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Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease
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Studies have indicated that the levels of expression of AQP4 increased in mouse models of AD and in humans with the disease, a situation that may favor the reported disturbances in water homeostasis and increased BBB permeability.
“Studies have indicated that the levels of expression of AQP4 increased in mouse models of AD and in humans with the disease, a situation that may favor the reported disturbances in water homeostasis and increased BBB permeability (Wilcock et al. 2009).”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Wilcock et al. 2009
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Cites
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994
Neurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213
Davis, J., Xu, F., Deane, R., Romanov, G., Previti, M. L., Zeigler, K., Zlokovic, B. V., & Van Nostrand, W. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312946200 · Cited by 373
The role of neuronal signaling in controlling cerebral blood flow
DRAKE, C., & IADECOLA, C. (2007) · Brain and Language · doi:10.1016/j.bandl.2006.08.002 · Cited by 177
Flagged first, then by citations
Research works printed but not linked: 52
- Abbott, 2002, Astrocyte-endothelial interactions and blood-brain barrier permeability, J Anat, 200, 629, 10.1046/j.1469-7580.2002.00064.x · DOI · Paper page
- Akiguchi, 1997, Alterations in glia and axons in the brains of Binswanger's disease patients, Stroke, 28, 1423, 10.1161/01.STR.28.7.1423 · DOI
- Amiry-Moghaddam, 2003, An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain, Proc Natl Acad Sci U S A, 100, 2106, 10.1073/pnas.0437946100 · DOI · Paper page
- Amiry-Moghaddam, 2003, Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice, Proc Natl Acad Sci U S A, 100, 13615, 10.1073/pnas.2336064100 · DOI
- Badaut, 2002, Aquaporins in brain: distribution, physiology, and pathophysiology, J Cereb Blood Flow Metab, 22, 367, 10.1097/00004647-200204000-00001 · DOI
- Carre-Pierrat, 2006, The SLO-1 BK channel of Caenorhabditis elegans is critical for muscle function and is involved in dystrophin-dependent muscle dystrophy, J Mol Biol, 358, 387, 10.1016/j.jmb.2006.02.037 · DOI
- Colton, 2006, Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD, J Neuroinflammation, 3, 27, 10.1186/1742-2094-3-27 · DOI · Paper page
- Colton, 2006, NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease, Proc Natl Acad Sci U S A, 103, 12867, 10.1073/pnas.0601075103 · DOI · Paper page
- Connors, 2004, The potassium channel Kir41 associates with the dystrophin-glycoprotein complex via alpha-syntrophin in glia, J Biol Chem, 279, 28387, 10.1074/jbc.M402604200 · DOI
- Davis, 2006, Deficient cerebral clearance of vasculotropic mutant Dutch/Iowa double A beta in human A betaPP transgenic mice, Neurobiol Aging, 27, 946, 10.1016/j.neurobiolaging.2005.05.031 · DOI
- de la Torre, 2002, Alzheimer disease as a vascular disorder: nosological evidence, Stroke, 33, 1152, 10.1161/01.STR.0000014421.15948.67 · DOI
- Djukic, 2007, Conditional knock-out of Kir41 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation, J Neurosci, 27, 11354, 10.1523/JNEUROSCI.0723-07.2007 · DOI
- Eid, 2005, Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus, Proc Natl Acad Sci U S A, 102, 1193, 10.1073/pnas.0409308102 · DOI
- Filosa, 2006, Local potassium signaling couples neuronal activity to vasodilation in the brain, Nat Neurosci, 9, 1397, 10.1038/nn1779 · DOI
- Fort, 2008, Kir41 and AQP4 associate with Dp71- and utrophin-DAPs complexes in specific and defined microdomains of Muller retinal glial cell membrane, Glia, 56, 597, 10.1002/glia.20633 · DOI
- Frydenlund, 2006, Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice, Proc Natl Acad Sci U S A, 103, 13532, 10.1073/pnas.0605796103 · DOI
- Gordon, 2007, Astrocyte control of the cerebrovasculature, Glia, 55, 1214, 10.1002/glia.20543 · DOI
- Higashi, 2001, An inwardly rectifying K(+) channel, Kir41, expressed in astrocytes surrounds synapses and blood vessels in brain, Am J Physiol Cell Physiol, 281, C922, 10.1152/ajpcell.2001.281.3.C922 · DOI
- Horiuchi, 2002, Mechanism of extracellular K+-induced local and conducted responses in cerebral penetrating arterioles, Stroke, 33, 2692, 10.1161/01.STR.0000034791.52151.6B · DOI
- Hsiao, 1996, Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice, Science, 274, 99, 10.1126/science.274.5284.99 · DOI · Paper page
- Iandiev, 2006, Differential regulation of Kir41 and Kir21 expression in the ischemic rat retina, Neurosci Lett, 396, 97, 10.1016/j.neulet.2005.11.016 · DOI
- Jancsik, 1999, The demonstration of immunoreactive dystrophin and its developmental expression in perivascular astrocytes, Brain Res, 831, 200, 10.1016/S0006-8993(99)01445-6 · DOI
- Kalaria, 1999, Overlap between pathology of Alzheimer disease and vascular dementia, Alzheimer Dis Assoc Disord, 13, S115, 10.1097/00002093-199912003-00017 · DOI
