The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3
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Consolidation of long-term memories depends on de novo protein synthesis. Several translational regulators have been identified, and their contribution to the formation of memory has been assessed in the mouse hippocampus. None of them, however, has been implicated in the persistence of memory. Although persistence is a key feature of long-term memory, how this occurs, despite the rapid turnover of its molecular substrates, is poorly understood. Here we find that both memory storage and its underlying synaptic plasticity are mediated by the increase in level and in the aggregation of the prion-like translational regulator CPEB3 (cytoplasmic polyadenylation element-binding protein). Genetic ablation of CPEB3 impairs the maintenance of both hippocampal long-term potentiation and hippocampus-dependent spatial memory. We propose a model whereby persistence of long-term memory results from the assembly of CPEB3 into aggregates. These aggregates serve as functional prions and regulate local protein synthesis necessary for the maintenance of long-term memory.
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Positive feedback loops that maintain key kinases and other molecules in persistently active states at strengthened synapses may also contribute to long-term memory storage.
“Positive feedback loops that maintain key kinases and other molecules in persistently active states at strengthened synapses may also contribute to such long-term memory storage75–79.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [79]
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- Authors
- Fioriti, L., Myers, C., Huang, Y.-Y., Li, X., Stephan, J. S., Trifilieff, P., Colnaghi, L., Kosmidis, S., Drisaldi, B., Pavlopoulos, E., & Kandel, E. R.
- Affiliations
- Columbia University (US)
- Howard Hughes Medical Institute (US)
- NutriNeuro (FR)
- Corresponding author
- Kandel, Eric R.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 86
- Issue
- 6
- Pages
- 1433-1448
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1905375199
- Cited by
- 221
- References
- 54
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 14 · 2023: 30 · 2022: 16 · 2021: 20 · 2020: 28 · 2019: 18 · 2018: 18 · 2017: 15 · 2016: 24 · 2015: 9
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- CPEB3, memory consolidation, de novo protein synthesis, translational regulation, long-term potentiation, spatial memory, hippocampus, synaptic plasticity, memory storage
- MeSH terms
- Animals, Anxiety, Conditioning, Psychological, Exploratory Behavior, Fear, Hippocampus, Locomotion, Male, Memory, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Neurons, Phosphopyruvate Hydratase, Reaction Time, RNA-Binding Proteins, Long-Term Potentiation, Glutamic Acid, Maze Learning, Mice, In Vitro Techniques
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