REST and neural gene network dysregulation in iPSC models of Alzheimer’s disease
Open accessAbstract
The molecular basis of the earliest neuronal changes that lead to Alzheimer's disease (AD) is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene-edited and control induced pluripotent stem cells (iPSCs). We observe major differences in iPSC-derived neural progenitor (NP) cells and neurons in gene networks related to neuronal differentiation, neurogenesis, and synaptic transmission. The iPSC-derived neural cells from SAD patients exhibit accelerated neural differentiation and reduced progenitor cell renewal. Moreover, a similar phenotype appears in NP cells and cerebral organoids derived from APOE4 iPSCs. Impaired function of the transcriptional repressor REST is strongly implicated in the altered transcriptome and differentiation state. SAD and APOE4 expression result in reduced REST nuclear translocation and chromatin binding, and disruption of the nuclear lamina. Thus, dysregulation of neural gene networks may set in motion the pathologic cascade that leads to AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Three ApoE3 and ApoE4 isogenic iPSC pairs were used to determine the effect of APOE4 genotype without inter-donor variability.
“Three ApoE3 and ApoE4 isogenic iPSCs pairs were used to determine the effect of APOE4 genotype without inter-donor variability.5”
From ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes (2023) · cites this paper as [40]
The Results section (‘APOE4 Induces Early Neuronal Differentiation and Dysregulation of REST’; page not provided) says the authors used isogenic iPSC lines differing only in APOE genotype to study its effects, which supports the rationale of avoiding inter-donor differences within a comparison. It describes editing lines from two donor backgrounds, not using three isogenic APOE3/APOE4 pairs. The three biological replicates reported in Methods are organoid samples, not three pairs. (LLM, conf=0.87)
Experimental — accuracy not yet measuredGene expression alteration of Pcdh-γC5 has been detected in the brain of Alzheimer's disease patients and animal models of Alzheimer's disease, as well as neural cells generated from human iPSCs that express APOE4.
“The gene expression alteration of Pcdh-γC5 has also been detected in the brain of AD patients and animal models of AD, as well as neural cells generated from human iPSCs that express APOE4, a prevalent genetic AD risk factor (Nativio et al., 2018;Meyer et al., 2019).”
From Cell Adhesion Molecule Protocadherin-γC5 Ameliorates Aβ Plaque Pathogenesis by Modulating Astrocyte Function in Alzheimer's Disease (2025) · cites this paper as Meyer et al., 2019
The Results section on APOE4 and neuronal differentiation reports altered expression of other genes in APOE4 iPSC-derived neural progenitors and cerebral organoids. Our copy does not identify Pcdh-γC5 among them; searches for Pcdh-γC5, PCDHGC5, and protocadherin found no passage establishing the gene-specific claim. It also does not establish that alteration in AD patient or animal-model brains. (LLM, conf=0.80)
Experimental — accuracy not yet measuredFor studying age-related vulnerability and mechanisms relevant to AD, iNs have advantages over iPSC models and complement isogenic iPSC strategies.
“Collectively, for studying age-related vulnerability and mechanisms relevant to AD, iNs have advantages over iPSC models and thus complement isogenic iPSC strategies (van der Kant et al., 2019; Meyer et al., 2019; Woodruff et al., 2013).”
From Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients (2021) · cites this paper as Meyer et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma’ayan, A. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-128 · Cited by 7,814 · see citing works
Cerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372 · see citing works
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 2× · see citing works
“Since protein interaction and recruitment of PRC2 by REST have been reported (Dietrich et al., 2012; Mozzetta et al., 2014; Tsai et al., 2010), we further validated the contribution of REST to global gene expression changes in SAD and APOE4 NP cells.”
