Genetically identified amygdala–striatal circuits for valence-specific behaviors
Open accessAbstract
The basolateral amygdala (BLA) plays essential roles in behaviors motivated by stimuli with either positive or negative valence, but how it processes motivationally opposing information and participates in establishing valence-specific behaviors remains unclear. Here, by targeting Fezf2-expressing neurons in the BLA, we identify and characterize two functionally distinct classes in behaving mice, the negative-valence neurons and positive-valence neurons, which innately represent aversive and rewarding stimuli, respectively, and through learning acquire predictive responses that are essential for punishment avoidance or reward seeking. Notably, these two classes of neurons receive inputs from separate sets of sensory and limbic areas, and convey punishment and reward information through projections to the nucleus accumbens and olfactory tubercle, respectively, to drive negative and positive reinforcement. Thus, valence-specific BLA neurons are wired with distinctive input-output structures, forming a circuit framework that supports the roles of the BLA in encoding, learning and executing valence-specific motivated behaviors.
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Basolateral amygdala dopamine transmits emotional salience
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Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States
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Dynorphin modulates reward-seeking actions through a pallido-amygdala cholinergic circuit
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Targeting Histamine and Histamine Receptors for Memory Regulation: An Emotional Perspective
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The distinct subpopulations in parafascicular thalamic nucleus encoding innate emotional valence.
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Prefrontal neural geometry of learned cues guides motivated behaviours
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A neuromodulatory circuit-to-molecular pathway for reformatting aversive memories during recall
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Diverse Roles of Serotonergic Projections to the Basolateral Amygdala
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Arousal effects on oscillatory dynamics in the non-human primate brain
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Projection-specific roles of basolateral amygdala Thy1 neurons in alcohol-induced place preference
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A new player in neural circuits of emotions
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Accentuated Paralimbic and Reduced Mesolimbic D2/3-Impulsivity Associations in Parkinson's Disease
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Prefrontal top-down projections control context-dependent strategy selectionPreprint
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The Role of Basolateral Amygdalar Cholinergic Neuromodulation in Emotional Learning
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A Short Glance at the Role of Olfactory Tubercle in Odour Processing
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Feature-specific threat coding in lateral septum guides defensive action
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The geometry of appetitive-aversive value representations in medial prefrontal networksPreprint
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Glymphatic Inhibition Exacerbates Tau Propagation in an Alzheimer’s Disease ModelPreprint
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A cortical circuit for orchestrating oromanual food manipulation
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Lymphotoxin-beta receptor controls the development of chronic pain
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Memory reactivation underlies experience-dependent adaptive regulation of sleep
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Emotional association enhances perceptual memory through amygdalo-cortical inputs during NREM sleepPreprint
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Breaking Balance: Encoding local error signals in perturbations of excitation-inhibition balancePreprint
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KMT2E haploinsufficiency manifests autistic-like phenotypes and amygdala abnormality in micePreprint
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Basolateral amygdala circuits supporting negative emotional bias in a mouse model for depressionPreprint
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Differential contribution of distinct neuronal populations to danger representationsPreprint
Menegolla, A. P., Lopez-Fernandez, G., Herry, C., & Martín‐Fernández, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.24.577067
- Authors
- Zhang, X., Guan, W., Yang, T., Furlan, A., Xiao, X., Yu, K., An, X., Galbavy, W., Ramakrishnan, C., Deisseroth, K., Ritola, K., Hantman, A., He, M., Josh Huang, Z., & Li, B.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Duke University (US)
- Howard Hughes Medical Institute (US)
- Fudan University (CN)
- Corresponding author
- Zhang, Xian
- Li, Bo
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2021-10-18
- Volume
- 24
- Issue
- 11
- Pages
- 1586-1600
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC8556347
- OpenAlex
- W3206682102
- Cited by
- 126
- References
- 67
- Citations by year
- 2026: 22 · 2025: 24 · 2024: 33 · 2023: 27 · 2022: 17 · 2021: 3
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (R01MH101214, R01MH108924, R01NS104944)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- basolateral amygdala, Fezf2, nucleus accumbens, olfactory tubercle, punishment avoidance, reward seeking, neural circuits, motivated behavior
- MeSH terms
- Amygdala, Animals, Attention, Avoidance Learning, Corpus Striatum, DNA-Binding Proteins, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Motivation, Nerve Net, Nerve Tissue Proteins, Mice
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