., Holmes, A., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.06.019 · Cited by 183
“Moreover, optogenetic excitation of BLA→dmPFC PNs has been shown to increase conditioned fear after extinction (19).”
BackgroundManipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex
Klavir, O., Prigge, M., Sarel, A., Paz, R., & Yizhar, O. (2017) · Nature Neuroscience · doi:10.1038/nn.4523 · Cited by 179
Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons
Chatterjee, S., Sullivan, H. A., MacLennan, B. J., Xu, R., Hou, Y., Lavin, T. K., Lea, N. E., Michalski, J. E., Babcock, K. R., Dietrich, S., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0091-7 · Cited by 177
Adaptive disinhibitory gating by VIP interneurons permits associative learning
Krabbe, S., Paradiso, E., d‘Aquin, S., Bitterman, Y., Courtin, J., Xu, C., Yonehara, K., Marković, M., Müller, C. R., Eichlisberger, T., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0508-y · Cited by 171
Viewpoints: Dialogues on the functional role of the ventromedial prefrontal cortex
Delgado, M. R., Beer, J. S., Fellows, L. K., Huettel, S. A., Platt, M. L., Quirk, G. J., & Schiller, D. (2016) · Nature Neuroscience · doi:10.1038/nn.4438 · Cited by 173
Neural circuits underlying a psychotherapeutic regimen for fear disorders
Baek, J., Lee, S., Cho, T., Kim, S.-W., Kim, M., Yoon, Y., Kim, K. K., Byun, J., Kim, S. J., Jeong, J., et al. (2019) · Nature · doi:10.1038/s41586-019-0931-y · Cited by 166
How the amygdala affects emotional memory by altering brain network properties
Hermans, E. J., Battaglia, F. P., Atsak, P., de Voogd, L. D., Fernández, G., & Roozendaal, B. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.02.005 · Cited by 173
“…both cell classes project strongly to the medial prefrontal cortex, neurons activated during fear expression predominantly target the prelimbic subregion of the medial prefrontal cortex, while those activated during extinction selectively target the infralimbic subregion (Senn et al., 2014).”
BackgroundNassi, J. J., Cepko, C. L., Born, R. T., & Beier, K. T. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00080 · Cited by 161
“Other strains, such as the HSV-1 strain H129 (Zemanick et al., 1991; Sun et al., 1996), appear to transmit transsynaptically only in the anterograde direction.”
MethodInfluentialSchubert, D., Martens, G. J. M., & Kolk, S. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.147 · Cited by 157
Sangha, S., Diehl, M. M., Bergstrom, H. C., & Drew, M. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.006 · Cited by 151
Reppucci, C. J., & Petrovich, G. D. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1081-0 · Cited by 155
“…of distinct cell groups that mediate different functions (e.g., Ashwell and Ito 2014; Burgos-Robles et al. 2013; Cole et al. 2013; Heidbreder and Groenewegen 2003; Knapska et al. 2012; Maeng and Shors 2013; Martinez et al. 2013; Mendoza et al. 2014; Senn et al. 2014; Swanson and Petrovich 1998).”
Prefrontal Cortex Drives Distinct Projection Neurons in the Basolateral Amygdala
McGarry, L. M., & Carter, A. G. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.046 · Cited by 158
“By preferentially activating AC and AH neurons, the PFC may be able to rapidly regulate behaviors associatedwith fear andanxiety (Felix-Ortiz et al., 2013, 2016; Herry et al., 2008; Likhtik et al., 2014; Senn et al., 2014).”
