The Many Faces of Astrocytes in Alzheimer's Disease
Open accessAbstract
Alzheimer's disease (AD) is a progressive neurodegenerative disease and is the most common cause of dementia in an aging population. The majority of research effort has focused on the role of neurons in neurodegeneration and current therapies have limited ability to slow disease progression. Recently more attention has been given to the role of astrocytes in the process of neurodegeneration. Specifically, reactive astrocytes have both advantageous and adverse effects during neurodegeneration. The ability to isolate and depict astrocyte phenotype has been challenging. However, with the recent development of single-cell sequencing technologies researchers are provided with the resource to delineate specific biomarkers associated with reactive astrocytes in AD. In this review, we will focus on the role of astrocytes in normal conditions and the pathological development of AD. We will further review recent developments in the understanding of astrocyte heterogeneity and associated biomarkers. A better understanding of astrocyte contributions and phenotypic changes in AD can ultimately lead to more effective therapeutic targets.
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Glial cells are the primary cells involved in neuroinflammation and neurodegeneration.
“As we have discussed above, glial cells are the primary cells involved in neuroinflammation and neurodegeneration. Their crucial function in the development and progression of neurodegenerative diseases has also been elaborated in many reviews in the past year.275,468,469”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [468]
In “Astrocytes in Alzheimer’s Disease” (page unavailable), the review calls microglia the primary inflammatory cells of the CNS and describes astrocyte involvement in neuroinflammation and Alzheimer’s pathology. It does not establish that glial cells as a whole are the primary cells involved in neurodegeneration across diseases. (LLM, conf=0.83)
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- Authors
- Monterey, M. D., Wei, H., Wu, X., & Wu, J. Q.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Wu, Jia Qian
- Venue
- Frontiers in Neurology
- Publisher
- Frontiers Media SA
- Published
- 2021-08-31
- Volume
- 12
- Pages
- 619626-619626
- ISSN
- 1664-2295 (ISSN-L)
- PMC
- PMC8438135
- OpenAlex
- W3197066362
- Cited by
- 117
- References
- 127
- Citations by year
- 2026: 12 · 2025: 27 · 2024: 34 · 2023: 29 · 2022: 15
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neurology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Eye Institute (R21EY028647)
- National Institute of Neurological Disorders and Stroke (R21NS113068, R01NS088353)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Alzheimer's disease, astrocytes, reactive astrocytes, astrocyte heterogeneity, neurodegeneration, single-cell sequencing, therapeutic target
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