The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding
Open accessAbstract
Decreased hippocampal-prefrontal synchrony may mediate cognitive deficits in schizophrenia, but it remains unclear which cells orchestrate this long-range synchrony. Parvalbumin (PV)- and somatostatin (SOM)-expressing interneurons show histological abnormalities in individuals with schizophrenia and are hypothesized to regulate oscillatory synchrony within the prefrontal cortex. To examine the relationship between interneuron function, long-range hippocampal-prefrontal synchrony, and cognition, we optogenetically inhibited SOM and PV neurons in the medial prefrontal cortex (mPFC) of mice performing a spatial working memory task while simultaneously recording neural activity in the mPFC and the hippocampus (HPC). We found that inhibiting SOM, but not PV, interneurons during the encoding phase of the task impaired working memory accuracy. This behavioral impairment was associated with decreased hippocampal-prefrontal synchrony and impaired spatial encoding in mPFC neurons. These findings suggest that interneuron dysfunction may contribute to cognitive deficits associated with schizophrenia by disrupting long-range synchrony between the HPC and PFC.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“suggesting that SST+ interneurons are uniquely involved in facilitating hippocampal-prefrontal synchrony and prefrontal spatial encoding.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [39]
In the citing paper
“During a spatial WM task, optogenetically inhibiting PFC SST+, but not PV+, interneurons decreases the long-range synchrony between hippocampus and PFC and impairs working memory accuracy 39”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Green, M. F., Kern, R. S., Braff, D. L., & Mintz, J. (2000) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033430 · Cited by 2,999
A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828
The importance of mixed selectivity in complex cognitive tasks
Rigotti, M., Barak, O., Warden, M. R., Wang, X.-J., Daw, N. D., Miller, E. K., & Fusi, S. (2013) · Nature · doi:10.1038/nature12160 · Cited by 1,639
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
Madisen, L., Mao, T., Koch, H., Zhuo, J.-M., Berenyi, A., Fujisawa, S., Hsu, Y.-W. A., Garcia, A. J., Gu, X., Zanella, S., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3078 · Cited by 1,398
MARTINUSSEN, R., HAYDEN, J., HOGG-JOHNSON, S., & TANNOCK, R. (2005) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000153228.72591.73 · Cited by 1,297
High-performance genetically targetable optical neural silencing by light-driven proton pumps
Chow, B. Y., Han, X., Dobry, A. S., Qian, X., Chuong, A. S., Li, M., Henninger, M. A., Belfort, G. M., Lin, Y., Monahan, P. E., et al. (2010) · Nature · doi:10.1038/nature08652 · Cited by 1,188
Neuropsychological Function in Schizophrenia
Saykin, A. J. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310036007 · Cited by 1,160
Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia
Saykin, A. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020048005 · Cited by 1,086
Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task
Jones, M. W., & Wilson, M. A. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030402 · Cited by 1,036
Schizophrenics Show Spatial Working Memory Deficits
Park, S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120063009 · Cited by 953
Hashimoto, T., Volk, D. W., Eggan, S. M., Mirnics, K., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06315.2003 · Cited by 938
Mattis, J., Tye, K. M., Ferenczi, E. A., Ramakrishnan, C., O'Shea, D. J., Prakash, R., Gunaydin, L. A., Hyun, M., Fenno, L. E., Gradinaru, V., et al. (2012) · Nature Methods · doi:10.1038/nmeth.1808 · Cited by 780
Disynaptic Inhibition between Neocortical Pyramidal Cells Mediated by Martinotti Cells
Silberberg, G., & Markram, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.012 · Cited by 768
Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives
Arts, B. M. G., Jabben, N., Krabbendam, L., & van Os, J. (2007) · Psychological Medicine · doi:10.1017/s0033291707001675 · Cited by 726
Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia
Sigurdsson, T., Stark, K. L., Karayiorgou, M., Gogos, J. A., & Gordon, J. A. (2010) · Nature · doi:10.1038/nature08855 · Cited by 702
Self-citationBehavior-dependent short-term assembly dynamics in the medial prefrontal cortex
