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Cited by 118Parkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on BehaviorStroke Rehabilitation and Recovery

Running wheel exercise enhances recovery from nigrostriatal dopamine injury without inducing neuroprotection

O’Dell, S.J., Gross, N.B., Fricks, A.N., Casiano, B.D., Nguyen, T.B., Marshall, J.F.·2007·Neuroscience
DOI 10.1016/j.neuroscience.2006.10.042
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Abstract

Forced use of the forelimb contralateral to a unilateral injection of the dopaminergic neurotoxin 6-hydroxydopamine can promote recovery of motor function in that limb and can significantly decrease damage to dopamine terminals. The present study was conducted to determine (1) whether a form of voluntary exercise, wheel running, would improve motor performance in rats with such lesions, and (2) whether any beneficial effects of wheel running are attributable to ameliorating the dopaminergic damage. In experiment 1, rats were allowed to run in exercise wheels or kept in home cages for 2 1/2 weeks, then given stereotaxic infusions of 6-hydroxydopamine into the left striatum. The rats were replaced into their original environments (wheels or home cages) for four additional weeks, and asymmetries in forelimb use were quantified at 3, 10, 17, and 24 days postoperatively. After killing, dopaminergic damage was assessed by both quantifying 3 beta-(4-iodophenyl)tropan-2 beta-carboxylic acid methyl ester ([(125)I]RTI-55) binding to striatal dopamine transporters and counting tyrosine hydroxylase-positive cells in the substantia nigra. Exercised 6-hydroxydopamine-infused rats showed improved motor outcomes relative to sedentary lesioned controls, effects that were most apparent at postoperative days 17 and 24. Despite this behavioral improvement, 6-hydroxydopamine-induced loss of striatal dopamine transporters and tyrosine hydroxylase-positive nigral cells in exercised and sedentary groups did not differ. Since prior studies suggested that forced limb use improves motor performance by sparing nigrostriatal dopaminergic neurons from 6-hydroxydopamine damage, experiment 2 used a combined regimen of forced plus voluntary wheel running. Again, we found that the motor performance of exercised rats improved more rapidly than that of sedentary controls, but that there were no differences between these groups in the damage produced by 6-hydroxydopamine. It appears that voluntary exercise can facilitate recovery from partial nigrostriatal injury, but it does so without evident sparing of dopamine nerve terminals.

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  • In these toxin models, neuroprotection has been principally attributed to an exercise-induced increase of neurotrophic factors such as brain-derived neurotrophic factor or glial-derived neurotrophic factor.

    “In these toxin models, neuroprotection has been principally attributed to an exercise-induced increase of neurotrophic factors such as brain-derived neurotrophic factor (BDNF) or glial-derived neurotrophic factor (GDNF) 78–81.”

    From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [79]

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Authors
O’Dell, S. J., Gross, N. B., Fricks, A. N., Casiano, B. D., Nguyen, T. B., & Marshall, J. F.
Affiliations
University of California, Irvine (US)
Corresponding author
O’Dell, S.J.
ORCID
Marshall, J.F.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2007-02
Volume
144
Issue
3
Pages
1141-1151
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2006.10.042
OpenAlex
W2007442312
Cited by
118
References
51
Citations by year
2024: 5 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 2 · 2015: 7 · 2014: 12 · 2013: 18 · 2012: 6
FWCI
2.78
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS22698, R01NS022698)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Keywords
voluntary wheel running, physical activity, 6-hydroxydopamine, motor recovery, dopamine transporter, tyrosine hydroxylase, substantia nigra, striatum, neuroprotection, Parkinson's disease model
MeSH terms
Animals, Binding, Competitive, Cell Survival, Cocaine, Corpus Striatum, Dopamine, Exercise Therapy, Male, Nerve Degeneration, Neural Pathways, Physical Conditioning, Animal, Substantia Nigra, Tyrosine 3-Monooxygenase, Volition, Up-Regulation, Oxidopamine, Treatment Outcome, Rats, Sprague-Dawley, Cytoprotection, Recovery of Function, Parkinsonian Disorders, Dopamine Plasma Membrane Transport Proteins, Rats

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