The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Delayed Coupling to Feedback Inhibition during a Critical Period for the Integration of Adult-Born Granule Cells
Open accessAbstract
SUMMARY Developing granule cells (GCs) of the adult dentate gyrus undergo a critical period of enhanced activity and synaptic plasticity before becoming mature. The impact of developing GCs on the activity of preexisting dentate circuits remains unknown. Here we combine optogenetics, acute slice electrophysiology, and in vivo chemogenetics to activate GCs at different stages of maturation to study the recruitment of local target networks. We show that immature (four-week-old) GCs can efficiently drive distal CA3 targets, but poorly activate proximal interneurons responsible for feedback inhibition (FBI). As new GCs transition towards maturity, they reliably recruit GABAergic feedback loops that restrict spiking of neighbor GCs, a mechanism that would promote sparse coding. Such inhibitory loop impinges only weakly in new cohorts of young GCs. A computational model reveals that the delayed coupling of new GCs to FBI could be crucial to achieve a fine-grain representation of novel inputs in the dentate gyrus.
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Metadata
- Authors
- Temprana, S. G., Mongiat, L. A., Yang, S. M., Trinchero, M. F., Alvarez, D. D., Kropff, E., Giacomini, D., Beltramone, N., Lanuza, G. M., & Schinder, A. F.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 85
- Issue
- 1
- Pages
- 116-130
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1981917260
- Cited by
- 198
- References
- 17
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Temprana, S. G., Mongiat, L. A., Yang, S. M., Trinchero, M. F., Alvarez, D. D., Kropff, E., Giacomini, D., Beltramone, N., Lanuza, G. M., & Schinder, A. F. (2015). Delayed Coupling to Feedback Inhibition during a Critical Period for the Integration of Adult-Born Granule Cells. Neuron. https://doi.org/10.1016/j.neuron.2014.11.023
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