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Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval
Open accessAbstract
Although the basolateral amygdala (BLA) is known to play a critical role in the formation of memories of both positive and negative valence, the coding and routing of valence-related information is poorly understood. Here, we recorded BLA neurons during the retrieval of associative memories and used optogenetic-mediated phototagging to identify populations of neurons that synapse in the nucleus accumbens (NAc), the central amygdala (CeA), or ventral hippocampus (vHPC). We found that despite heterogeneous neural responses within each population, the proportions of BLA-NAc neurons excited by reward predictive cues and of BLA-CeA neurons excited by aversion predictive cues were higher than within the entire BLA. Although the BLA-vHPC projection is known to drive behaviors of innate negative valence, these neurons did not preferentially code for learned negative valence. Together, these findings suggest that valence encoding in the BLA is at least partially mediated via divergent activity of anatomically defined neural populations.
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“This work has, for instance, proposed that BLA PNs innervating the NAc and vHPC primarily encode information with positive and negative valence, respectively (17,20,22,23).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [17]
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“They [29,30] showed parsing of reward and aversion in basolateral amygdala microcircuits. Specifically, they provided evidence of valence coding in the basolateral amygdala, that could bias motivated action to appetitive cues via projections to the accumbens and to aversive cues via projections to the central nucleus of the amygdala.”
From Development of the emotional brain (2019) · cites this paper as [29]
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“Notably, there appears to be relatively little collateralization of BLA PNs to these target regions (17), suggesting a high degree of projection specificity.”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [17]
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“Moreover, BLA PNs projecting to the vHPC or NAc have been shown to sparsely innervate the dmPFC (17).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [17]
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“in which anticipatory licking provides a reliable, trial-by-trial index of memory expression.”
From Infraslow histaminergic dynamics govern priming states to gate moment-to-moment memory accessibility (2026) · cites this paper as [26]
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Metadata
- Authors
- Beyeler, A., Namburi, P., Glober, G. F., Simonnet, C., Calhoon, G. G., Conyers, G. F., Luck, R., Wildes, C. P., & Tye, K. M.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Tye, Kay M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 90
- Issue
- 2
- Pages
- 348-361
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4854303
- OpenAlex
- W2318838494
- Cited by
- 412
- References
- 44
- Citations by year
- 2026: 23 · 2025: 28 · 2024: 64 · 2023: 37 · 2022: 32 · 2021: 52 · 2020: 48 · 2019: 44 · 2018: 41 · 2017: 31 · 2016: 12
- FWCI
- 27.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Mental Health (R01MH102441)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP2DK102256)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- basolateral amygdala, memory retrieval, positive and negative valence, nucleus accumbens, central amygdala, ventral hippocampus, reward-predictive cues, associative memory
- MeSH terms
- Animals, Cues, Hippocampus, Male, Neural Pathways, Nucleus Accumbens, Mental Recall, Mice, Basolateral Nuclear Complex, Central Amygdaloid Nucleus
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