BackgroundEvolving gene/transcript definitions significantly alter the interpretation of GeneChip data
Dai, M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni179 · Cited by 1,797 · see citing works
Rapid single-step induction of functional neurons from human pluripotent stem cells
Zhang, Y., Pak, C., Han, Y., Ahlenius, H., Zhang, Z., Chanda, S., Marro, S., Patzke, C., Acuna, C., Covy, J., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.029 · Cited by 1,644 · see citing works
Doublecortin Is a Microtubule-Associated Protein and Is Expressed Widely by Migrating Neurons
Gleeson, J. G., Lin, P. T., Flanagan, L. A., & Walsh, C. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80778-3 · Cited by 1,341 · see citing works
Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
Israel, M. A., Yuan, S. H., Bardy, C., Reyna, S. M., Mu, Y., Herrera, C., Hefferan, M. P., Van Gorp, S., Nazor, K. L., Boscolo, F. S., et al. (2012) · Nature · doi:10.1038/nature10821 · Cited by 1,253 · see citing works
Lin, Y.-T., Seo, J., Gao, F., Feldman, H. M., Wen, H.-L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.008 · Cited by 1,125 · see citing works
Self-citationREST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
Chong, J. A., Tapia-Ramı́rez, J., Kim, S. S. Y., Toledo‐Aral, J. J., Zheng, Y., Boutros, M., Altshuller, Y. M., Frohman, M. A., Kraner, S. D., & Mandel, G. (1995) · Cell · doi:10.1016/0092-8674(95)90298-8 · Cited by 1,089 · see citing works
Schoenherr, C. J., & Anderson, D. J. (1995) · Science · doi:10.1126/science.7871435 · Cited by 1,088 · see citing works
(2016) · London School of Economics and Political Science Research Online (London School of Economics and Political Science) · Cited by 874 · see citing works
Mertens, J., Paquola, A. C. M., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J. R., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.001 · Cited by 765 · see citing works
Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy
Akers, K. G., Martinez-Canabal, A., Restivo, L., Yiu, A. P., De Cristofaro, A., Hsiang, H.-L. (., Wheeler, A. L., Guskjolen, A., Niibori, Y., Shoji, H., et al. (2014) · Science · doi:10.1126/science.1248903 · Cited by 761 · see citing works
REST and stress resistance in ageing and Alzheimer’s disease
Lu, T., Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y., Yang, T.-H., Kim, H., Drake, D., Liu, X., et al. (2014) · Nature · doi:10.1038/nature13163 · Cited by 760 · see citing works
Self-citationKondo, T., Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.009 · Cited by 741 · see citing works
Modeling familial Alzheimer's disease with induced pluripotent stem cells
Yagi, T., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Yoshizaki, T., Yamanaka, S., Okano, H., & Suzuki, N. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr394 · Cited by 599 · see citing works
Kurosawa, H. (2007) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.103.389 · Cited by 520 · see citing works
Tau promotes neurodegeneration through global chromatin relaxation
Frost, B., Hemberg, M., Lewis, J., & Feany, M. B. (2014) · Nature Neuroscience · doi:10.1038/nn.3639 · Cited by 519 · cited 1× · see citing works
“These changes in nuclear membrane structure and changes in chromatin were associated with increased activity of the tau kinase CDK5 and abnormal tau phosphorylation (Chang et al., 2011; Frost et al., 2014).”
BackgroundA functionally characterized test set of human induced pluripotent stem cells
Boulting, G. L., Kiskinis, E., Croft, G. F., Amoroso, M. W., Oakley, D. H., Wainger, B. J., Williams, D. J., Kahler, D. J., Yamaki, M., Davidow, L. S., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1783 · Cited by 489 · see citing works
Generation of human-induced pluripotent stem cells
Park, I.-H., Lerou, P., Zhao, R., Huo, H.-G., & Daley, G. (2008) · Nature Protocols · doi:10.1038/nprot.2008.92 · Cited by 451 · see citing works
The many faces of REST oversee epigenetic programming of neuronal genes
Ballas, N., & Mandel, G. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.015 · Cited by 441 · see citing works
Apolipoprotein E in Alzheimer's Disease: An Update
Yu, J.-T., Tan, L., & Hardy, J. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014300 · Cited by 394 · see citing works
Yuan, S. H., Martin, J., Elia, J., Flippin, J. D., Paramban, R. I., Hefferan, M. P., Vidal, J. G., Mu, Y., Killian, R. L., Israel, M. A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017540 · Cited by 383 · see citing works
Muratore, C. R., Rice, H. C., Srikanth, P., Callahan, D. G., Shin, T., Benjamin, L. N. P., Walsh, D. M., Selkoe, D. J., & Young-Pearse, T. L. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu064 · Cited by 379 · see citing works
Winston, C. N., Goetzl, E. J., Akers, J. C., Carter, B. S., Rockenstein, E. M., Galasko, D. R., Masliah, E., & Rissman, R. A. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.04.001 · Cited by 379 · see citing works
