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Functional deactivations: Change with age and dementia of the Alzheimer type
Open accessAbstract
Young adults typically deactivate specific brain regions during active task performance. Deactivated regions overlap with those that show reduced resting metabolic activity in aging and dementia, raising the possibility of a relation. Here, the magnitude and dynamic temporal properties of these typically deactivated regions were explored in aging by using functional MRI in 82 participants. Young adults ( n = 32), older adults without dementia ( n = 27), and older adults with early-stage dementia of the Alzheimer type (DAT) ( n = 23) were imaged while alternating between blocks of an active semantic classification task and a passive fixation baseline. Deactivation in lateral parietal regions was equivalent across groups; in medial frontal regions, it was reduced by aging but was not reduced further by DAT. Of greatest interest, a medial parietal/ posterior cingulate region showed differences between young adults and older adults without dementia and an even more marked difference with DAT. The temporal profile of the medial parietal/posterior cingulate response suggested that it was initially activated by all three groups, but the response in young adults quickly reversed sign, whereas DAT individuals maintained activation throughout the task block. Exploratory whole-brain analyses confirmed the importance of medial parietal/posterior cingulate cortex differences in aging and DAT. These results introduce important opportunities to explore the functional properties of regions showing deactivations, how their dynamic functional properties relate to their baseline metabolic rates, and how they change with age and dementia.
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AD patients show reduced ability to deactivate the DMN during memory encoding.
“Reduced ability to deactivate the DMN during memory encoding is found in AD patients [168–170]”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [170]
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Metadata
- Authors
- Lustig, C., Snyder, A. Z., Bhakta, M., O'Brien, K. C., McAvoy, M., Raichle, M. E., Morris, J. C., & Buckner, R. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2003-11-07
- Volume
- 100
- Issue
- 24
- Pages
- 14504-14509
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC283621
- OpenAlex
- W2070069429
- Semantic Scholar
- 1bbd40639f487f665e5410c9b895466d871d53b5
- Cited by
- 720
- References
- 8
- Citations by year
- 2026: 4 · 2025: 23 · 2024: 7 · 2023: 16 · 2022: 17 · 2021: 25 · 2020: 25 · 2019: 22 · 2018: 25 · 2017: 29 · 2016: 28 · 2015: 32 · 2014: 56 · 2013: 64 · 2012: 46
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- James S. McDonnell Foundation
- Alzheimer's Association (AG05681)
- National Institutes of Health (NS06833, AG05681, AG 03991)
- National Institute on Aging (P50AG005681, P01AG003991, T32AG000030)
- National Institute of Neurological Disorders and Stroke (P50NS006833)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- brain aging, Alzheimer's disease, dementia, resting metabolic rate, medial parietal cortex, posterior cingulate cortex, older adults, young adults
- MeSH terms
- Adult, Aged, Aging, Alzheimer Disease, Basal Metabolism, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Task Performance and Analysis
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