BDNF genotype moderates the relation between physical activity and depressive symptoms.
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OBJECTIVE: To test whether the BDNF gene interacts with exercise to predict depressive symptoms. Physical activity is associated with a range of positive health outcomes, including fewer depressive symptoms. One plausible mechanism underlying these findings involves Brain-Derived Neurotrophic Factor (BDNF), a protein hypothesized to limit or repair the damage caused by stress. Physical activity increases expression of BDNF, which may enhance brain health. BDNF expression is controlled by the BDNF gene. Compared with individuals without a BDNF met allele, met-allele carriers have a lower expression of BDNF, which has been associated with Major Depressive Disorder. DESIGN: Eighty-two healthy adolescent girls were genotyped for the BDNF val66met polymorphism, and their depressive symptoms and physical activity were assessed using questionnaires. MAIN OUTCOME MEASURES: BDNF genotype, Children's Depression Inventory, and the Physical Activity Questionnaire for Older Children and Adolescents. RESULTS: The BDNF polymorphism was found to moderate the relation between exercise and depressive symptoms: being physically active was protective for girls with a BDNF met allele (fewer depressive symptoms) but not for girls with the val/val polymorphism. CONCLUSION: By integrating psychological and biological factors, the present study enhances our understanding of how physical activity contributes to resilience to psychopathology.
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Adolescent girls with an allele for high BDNF received no protective effects against depression and anxiety symptoms by avoiding physical inactivity, while those with the allele causing lower BDNF level were protected.
“Lastly, adolescent girls with an allele for high BDNF received no protective effects against depression and anxiety symptoms by avoiding physical inactivity, while those with the allele causing lower BDNF level were protected (330).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [330]
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- Authors
- Mata, J., Thompson, R. J., & Gotlib, I. H.
- Affiliations
- Stanford University (US)
- Venue
- Health Psychology
- Published
- 2010
- Volume
- 29
- Issue
- 2
- Pages
- 130-133
- ISSN
- 0278-6133 (ISSN-L)
- 1930-7810
- PMC
- PMC2847262
- OpenAlex
- W2096111444
- Cited by
- 119
- References
- 49
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 11 · 2013: 11 · 2012: 16
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Health Psychology (publishedVersion)
- PubMed (publishedVersion)
- MADOC (University of Mannheim) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Fundaçã para a Ciência e a Tecnologia (SFRH/BPD/35953/2007)
- Deutsche Forschungsgemeinschaft (Wi3496/41)
- National Institute of Mental Health (MH74849)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, physical activity, depressive symptoms, gene-environment interaction, adolescents, girls, major depressive disorder
- MeSH terms
- Adolescent, Alleles, Child, Depression, Female, Gene Frequency, Genotype, Humans, Motor Activity, Personality Inventory, Polymorphism, Genetic, Exercise, Brain-Derived Neurotrophic Factor
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