Afferents to anterior cingulate areas 24a and 24b and midcingulate areas 24a′ and 24b′ in the mouse
Fillinger, C., Yalçın, İ., Barrot, M., & Veinante, P. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1290-1 · Cited by 144
Basolateral amygdala circuitry in positive and negative valence
O’Neill, P.-K., Gore, F., & Salzman, C. D. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.012 · Cited by 141
Architectural Representation of Valence in the Limbic System
Namburi, P., Al‐Hasani, R., Calhoon, G. G., Bruchas, M. R., & Tye, K. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.358 · Cited by 148
“…that some of the projection-target-defined populations of BLA neurons are largely nonoverlapping, such as vHPC vs mPFC-projecting BLA neurons (Senn et al, 2014), whereas other projectiontarget-defined BLA neurons are largely overlapping, especially striatal and prefrontal cortex-projecting…”
BackgroundInfluentialControl of amygdala circuits by 5-HT neurons via 5-HT and glutamate cotransmission
Sengupta, A., Bocchio, M., Bannerman, D. M., Sharp, T., & Capogna, M. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2238-16.2016 · Cited by 136
Role of the bed nucleus of the stria terminalis in aversive learning and memoryPreprint
Goode, T. D., & Maren, S. (2017) · Learning & Memory · doi:10.1101/lm.044206.116 · Cited by 149
“…or -inhibiting neurons within the amygdala (Vertes 2004; Quirk et al. 2006; Hoover and Vertes 2007; Herry et al. 2008; Knapska et al. 2012; Senn et al. 2014; Adhikari et al. 2015; Rozeske et al. 2015; Giustino and Maren 2015; Gourley and Taylor 2016)—processes that are regulated by the…”
BackgroundSynaptic encoding of fear memories in the amygdala
Ressler, R. L., & Maren, S. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.08.012 · Cited by 138
Prefrontal cortex reactivity underlies trait vulnerability to chronic social defeat stress
Kumar, S., Hultman, R. C., Hughes, D. N., Michel, N., Katz, B. M., & Dzirasa, K. (2014) · Nature Communications · doi:10.1038/ncomms5537 · Cited by 131
Prefrontal–Amygdala Dysregulation to Threat in Pediatric Posttraumatic Stress Disorder
Wolf, R. C., & Herringa, R. J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.209 · Cited by 128
Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress
Perusini, J. N., Meyer, E. M., Long, V., Rau, V., Nocera, N. A., Avershal, J., Maksymetz, J., Spigelman, I., & Fanselow, M. S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.224 · Cited by 128
Serotonin in fear conditioning processes
Bauer, E. P. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.028 · Cited by 136
Sex differences in fear extinction
Velasco, E. R., Florido, A., Milad, M. R., & Andero, R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.020 · Cited by 132
“Moreover, BA projections to the ventral hippocampus, or the prelimbic cortex (PrL) promote fear expression, while BA projections to the infralimbic cortex (IL) promote fear inhibition (Herry et al., 2008; Knapska et al., 2012; Senn et al., 2014).”
BackgroundConnectivity characterization of the mouse basolateral amygdalar complex
Hintiryan, H., Bowman, I., Johnson, D. L., Korobkova, L., Zhu, M., Khanjani, N., Gou, L., Gao, L., Yamashita, S., Bienkowski, M. S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22915-5 · Cited by 127
Pathway-Selective Adjustment of Prefrontal-Amygdala Transmission during Fear Encoding
Arruda-Carvalho, M., & Clem, R. L. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2664-14.2014 · Cited by 127
“In addition, due to reciprocity of mPFC-BLA connectivity (Little and Carter, 2013; Senn et al., 2014), experiments should also examine whether BLA synapses onto mPFC neurons exhibit fear-related plasticity.”
Chen, Y.-H., Wu, J., Hu, N.-Y., Zhuang, J.-P., Li, W., Zhang, S.-R., Li, X.-W., Yang, J., & Gao, T. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145692 · Cited by 126
Déjean, C., Courtin, J., Rozeske, R. R., Bonnet, M. C., Dousset, V., Michelet, T., & Herry, C. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.017 · Cited by 130
“Conversely, optogenetic activation or inhibition of BLA neurons projecting to the IL region reduced or promoted fear recovery (79).”
