Cited by 97Cannabis and Cannabinoid ResearchMemory and Neural MechanismsMemory Processes and Influences

Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory

Clarke, Julia R., Rossato, Janine I., Monteiro, Siomara, Bevilaqua, Lia R.M., Izquierdo, Iván, Cammarota, Martín·2008·Neurobiology of Learning and Memory

Abstract

Evidence indicates that brain endocannabinoids are involved in memory processing. However, the participation of CB1 and CB2 cannabinoid receptors in recognition memory has not been yet conclusively determined. Therefore, we evaluated the effect of the posttraining activation of hippocampal cannabinoid receptors on the consolidation of object recognition memory. Rats with infusion cannulae stereotaxically aimed to the CA1 region of the dorsal hippocampus were trained in an object recognition learning task involving exposure to two different stimulus objects. Memory retention was assessed at different times after training. In the test sessions, one of the objects presented during training was replaced by a novel one. When infused in the CA1 region immediately after training, the non-selective cannabinoid receptor agonist WIN-55,212-2 and the endocannabinoid membrane transporter inhibitor VDM-11 blocked long-term memory retention in a dose-dependent manner without affecting short-term memory, exploratory behavior, anxiety state or the functionality of the hippocampus. The amnesic effect of WIN-55,212-2 and VDM-11 was not due to state-dependency and was completely reversed by co-infusion of the CB1 receptor antagonist AM-251 and mimicked by the CB1 receptor agonist ACEA but not by the CB2 receptor agonists JWH-015 and palmitoylethanolamide. Our data indicate that activation of hippocampal CB1 receptors early after training hampers consolidation of object recognition memory.

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Crossref · 10.1016/j.nlm.2008.04.009

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Authors
Clarke, J. R., Rossato, J. I., Monteiro, S., Bevilaqua, L. R. M., Izquierdo, I., & Cammarota, M.
Affiliations
  • Pontifícia Universidade Católica do Rio Grande do Sul (BR)
  • Centro Universitário Metodista IPA (BR)
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
2008-09
Volume
90
Issue
2
Pages
374-381
ISSN
1074-7427 (ISSN-L)
OpenAlex
W2087674179
Cited by
97
References
76
Citations by year
2026: 1 · 2025: 4 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 12 · 2013: 5 · 2012: 9
FWCI
5.85
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Universidade Federal do Rio Grande do Sul
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
CB1 receptor, CB2 receptor, object recognition memory, long-term memory consolidation, dorsal hippocampus, CA1 region, WIN 55,212-2, AM251, ACEA, JWH-015, palmitoylethanolamide, endocannabinoids, memory impairment
MeSH terms
Animals, Arachidonic Acids, Avoidance Learning, Dominance, Cerebral, Dose-Response Relationship, Drug, Electroshock, Escape Reaction, Exploratory Behavior, Fear, Hippocampus, Male, Memory, Short-Term, Morpholines, Motor Activity, Naphthalenes, Pattern Recognition, Visual, Retention, Psychology, Rats, Wistar, Maze Learning, Receptor, Cannabinoid, CB1, Benzoxazines, Rats

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