The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain
Open accessAbstract
SUMMARY Chronic pain can lead to anxiety and anxiety can enhance the sensation of pain. Unfortunately, little is known about the synaptic mechanisms that mediate these re-enforcing interactions. Here we characterized two forms of long-term potentiation (LTP) in the anterior cingulate cortex (ACC); a presynaptic form (pre-LTP) that requires kainate receptors and a postsynaptic form (post-LTP) that requires N-methyl-D-aspartate receptors. Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed via a mechanism involving hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Interestingly, chronic pain and anxiety both result in selective occlusion of pre-LTP. Significantly, microinjection of the HCN blocker ZD7288 into the ACC in vivo produces both anxiolytic and analgesic effects. Our results provide a mechanism by which two forms of LTP in the ACC may converge to mediate the interaction between anxiety and chronic pain.
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Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain
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Metadata
- Authors
- Koga, K., Descalzi, G., Chen, T., Ko, H.-G., Lu, J., Li, S., Son, J., Kim, T., Kwak, C., Huganir, R. L., Zhao, M.-G., Kaang, B.-K., Collingridge, G. L., & Zhuo, M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 85
- Issue
- 2
- Pages
- 377-389
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2042726169
- Cited by
- 364
- References
- 76
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Koga, K., Descalzi, G., Chen, T., Ko, H.-G., Lu, J., Li, S., Son, J., Kim, T., Kwak, C., Huganir, R. L., Zhao, M.-G., Kaang, B.-K., Collingridge, G. L., & Zhuo, M. (2015). Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain. Neuron. https://doi.org/10.1016/j.neuron.2014.12.021
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