Li, G., Bien-Ly, N., Andrews-Zwilling, Y., Xu, Q., Bernardo, A., Ring, K., Halabisky, B., Deng, C., Mahley, R. W., & Huang, Y. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.10.015 · Cited by 288 · see citing works
Mozzetta, C., Pontis, J., Fritsch, L., Robin, P., Portoso, M., Proux, C., Margueron, R., & Ait‐Si‐Ali, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.005 · Cited by 278 · see citing works
Dean, D. C., Jerskey, B. A., Chen, K., Protas, H., Thiyyagura, P., Roontiva, A., O'Muircheartaigh, J., Dirks, H., Waskiewicz, N., Lehman, K., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.4544 · Cited by 263 · see citing works
Gao, Z., Ure, K., Ding, P., Nashaat, M. A., Yuan, L., Ma, J., Hammer, R. E., & Hsieh, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1604-11.2011 · Cited by 248 · see citing works
Lamin Dysfunction Mediates Neurodegeneration in Tauopathies
Frost, B., Bardai, F. H., & Feany, M. B. (2016) · Current Biology · doi:10.1016/j.cub.2015.11.039 · Cited by 226 · see citing works
Pruszak, J., Ludwig, W. W., Blak, A. A., Alavian, K. N., & Ole Isacson, A. (2009) · Stem Cells · doi:10.1002/stem.211 · Cited by 225 · see citing works
Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
von Schimmelmann, M., Feinberg, P. A., Sullivan, J. M., Ku, S. M., Badimon, A., Duff, M. K., Wang, Z., Lachmann, A., Dewell, S., Ma'ayan, A., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4360 · Cited by 225 · see citing works
Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth
Hoe, H.-S., Lee, K. J., Carney, R. S. E., Lee, J., Markova, A., Lee, J.-Y., Howell, B. W., Hyman, B. T., Pak, D. T. S., Bu, G., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4872-08.2009 · Cited by 219 · see citing works
Lin, Y.-T., Seo, J., Gao, F., Feldman, H. M., Wen, H.-L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.011 · Cited by 210 · see citing works
Self-citationThe critical role of cyclin D2 in adult neurogenesis
Kowalczyk, A. E., Filipkowski, R. K., Rylski, M., Wilczynski, G. M., Konopacki, F. A., Jaworski, J., Ciemerych, M. A., Siciński, P., & Kaczmarek, L. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200404181 · Cited by 184 · see citing works
Sproul, A. A., Jacob, S., Prè, D., Kim, S. H., Nestor, M. W., Navarro-Sobrino, M., Santa‐María, I., Zimmer, M., Aubry, S., Steele, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084547 · Cited by 179 · see citing works
Yang, Y. J., Baltus, A. E., Mathew, R. S., Murphy, E. A., Evrony, G. D., Gonzalez, D. M., Wang, E. P., Marshall-Walker, C. A., Barry, B. J., Murn, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.043 · Cited by 176 · see citing works
Increased Neurogenesis in Young Transgenic Mice Overexpressing Human APPSw,Ind
López-Toledano, M. A., & Shelanski, M. L. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12304 · Cited by 175 · see citing works
REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells
Dietrich, N., Lerdrup, M., Landt, E., Singh, S. A., Bak, M., Tommerup, N., Rappsilber, J., Södersten, E., & Hansen, K. H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002494 · Cited by 173 · see citing works
Zhu, L., Zhong, M., Elder, G. A., Sano, M., Holtzman, D. M., Gandy, S., Cardozo, C., Haroutunian, V., Robakis, N. K., & Cai, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510011112 · Cited by 160 · see citing works
Snowdon, D. A., Greiner, L. H., & Markesbery, W. R. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06347.x · Cited by 148 · see citing works
Hoe, H.-S., Wessner, D., Beffert, U., Becker, A. G., Matsuoka, Y., & Rebeck, G. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9259-9268.2005 · Cited by 122 · see citing works
ApoE is required for maintenance of the dentate gyrus neural progenitor pool
Yang, C.-P., Gilley, J. A., Zhang, G., & Kernie, S. G. (2011) · Development · doi:10.1242/dev.065540 · Cited by 109 · see citing works
Thrombospondin‐1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration
Blake, S. M., Strasser, V., Andrade, N., Duit, S., Hofbauer, R., Schneider, W. J., & Nimpf, J. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.223 · Cited by 107 · see citing works
mCD24 expression in the developing mouse brain and in zones of secondary neurogenesis in the adult
Calaora, V., Chazal, G., Nielsen, P. J., Rougon, G. N., & Moreau, H. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00042-5 · Cited by 103 · see citing works
Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice
Knoferle, J., Yoon, S. Y., Walker, D., Leung, L., Gillespie, A. K., Tong, L. M., Bien-Ly, N., & Huang, Y. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2281-14.2014 · Cited by 97 · see citing works
Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death
Chang, K., Multani, P. S., Sun, K.-H., Vincent, F., de Pablo, Y., Ghosh, S., Gupta, R., Lee, H.-P., Lee, H., Smith, M. A., et al. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-07-0654 · Cited by 76 · see citing works