Fujisawa, S., Amarasingham, A., Harrison, M. T., & Buzsáki, G. (2008) · Nature Neuroscience · doi:10.1038/nn.2134 · Cited by 696
Keefe, R. S. E., Silva, S. G., Perkins, D. O., & Lieberman, J. A. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033374 · Cited by 695
Hippocampal–prefrontal input supports spatial encoding in working memory
Spellman, T., Rigotti, M., Ahmari, S. E., Fusi, S., Gogos, J. A., & Gordon, J. A. (2015) · Nature · doi:10.1038/nature14445 · Cited by 693
Self-citationCarlén, M., Meletis, K., Siegle, J. H., Cardin, J. A., Futai, K., Vierling-Claassen, D., Rühlmann, C., Jones, S. R., Deisseroth, K., Sheng, M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.31 · Cited by 669
Thalamic amplification of cortical connectivity sustains attentional control
Schmitt, L. I., Wimmer, R. D., Nakajima, M., Happ, M., Mofakham, S., & Halassa, M. M. (2017) · Nature · doi:10.1038/nature22073 · Cited by 663
Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuli
Atallah, B. V., Bruns, W., Carandini, M., & Scanziani, M. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.013 · Cited by 612
Thalamic projections sustain prefrontal activity during working memory maintenance
Bolkan, S. S., Stujenske, J. M., Parnaudeau, S., Spellman, T., Rauffenbart, C., Abbas, A. I., Harris, A. Z., Gordon, J. A., & Kellendonk, C. (2017) · Nature Neuroscience · doi:10.1038/nn.4568 · Cited by 547
Self-citationPrefrontal parvalbumin interneurons shape neuronal activity to drive fear expression
Courtin, J., Chaudun, F., Rozeske, R. R., Karalis, N., Gonzalez-Campo, C., Wurtz, H., Abdi, A., Baufreton, J., Bienvenu, T. C. M., & Herry, C. (2014) · Nature · doi:10.1038/nature12755 · Cited by 524
Distinct behavioural and network correlates of two interneuron types in prefrontal cortex
Kvitsiani, D., Ranade, S., Hangya, B., Taniguchi, H., Huang, J. Z., & Kepecs, A. (2013) · Nature · doi:10.1038/nature12176 · Cited by 516
Hashimoto, T., Arion, D., Unger, T., Maldonado-Avilés, J. G., Morris, H. M., Volk, D. W., Mirnics, K., & Lewis, D. A. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002011 · Cited by 490
Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex
Gentet, L. J., Kremer, Y., Taniguchi, H., Huang, Z. J., Staiger, J. F., & Petersen, C. C. H. (2012) · Nature Neuroscience · doi:10.1038/nn.3051 · Cited by 438
Regulation of neuronal input transformations by tunable dendritic inhibition
Lovett-Barron, M., Turi, G. F., Kaifosh, P., Lee, P. H., Bolze, F., Sun, X.-H., Nicoud, J.-F., Zemelman, B. V., Sternson, S. M., & Losonczy, A. (2012) · Nature Neuroscience · doi:10.1038/nn.3024 · Cited by 417
Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition
Parnaudeau, S., O’Neill, P.-K., Bolkan, S. S., Ward, R. D., Abbas, A. I., Roth, B. L., Balsam, P. D., Gordon, J. A., & Kellendonk, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.038 · Cited by 387
Self-citationCortical gamma band synchronization through somatostatin interneurons
Veit, J., Hakim, R., Jadi, M. P., B, T. J. S. A., & Adesnik, H. (2017) · Nature Neuroscience · doi:10.1038/nn.4562 · Cited by 376
Somatostatin-expressing neurons in cortical networks
Urban-Ciecko, J., & Barth, A. L. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.53 · Cited by 374
Fung, S. J., Webster, M. J., Sivagnanasundaram, S., Duncan, C., Elashoff, M., & Weickert, C. S. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09060784 · Cited by 366
Recurrent network models of sequence generation and memory
Rajan, K., Harvey, C. D., & Tank, D. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.009 · Cited by 351
Distinct inhibitory circuits orchestrate cortical beta and gamma band oscillations
Chen, G., Zhang, Y., Li, X., Zhao, X., Ye, Q., Lin, Y., Tao, H. W., Rasch, M. J., & Zhang, X. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.033 · Cited by 345
O’Neill, P.-K., Gordon, J. A., & Sigurdsson, T. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2378-13.2013 · Cited by 297
Self-citationGreen, M. F. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14074su1c.02 · Cited by 290
Lee, I., & Kesner, R. P. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01517.2003 · Cited by 287
Lai, C. L. E., Lau, Z., Lui, S. S. Y., Lok, E., Tam, V., Chan, Q., Cheng, K. M., Lam, S. M., & Cheung, E. F. C. (2017) · Autism Research · doi:10.1002/aur.1723 · Cited by 250
Neuropsychological function in nonpsychotic unipolar major depression.
