The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Altered deactivation in individuals with genetic risk for Alzheimer's disease
Abstract
Regions that show task-induced deactivations may be part of a default-mode network related to processes that are more engaged during passive than active task conditions. Alteration of task-induced deactivations with age and dementia is indicated by atypical engagement of default-mode network regions. Genetic studies show a relation between the apolipoprotein E4 (APOE4) allele and the common form of Alzheimer's disease (AD), and altered functional brain activation has been observed in non-demented APOE4 carriers compared to non-carriers. Here we investigate the hypothesis of altered default-mode network brain responses in individuals with genetic risk for AD. Functional MRI was used to assess task-induced deactivation in 60 subjects of which 30 carried at least one copy of the APOE4 allele, and 30 non-carriers. Subjects were scanned while performing a semantic categorization task shown to promote episodic memory encoding. The results show patterns of deactivation consistent with the default-mode network. We also found reduced deactivation in non-demented APOE4 carriers compared to non-carriers, suggesting alterations in the default-mode network in the absence of dementia. These results implicate possibilities for investigating altered properties of task-induced deactivations in individuals with genetic risk for AD, and may prove useful for pre-clinical identification of individuals susceptible to memory problems and AD.
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“First, cognitively normal apoE4 carriers show reduced task-induced deactivation of the default mode network (DMN) [162–164].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [162]
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Sperling, R. A., LaViolette, P. S., O'Keefe, K., O'Brien, J., Rentz, D. M., Pihlajamaki, M., Marshall, G., Hyman, B. T., Selkoe, D. J., Hedden, T., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.003 · Cited by 1,027
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“Other recent studies have demonstrated altered default network activity in older ApoE e4 carriers (Persson et al. 2008).”
BackgroundGenetic control over the resting brain
Glahn, D. C., Winkler, A. M., Kochunov, P., Almasy, L., Duggirala, R., Carless, M. A., Curran, J. C., Olvera, R. L., Laird, A. R., Smith, S. M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909969107 · Cited by 450
“Individuals at genetic risk for Alzheimer’s disease (14) and schizophrenia (15) have abnormal default-mode connectivity.”
BackgroundAlves, P. N., Foulon, C., Karolis, V., Bzdok, D., Margulies, D. S., Volle, E., & Thiebaut de Schotten, M. (2019) · Communications Biology · doi:10.1038/s42003-019-0611-3 · Cited by 357
Metadata
- Authors
- Persson, J., Lind, J., Larsson, A., Ingvar, M., Sleegers, K., Van Broeckhoven, C., Adolfsson, R., Nilsson, L.-G., & Nyberg, L.
- Affiliations
- Stockholm University (SE)
- Karolinska University Hospital (SE)
- Umeå University (SE)
- University of Antwerp (BE)
- Corresponding author
- Persson, J.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 46
- Issue
- 6
- Pages
- 1679-1687
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2140074909
- Cited by
- 102
- References
- 42
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 10 · 2013: 6 · 2012: 7
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, APOE ε4, default mode network, task-induced deactivation, genetic risk, semantic classification, episodic memory encoding, preclinical Alzheimer's disease, functional brain activation
- MeSH terms
- Aged, Alzheimer Disease, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neuropsychological Tests, Oxygen, Semantics, Apolipoprotein E4
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