Functional neuroanatomy of the parahippocampal region: The lateral and medial entorhinal areas
Abstract
The entorhinal cortex (EC) serves a pivotal role in corticohippocampal interactions, but a complete description of its extrinsic connections has not been presented. Here, we have summarized the cortical, subcortical, and hippocampal connections of the lateral entorhinal area (LEA) and the medial entorhinal area (MEA) in the rat. We found that the targets and relative strengths of the entorhinal connections are strikingly different for the LEA and MEA. For example, the LEA receives considerably heavier input from the piriform and insular cortices, whereas the MEA is more heavily targeted by the visual, posterior parietal, and retrosplenial cortices. Regarding subcortical connections, the LEA receives heavy input from the amygdala and olfactory structures, whereas the MEA is targeted by the dorsal thalamus, primarily the midline nuclei and also the dorsolateral and dorsoanterior thalamic nuclei. Differences in the LEA and MEA connections with hippocampal and parahippocampal structures are also described. In addition, because the EC is characterized by bands of intrinsic connectivity that span the LEA and MEA and project to different septotemporal levels of the dentate gyrus, special attention was paid to the efferents and afferents of those bands. Finally, we summarized the connections of the dorsocaudal MEA, the region in which the entorhinal "grid cells" were discovered. The subregional differences in entorhinal connectivity described here provide further evidence for functio…
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EC provides output to the subiculum, while receives inputs from the sensory cortex including the visual cortex.
“EC provide output to the subiculum ( O'Mara, 2005), while receives inputs from the sensory cortex including the visual cortex (Kerr et al., 2007).”
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“EC provide output to the subiculum (O’Mara, 2005), while receives inputs from the sensory cortex including the visual cortex (Kerr et al., 2007).”
Background
- Authors
- Kerr, K. M., Agster, K. L., Furtak, S. C., & Burwell, R. D.
- Affiliations
- Brown University (US)
- Corresponding author
- Burwell, Rebecca D.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2007-07-02
- Volume
- 17
- Issue
- 9
- Pages
- 697-708
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2068134369
- Cited by
- 433
- References
- 0
- Citations by year
- 2026: 18 · 2025: 19 · 2024: 26 · 2023: 24 · 2022: 22 · 2021: 39 · 2020: 18 · 2019: 21 · 2018: 18 · 2017: 24 · 2016: 22 · 2015: 24 · 2014: 22 · 2013: 33 · 2012: 26
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- entorhinal cortex, parahippocampal region, intrinsic functional connectivity, dentate gyrus, amygdala, thalamus, piriform cortex, insula, grid cells, functional diversity, learning and memory, rats
- MeSH terms
- Animals, Models, Biological, Neural Pathways, Neuroanatomy, Parahippocampal Gyrus, Rats
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