Distinct roles of medial and lateral entorhinal cortex in spatial cognition
Abstract
It is known that the entorhinal cortex plays a crucial role in spatial cognition in rodents. Neuroanatomical and electrophysiological data suggest that there is a functional distinction between 2 subregions within the entorhinal cortex, the medial entorhinal cortex (MEC), and the lateral entorhinal cortex (LEC). Rats with MEC or LEC lesions were trained in 2 navigation tasks requiring allothetic (water maze task) or idiothetic (path integration) information processing and 2-object exploration tasks allowing testing of spatial and nonspatial processing of intramaze objects. MEC lesions mildly affected place navigation in the water maze and produced a path integration deficit. They also altered the processing of spatial information in both exploration tasks while sparing the processing of nonspatial information. LEC lesions did not affect navigation abilities in both the water maze and the path integration tasks. They altered spatial and nonspatial processing in the object exploration task but not in the one-trial recognition task. Overall, these results indicate that the MEC is important for spatial processing and path integration. The LEC has some influence on both spatial and nonspatial processes, suggesting that the 2 kinds of information interact at the level of the EC.
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Impaired spatial recognition was also reported in LEC-lesioned rats tested by the SNOP paradigm.
“Impaired spatial recognition was also reported in the LEC-lesioned rats tested by the SNOP paradigm (Van Cauter et al., 2013), but see (Rodo et al., 2017).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Van Cauter et al., 2013
Lesions of the LEC did not affect OPP memory, but impaired object-location recognition in a test in which two distinct objects were replaced by two identical ones, chosen from either of the explored type.
“Lesions of the LEC, on the other hand, did not affect OPP memory (Van Cauter et al., 2013; Wilson et al., 2013c), but impaired object-location recognition in a test in which two distinct objects were replaced by two identical ones, chosen from either of the explored type (Wilson et al., 2013c).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Van Cauter et al., 2013
In an OPP-like paradigm to test spatial object exploration, memory was disrupted in animals with lesion of the MEC, but not LEC.
“In an OPP-like paradigm to test spatial (where) object exploration, in which a single object was presented in the sample trial and another identical object was placed together with the familiar one in the test trial, memory was disrupted in animals with lesion of the MEC, but not LEC (Van Cauter et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Van Cauter et al., 2013
In the SNOP test, impaired spatial recognition was found after lesion of the MEC.
“In the SNOP test, impaired spatial recognition was found after lesion of the MEC (Rodo et al., 2017; Van Cauter et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Van Cauter et al., 2013
In the SNOP test, object recognition was compromised when four distinct, but not identical, objects were required to be remembered by LEC-lesioned rats.
“Evidence from the SNOP test has supported this perspective, as object recognition was compromised when four distinct, but not identical, objects were required to be remembered by LEC lesioned rats (Rodo et al., 2017; Van Cauter et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Van Cauter et al., 2013
Lesions of the LEC of rats spared memory in the classic NOP test, but impaired object memory when 3 or 4 distinct objects were used during the learning.
“In non-spatial (what) object exploration tests, lesions of the LEC of rats spared memory in the classic NOP test (Kuruvilla and Ainge, 2017; Van Cauter et al., 2013; Wilson et al., 2013b; Wilson et al., 2013c), but impaired object memory when 3 or 4 distinct objects were used during the learning (Hunsaker et al., 2013; Kuruvilla and Ainge, 2017).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Van Cauter et al., 2013
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- Authors
- Van Cauter, T., Camon, J., Alvernhe, A., Elduayen, C., Sargolini, F., & Save, E.
- Affiliations
- Charles Darwin University (AU)
- Institute of Science and Technology Austria (AT)
- Aix-Marseille Université (FR)
- Laboratoire de Neurosciences Cognitives (FR)
- ORCID
- Sargolini, F.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-02-22
- Volume
- 23
- Issue
- 2
- Pages
- 451-459
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2128520379
- Cited by
- 196
- References
- 48
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 18 · 2023: 12 · 2022: 12 · 2021: 15 · 2020: 12 · 2019: 13 · 2018: 11 · 2017: 19 · 2016: 12 · 2015: 14 · 2014: 20 · 2013: 14
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Institute of Science and Technology Austria (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- medial entorhinal cortex, lateral entorhinal cortex, entorhinal cortex, spatial cognition, path integration, place navigation, water maze, object exploration, object recognition, lesion studies, rats
- MeSH terms
- Animals, Cognition, Exploratory Behavior, Male, Space Perception, Spatial Behavior, Entorhinal Cortex, Maze Learning, Rats, Long-Evans, Rats
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