The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding
Open accessAbstract
Decreased hippocampal-prefrontal synchrony may mediate cognitive deficits in schizophrenia, but it remains unclear which cells orchestrate this long-range synchrony. Parvalbumin (PV)- and somatostatin (SOM)-expressing interneurons show histological abnormalities in individuals with schizophrenia and are hypothesized to regulate oscillatory synchrony within the prefrontal cortex. To examine the relationship between interneuron function, long-range hippocampal-prefrontal synchrony, and cognition, we optogenetically inhibited SOM and PV neurons in the medial prefrontal cortex (mPFC) of mice performing a spatial working memory task while simultaneously recording neural activity in the mPFC and the hippocampus (HPC). We found that inhibiting SOM, but not PV, interneurons during the encoding phase of the task impaired working memory accuracy. This behavioral impairment was associated with decreased hippocampal-prefrontal synchrony and impaired spatial encoding in mPFC neurons. These findings suggest that interneuron dysfunction may contribute to cognitive deficits associated with schizophrenia by disrupting long-range synchrony between the HPC and PFC.
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“suggesting that SST+ interneurons are uniquely involved in facilitating hippocampal-prefrontal synchrony and prefrontal spatial encoding.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [39]
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“During a spatial WM task, optogenetically inhibiting PFC SST+, but not PV+, interneurons decreases the long-range synchrony between hippocampus and PFC and impairs working memory accuracy 39”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [39]
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Schizophrenics Show Spatial Working Memory Deficits
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Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice
Scheggia, D., Managò, F., Maltese, F., Bruni, S., Nigro, M., Dautan, D., Latuske, P., Contarini, G., Gomez-Gonzalo, M., Requie, L. M., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0551-8 · Cited by 192
Metadata
- Authors
- Abbas, A. I., Sundiang, M. J. M., Henoch, B., Morton, M. P., Bolkan, S. S., Park, A. J., Harris, A. Z., Kellendonk, C., & Gordon, J. A.
- Affiliations
- New York State Psychiatric Institute (US)
- National Institute of Mental Health (US)
- Corresponding author
- Gordon, Joshua A.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 100
- Issue
- 4
- Pages
- 926-939.e3
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC6262834
- OpenAlex
- W2896362483
- Cited by
- 183
- References
- 58
- Citations by year
- 2026: 13 · 2025: 26 · 2024: 30 · 2023: 27 · 2022: 20 · 2021: 22 · 2020: 33 · 2019: 11
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- NIMH (R01 MH096274, T32 MH018870-29)
- the Leon Levy Foundation
- BBRF/NARSAD Young Investigator Grant
- Irma Hirschl Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- somatostatin interneurons, parvalbumin interneurons, medial prefrontal cortex, spatial working memory, spatial coding, schizophrenia, optogenetic inhibition, neural oscillations, cognitive impairment
- MeSH terms
- Animals, Hippocampus, Interneurons, Mice, Inbred C57BL, Neural Pathways, Parvalbumins, Somatostatin, Prefrontal Cortex, Mice, Mice, 129 Strain, Optogenetics
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