Lee, S. W., Oh, Y. M., Lu, Y.-L., Kim, W. K., & Yoo, A. S. J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.007 · Cited by 73 · see citing works
The roles and regulation of Polycomb complexes in neural development
Corley, M., & Kroll, K. L. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-2011-9 · Cited by 69 · see citing works
Ashton, N. J., Hye, A., Leckey, C. A., Jones, A., Gardner, A., Elliott, C., Wetherell, J. L., Lenze, E. J., Killick, R., & Marchant, N. L. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.113 · Cited by 53 · see citing works
Adeosun, S. O., Hou, X., Zheng, B., Stockmeier, C. A., Ou, X., Paul, I. A., Mosley, T. H., Weisgraber, K. H., & Wang, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497909 · Cited by 44 · see citing works
Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation
Levi, O., Lütjohann, D., Devir, A., von Bergmann, K., Hartmann, T., & Michaelson, D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03441.x · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Amyloid-β-independent regulators of tau pathology in Alzheimer disease
van der Kant, R., Goldstein, L. S. B., & Ossenkoppele, R. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0240-3 · Cited by 580 · see citing works
Modeling Alzheimer’s disease with iPSC-derived brain cells
Penney, J., Ralvenius, W. T., & Tsai, L.-H. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0468-3 · Cited by 471 · see citing works
Self-citationZhao, J., Fu, Y., Yamazaki, Y., Ren, Y., Davis, M. D., Liu, C.-C., Lu, W., Wang, X., Chen, K., Cherukuri, Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19264-0 · Cited by 374 · see citing works
Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease
Jia, L., Piña-Crespo, J., & Li, Y. (2019) · Molecular Brain · doi:10.1186/s13041-019-0525-5 · Cited by 288 · see citing works
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients
Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.04.004 · Cited by 240 · see citing works
Neurogenesis in aging and age-related neurodegenerative diseases
Čulig, L., Chu, X., & Bohr, V. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101636 · Cited by 192 · see citing works
Tijms, B. M., Vromen, E. M., Mjaavatten, O., Holstege, H. H., Reus, L. M., van der Lee, S. J., Wesenhagen, K. E. J., Lorenzini, L., Vermunt, L., Venkatraghavan, V., et al. (2024) · Nature Aging · doi:10.1038/s43587-023-00550-7 · Cited by 222 · see citing works
Pathophysiological subtypes of Alzheimer’s disease based on cerebrospinal fluid proteomics
Tijms, B. M., Gobom, J., Reus, L. M., Jansen, I. E., Hong, S., Dobričić, V., Kilpert, F., ten Kate, M., Barkhof, F., Tsolaki, M., et al. (2020) · Brain · doi:10.1093/brain/awaa325 · Cited by 192 · see citing works
Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation
Hulme, A. E., Maksour, S., Clair‐Glover, M. S., Miellet, S., & Dottori, M. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.11.015 · Cited by 147 · see citing works
Protective genes and pathways in Alzheimer’s disease: moving towards precision interventions
Seto, M., Weiner, R. L., Dumitrescu, L., & Hohman, T. J. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00452-5 · Cited by 135 · see citing works
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation
Vandana, J. J., Manrique, C., Lacko, L. A., & Chen, S. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.04.011 · Cited by 132 · see citing works
Ryu, W., Bormann, M. K., Shen, M., Kim, D., Forester, B. P., Park, Y., So, J., Seo, H., Sonntag, K., & Cohen, B. M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01068-3 · Cited by 125 · see citing works
Familial Alzheimer’s disease mutations in PSEN1 lead to premature human stem cell neurogenesis
Arber, C., Lovejoy, C., Harris, L., Willumsen, N., Alatza, A., Casey, J. M., Lines, G., Kerins, C., Mueller, A. K., Zetterberg, H., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108615 · Cited by 116 · see citing works
Fu, C.-H., Iascone, D. M., Petrof, I., Hazra, A., Zhang, X., Pyfer, M. S., Tosi, U., Corbett, B. F., Cai, J., Lee, J., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.101 · Cited by 107 · see citing works
Lee, S.-I., Jeong, W., Lim, H., Cho, S., Lee, H., Jang, Y., Cho, J., Bae, S., Lin, Y.-T., Tsai, L.-H., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.07.017 · Cited by 105 · see citing works
Self-citationBarák, M., Fedorová, V., Pospíšilová, V., Raška, J., Vochyánová, S., Sedmík, J., Hříbková, H., Klímová, H., Váňová, T., & Bohačiaková, D. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10254-3 · Cited by 100 · see citing works
Lee, H., Cho, S., Kim, M.-J., Park, Y. J., Cho, E., Jo, Y. S., Kim, Y.-S., Lee, J. Y., Thoudam, T., Woo, S.-H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113183 · Cited by 93 · see citing works
Self-citationNucleocytoplasmic transport defects in neurodegeneration — Cause or consequence?
