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Cited by 353

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Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development

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Nowakowski, Tomasz J., Pollen, Alex A., Sandoval-Espinosa, Carmen, Kriegstein, Arnold R.·2016·Neuron
DOI 10.1016/j.neuron.2016.09.005
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Abstract

The classic view of cortical development, embodied in the radial unit hypothesis highlights the ventricular radial glia (vRG) scaffold as a key architectonic feature of the developing neocortex. The scaffold includes continuous fibers spanning the thickness of the developing cortex during neurogenesis across mammals. However, we find that in humans, the scaffold transforms into a physically discontinuous structure during the transition from infragranular to supragranular neuron production. As a consequence of this transformation, supragranular layer neurons arrive at their terminal positions in the cortical plate along outer radial glia (oRG) cell fibers. In parallel, the radial glia that contact the ventricle develop a distinct “truncated” morphology and a unique gene expression profile. We propose a supragranular layer expansion hypothesis that posits a deterministic role of oRG cells in the radial and tangential expansion of supragranular layers in primates, with implications for patterns of neuronal migration, area patterning, and cortical folding.

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Metadata

Authors
Nowakowski, T. J., Pollen, A. A., Sandoval-Espinosa, C., & Kriegstein, A. R.
Venue
Neuron
Publisher
Elsevier BV
Published
2016-09
Volume
91
Issue
6
Pages
1219-1227
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2016.09.005
OpenAlex
W2521106965
Cited by
353
References
15
FWCI
11.62
Type
journal article
Language
en
Open access
bronze
Licence

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Nowakowski, T. J., Pollen, A. A., Sandoval-Espinosa, C., & Kriegstein, A. R. (2016). Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development. Neuron. https://doi.org/10.1016/j.neuron.2016.09.005

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