Cited by 79Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

The bed nucleus of the stria terminalis in drug-associated behavior and affect: a circuit-based perspective

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Vranjkovic, Oliver, Pina, Melanie, Kash, Thomas L., Winder, Danny G.·2017·Neuropharmacology

Abstract

The bed nucleus of the stria terminalis was first described nearly a century ago and has since emerged as a region central to motivated behavior and affective states. The last several decades have firmly established a role for the BNST in drug-associated behavior and implicated this region in addiction-related processes. Whereas past approaches used to characterize the BNST have focused on a more general role of this region and its subnuclei in behavior, more recent work has begun to reveal its elaborate circuitry and cellular components. Such recent developments are largely owed to methodological advances, which have made possible efforts previously deemed intractable, such as tracing of long-range cell-type specific projections and identifying functional efferent and afferent connections. In this review, we integrate earlier foundational work with more recent and advanced studies to construct a broad overview of the molecular neurocircuitry of the BNST in drug-associated behavior and affect. This article is part of the Special Issue entitled "Alcoholism".

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  1. De Olmos JS Beltramino CA Alheid G 2004 CHAPTER 19 - Amygdala and Extended Amygdala of the Rat: A Cytoarchitectonical, Fibroarchitectonical, and Chemoarchitectonical Survey A2 - Paxinos, George The Rat Nervous System (THIRD EDITION) 509 603 Burlington Academic Press
  2. Vranjkovic O Gasser PJ Gerndt CH Baker DA Mantsch JR 2014 Stress-induced cocaine seeking requires a beta-2 adrenergic receptor-regulated pathway from the ventral bed nucleus of the stria terminalis that regulates CRF actions in the ventral tegmental area J Neurosci 34 37 12504 12514 10.1523/JNEUROSCI.0680-14.2014 25209288 PMC4160780 · DOI

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Authors
Vranjkovic, O., Pina, M., Kash, T. L., & Winder, D. G.
Affiliations
  • Vanderbilt University (US)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Winder, Danny G.
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2017-08
Volume
122
Pages
100-106
ISSN
0028-3908 (ISSN-L)
OpenAlex
W2602135970
Cited by
79
References
101
Citations by year
2026: 2 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 13 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 5
FWCI
1.25
Type
journal article
Language
en
Open access
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH/NIAAA (R37-AA019455 to DGW, R01-AA019454, U01-AA020911 to TLK)
  • NIH/NIDA (R01-DA042475 to DGW)
  • NIH/NIMH (T32-MH065215 to OV)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
bed nucleus of the stria terminalis, addiction, affect, neurocircuitry, afferent and efferent connections, motivated behavior, alcoholism
MeSH terms
Alcohol Drinking, Alcoholism, Animals, Humans, Neural Pathways, Septal Nuclei, Drug-Seeking Behavior

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