Landrø, N. I., Stiles, T. C., & Sletvold, H. (2001) · PubMed · Cited by 241
Parvalbumin-Expressing Inhibitory Interneurons in Auditory Cortex Are Well-Tuned for Frequency
Moore, A. K., & Wehr, M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0663-13.2013 · Cited by 225
Ventral Midline Thalamus Is Critical for Hippocampal-Prefrontal Synchrony and Spatial Working Memory
Hallock, H. L., Wang, A., & Griffin, A. L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0991-16.2016 · Cited by 217
Medial Prefrontal Cortex Reduces Memory Interference by Modifying Hippocampal Encoding
Guise, K. G., & Shapiro, M. L. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.011 · Cited by 212
Delay activity of specific prefrontal interneuron subtypes modulates memory-guided behavior
Kamigaki, T., & Dan, Y. (2017) · Nature Neuroscience · doi:10.1038/nn.4554 · Cited by 208
Wang, G.-W., & Cai, J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.002 · Cited by 205
Gandal, M. J., Sisti, J., Klook, K., Ortinski, P. I., Leitman, V, Liang, Y., Thieu, T., Anderson, R., Pierce, R. C., Jonak, G., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.69 · Cited by 204
Canetta, S., Bolkan, S., Padilla-Coreano, N., Song, L. J., Sahn, R., Harrison, N. L., Gordon, J. A., Brown, A., & Kellendonk, C. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.222 · Cited by 201
Self-citationDistinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory
Kim, D., Jeong, H., Lee, J., Ghim, J.-W., Her, E. S., Lee, S.-H., & Jung, M. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.023 · Cited by 201
Brekke, J. S., Hoe, M., Long, J. D., & Green, M. F. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl072 · Cited by 189
Brain-Wide Maps of Synaptic Input to Cortical Interneurons
Wall, N. R., Parra, M. D. L., Sorokin, J. M., Taniguchi, H., Huang, Z. J., & Callaway, E. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3967-15.2016 · Cited by 186
Somatostatin-Expressing Inhibitory Interneurons in Cortical Circuits
Yavorska, I., & Wehr, M. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00076 · Cited by 185
Murray, A., Wołoszynowska-Fraser, M. U., Ansel-Bollepalli, L., Marshall-Phelps, K. L., Foggetti, A., Crouch, B., Riedel, G., & Wulff, P. (2015) · Scientific Reports · doi:10.1038/srep16778 · Cited by 173
Identification of the Hippocampal Input to Medial Prefrontal Cortex In Vitro
Parent, M. A., Wang, L., Su, J., Netoff, T. I., & Yuan, L. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp108 · Cited by 165
Churchwell, J. C., & Kesner, R. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.045 · Cited by 154
Direct dorsal hippocampal–prelimbic cortex connections strengthen fear memories
Ye, X., Kapeller-Libermann, D., Travaglia, A., Inda, M. C., & Alberini, C. M. (2016) · Nature Neuroscience · doi:10.1038/nn.4443 · Cited by 140
Akhlaghpour, H., Wiskerke, J., Choi, J. Y., Taliaferro, J. P., Au, J., & Witten, I. B. (2016) · eLife · doi:10.7554/elife.19507 · Cited by 112
Fung, S. J., Fillman, S. G., Webster, M. J., & Weickert, C. S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.02.021 · Cited by 98
Horst, N. K., & Laubach, M. (2012) · Journal of Neurophysiology · doi:10.1152/jn.01192.2011 · Cited by 87
Lagler, M., Ozdemir, A. T., Lagoun, S., Malagon-Vina, H., Borhegyi, Z., Hauer, R., Jelem, A., & Klausberger, T. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.010 · Cited by 67
Urban, K. R., Layfield, D. M., & Griffin, A. L. (2014) · Behavioral Neuroscience · doi:10.1037/bne0000020 · Cited by 25
Flagged first, then by citations
Cited by
Sorted by citations
Memory engrams: Recalling the past and imagining the future
Josselyn, S. A., & Tonegawa, S. (2020) · Science · doi:10.1126/science.aaw4325 · Cited by 1,087
Yan, Z., & Rein, B. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01092-3 · Cited by 300
Prévot, T. D., & Sibille, E. L. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0727-3 · Cited by 238
The mouse prefrontal cortex: Unity in diversity
Le Merre, P., Ährlund-Richter, S., & Carlén, M. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.035 · Cited by 207
Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice
Scheggia, D., Managò, F., Maltese, F., Bruni, S., Nigro, M., Dautan, D., Latuske, P., Contarini, G., Gomez-Gonzalo, M., Requie, L. M., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0551-8 · Cited by 192
Metadata
- Authors
- Abbas, A. I., Sundiang, M. J. M., Henoch, B., Morton, M. P., Bolkan, S. S., Park, A. J., Harris, A. Z., Kellendonk, C., & Gordon, J. A.
- Affiliations
- New York State Psychiatric Institute (US)
- National Institute of Mental Health (US)
- Corresponding author
- Gordon, Joshua A.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 100
- Issue
- 4
- Pages
- 926-939.e3
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC6262834
- OpenAlex
- W2896362483
- Cited by
- 183
- References
- 58
- Citations by year
- 2026: 13 · 2025: 26 · 2024: 30 · 2023: 27 · 2022: 20 · 2021: 22 · 2020: 33 · 2019: 11
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- NIMH (R01 MH096274, T32 MH018870-29)
- the Leon Levy Foundation
- BBRF/NARSAD Young Investigator Grant
- Irma Hirschl Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- somatostatin interneurons, parvalbumin interneurons, medial prefrontal cortex, spatial working memory, spatial coding, schizophrenia, optogenetic inhibition, neural oscillations, cognitive impairment
- MeSH terms
- Animals, Hippocampus, Interneurons, Mice, Inbred C57BL, Neural Pathways, Parvalbumins, Somatostatin, Prefrontal Cortex, Mice, Mice, 129 Strain, Optogenetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
