Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study
Open accessAbstract
Activity and reactivity of the default mode network in the brain was studied using functional magnetic resonance imaging (fMRI) in 28 nondemented individuals with mild cognitive impairment (MCI), 18 patients with mild Alzheimer's disease (AD), and 41 healthy elderly controls (HC). The default mode network was interrogated by means of decreases in brain activity, termed deactivations, during a visual encoding task and during a nonspatial working memory task. Deactivation was found in the default mode network involving the anterior frontal, precuneus, and posterior cingulate cortex. MCI patients showed less deactivation than HC, but more than AD. The most pronounced differences between MCI, HC, and AD occurred in the very early phase of deactivation, reflecting the reactivity and adaptation of the network. The default mode network response in the anterior frontal cortex significantly distinguished MCI from both HC (in the medial frontal) and AD (in the anterior cingulate cortex). The response in the precuneus could only distinguish between patients and HC, not between MCI and AD. These findings may be consistent with the notion that MCI is a transitional state between healthy aging and dementia and with the proposed early changes in MCI in the posterior cingulate cortex and precuneus. These findings suggest that altered activity in the default mode network may act as an early marker for AD pathology.
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The dynamics of functional connectivity alteration, both spatial and temporal, differ from patterns observed in Alzheimer's disease patients.
“The dynamics of alteration, both spatial and temporal, differ from patterns observed in AD patients, which is marked with early altered FC in the default mode network and aggravated FC in the transition from mild cognitive impairments to AD (Greicius et al., 2004;Rombouts et al., 2005;Sorg et al., 2007;Sheline et al., 2010a,b).”
From Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis (2014) · cites this paper as Rombouts et al., 2005
The fMRI data and Discussion (page unavailable) report spatial differences in default-mode deactivation between MCI and AD, as well as a different early temporal response in the anterior cingulate. They also describe deactivation as further diminished in AD. The study measured task-related BOLD deactivation, however, not functional connectivity directly or longitudinal changes during an individual's transition from MCI to AD. (LLM, conf=0.86)
Experimental — accuracy not yet measuredDefault mode network connectivity was reported affected in subjects at risk of developing Alzheimer's disease, including patients with mild cognitive impairment, cognitively healthy elders with amyloid deposits, and midlife carriers of the APOE4 risk allele.
“Additionally, DMN connectivity was reported affected in subjects at risk of developing AD including patients with mild cognitive impairment (Rombouts et al., 2005;Sorg et al., 2007), in cognitively healthy elders with amyloid deposits (Hedden et al., 2009;Sperling et al., 2009;Sheline et al., 2010b), and in midlife carriers of APO 4 risk allele (Sheline et al., 2010a;Canuet et al., 2012).”
From Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis (2014) · cites this paper as Rombouts et al., 2005
The Abstract and Discussion report altered default mode network deactivation in patients with mild cognitive impairment compared with healthy controls. But the study measured task-related deactivation, not connectivity directly; the Discussion's mention of altered resting connectivity concerns AD and cites another study. The other risk groups in the citing sentence have separate citations and are not attributed to Rombouts et al. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe marginal decline in FC in ArcAβ mice between 5 and 21 months is inconsistent with the observed aggravation of FC associated with transition from preclinical to clinical Alzheimer's disease.
“but inconsistent with the observed aggravation of FC associated with transition from preclinical to clinical AD (Rombouts et al., 2005).”
From Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis (2014) · cites this paper as Rombouts et al., 2005
The Discussion reports that default-mode-network deactivation is altered in MCI and further affected in mild AD, supporting a worsening difference between the groups. But the study measured task-related deactivation in separate groups, not functional connectivity (FC) during an observed transition from preclinical to clinical AD. The cited passages provide no page number. (LLM, conf=0.86)
Experimental — accuracy not yet measured
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- Authors
- Rombouts, S. A. R. B., Barkhof, F., Goekoop, R., Stam, C. J., & Scheltens, P.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2005-06-13
- Volume
- 26
- Issue
- 4
- Pages
- 231-239
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6871685
- OpenAlex
- W2134858198
- Cited by
- 734
- References
- 8
- Citations by year
- 2026: 12 · 2025: 8 · 2024: 12 · 2023: 13 · 2022: 31 · 2021: 27 · 2020: 31 · 2019: 45 · 2018: 26 · 2017: 47 · 2016: 46 · 2015: 34 · 2014: 60 · 2013: 58 · 2012: 43
- FWCI
- 18.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (916.36.117)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- default mode network, resting-state networks, mild cognitive impairment, mild Alzheimer's disease, brain deactivation, working memory task, anterior cingulate cortex, precuneus, posterior cingulate cortex, healthy aging
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain Mapping, Cerebral Cortex, Cognition, Cognition Disorders, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Nerve Net, Neural Pathways, Neuropsychological Tests, Parietal Lobe, Photic Stimulation, Psychomotor Performance, Prefrontal Cortex
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