Hutten, S., & Dormann, D. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.020 · Cited by 82 · see citing works
Visser, P. J., Reus, L. M., Gobom, J., Jansen, I. E., Dicks, E., van der Lee, S. J., Tsolaki, M., Verhey, F. R. J., Popp, J., Martínez‐Lage, P., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00521-3 · Cited by 88 · see citing works
Innovations in 3D Tissue Models of Human Brain Physiology and Diseases
Lovett, M. L., Nieland, T. J. F., Dingle, Y. L., & Kaplan, D. L. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909146 · Cited by 85 · see citing works
Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework
Mentis, A. A., Dardiotis, E., & Chrousos, G. P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0731-7 · Cited by 82 · see citing works
Hernández, D., Rooney, L. A., Daniszewski, M., Gulluyan, L. M., Liang, H. H., Cook, A. L., Hewitt, A. W., & Pébay, A. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10147-5 · Cited by 79 · see citing works
Váňová, T., Sedmík, J., Raška, J., Černá, K. A., Tauš, P., Pospisilova, V., Nezvedová, M., Fedorová, V., Kadakova, S., Klímová, H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113310 · Cited by 76 · see citing works
Qiao, H., Guo, M., Shang, J., Zhao, W., Wang, Z., Liu, N., Li, B., Zhou, Y., Wu, Y., & Chen, P. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008899 · Cited by 72 · see citing works
Genome Editing in iPSC-Based Neural Systems: From Disease Models to Future Therapeutic Strategies
McTague, A., Rossignoli, G., Ferrini, A., Barral, S., & Kurian, M. A. (2021) · Frontiers in Genome Editing · doi:10.3389/fgeed.2021.630600 · Cited by 67 · see citing works
Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel in situ analyses
Liu, S., Punthambaker, S., Iyer, E. P. R., Ferrante, T. C., Goodwin, D., Fürth, D., Pawlowski, A. C., Jindal, K., Tam, J. M., Mifflin, L., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab120 · Cited by 67 · see citing works
Self-citationCommon Factors in Neurodegeneration: A Meta-Study Revealing Shared Patterns on a Multi-Omics Scale
Ruffini, N., Klingenberg, S., Schweiger, S., & Gerber, S. (2020) · Cells · doi:10.3390/cells9122642 · Cited by 65 · see citing works
The future of stem cell therapies of Alzheimer's disease.
Wang, Z.-B., Wang, Z.-T., Sun, Y., Tan, L., & Yu, J.-T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101655 · Cited by 48 · see citing works
Chaves, J. C. S., Dando, S. J., White, A. R., & Oikari, L. E. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166967 · Cited by 62 · see citing works
Scopa, C., Barnada, S. M., Cicardi, M., Mo, S.-E., Trotti, D., & Trizzino, M. (2022) · bioRxiv · doi:10.1038/s41467-023-43728-8 · Cited by 48 · see citing works
Venkataraman, L., Fair, S. R., McElroy, C. A., Hester, M. E., & Fu, H. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10068-9 · Cited by 54 · see citing works
In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons
Najm, R., Zalocusky, K. A., Zilberter, M., Yoon, S. Y., Hao, Y., Koutsodendris, N., Nelson, M., Rao, A., Taubes, A., Jones, E. A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107962 · Cited by 52 · see citing works
More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment
Maksour, S., Ooi, L., & Dottori, M. (2020) · eNeuro · doi:10.1523/eneuro.0337-19.2020 · Cited by 53 · see citing works
Vance, J. M., Farrer, L. A., Huang, Y., Cruchaga, C., Hyman, B. T., Pericak‐Vance, M. A., Goate, A. M., Greicius, M. D., Griswold, A. J., Haines, J. L., et al. (2024) · Annals of Neurology · doi:10.1002/ana.26864 · Cited by 52 · see citing works
Self-citationRole of primary aging hallmarks in Alzheimer´s disease
Zhao, J., & Huai, J. (2023) · Theranostics · doi:10.7150/thno.79535 · Cited by 50 · see citing works
Modeling neurological disorders using brain organoids
Zhang, D. Y., Song, H., & Ming, G. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.05.026 · Cited by 52 · see citing works
Fanizza, F., Campanile, M., Forloni, G., Giordano, C., & Albani, D. (2022) · Journal of Tissue Engineering · doi:10.1177/20417314221095339 · Cited by 51 · see citing works
The role of genetic risk factors of Alzheimer’s disease in synaptic dysfunction
Fu, W.-Y., & Ip, N. Y. (2023) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2022.07.011 · Cited by 48 · see citing works
REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain
Mampay, M., & Sheridan, G. K. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.04.001 · Cited by 45 · see citing works
Quercetin Regulates the Integrated Stress Response to Improve Memory
Nakagawa, T., & Ohta, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112761 · Cited by 43 · see citing works
Clustered Protocadherins Emerge as Novel Susceptibility Loci for Mental Disorders
