Infusion of protein synthesis inhibitors in the entorhinal cortex blocks consolidation but not reconsolidation of object recognition memory

Lima, Ramón H.; Rossato, Janine I.; Furini, Cristiane R.; Bevilaqua, Lia R.; Izquierdo, Iván; Cammarota, Martín

doi:10.1016/j.nlm.2008.12.009

Cited by 49Memory and Neural MechanismsMemory Processes and InfluencesSleep and Wakefulness Research

Infusion of protein synthesis inhibitors in the entorhinal cortex blocks consolidation but not reconsolidation of object recognition memory

Lima, Ramón H., Rossato, Janine I., Furini, Cristiane R., Bevilaqua, Lia R., Izquierdo, Iván, Cammarota, Martín·2009·Neurobiology of Learning and Memory

DOI 10.1016/j.nlm.2008.12.009

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Abstract

Memory consolidation and reconsolidation require the induction of protein synthesis in some areas of the brain. Here, we show that infusion of the protein synthesis inhibitors anisomycin, emetine and cycloheximide in the entorhinal cortex immediately but not 180 min or 360 min after training in an object recognition learning task hinders long-term memory retention without affecting short-term memory or behavioral performance. Inhibition of protein synthesis in the entorhinal cortex after memory reactivation involving either a combination of familiar and novel objects or two familiar objects does not affect retention. Our data suggest that protein synthesis in the entorhinal cortex is necessary early after training for consolidation of object recognition memory. However, inhibition of protein synthesis in this cortical region after memory retrieval does not seem to affect the stability of the recognition trace.

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The disruption of NOP memory by intra-EC protein synthesis inhibitors was time-dependent, found when infusions were made immediately, but not 3 or 6 hours, after the sample.
“This disruption was time-dependent as the effect was found when infusions were made immediately, but not 3 or 6 hours, after the sample (Lima et al., 2009).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Lima et al., 2009
Post-sample intra-EC infusions of the protein synthesis inhibitors anisomycin, emetine or cycloheximide disrupted long-term (24 hours), but not short-term (3 hours), NOP memory.
“Post-sample intra-EC infusions of the protein synthesis inhibitors, anisomycin, emetine or cycloheximide, disrupted long-term (24 hours), but not short-term (3 hours), NOP memory.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Lima et al., 2009
The whole EC is likely to engage in long-term object memory, given that EC-lesioned or inactivated animals exhibited deficits in the NOP test when tested 24 hours later.
“The whole EC is likely to engage in long-term object memory, given that EC-lesioned or inactivated animals exhibited deficits in the NOP test when tested 24 hours later (Lima et al., 2009; Nyakas et al., 2009).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Lima et al., 2009

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Authors: Lima, R. H., Rossato, J. I., Furini, C. R., Bevilaqua, L. R., Izquierdo, I., & Cammarota, M.
Affiliations: Instituto do Cérebro (BR)
ORCID: Rossato, Janine I.
Furini, Cristiane R.
Bevilaqua, Lia R.
Izquierdo, Iván
Venue: Neurobiology of Learning and Memory
Publisher: Elsevier BV
Published: 2009-05
Volume: 91
Issue: 4
Pages: 466-472
ISSN: 1074-7427 (ISSN-L)
DOI: 10.1016/j.nlm.2008.12.009
OpenAlex: W2084582233
Cited by: 49
References: 78
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 5
FWCI: 1.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Learning and Memory (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: protein synthesis, entorhinal cortex, memory consolidation, memory reconsolidation, object recognition memory, anisomycin, emetine, cycloheximide, memory reactivation, long-term memory retention, short-term memory
MeSH terms: Animals, Anisomycin, Cycloheximide, Emetine, Male, Memory, Short-Term, Protein Synthesis Inhibitors, Rats, Wistar, Entorhinal Cortex, Recognition, Psychology, Pattern Recognition, Physiological, Rats

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Infusion of protein synthesis inhibitors in the entorhinal cortex blocks consolidation but not reconsolidation of object recognition memory

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