- Knot, 1996, Extracellular K(+)-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K(+) channels, J Physiol, 492, 419, 10.1113/jphysiol.1996.sp021318 · DOI
- Kofuji, 2004, Potassium buffering in the central nervous system, Neuroscience, 129, 1045, 10.1016/j.neuroscience.2004.06.008 · DOI
- Lozsadi, 2006, Prevalence and causes of seizures at the time of diagnosis of probable Alzheimer's disease, Dement Geriatr Cogn Disord, 22, 121, 10.1159/000093664 · DOI
- Mendez, 1994, Seizures in Alzheimer's disease: clinicopathologic study, J Geriatr Psychiatry Neurol, 7, 230, 10.1177/089198879400700407 · DOI
- Milner, 2008, The rapid decrease in astrocyte-associated dystroglycan expression by focal cerebral ischemia is protease-dependent, J Cereb Blood Flow Metab, 28, 812, 10.1038/sj.jcbfm.9600585 · DOI
- Mulligan, 2004, Calcium transients in astrocyte endfeet cause cerebrovascular constrictions, Nature, 431, 195, 10.1038/nature02827 · DOI
- Nagelhus, 1999, Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Muller cells is mediated by a coenrichment of Kir41 and AQP4 in specific membrane domains, Glia, 26, 47, 10.1002/(SICI)1098-1136(199903)26:1<47::AID-GLIA5>3.0.CO;2-5 · DOI
- Neely, 2001, Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein, Proc Natl Acad Sci U S A, 98, 14108, 10.1073/pnas.241508198 · DOI
- Newman, 1986, High potassium conductance in astrocyte endfeet, Science, 233, 453, 10.1126/science.3726539 · DOI
- Newman, 1984, Control of extracellular potassium levels by retinal glial cell K+ siphoning, Science, 225, 1174, 10.1126/science.6474173 · DOI
- Nicoll, 2004, Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease, Neurobiol Aging, 25, 589, 10.1016/j.neurobiolaging.2004.02.003 · DOI
- Orkand, 1966, Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of Amphibia, J Neurophysiol, 29, 788, 10.1152/jn.1966.29.4.788 · DOI
- Pannicke, 2004, A potassium channel-linked mechanism of glial cell swelling in the postischemic retina, Mol Cell Neurosci, 26, 493, 10.1016/j.mcn.2004.04.005 · DOI
- Price, 2002, Distribution of rSlo Ca2+-activated K+ channels in rat astrocyte perivascular endfeet, Brain Res, 956, 183, 10.1016/S0006-8993(02)03266-3 · DOI
- Rusznak, 2004, Differential distribution of task-1, task-2 and task-3 immunoreactivities in the rat and human cerebellum, Cell Mol Life Sci, 61, 1532, 10.1007/s00018-004-4082-3 · DOI
- Smart, 1997, Identification of the delayed rectifier potassium channel, Kv16, in cultured astrocytes, Glia, 20, 127, 10.1002/(SICI)1098-1136(199706)20:2<127::AID-GLIA4>3.0.CO;2-6 · DOI
- Stansfeld, 2008, Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations, Biochemistry, 47, 7414, 10.1021/bi800475j · DOI
- Takano, 2006, Astrocyte-mediated control of cerebral blood flow, Nat Neurosci, 9, 260, 10.1038/nn1623 · DOI
- Taverna, 2005, Differential expression of TASK channels between horizontal interneurons and pyramidal cells of rat hippocampus, J Neurosci, 25, 9162, 10.1523/JNEUROSCI.2454-05.2005 · DOI · Paper page
- Vajda, 2002, Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice, Proc Natl Acad Sci U S A, 99, 13131, 10.1073/pnas.192457099 · DOI
- Wallraff, 2004, Distinct types of astroglial cells in the hippocampus differ in gap junction coupling, Glia, 48, 36, 10.1002/glia.20040 · DOI
- Walz, 2000, Controversy surrounding the existence of discrete functional classes of astrocytes in adult gray matter, Glia, 31, 95, 10.1002/1098-1136(200008)31:2<95::AID-GLIA10>3.0.CO;2-6 · DOI
- Wang, 2008, Mild brain ischemia induces unique physiological properties in striatal astrocytes, Glia, 56, 925, 10.1002/glia.20660 · DOI
- Warth, 2005, Redistribution of the water channel protein aquaporin-4 and the K+ channel protein Kir41 differs in low- and high-grade human brain tumors, Acta Neuropathol, 109, 418, 10.1007/s00401-005-0984-x · DOI
- Wilcock, 2006, Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain, Nat Protoc, 1, 1591, 10.1038/nprot.2006.277 · DOI
- Wilcock, 2008, Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2, J Neurosci, 28, 1537, 10.1523/JNEUROSCI.5066-07.2008 · DOI · Paper page
- Wilcock, 2004, Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition, J Neurosci, 24, 6144, 10.1523/JNEUROSCI.1090-04.2004 · DOI
- Yang, 1995, cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel, J Biol Chem, 270, 22907, 10.1074/jbc.270.39.22907 · DOI
- Zlokovic, 2005, Neurovascular mechanisms of Alzheimer's neurodegeneration, Trends Neurosci, 28, 202, 10.1016/j.tins.2005.02.001 · DOI · Paper page
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“1 and BK, a calcium-sensitive large conductance potassium channel, were low in autopsied human AD brain tissues (Wilcock et al. 2009).”
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Metadata
- Authors
- Wilcock, D. M., Vitek, M. P., & Colton, C. A.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 159
- Issue
- 3
- Pages
- 1055-1069
- ISSN
- 0306-4522
- PMC
- PMC2699894
- Cited by
- 237
- References
- 6
- Language
- en
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