Jia, Z., & Wu, Q. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.587819 · Cited by 43 · see citing works
Raman, S., Brookhouser, N., & Brafman, D. A. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104788 · Cited by 40 · see citing works
REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons
Rocchi, A., Carminati, E., Fusco, A. D., Kowalska, J. A., Floß, T., & Benfenati, F. (2021) · Aging Cell · doi:10.1111/acel.13471 · Cited by 42 · see citing works
Region Specific Brain Organoids to Study Neurodevelopmental Disorders
Susaimanickam, P. J., Kiral, F. R., & Park, I. (2022) · International Journal of Stem Cells · doi:10.15283/ijsc22006 · Cited by 43 · see citing works
Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia
Albert, K., Niskanen, J., Kälvälä, S., & Lehtonen, Š. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094334 · Cited by 39 · see citing works
Qiao, H., Zhao, W., Guo, M., Zhu, L., Chen, T., Wang, J., Xu, X., Zhang, Z., Wu, Y., & Chen, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115981 · Cited by 42 · see citing works
Stem Cell Therapy for Alzheimer’s Disease: A Scoping Review for 2017–2022
Duan, Y., Lyu, L., & Zhan, S. (2023) · Biomedicines · doi:10.3390/biomedicines11010120 · Cited by 38 · see citing works
Strategies for modeling aging and age-related diseases
Jothi, D., & Kulka, L. A. M. (2024) · npj Aging · doi:10.1038/s41514-024-00161-5 · Cited by 36 · see citing works
Zhao, X., Zhu, N., Yin, X., Lin, R., Fan, X.-L., Chen, S., & Zhu, Y.-M. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.265565 · Cited by 36 · see citing works
The application of in vitro ‐derived human neurons in neurodegenerative disease modeling
D’Souza, G. X., Rose, S. E., Knupp, A., Nicholson, D. A., Keene, C. D., & Young, J. E. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24615 · Cited by 35 · see citing works
García‐León, J. A., Cáceres-Palomo, L., Sánchez‐Mejías, E., Mejias‐Ortega, M., Nuñez‐Diaz, C., Fernandez-Valenzuela, J. J., Sanchez-Varo, R. M., Dávila, J. C., Vitórica, J., & Gutiérrez, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186867 · Cited by 35 · see citing works
Ryan, B. J., Bengoa‐Vergniory, N., Williamson, M. G., Kirkiz, E., Roberts, R. F., Corda, G., Sloan, M., Saqlain, S., Cherubini, M., Poppinga, J., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1478-20.2021 · Cited by 35 · see citing works
de Sá, R. V., Sudrià-Lopez, E., Luna, M. C., Harschnitz, O., van den Heuvel, D. M. A., Kling, S., Vonk, D., Westeneng, H., Karst, H., Bloemenkamp, L. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51676-0 · Cited by 35 · see citing works
Lim, E. T., Chan, Y., Dawes, P., Guo, X., Erdin, S., Tai, D. J. C., Liu, S., Reichert, J. M., Burns, M. J., Chan, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30968-3 · Cited by 33 · see citing works
Self-citationSalwa, & Kumar, L. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.09.007 · Cited by 32 · see citing works
Brain Organoids: Filling the Need for a Human Model of Neurological Disorder
Jalink, P., & Caiazzo, M. (2021) · Biology · doi:10.3390/biology10080740 · Cited by 30 · see citing works
Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?
Rodríguez-Jiménez, F. J., Ureña‐Peralta, J. R., Jendelová, P., & Erceg, S. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.01.006 · Cited by 33 · see citing works
Review of Artificial Intelligence Applications and Algorithms for Brain Organoid Research
Badai, J., Bu, Q., & Zhang, L. (2020) · Interdisciplinary Sciences Computational Life Sciences · doi:10.1007/s12539-020-00386-4 · Cited by 28 · see citing works
MacDougall, G., Brown, L. Y., Kantor, B., & Chiba‐Falek, O. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.01.001 · Cited by 29 · see citing works
Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches
Trujillo‐Estrada, L., Sánchez‐Mejías, E., Sanchez-Varo, R. M., García‐León, J. A., Nuñez‐Diaz, C., Dávila, J. C., Vitórica, J., LaFerla, F. M., Moreno‐González, I., Gutiérrez, A., et al. (2021) · The Neuroscientist · doi:10.1177/10738584211001753 · Cited by 28 · see citing works
Nassar, A., Satarker, S., Gurram, P. C., Upadhya, D., Fayaz, S., & Nampoothiri, M. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03437-1 · Cited by 27 · see citing works
Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4
Lee, S. J., Yu, J. J., Lee, H. G., Kim, B., Jang, M. J., Jo, H., Kim, N. Y., Pak, M. E., Kim, J. K., Cho, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62995-1 · Cited by 27 · see citing works
Self-citationChapman, G., Alsaqati, M., Lunn, S., Singh, T., Linden, S. C., Linden, D. E. J., van den Bree, M. B. M., Ziller, M., Owen, M. J., Hall, J., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01182-2 · Cited by 28 · see citing works
