Cited by 119Cerebrospinal fluid and hydrocephalusIon Transport and Channel RegulationTraumatic Brain Injury and Neurovascular Disturbances

Astrogliosis and impaired aquaporin‐4 and dystrophin systems in idiopathic normal pressure hydrocephalus

Eide, P. K., Hansson, H.‐A.·2018·Neuropathology and Applied Neurobiology

Abstract

Aims: Idiopathic normal pressure hydrocephalus (iNPH) is one subtype of dementia that may improve following drainage of cerebrospinal fluid (CSF). This prospective observational study explored whether expression of the water channel aquaporin‐4 (AQP4) and the anchoring molecule dystrophin 71 (Dp71) are altered at astrocytic perivascular endfeet and in adjacent neuropil of iNPH patient. Observations were related to measurements of pulsatile and static intracranial pressure (ICP). Methods: The study included iNPH patients undergoing overnight monitoring of the pulsatile/static ICP in whom a biopsy was taken from the frontal cerebral cortex during placement of the ICP sensor. Reference (Ref) biopsies were sampled from 13 patients who underwent brain surgery for epilepsy, tumours or cerebral aneurysms. The brain tissue specimens were examined by light microscopy, immunohistochemistry, densitometry and morphometry. Results: iNPH patients responding to surgery ( n = 44) had elevated pulsatile ICP, indicative of impaired intracranial compliance. As compared to the Ref patients, the cortical biopsies of iNPH patients revealed prominent astrogliosis and reduced expression of AQP4 and Dp71 immunoreactivities in the astrocytic perivascular endfeet and in parts of the adjacent neuropil. There was a significant correlation between degree of astrogliosis and reduction of AQP4 and Dp71 at astrocytic perivascular endfeet. Conclusions: Idiopathic normal pressure hydrocephalus patients responding to CSF diversion present with abnormal pulsatile ICP, indicative of impaired intracranial compliance. A main histopathological finding was astrogliosis and reduction of AQP4 and of Dp71 in astrocytic perivascular endfeet. We propose that the altered AQP4 and Dp71 complex contributes to the subischaemia prevalent in the brain tissue of iNPH.

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Crossref · 10.1111/nan.12420

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Authors
Eide, P. K., & Hansson, H. ‐.
Affiliations
  • Oslo University Hospital (NO)
  • University of Gothenburg (SE)
Corresponding author
Eide, P. K.
Venue
Neuropathology and Applied Neurobiology
Publisher
Wiley
Published
2017-07-19
Volume
44
Issue
5
Pages
474-490
ISSN
  • 0305-1846 (ISSN-L)
  • 1365-2990
OpenAlex
W2664710281
Cited by
119
References
64
Citations by year
2026: 13 · 2025: 18 · 2024: 14 · 2023: 18 · 2022: 18 · 2021: 13 · 2020: 7 · 2019: 9 · 2018: 7 · 2017: 2
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropathology and Applied Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Stiftelserna Wilhelm och Martina Lundgrens
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
idiopathic normal pressure hydrocephalus, astrocyte activation, aquaporin-4, intracranial compliance, cerebrospinal fluid drainage
MeSH terms
Aged, Female, Gliosis, Humans, Hydrocephalus, Normal Pressure, Male, Middle Aged, Dystrophin, Aquaporin 4

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