The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics
Open accessAbstract
Neurons differ in their responses to injury but the underlying mechanisms remain poorly understood. Using quantitative proteomics, we characterized the injury-triggered response from purified intact and axotomized retinal ganglion cells (RGCs). Subsequent informatics analyses revealed a network of injury-response signaling hubs. In addition to confirm known players, such as mTOR, this also identified new candidates, such as c-myc, NFkB and Huntingtin. Similar to mTOR, c-myc has been implicated as key regulators of anabolic metabolism and is down-regulated by axotomy. Forced expression of c-myc in RGCs, either before or after injury, promotes dramatic RGCs neuronal survival and axon regeneration after optic nerve injury. Finally, in contrast to RGCs, neither c-myc nor mTOR was down-regulated in injured peripheral sensory neurons. Our studies suggest that c-myc and other injury responsive pathways are critical to the intrinsic regenerative mechanisms and might represent a novel target for developing neural repair strategies in adults.
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Cites
A draft map of the human proteome
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Ras, PI(3)K and mTOR signalling controls tumour cell growth
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Self-citationSustained axon regeneration induced by co-deletion of PTEN and SOCS3
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Tran, N. M., Shekhar, K., Whitney, I. E., Jacobi, A., Benhar, I., Hong, G., Yan, W., Adiconis, X., Arnold, M. E., Lee, J. M., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.11.006 · Cited by 627
Self-citationRegulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
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Wareham, L. K., Liddelow, S. A., Temple, S., Benowitz, L. I., Di Polo, A., Wellington, C., Goldberg, J. L., He, Z., Duan, X., Bu, G., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00524-0 · Cited by 324
Self-citationInjured adult neurons regress to an embryonic transcriptional growth state
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Self-citationLi, F., Sami, A., Noristani, H. N., Slattery, K., Qiu, J., Groves, T., Wang, S., Veerasammy, K., Chen, Y. X., Morales, J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.08.015 · Cited by 147
Two PTP receptors mediate CSPG inhibition by convergent and divergent signaling pathways in neurons
Ohtake, Y., Wong, D., Abdul-Muneer, P. M., Selzer, M. E., & Li, S. (2016) · Scientific Reports · doi:10.1038/srep37152 · Cited by 59
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Metadata
- Authors
- Belin, S., Nawabi, H., Wang, C., Tang, S., Latremoliere, A., Warren, P., Schorle, H., Uncu, C., Woolf, C. J., He, Z., & Steen, J. A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 86
- Issue
- 4
- Pages
- 1000-1014
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2028585054
- Cited by
- 259
- References
- 6
- FWCI
- 10.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
