The bed nucleus of the stria terminalis in drug-associated behavior and affect: a circuit-based perspective
Open accessAbstract
The bed nucleus of the stria terminalis was first described nearly a century ago and has since emerged as a region central to motivated behavior and affective states. The last several decades have firmly established a role for the BNST in drug-associated behavior and implicated this region in addiction-related processes. Whereas past approaches used to characterize the BNST have focused on a more general role of this region and its subnuclei in behavior, more recent work has begun to reveal its elaborate circuitry and cellular components. Such recent developments are largely owed to methodological advances, which have made possible efforts previously deemed intractable, such as tracing of long-range cell-type specific projections and identifying functional efferent and afferent connections. In this review, we integrate earlier foundational work with more recent and advanced studies to construct a broad overview of the molecular neurocircuitry of the BNST in drug-associated behavior and affect. This article is part of the Special Issue entitled "Alcoholism".
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- Authors
- Vranjkovic, O., Pina, M., Kash, T. L., & Winder, D. G.
- Affiliations
- Vanderbilt University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Winder, Danny G.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 122
- Pages
- 100-106
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC5481847
- OpenAlex
- W2602135970
- Cited by
- 79
- References
- 101
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 13 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 5
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH/NIAAA (R37-AA019455 to DGW, R01-AA019454, U01-AA020911 to TLK)
- NIH/NIDA (R01-DA042475 to DGW)
- NIH/NIMH (T32-MH065215 to OV)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- bed nucleus of the stria terminalis, addiction, affect, neurocircuitry, afferent and efferent connections, motivated behavior, alcoholism
- MeSH terms
- Alcohol Drinking, Alcoholism, Animals, Humans, Neural Pathways, Septal Nuclei, Drug-Seeking Behavior
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