BackgroundAmygdala signaling during foraging in a hazardous environment
Amir, A., Lee, S.-C., Headley, D. B., Herzallah, M. M., & Pare, D. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.0407-15.2015 · Cited by 104
Intercalated amygdala clusters orchestrate a switch in fear state
Hagihara, K. M., Bukalo, O., Zeller, M., Aksoy‐Aksel, A., Karalis, N., Limoges, A., Rigg, T., Campbell, T. L., Mendez, A., Weinholtz, C. A., et al. (2021) · Nature · doi:10.1038/s41586-021-03593-1 · Cited by 119
Hübner, C., Bosch, D., Gall, A., Lüthi, A., & Ehrlich, I. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00064 · Cited by 115
Self-citationParaventricular Thalamus Balances Danger and Reward
Choi, E. A., & McNally, G. P. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3320-16.2017 · Cited by 120
“…respond to danger relies on amygdala, hippocampal, and prefrontal circuitries, among others, that encode fear associations (Maren and Quirk, 2004; Senn et al., 2014; Tovote et al., 2015) and interface with hypothalamic and brainstem circuitries for production of scalable defensive responses…”
BackgroundGiustino, T. F., Ramanathan, K. R., Totty, M. S., Miles, O. W., & Maren, S. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1092-19.2019 · Cited by 110
CAV-2—why a canine virus is a neurobiologist's best friend
Junyent, F., & Kremer, E. J. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.08.004 · Cited by 120
Valence coding in amygdala circuits
Pignatelli, M., & Beyeler, A. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.10.010 · Cited by 133
Artificially Enhancing and Suppressing Hippocampus-Mediated Memories
Chen, B. K., Murawski, N. J., Cincotta, C., McKissick, O. P., Finkelstein, A. B., Hamidi, A., Merfeld, E., Doucette, E., Grella, S. L., Shpokayte, M., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.04.065 · Cited by 112
A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory
Sengupta, A., & Holmes, A. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.029 · Cited by 123
Marek, R., Xu, L., Sullivan, R., & Sah, P. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0137-x · Cited by 110
Role of Human Ventromedial Prefrontal Cortex in Learning and Recall of Enhanced Extinction
Dunsmoor, J. E., Kroes, M. C. W., Li, J., Daw, N. D., Simpson, H. B., & Phelps, E. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2713-18.2019 · Cited by 110
Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening
Marcus, D. J., Bedse, G., Gaulden, A. D., Ryan, J. D., Kondev, V., Winters, N. D., Rosas-Vidal, L. E., Altemus, M., Mackie, K., Lee, F. S., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.024 · Cited by 104
“Consistent with these findings, activation of rodent basolateral amygdala (BLA) inputs to the prelimbic PFC (plPFC), a rodent homologue of the human dmPFC, generates anxiety-like behaviors and biases behavior toward fear responses in the face of uncertainty (Burgos-Robles et al., 2017; Felix-Ortiz et al., 2015; Senn e…”
Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress
Fitzgerald, P. J., Giustino, T. F., Seemann, J. R., & Maren, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500682112 · Cited by 109
Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex
Diehl, M. M., Bravo-Rivera, C., Rodríguez-Romaguera, J., Pagan-Rivera, P. A., Burgos-Robles, A., Roman-Ortiz, C., & Quirk, G. J. (2018) · eLife · doi:10.7554/elife.34657 · Cited by 108
Asede, D., Bosch, D., Lüthi, A., Ferraguti, F., & Ehrlich, I. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.008 · Cited by 109
Rodent models of impaired fear extinction
Singewald, N., & Holmes, A. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5054-x · Cited by 110
Martinelli, D. C., Chew, K. S., Rohlmann, A., Lum, M. Y., Ressl, S., Hattar, S. S., Brünger, A. T., Missler, M., & Südhof, T. C. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.002 · Cited by 100
“For example, ‘‘fear neurons’’ project from the BLA to the prelimbic cortex and are active during fear training, while ‘‘extinction neurons’’ project from the BLA to the infralimbic cortex and are active during fear memory extinction training (Herry et al., 2008; Senn et al., 2014).”
