Spontaneous Infra-slow Brain Activity Has Unique Spatiotemporal Dynamics and Laminar Structure
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Systems-level organization in spontaneous infra-slow (<0.1Hz) brain activity, measured using blood oxygen signals in fMRI and optical imaging, has become a major theme in the study of neural function in both humans and animal models. Yet the neurophysiological basis of infra-slow activity (ISA) remains unresolved. In particular, is ISA a distinct physiological process, or is it a low-frequency analog of faster neural activity? Here, using whole-cortex calcium/hemoglobin imaging in mice, we show that ISA in each of these modalities travels through the cortex along stereotypical spatiotemporal trajectories that are state dependent (wake versus anesthesia) and distinct from trajectories in delta (1-4 Hz) activity. Moreover, mouse laminar electrophysiology reveals that ISA travels through specific cortical layers and is organized into unique cross-laminar temporal dynamics that are different from higher frequency local field potential activity. These findings suggest that ISA is a distinct neurophysiological process that is reflected in fMRI blood oxygen signals.
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Large-scale anterior-to-posterior propagation patterns were observed upon REM sleep onset.
“Large-scale anterior to posterior propagation patterns were observed upon REM sleep onset, and related propagation dynamics have also been reported under anesthesia50, suggesting that such activity may reflect a general organizing principle of large-scale brain dynamics across states.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [50]
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Self-citation
- Authors
- Mitra, A., Kraft, A., Wright, P., Acland, B., Snyder, A. Z., Rosenthal, Z., Czerniewski, L., Bauer, A., Snyder, L., Culver, J., Lee, J.-M., & Raichle, M. E.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Mitra, Anish
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 98
- Issue
- 2
- Pages
- 297-305.e6
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5910292
- OpenAlex
- W2794779684
- Cited by
- 193
- References
- 41
- Citations by year
- 2026: 17 · 2025: 14 · 2024: 22 · 2023: 18 · 2022: 21 · 2021: 18 · 2020: 30 · 2019: 32 · 2018: 20 · 2017: 1
- FWCI
- 14.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (F30MH106253, NS080675, R01NS084028, R01NS085419, R01NS094692, F31NS089135, MH102471, R01 NS099429, R01 NS078223)
- McDonnell Center for Systems Neuroscience
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- spontaneous neuronal activity, spatiotemporal dynamics, delta oscillations, local field potentials, blood oxygenation, calcium imaging, wakefulness, mouse cortex
- MeSH terms
- Anesthesia, Animals, Brain, Brain Mapping, Magnetic Resonance Imaging, Mice, Inbred C57BL, Mice, Transgenic, Time Factors, Wakefulness, Mice, Brain Waves
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