Progress and challenges in directing the differentiation of human iPSCs into spinal motor neurons
Bautista, C. M. C., & Sterneckert, J. L. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1089970 · Cited by 27 · see citing works
Grass, T., Dokuzluoglu, Z., Büchner, F., Rosignol, I., Thomas, J., Caldarelli, A., Dalinskaya, A., Becker, J., Rost, F., Marass, M., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101659 · Cited by 30 · see citing works
Cavalli, E., Battaglia, G., Basile, M. S., Bruno, V., Petralia, M., Lombardo, S., Pennisi, M., Kalfin, R., Tancheva, L., Fagone, P., et al. (2020) · Brain Science · doi:10.3390/brainsci10030166 · Cited by 19 · see citing works
Marei, H., Khan, M. U. A., & Hasan, A. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00504-2 · Cited by 21 · see citing works
Onset of Preclinical Alzheimer Disease in Monozygotic Twins
Konijnenberg, E., Tomassen, J., den Braber, A., ten Kate, M., Yaqub, M. M., Mulder, S. D., Nivard, M. G., Vanderstichele, H., Lammertsma, A. A., Teunissen, C. E., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26048 · Cited by 25 · see citing works
Gene Therapy for Neurodegenerative Disease: Clinical Potential and Directions
Zhu, X., Zhang, Y., Yang, X., Hao, C., & Duan, H. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.618171 · Cited by 25 · see citing works
Wu, L., Kalish, B. T., Finander, B., Cao, T., Jin, G., Yahya, T., Levy, E. S., Kukreja, B., LaRovere, E. S., Chung, J. Y., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0682-21.2021 · Cited by 26 · see citing works
Complexity of Sex Differences and Their Impact on Alzheimer’s Disease
Kadlecová, M., Freude, K., & Haukedal, H. (2023) · Biomedicines · doi:10.3390/biomedicines11051261 · Cited by 26 · see citing works
The Use of Patient-Derived Induced Pluripotent Stem Cells for Alzheimer’s Disease Modeling
Lee, C., Willerth, S. M., & Nygaard, H. B. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101804 · Cited by 24 · see citing works
Tijms, B. M., Gobom, J., Teunissen, C. E., Dobričić, V., Tsolaki, M., Verhey, F. R. J., Popp, J., Martínez‐Lage, P., Vandenberghe, R. R., Lleó, A., et al. (2021) · Proteomes · doi:10.3390/proteomes9030036 · Cited by 23 · see citing works
Qu, W., Canoll, P., & Hargus, G. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.05.006 · Cited by 22 · see citing works
Volloch, V., Olsen, B. R., & Rits‐Volloch, S. (2019) · Annals of Integrative Molecular Medicine · doi:10.33597/aimm.02-1007 · Cited by 23 · see citing works
Brain Organoids: A Promising Living Biobank Resource for Neuroscience Research
Li, S., Wang, M., & Zhou, J. (2020) · Biopreservation and Biobanking · doi:10.1089/bio.2019.0111 · Cited by 22 · see citing works
Zhang, L., Xu, M., Ren, Q., Liu, G., Meng, S., Xiahou, K., Zhang, Y., Jiang, N., & Zhou, W. (2020) · Stem Cells and Development · doi:10.1089/scd.2020.0103 · Cited by 20 · see citing works
Ghosh, I., Liu, C. S., Swardfager, W., Lanctôt, K. L., & Anderson, N. D. (2021) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2021.103683 · Cited by 20 · see citing works
Systematic analysis identifies REST as an oncogenic and immunological biomarker in glioma
Wang, G., Yang, X., Qi, M., Li, M., Dong, M., Xu, R., & Zhang, C. (2023) · Scientific Reports · doi:10.1038/s41598-023-30248-0 · Cited by 20 · see citing works
Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer’s disease
Merchant, J. P., Zhu, K., Henrion, M., Zaidi, S. S. A., Lau, B., Moein, S., Alamprese, M. L., Pearse, R. V., Bennett, D. A., Ertekin‐Taner, N., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04791-5 · Cited by 22 · see citing works
Current insights into apolipoprotein E and the immune response in Alzheimer's disease
Lin, P. B., & Holtzman, D. M. (2024) · Immunological Reviews · doi:10.1111/imr.13414 · Cited by 19 · see citing works
APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids
Meyer-Acosta, K. K., Díaz‐Guerra, E., Varma, P., Aruk, A., Mirsadeghi, S., Perez, A. M., Rafati, Y., Hosseini, A., Nieto‐Estévez, V., Giugliano, M., et al. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102537 · Cited by 19 · see citing works
Alsaqati, M., Davis, B. A., Wood, J., Jones, M. M., Jones, L., Westwood, A., Petter, O., Isles, A. R., Linden, D. E. J., van den Bree, M. B. M., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02199-z · Cited by 19 · see citing works
Regulation of Aging and Longevity by Ion Channels and Transporters
Venkatachalam, K. (2022) · Cells · doi:10.3390/cells11071180 · Cited by 18 · see citing works
REST in the Road Map of Brain Development
Lam, X.-J., Maniam, S., Cheah, P.-S., & Ling, K. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01394-w · Cited by 18 · see citing works