Cheriyan, J., Kaushik, M. K., Ferreira, A. N., & Sheets, P. L. (2016) · eNeuro · doi:10.1523/eneuro.0002-16.2016 · Cited by 106
“Our findings indicate that increased BLA input to the IL detected during fear extinction (Senn et al., 2014) directly affects the activity of L5 IL-CP neurons, which target the ventral PAG (Ferreira et al., 2015).”
BackgroundInfluentialWolosker, H., & Balu, D. T. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00870-x · Cited by 106
Efferents of anterior cingulate areas 24a and 24b and midcingulate areas 24aʹ and 24bʹ in the mouse
Fillinger, C., Yalçın, İ., Barrot, M., & Veinante, P. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1585-x · Cited by 101
Oscillations Synchronize Amygdala-to-Prefrontal Primate Circuits during Aversive Learning
Taub, A. H., Perets, R., Kahana, E., & Paz, R. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.042 · Cited by 93
Benarroch, E. E. (2014) · Neurology · doi:10.1212/wnl.0000000000001171 · Cited by 103
Uematsu, A., Tan, B. Z., & Johansen, J. P. (2015) · Learning & Memory · doi:10.1101/lm.037283.114 · Cited by 89
Walker, A. G., Wenthur, C. J., Xiang, Z., Rook, J. M., Emmitte, K. A., Niswender, C. M., Lindsley, C. W., & Conn, P. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416196112 · Cited by 94
Retrieving fear memories, as time goes by…
Monte, F. H. D., Quirk, G. J., Li, B., & Penzo, M. A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.78 · Cited by 98
de Kloet, S. F., Bruinsma, B., Terra, H., Heistek, T. S., Passchier, E. M. J., van den Berg, A. R., Luchicchi, A., Min, R., Pattij, T., & Mansvelder, H. D. (2021) · Nature Communications · doi:10.1038/s41467-021-22260-7 · Cited by 100
Illuminating circuitry relevant to psychiatric disorders with optogenetics
Steinberg, E. E., Christoffel, D. J., Deisseroth, K., & Malenka, R. C. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.08.004 · Cited by 92
“Accordingly, optogenetic inhibition of IL-projecting neurons impaired extinction learning, while inhibition of PLprojecting neurons resulted in enhanced extinction learning [27].”
Background
Metadata
- Authors
- Senn, V., Wolff, S. B. E., Herry, C., Grenier, F., Ehrlich, I., Gründemann, J., Fadok, J. P., Müller, C., Letzkus, J. J., & Lüthi, A.
- Affiliations
- University of Basel (CH)
- Friedrich Miescher Institute (CH)
- Corresponding author
- Lüthi, Andreas
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 81
- Issue
- 2
- Pages
- 428-437
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1977502547
- Cited by
- 522
- References
- 38
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 35 · 2023: 35 · 2022: 40 · 2021: 55 · 2020: 45 · 2019: 52 · 2018: 55 · 2017: 47 · 2016: 30 · 2015: 49 · 2014: 34
- FWCI
- 29.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- amygdala, medial prefrontal cortex, fear extinction, long-range connectivity, prelimbic cortex, infralimbic cortex, memory extinction, optogenetic manipulation, fear conditioning
- MeSH terms
- Channelrhodopsins, Acoustic Stimulation, Action Potentials, Amygdala, Analysis of Variance, Animals, Bacterial Proteins, Biophysics, Cell Count, Conditioning, Classical, Elapid Venoms, Electric Stimulation, Extinction, Psychological, Fear, Hippocampus, Light, Luminescent Proteins, Male, Neural Pathways, Neurons, Peptides, Time Factors, Oncogene Proteins v-fos, Prefrontal Cortex, Herpesvirus 1, Human, Patch-Clamp Techniques, Mice, Biophysical Phenomena, Optogenetics, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
