Cited by 183Neural dynamics and brain functionSchizophrenia research and treatmentNeuroscience and Neuropharmacology Research

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Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding

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Abbas, Atheir I., Sundiang, Marina J.M., Henoch, Britt, Morton, Mitchell P., Bolkan, Scott S., Park, Alan J., Harris, Alexander Z., Kellendonk, Christoph, Gordon, Joshua A.·2018·Neuron

DOI 10.1016/j.neuron.2018.09.029PMC PMC6262834

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Abstract

Decreased hippocampal-prefrontal synchrony may mediate cognitive deficits in schizophrenia, but it remains unclear which cells orchestrate this long-range synchrony. Parvalbumin (PV)- and somatostatin (SOM)-expressing interneurons show histological abnormalities in individuals with schizophrenia and are hypothesized to regulate oscillatory synchrony within the prefrontal cortex. To examine the relationship between interneuron function, long-range hippocampal-prefrontal synchrony, and cognition, we optogenetically inhibited SOM and PV neurons in the medial prefrontal cortex (mPFC) of mice performing a spatial working memory task while simultaneously recording neural activity in the mPFC and the hippocampus (HPC). We found that inhibiting SOM, but not PV, interneurons during the encoding phase of the task impaired working memory accuracy. This behavioral impairment was associated with decreased hippocampal-prefrontal synchrony and impaired spatial encoding in mPFC neurons. These findings suggest that interneuron dysfunction may contribute to cognitive deficits associated with schizophrenia by disrupting long-range synchrony between the HPC and PFC.

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Authors: Abbas, A. I., Sundiang, M. J. M., Henoch, B., Morton, M. P., Bolkan, S. S., Park, A. J., Harris, A. Z., Kellendonk, C., & Gordon, J. A.
Affiliations: New York State Psychiatric Institute (US)
National Institute of Mental Health (US)
Corresponding author: Gordon, Joshua A.
ORCID: Abbas, Atheir I.
Morton, Mitchell P.
Park, Alan J.
Harris, Alexander Z.
Kellendonk, Christoph
Gordon, Joshua A.
Venue: Neuron
Publisher: Elsevier BV
Published: 2018-11
Volume: 100
Issue: 4
Pages: 926-939.e3
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2018.09.029
PMC: PMC6262834
OpenAlex: W2896362483
Cited by: 183
References: 58
Citations by year: 2026: 13 · 2025: 26 · 2024: 30 · 2023: 27 · 2022: 20 · 2021: 22 · 2020: 33 · 2019: 11
FWCI: 9.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: NIMH (R01 MH096274, T32 MH018870-29)
the Leon Levy Foundation
BBRF/NARSAD Young Investigator Grant
Irma Hirschl Trust
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: somatostatin interneurons, parvalbumin interneurons, medial prefrontal cortex, spatial working memory, spatial coding, schizophrenia, optogenetic inhibition, neural oscillations, cognitive impairment
MeSH terms: Animals, Hippocampus, Interneurons, Mice, Inbred C57BL, Neural Pathways, Parvalbumins, Somatostatin, Prefrontal Cortex, Mice, Mice, 129 Strain, Optogenetics

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Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding

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