Deficits in sensory prediction are related to delusional ideation in healthy individuals
Open accessAbstract
Motor control strongly relies on neural processes that predict the sensory consequences of self-generated actions. Previous research has demonstrated deficits in such sensory-predictive processes in schizophrenic patients and these low-level deficits are thought to contribute to the emergence of delusions of control. Here, we examined the extent to which individual differences in sensory prediction are associated with a tendency towards delusional ideation in healthy participants. We used a force-matching task to quantify sensory-predictive processes, and administered questionnaires to assess schizotypy and delusion-like thinking. Individuals with higher levels of delusional ideation showed more accurate force matching suggesting that such thinking is associated with a reduced tendency to predict and attenuate the sensory consequences of self-generated actions. These results suggest that deficits in sensory prediction in schizophrenia are not simply consequences of the deluded state and are not related to neuroleptic medication. Rather they appear to be stable, trait-like characteristics of an individual, a finding that has important implications for our understanding of the neurocognitive basis of delusions.
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The illusion is attenuated in normal subjects that score highly on ratings of delusional beliefs.
“The illusion is attenuated in normal subjects that score highly on ratings of delusional beliefs (Teufel et al., 2010).”
From The Computational Anatomy of Psychosis (2013) · cites this paper as Teufel et al., 2010
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Peters, E. R., Joseph, S. A., & Garety, P. A. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033401 · Cited by 771 · see citing works
Measuring Delusional Ideation: The 21-Item Peters et al. Delusions Inventory (PDI)
Peters, E., Joseph, S., Day, S., & Garety, P. (2004) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007116 · Cited by 607 · see citing works
Evidence for sensory prediction deficits in schizophrenia
Shergill, S. S., Samson, G., Bays, P. M., Frith, C. D., & Wolpert, D. M. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.12.2384 · Cited by 432 · see citing works
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Research works printed but not linked: 18
- Bays P.M. Flanagan J.R. Wolpert D.M. Attenuation of self-generated tactile sensations is predictive, not postdictive PLoS Biology 4 2006 281 284 PMC1334241 16402860
- Bays P.M. Wolpert D.M. Predictive attenuation in the perception of touch Haggard P. Rosetti Y. Kawato M. Attention & performance XXII: Sensorimotor foundations of higher cognition 2007 Oxford University Press Oxford 339 358
- Bays P.M. Wolpert D.M. Flanagan J.R. Perception of the consequences of self-action is temporally tuned and event driven Current Biology 15 2005 1125 1128 15964278
- Blakemore S.J. Wolpert D.M. Frith C.D. Central cancellation of self-produced tickle sensation Nature Neuroscience 1 1998 635 640 10196573
- Chapman L.J. Chapman J.P. Kwapil T.R. Eckblad M. Zinser M.C. Putatively psychosis-prone subjects 10 years later Journal of Abnormal Psychology 103 1994 171 183 8040487
- Chapman L.J. Chapman J.P. Raulin M.L. Body-image aberration in schizophrenia Journal of Abnormal Psychology 87 1978 399 407 681612
- Claridge G. Single indicator of risk for schizophrenia: Probable fact or likely myth Schizophrenia Bulletin 20 1994 151 168 8197412
- Crow T.J. From Kraepelin to Kretschmer leavened by Schneider: The transition from categories of psychosis to dimensions of variation intrinsic to Homo sapiens Archives Of General Psychiatry 55 1998 502 504 9633667
- Eckblad M. Chapman L.J. Magical ideation as an indicator of schizotypy Journal of Consulting and Clinical Psychology 51 1983 215 225 6841765
- Fletcher P.C. Frith C.D. Perceiving is believing: A Bayesian approach to explaining the positive symptoms of schizophrenia Nature Reviews Neuroscience 10 2009 48 58 19050712
- Frith C.D. Blakemore S.J. Wolpert D.M. Abnormalities in the awareness and control of action Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 355 2000 1771 1788 11205340 PMC1692910
- Levenson H. Multidimensional locus of control in psychiatric patients Journal of Consulting and Clinical Psychology 41 1973 397 404 4803272
- Lindner A. Haarmeier T. Erb M. Grodd W. Thier P. Cerebrocerebellar circuits for the perceptual cancellation of eye-movement-induced retinal image motion Journal of Cognitive Neuroscience 18 2006 1899 1912 17069480
- Lindner A. Thier P. Kircher T.T.J. Haarmeier T. Leube D.T. Disorders of agency in schizophrenia correlate with an inability to compensate for the sensory consequences of actions Current Biology 15 2005 1119 1124 15964277
- Oldfield R.C. Assessment and analysis of handedness: The Edinburgh inventory Neuropsychologia 9 1971 97 113 5146491
- Shergill S.S. Bays P.M. Frith C.D. Wolpert D.M. Two eyes for an eye: The neuroscience of force escalation Science 301 2003 187 1187 12855800
- Synofzik M. Thier P. Leube D.T. Schlotterbeck P. Lindner A. Misattributions of agency in schizophrenia are based on imprecise predictions about the sensory consequences of one's actions Brain 133 2010 262 271 19995870
- Wolpert D.M. Flanagan J.R. Motor prediction Current Biology 11 2001 R729 R732 11566114
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The Computational Anatomy of Psychosis
Adams, R. A., Stephan, K. E., Brown, H. R., Frith, C. D., & Friston, K. J. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00047 · Cited by 850 · see citing works
“The illusion is attenuated in normal subjects that score highly on ratings of delusional beliefs (Teufel et al., 2010).”
BackgroundActive inference, sensory attenuation and illusions
Brown, H., Adams, R. A., Parees, I., Edwards, M., & Friston, K. (2013) · Cognitive Processing · doi:10.1007/s10339-013-0571-3 · Cited by 488 · see citing works
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Jardri, R., & Denève, S. (2013) · Brain · doi:10.1093/brain/awt257 · Cited by 201 · see citing works
Delusions and the role of beliefs in perceptual inference
Schmack, K., Gòmez-Carrillo de Castro, A., Rothkirch, M., Sekutowicz, M., Rössler, H., Haynes, J.-D., Heinz, A., Petrovic, P., & Sterzer, P. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1778-13.2013 · Cited by 198 · see citing works
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Corlett, P. R., Honey, G. D., & Fletcher, P. C. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116650087 · Cited by 142 · see citing works
Self-citationSubjective signal strength distinguishes reality from imagination
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- Authors
- Teufel, C., Kingdon, A., Ingram, J. N., Wolpert, D. M., & Fletcher, P. C.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Teufel, Christoph
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 48
- Issue
- 14
- Pages
- 4169-4172
- ISSN
- 0028-3932 (ISSN-L)
- PMC
- PMC3142618
- OpenAlex
- W2143555335
- Cited by
- 71
- References
- 3
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 7 · 2012: 2
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuropsychologia (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cambridge University Engineering Department Publications Database (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Wellcome Trust (064351)
- Isaac Newton Trust
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Free Will and Agency
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- sensory prediction, delusional ideation, delusions of control, schizotypy, force-matching task, self-generated action, individual differences, schizophrenia, antipsychotic drugs
- MeSH terms
- Adolescent, Adult, Awareness, Decision Making, Delusions, Female, Humans, Male, Neuropsychological Tests, Predictive Value of Tests, Surveys and Questionnaires, Regression Analysis, Young Adult
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