Structural brain correlates of loneliness among older adults
Open accessAbstract
Ample evidence indicates that loneliness in old age is associated with poor bodily and mental health. However, little is known about structural cerebral correlates of loneliness in healthy older adults. We examined such correlates in a magnetic resonance imaging (MRI) subsample of 319 older adults aged 61 to 82 years drawn from the Berlin Aging Study II. Using voxel-based morphometry (VBM) and structural equation modeling (SEM), latent hierarchical regression analyses were performed to examine associations of (i) loneliness, (ii) a range of covariates, and (iii) loneliness by covariate interactions with latent brain volume estimates of brain structures known to be involved in processing, expressing, and regulating emotions. Results from whole-brain VBM analyses showed that individuals with higher loneliness scores tended to have smaller gray matter volumes in three clusters comprising (i) the left amygdala/anterior hippocampus, (ii) the left posterior parahippocampus and (iii) the left cerebellum. Significant associations and interactions between loneliness and latent factors for the amygdala and the hippocampus were confirmed with a region-of-interest (ROI)-based approach. These findings suggest that individual differences in loneliness among older adults are correlated with individual differences in the volumes of brain regions that are central to cognitive processing and emotional regulation, also after correcting for confounders such as social network size. We discuss possible mechanisms underlying these associations and their implications.
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Greater loneliness is significantly associated with reduced brain volume in areas in the left medial temporal lobe involved in memory and affected by AD.
“greater loneliness has also been found to be significantly associated with reduced brain volume in areas in the left medial temporal lobe involved in memory and harshly affected by AD (10).”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [10]
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- Authors
- Düzel, S., Drewelies, J., Gerstorf, D., Demuth, I., Steinhagen-Thiessen, E., Lindenberger, U., & Kühn, S.
- Affiliations
- Max Planck Institute for Human Development (DE)
- Humboldt-Universität zu Berlin (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Düzel, Sandra
- Venue
- Scientific Reports
- Published
- 2019-09-19
- Volume
- 9
- Issue
- 1
- Pages
- 13569-13569
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6753249
- OpenAlex
- W2974655760
- Cited by
- 111
- References
- 81
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 16 · 2023: 11 · 2022: 21 · 2021: 18 · 2020: 7
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Bundesministerium für Bildung und Forschung (16SV5537/16SV5837/16SV5538/16SV5536K/01UW0808/01UW0706)
- Topics
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- loneliness, older adults, gray matter volume, amygdala, hippocampus, cerebellum, emotion regulation, brain structure, social network size, aging
- MeSH terms
- Aged, Aged, 80 and over, Amygdala, Brain Mapping, Female, Hippocampus, Humans, Loneliness, Magnetic Resonance Imaging, Male, Middle Aged, Multivariate Analysis, Gray Matter
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