Self-citationSupakul, S., Murakami, R., Oyama, C., Shindo, T., Hatakeyama, Y., Itsuno, M., Bannai, H., Shibata, S., Maeda, S., & Okano, H. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-023-00310-5 · Cited by 18 · see citing works
Extra-telomeric impact of telomeres: Emerging molecular connections in pluripotency or stemness
Vinayagamurthy, S., Ganguly, A., & Chowdhury, S. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.009710 · Cited by 18 · see citing works
Cell models for Down syndrome-Alzheimer’s disease research
Wu, Y., West, N. R., Bhattacharyya, A., & Wiseman, F. K. (2022) · Neuronal Signaling · doi:10.1042/ns20210054 · Cited by 17 · see citing works
Kim, M.-Y., Kim, M. J., Lee, C., Lee, J., Kim, S. S., Hong, S., Kim, H., Seo, J., Yoon, K.-J., & Han, S. M. (2023) · Experimental and Molecular Medicine · doi:10.1038/s12276-023-01073-2 · Cited by 11 · see citing works
Self-citationCalzari, L., Barcella, M., Alari, V., Braga, D., Muñoz‐Viana, R., Barlassina, C., Finelli, P., Gervasini, C., Barco, Á., Russo, S., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01983-6 · Cited by 18 · see citing works
Zwi‐Dantsis, L., Jayarajan, V., Church, G. M., Kamm, R. D., de Magalhães, J. P., & Moeendarbary, E. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202500217 · Cited by 15 · see citing works
Self-citationA new age in understanding adult hippocampal neurogenesis in Alzheimer’s disease
Hanspal, M. A., & Gillotin, S. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.339472 · Cited by 11 · see citing works
Ruffini, N., Klingenberg, S., Heese, R., Schweiger, S., & Gerber, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.866886 · Cited by 14 · see citing works
Decoding molecular mechanisms: brain aging and Alzheimer’s disease
Hayat, M., Syed, R. A., Qaiser, H., Uzair, M., Al-Regaiey, K., Khallaf, R. A., Albassam, L. A. M., Kaleem, I., Wang, X., Wang, R., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01403 · Cited by 14 · see citing works
Discovery of new epigenomics-based biomarkers and the early diagnosis of neurodegenerative diseases
Lee, D., Choi, Y. H., Seo, J., Kim, J. K., & Lee, S. B. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101069 · Cited by 14 · see citing works
Self-citationSexual dimorphism in immunity and longevity among the oldest old
Arakelyan, N. A., Kupriyanova, D. A., Vasiļevska, J., & Rogaev, E. I. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1525948 · Cited by 14 · see citing works
Cho, S. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042211 · Cited by 12 · see citing works
Bensalel, J., Xu, H., Lu, M. L., Capobianco, E., & Wei, J. (2021) · BMC Medical Genomics · doi:10.1186/s12920-021-01022-w · Cited by 13 · see citing works
Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone
Poiana, G., Gioia, R., Sineri, S., Cardarelli, S., Lupo, G., & Cacci, E. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.280301 · Cited by 13 · see citing works
Ryu, W., Cohen, B. M., & Sonntag, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.697578 · Cited by 14 · see citing works
- Authors
- Meyer, K., Feldman, H. M., Lu, T., Drake, D., Lim, E. T., Ling, K.-H., Bishop, N. A., Pan, Y., Seo, J., Lin, Y.-T., Su, S. C., Church, G. M., Tsai, L.-H., & Yankner, B. A.
- Affiliations
- Harvard University (US)
- Universiti Putra Malaysia (MY)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Yankner, Bruce A.
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 26
- Issue
- 5
- Pages
- 1112-1127.e9
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC6386196
- OpenAlex
- W2913604250
- Cited by
- 216
- References
- 52
- Citations by year
- 2026: 12 · 2025: 26 · 2024: 31 · 2023: 25 · 2022: 31 · 2021: 43 · 2020: 38 · 2019: 10
- FWCI
- 21.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion, other-oa)
- PubMed Central (acceptedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- NIH (DP1OD006849, R01AG046174, RF1AG048056, RF1AG048029, RM1HG008525)
- Paul F. Glenn Foundation for Medical Research
- Fidelity Biosciences Research Initiative
- Robert A. and Renee E. Belfer Family Foundation
- Cure Alzheimer's Fund
- DFG (ME 4810/1-1)
- IBRO/ISN
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Alzheimer's disease, rest, APOE ε4, induced pluripotent stem cells, iPSC-derived neural progenitor cells, iPSC-derived neurons, brain organoids, neuronal differentiation, neurogenesis, synaptic transmission, gene regulatory networks, nuclear lamina, sporadic Alzheimer's disease
- MeSH terms
- RE1-Silencing Transcription Factor, Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Cell Differentiation, Fibroblasts, Gene Expression Regulation, Humans, Middle Aged, Neurons, Repressor Proteins, Amyloid beta-Peptides, Nuclear Lamina, Gene Regulatory Networks, Neurogenesis, Induced Pluripotent Stem Cells, Neural Stem Cells, Cellular Reprogramming
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
